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IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses by Meryem Aloulou, Sanae Ben Mkaddem, Martine Biarnes-Pelicot, Tarek Boussetta, Hervé Souchet, Elisabetta Rossato, Marc Benhamou, Bruno Crestani, Zhou Zhu, Ulrich Blank, Pierre Launay, and Renato C. Monteiro Blood Volume 119(13):3084-3096 March 29, 2012 ©2012 by American Society of Hematology Bivalent crosslinking of mouse FcγRIII inhibits acLDL endocytosis. Meryem Aloulou et al. Blood 2012;119:3084-3096 ©2012 by American Society of Hematology Monomeric mouse IgG1 inhibits acLDL endocytosis through FcγRIII. Meryem Aloulou et al. Blood 2012;119:3084-3096 ©2012 by American Society of Hematology Human IVIg inhibits acLDL endocytosis through FcγRIII. Meryem Aloulou et al. Blood 2012;119:3084-3096 ©2012 by American Society of Hematology Bivalent crosslinking of human monocyte/macrophage-expressed FcγRIIIA but not neutrophilexpressed FcγRIIIB inhibits bacterial phagocytosis and ROS production. Meryem Aloulou et al. Blood 2012;119:3084-3096 ©2012 by American Society of Hematology Human FcγRIIIA mediates both inhibition and activation through the FcRγ ITAM depending on the type of ligand. Meryem Aloulou et al. Blood 2012;119:3084-3096 ©2012 by American Society of Hematology Monovalent and bivalent targeting of FcγRIII induce SHP-1 dependent ITAMi signaling and inhibisome formation. Meryem Aloulou et al. Blood 2012;119:3084-3096 ©2012 by American Society of Hematology FcγRIII targeting by IVIg and 2.4G2 F(ab′)2 reduces nonimmune inflammatory response in FcγRIIB−/− mice, but not in FcγRIII−/− mice. Meryem Aloulou et al. Blood 2012;119:3084-3096 ©2012 by American Society of Hematology
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