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Chapter 22: Microbial Diseases of the Nervous System The Nervous System Bacterial Diseases Fungal and Protozoan Diseases Prion Diseases Viral Diseases $100 $100 $100 $100 $100 $200 $200 $200 $200 $200 $300 $300 $300 $300 $300 $400 $400 $400 $400 $400 $500 $500 $500 $500 $500 FINAL ROUND © 2013 Pearson Education, Inc. Topic 1: The Nervous System $100 Question In the brain, cerebrospinal fluid flows through the a. b. c. d. subdural space. subarachnoid space. arachnoid mater. pia mater. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $100 Answer In the brain, cerebrospinal fluid flows through the a. b. c. d. subdural space. subarachnoid space. arachnoid mater. pia mater. BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $200 Question What is the order of the layer of meninges from the innermost to the outermost? a. b. c. d. arachnoid mater, dura mater, pia mater dura mater, arachnoid mater, pia mater pia mater, dura mater, arachnoid mater pia mater, arachnoid mater, dura mater ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $200 Answer What is the order of the layer of meninges from the innermost to the outermost? a. b. c. d. arachnoid mater, dura mater, pia mater dura mater, arachnoid mater, pia mater pia mater, dura mater, arachnoid mater pia mater, arachnoid mater, dura mater BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $300 Question Inflammation of the brain is called a. b. c. d. meningitis. encephalitis. neuritis. hydrocephalus. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $300 Answer Inflammation of the brain is called a. b. c. d. meningitis. encephalitis. neuritis. hydrocephalus. BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $400 Question Drugs can cross the blood–brain barrier ONLY if they are a. b. c. d. large-molecular-weight molecules. small-molecular-weight molecules. water-soluble. lipid-soluble. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $400 Answer Drugs can cross the blood–brain barrier ONLY if they are a. b. c. d. large-molecular-weight molecules. small-molecular-weight molecules. water-soluble. lipid-soluble. BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $500 Question Bacteria can grow well in cerebrospinal fluid because it has low levels of circulating antibodies and a. b. c. d. water. glucose. complement. sodium. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 1: The Nervous System $500 Answer Bacteria can grow well in cerebrospinal fluid because it has low levels of circulating antibodies and a. b. c. d. water. glucose. complement. sodium. BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $100 Question In adult patients, about 80% of the cases of bacterial meningitis are now caused by Neisseria meningitidis and a. b. c. d. Haemophilus influenzae type B. Streptococcus pneumoniae. Listeria monocytogenes. Clostridium tetani. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $100 Answer In adult patients, about 80% of the cases of bacterial meningitis are now caused by Neisseria meningitidis and a. b. c. d. Haemophilus influenzae type B. Streptococcus pneumoniae. Listeria monocytogenes. Clostridium tetani. BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $200 Question The manifestations of tetanus are due to a. b. c. d. neurotoxin. leukocidins. hemolysins. coagulase. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $200 Answer The manifestations of tetanus are due to a. b. c. d. neurotoxin. leukocidins. hemolysins. coagulase. BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $300 Question Which gram-positive rod is known to cause stillbirth and neurological disease in animals? a. b. c. d. Listeria monocytogenes Streptococcus pneumoniae Clostridium botulinum Haemophilus influenzae ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $300 Answer Which gram-positive rod is known to cause stillbirth and neurological disease in animals? a. b. c. d. Listeria monocytogenes Streptococcus pneumoniae Clostridium botulinum Haemophilus influenzae BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $400 Question A polysaccharide vaccine that can be much improved by conjugation with protein carriers exists against which form of bacterial meningitis? a. b. c. d. Haemophilus influenzae pneumococcal meningococcal Listeria monocytogenes ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $400 Answer A polysaccharide vaccine that can be much improved by conjugation with protein carriers exists against which form of bacterial meningitis? a. b. c. d. Haemophilus influenzae pneumococcal meningococcal Listeria monocytogenes BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $500 Question Which of the following statements about Mycobacterium leprae is FALSE? a. b. c. d. Patients must be put into isolation. Patients transmit the disease directly. Patients rarely die of the disease. A skin biopsy sample can be used for diagnosis. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $500 Answer Which of the following statements about Mycobacterium leprae is FALSE? a. b. c. d. Patients must be put into isolation. Patients transmit the disease directly. Patients rarely die of the disease. A skin biopsy sample can be used for diagnosis. BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $100 Question Trypanosoma brucei is transmitted by a. b. c. d. tsetse flies. body lice. houseflies. head lice. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $100 Answer Trypanosoma brucei is transmitted by a. b. c. d. tsetse flies. body lice. houseflies. head lice. BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $200 Question Which etiological agent that causes meningitis produces an extremely heavy (thick) polysaccharide capsule? a. b. c. d. Haemophilus influenzae Streptococcus pneumoniae Listeria monocytogenes Cryptococcus neoformans ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $200 Answer Which etiological agent that causes meningitis produces an extremely heavy (thick) polysaccharide capsule? a. b. c. d. Haemophilus influenzae Streptococcus pneumoniae Listeria monocytogenes Cryptococcus neoformans BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $300 Question Which of the following patients are the most susceptible to fungal infections? a. b. c. d. elderly patients infants immunocompromised patients cardiac patients ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $300 Answer Which of the following patients are the most susceptible to fungal infections? a. b. c. d. elderly patients infants immunocompromised patients cardiac patients BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $400 Question Which etiological agent has a mortality rate near 100%, with death occurring within a few days, after symptoms appear? a. b. c. d. Cryptococcus neoformans Acanthamoeba Naegleria fowleri Trypanosoma brucei ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $400 Answer Which etiological agent has a mortality rate near 100%, with death occurring within a few days, after symptoms appear? a. b. c. d. Cryptococcus neoformans Acanthamoeba Naegleria fowleri Trypanosoma brucei BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $500 Question Granulomatous amebic encephalitis is caused by a. b. c. d. Balamuthia mandrillaris. Naegleria fowleri. Trypansoma brucei. Cryptococcus neoformans. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $500 Answer Granulomatous amebic encephalitis is caused by a. b. c. d. Balamuthia mandrillaris. Naegleria fowleri. Trypansoma brucei. Cryptococcus neoformans. BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $100 Question Which of the following diseases is caused by a prion? a. b. c. d. rabies Creutzfeldt-Jakob disease polio wound botulism ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $100 Answer Which of the following diseases is caused by a prion? a. b. c. d. rabies Creutzfeldt-Jakob disease polio wound botulism BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $200 Question A prion is a(n) a. b. c. d. abnormally folded protein. protein subunit. form of a bacterium. viral particle. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $200 Answer A prion is a(n) a. b. c. d. abnormally folded protein. protein subunit. form of a bacterium. viral particle. BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $300 Question Which animal disease is similar to CreutzfeldtJacob disease? a. b. c. d. anthrax sheep scrapie kuru transmissible spongiform encephalopathy ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $300 Answer Which animal disease is similar to CreutzfeldtJacob disease? a. b. c. d. anthrax sheep scrapie kuru transmissible spongiform encephalopathy BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $400 Question One hypothesis of the origin of mad cow disease in cattle is a. cattle feed contaminated with scrapie. b. direct contact with animals infected with scrapie. c. direct contact with other infected species. d. hormones in cattle feed. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $400 Answer One hypothesis of the origin of mad cow disease in cattle is a. cattle feed contaminated with scrapie. b. direct contact with animals infected with scrapie. c. direct contact with other infected species. d. hormones in cattle feed. BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $500 Question What conditions does the WHO recommend to sterilize reusable instruments that might have been exposed to prions? a. strong solution of sulfuric acid with autoclaving at 134°C b. strong solution of sodium hydroxide with autoclaving at 115°C c. strong solution of sulfuric acid with extended autoclaving at 115°C d. strong solution of sodium hydroxide with extended ANSWER autoclaving at 134°C BACK TO GAME © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $500 Answer What conditions does the WHO recommend to sterilize reusable instruments that might have been exposed to prions? a. strong solution of sulfuric acid with autoclaving at 134°C b. strong solution of sodium hydroxide with autoclaving at 115°C c. strong solution of sulfuric acid with extended autoclaving at 115°C d. strong solution of sodium hydroxide with extended autoclaving at 134°C BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $100 Question Which disease has an incubation period that is usually long enough to allow immunity to develop from postexposure vaccination? a. b. c. d. polio rabies Hansen’s disease arboviral encephalitis ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $100 Answer Which disease has an incubation period that is usually long enough to allow immunity to develop from postexposure vaccination? a. b. c. d. polio rabies Hansen’s disease arboviral encephalitis BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $200 Question A vaccine against which disease occasionally reverts to a virulent form and causes disease? a. b. c. d. rabies Japanese encephalitis West Nile encephalitis polio ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $200 Answer A vaccine against which disease occasionally reverts to a virulent form and causes disease? a. b. c. d. rabies Japanese encephalitis West Nile encephalitis polio BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $300 Question A misdiagnosis of Guillain-Barré syndrome is often given to patients with a. b. c. d. arboviral encephalitis. furious rabies. polio. paralytic rabies. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $300 Answer A misdiagnosis of Guillain-Barré syndrome is often given to patients with a. b. c. d. arboviral encephalitis. furious rabies. polio. paralytic rabies. BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $400 Question Eastern equine encephalitis has a mortality rate of _____ or more. a. b. c. d. 20% 50% 30% 70% ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $400 Answer Eastern equine encephalitis has a mortality rate of _____ or more. a. b. c. d. 20% 50% 30% 70% BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $500 Question Arboviral encephalitis is usually diagnosed by a. b. c. d. agglutination tests. ELISA tests. Gram stain. titer. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $500 Answer Arboviral encephalitis is usually diagnosed by a. b. c. d. agglutination tests. ELISA tests. Gram stain. titer. BACK TO GAME © 2013 Pearson Education, Inc. FINAL ROUND Question The tetanus vaccine is a(n) a. b. c. d. conjugated vaccine. toxoid. attenuated whole-agent vaccine. inactivated whole-agent vaccine. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. FINAL ROUND Answer The tetanus vaccine is a(n) a. b. c. d. conjugated vaccine. toxoid. attenuated whole-agent vaccine. inactivated whole-agent vaccine. BACK TO GAME © 2013 Pearson Education, Inc.