Download Additional Data Table 32

Table S36. Canonical signaling pathways populated by extracted phosphoproteins
unique to non-stimulated or MeCh-stimulated CMP-state SH-SY5Y cells. Significantly
populated canonical signaling pathways, unique to a specific stimulation condition (nonstimulated or with a specific MeCh dose) are listed. Canonical signaling pathways were
considered enriched only if at least two proteins were present in each signaling pathway
and with a probability of ≤0.05. Hybrid signaling pathway scores indicated were
generated by multiplication of the pathway enrichment ratio with the negative log10 of the
probability result.
Canonical signaling pathway
Hybrid
10nM MeCh
100nM MeCh
Endothelin-1 Signaling
Role of BRCA1 in DNA Damage Response
Synaptic Long Term Depression
Thrombin Signaling
Cellular Effects of Sildenafil (Viagra)
Mitotic Roles of Polo-Like Kinase
18.6
14.7
13.6
10.5
7.86
5.72
1μM MeCh
Bladder Cancer Signaling
Neuregulin Signaling
Glycine, Serine and Threonine Metabolism
Leukocyte Extravasation Signaling
6.64
6.49
3.24
2.84
10μM MeCh
Systemic Lupus Erythematosus Signaling
Thrombopoietin Signaling
iCOS-iCOSL Signaling in T Helper Cells
IL-4 Signaling
Renal Cell Carcinoma Signaling
IL-3 Signaling
Ceramide Signaling
April Mediated Signaling
B Cell Activating Factor Signaling
IGF-1 Signaling
HMGB1 Signaling
EGF Signaling
Neuropathic Pain Signaling In Dorsal Horn Neurons
T Cell Receptor Signaling
Endometrial Cancer Signaling
IL-2 Signaling
CD28 Signaling in T Helper Cells
Angiopoietin Signaling
CD40 Signaling
Erythropoietin Signaling
Neurotrophin/TRK Signaling
Relaxin Signaling
FLT3 Signaling in Hematopoietic Progenitor Cells
Sphingolipid Metabolism
IL-17 Signaling
16.1
15.2
14.5
13.4
12.6
12.4
11.8
11.1
10.7
10.1
9.76
9.48
9.05
9.05
8.6
8.47
8.06
7.4
7.4
7.09
7.09
6.93
6.8
6.61
6.52
LPS-stimulated MAPK Signaling
PDGF Signaling
Prolactin Signaling
Chemokine Signaling
BMP signaling pathway
Aminoacyl-tRNA Biosynthesis
Regulation of Actin-based Motility by Rho
Factors Promoting Cardiogenesis in Vertebrates
Prostate Cancer Signaling
FAK Signaling
Starch and Sucrose Metabolism
Melanocyte Development and Pigmentation Signaling
Linoleic Acid Metabolism
Amyotrophic Lateral Sclerosis Signaling
IL-6 Signaling
SAPK/JNK Signaling
Chronic Myeloid Leukemia Signaling
Role of NFAT in Regulation of the Immune Response
HGF Signaling
Sphingosine-1-phosphate Signaling
Natural Killer Cell Signaling
fMLP Signaling in Neutrophils
IL-12 Signaling and Production in Macrophages
Histidine Metabolism
Actin Cytoskeleton Signaling
G-Protein Coupled Receptor Signaling
Huntington's Disease Signaling
Arachidonic Acid Metabolism
Hepatic Cholestasis
mTOR Signaling
Cardiac Hypertrophy Signaling
Eicosanoid Signaling
Dendritic Cell Maturation
cAMP-mediated Signaling
6.52
6.52
6.52
6.34
6.26
6.16
5.85
5.77
5.77
5.55
5.55
5.48
5.27
5.2
5.14
5.07
4.82
4.72
4.59
4.42
4.31
4.16
4.11
3.78
3.39
3.39
3.29
3.25
3.1
2.99
2.82
2.75
2.44
2.36
100μM MeCh
Aminosugars Metabolism
Lysine Degradation
ß-alanine Metabolism
Propanoate Metabolism
Pantothenate and CoA Biosynthesis
Valine, Leucine and Isoleucine Degradation
VDR/RXR Activation
O-Glycan Biosynthesis
PPARa/RXRa Activation
Fatty Acid Metabolism
13.1
8.96
7.83
7.11
6.57
6.3
5.44
5.2
3.86
2.75