Download NU-27 FEEDING REDUCED PROTEIN AND PHOSPHORUS FOOD

NU-27
FEEDING REDUCED PROTEIN AND PHOSPHORUS FOOD TO DOGS WITH
NATURALLY OCCURING RENAL DISEASE REDUCES SERUM CONCENTRATIONS OF
CREATININE AND SYMMETRIC DIMETHYLARGININE (SDMA).
D.E. Jewell a, D. Fritsch a, M. Yerramilli b, E. Obare b,
M. Yerramilli b, J.A. Hall c.
a Hill’s Pet Nutrition, Inc., Science and Technology Center, Topeka, KS, b IDEXX Laboratories,
Inc., One IDEXX Drive, Westbrook, Maine, c Department of Biomedical Sciences, Oregon State
University, Corvallis, OR.
Sixty two dogs with variable renal function, defined by serum blood urea nitrogen (BUN) and
creatinine concentrations, urine protein to creatinine ratio, and urine specific gravity (USG) sub2014 ACVIM Abstracts
sequently had serum concentrations of SDMA evaluated initially and up to 12 months later while
being fed a renal protective food (Prescription Diet k/d_). The study protocol was reviewed and
approved by the Institutional Animal Care and Use Committee, Hill’s Pet Nutrition, Inc., Topeka,
KS. All dogs were maintained in their owner’s home throughout the length of the study. There was a
significant correlation between serum SDMA and serum creatinine (r = 0.78, p < 0.0001) and BUN (r
= 0.69, p < 0.0001) concentrations, as well as between serum SDMA concentration and USG (r =
-0.28, p < 0.0002). Serum creatinine concentration was significantly correlated to BUN
concentration (r = 0.68, p < 0001), and USG (r = -0.19, p < 0.01). There was a significant correlation
between the change in serum SDMA and change in serum creatinine (r = 0.88, p < 0.0001) as well as
the change in SDMA and change in BUN (r = 0.92, p < 0.0001). The change in serum creatinine was
also significantly correlated to change in BUN (r = 0.90, p < 0.0001). There was a linear time-on-food
related decline (p < 0.05) in serum SDMA concentration. Normal dogs had a small reduction in
serum SDMA concentration (15%decline) in the first month, whereas dogs with severe loss of renal
function had a 36% reduction in SDMA concentration during the first month. This study shows that
serum SDMA concentra-tion is a sensitive indicator of change in renal function, and decreases in
dogs with renal disease that are fed a food with reduced protein and phosphorus content.