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DR. ANKIT JAIN APPROACH TO ASSESSMENT AND WEANING AT THE BED SIDE WHEN TO WEAN?? I WHEN TO WEAN?? 1. 2. Why was he ventilated?? Resolution/Reversal of Primary Pathology for which patient was ventilated. 1. 2. Clinical Evidence. Lab/Radiological Evidence. WHEN TO WEAN? Early Late WHEN TO WEAN? 1. Search and treat other causes that may contribute to ventilator dependence. 1. Know the causes of Ventilator Dependence/Failure to wean. FACTORS IN WEANING FAILURE CAUSES OF VENTILATOR DEPENDENCE AND FAILURE TO WEAN Causes of Respiratory Failure Neurological Factors Central Stroke Drugs Electrolytes Peripheral Neuropathies/Myopathies Drugs Respiratory Factors Chest Wall Parenchymal Disease Airway Disease CAUSES OF VENTILATOR DEPENDENCE AND FAILURE TO WEAN Non Respirator y Factor s. Cardiac Factors Acute LVF Acid-Base Factors Respiratory Alkalosis Metabolic Acidosis Metabolic Factors Hypo PO4 Hypo Mg Hypothyroid Pharmacological Agents Sedation NMBA Aminoglycosides Nutrition Malnutrition. Overfeeding Psychology WHEN TO WEAN? 1. Search and treat other causes that may contribute to ventilator dependence. 1. 2. Know the causes of Ventilator Dependence/Failure to wean. Structured bed side approach to identify these causes. (In Exam and in Clinical Practice.) BEDSIDE APPROACH TO IDENTIFY THESE CAUSES IDENTIFY THESE CAUSES AT THE BEDSIDE Keep the Causes in Mind. Structured Patient Examination The Environment Cubicle Patient Monitor Ventilator Infusions Equipment Drains Trends (Ask for in the Exam) Investigations (Ask for in the Exam) WHEN TO WEAN? 1. Search and treat other causes that may contribute to ventilator dependence. 1. 2. 3. Know the causes of Ventilator Dependence/Failure to wean. Structured bed side approach to identify these causes. (In Exam and in Clinical Practice.) Treat these causes! CERTAIN MEASURABLE CRITERIA TO BE FULFILLED CERTAIN MEASURABLE CRITERIA 1. Adequate Oxygenation 1. ABG 1. 2. 3. 4. 2. PaO2>60 with FiO2<0.4 PaO2/FiO2 >150 PEEP < 8 cm H20 pH >7.25 Hemodynamic Stability 1. 2. Clinically no Hypotension No or Low dose Vasopressors (EXCEPTIONS TO THE CRITERIA) “SUPERVISED” SPONTANEOUS BREATHING TRIAL III “SUPERVISED” SPONTANEOUS BREATHING TRIAL When?? Everything okay uptill now. (Step I and II cleared) Screening for few minutes Extended SBT Duration 30mins to 120 minutes Mode CPAP/PS T-Piece SIMV Complex Modes ATC, ASV, MMV “SUPERVISED” SPONTANEOUS BREATHING TRIAL Factors Assessed Respiratory Pattern Tidal Volume Respiratory Rate Rapid Shallow Breathing Index (RSBI) Reliable RR (breaths per minute) /T V (Liters) 1 minute after Disconnecting RSBI should be < 105 Normal 60 to 105 Complex Parameters (WOB, Dynamic Compliance, CROP index) Adequacy of Gas Exchange Monitor/SpO2 ABG HD Stability Subjective Comfort. SBT FAILED WHAT NOW?? FAILED SBT Back to the Drawing board Remember the Causes of Failure to Wean and How to identify them clinically?? CAUSES OF VENTILATOR DEPENDENCE AND FAILURE TO WEAN Causes of Respiratory Failure Neurological Factors Central Stroke Drugs Electrolytes Peripheral Neuropathies/Myopathies Drugs Respiratory Factors Chest Wall Parenchymal Disease Airway Disease CAUSES OF VENTILATOR DEPENDENCE AND FAILURE TO WEAN Non Respirator y Factor s. Cardiac Factors Acute LVF Acid-Base Factors Respiratory Acidosis Metabolic Acidosis Metabolic Factors Hypo PO4 Hypo Mg Hypothyroid Pharmacological Agents Sedation NMBA Aminoglycosides Nutrition Malnutrition. Overfeeding Psychology FAILED SBT Back to the Drawing board Remember the Causes of Failure to Wean and How to identify them clinically?? Identify and Treat these Cause. FAILED SBT No trial of SBT for another 24 hours Even twice daily SBTs offer no advantage. Do not reduce ventilator Support aggressively during these 24 hours. No evidence that a gradual support reduction strategy is better than providing full stable support between once daily SBTs. SBT SUCCESSFUL WHAT NEXT?? SBT SUCCESFUL Patient can be Weaned but….. Can he be Extubated???