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SGUL/LSHTM MRC London Intercollegiate Doctoral Training Partnership – 2017/18 Additional Studentships – Potential PhD Projects Title of PhD project Immunology, molecular biology and control of flaviviruses (Dengue and Zika) Supervisor Dr Julius Hafalla LSHTM Co-Supervisor Professor Martin Hibberd LSHTM Brief description of project Dengue and Zika viruses are both flaviviruses that are transmitted by Aedes aegypti mosquitoes and thus can experience synchronized epidemiology. While dengue continues to be a major burden on health services in The Philippines, with approximately 200,000 suspect cases of dengue per year, there is very little data on Zika infections. The goal of this project is increase our understanding of dengue and Zika infections in The Philippines using advanced immunological testing methodologies and genomic viral sequencing. When combined with epidemiological data, the project aims to identify ‘hotspots’ of where viral transmissions are occurring such that targeted control strategies may be designed and implemented. None. Particular prior educational requirements for a student undertaking this project Skills we expect a student to develop/acquire whilst pursuing this project Bioinformatics, viral genetics, statistical and population genetics, serology, immunology, molecular biology, epidemiology 1