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BIOGRAPHICAL SKETCH
NAME: Beeman, Scott
eRA COMMONS USER NAME (credential, e.g., agency login): SBEEMAN
POSITION TITLE: Assistant Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION
DEGREE
(if
applicable)
Completion
Date
MM/YYYY
FIELD OF STUDY
Arizona State University, Tempe, AZ
BSE
05/2007
Bioengineering
Arizona State University, Tempe, AZ
PhD
12/2012
Biomedical Engineering
Washington University, Saint Louis, MO
Postdoctoral 12/2016
Research
Associate
In Vivo Nuclear
Magnetic Resonance
A. PERSONAL STATEMENT
Scott Beeman, Ph.D., is an Assistant Professor in the Mallinckrodt Institute of Radiology’s Biomedical Magnetic
Resonance Laboratory (BMRL). Beeman has more than 13 years of experience in the field of nuclear magnetic
resonance, spanning basic NMR spectroscopy to functional brain mapping in a clinical setting. His research
efforts are broadly directed at developing and employing magnetic resonance (specifically 1H proton relaxation)
techniques to non-invasively elucidate biophysical and metabolic metrics. As a doctoral student at Arizona State
University, Beeman developed targeted exogenous proton relaxation agents to detect and measure the bloodfiltering fenestrated endothelial structures of the kidney and liver (1, 2). As a postdoctoral associate at
Washington University in Saint Louis, he focused on the fundamental physical and mathematic basis for proton
relaxation as it relates to tissue oxygenation and blood flow (3, 4). His current research interests are two-fold: (i)
to devise magnetic resonance (MR)-based experimental and mathematical techniques to directly quantify
physiology in vivo and (ii) to apply these techniques to advance the scientific understanding of metabolic
diseases and their downstream complications.
1. Beeman SC, Zhang M, Gubhaju L, Wu T, Bertram JF, et al. Measuring glomerular number and size in
perfused kidneys using MRI. Am J Physiol Renal Physiol. 2011 Jun;300(6):F1454-7.
2. Beeman SC, Mandarino LJ, Georges JF, Bennett KM. Cationized ferritin as a magnetic resonance
imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis. Magn
Reson Med. 2013 Feb 6;70(6):1728-1738
3. Beeman SC, Shui YB, Perez-Torres CJ, Engelbach JA, Ackerman JHH, Garbow JR. O2-sensitive MRI
distinguishes brain tumor versus radiation necrosis in murine models. Magn Res Med. 2015 Jul 14. doi:
10.1002/mrm.25821. [Epub ahead of print]
4. Beeman SC, Osei-Owusu P, Ackerman JHH, Blumer K, Garbow J. Renal DCE-MRI Model Selection
using Bayesian Probability Theory. Tomography. 2015 Sep;1(1):61-68
B. POSITIONS AND HONORS
Positions and Employment
2017 -
Assistant Professor, Washington University, Saint Louis, MO
2013 - 2017
Postdoctoral Research Associate, Washington University, Saint Louis, MO
2009
Teaching Assistant, Arizona State University, Tempe, AZ
2008 - 2013
Graduate Research Associate, Arizona State University, Tempe, AZ
2003 - 2008
Research Assistant, Barrow Neurological Institute, Phoenix, AZ
Other Experience and Professional Memberships
2010 -
Fellow-in-training, American Society of Nephrology
2009 -
Member, International Society for Magnetic Resonance in Medicine
Honors
2014
ISMRM Sunrise Educator, International Society for Magnetic Resonance in Medicine
2013
ASN Educational Topic of Interest, American Society of Nephrology
2012
Magna Cum Laude (Ph.D.), Arizona State University
2012
ISMRM Magna Cum Laude Award, International Society for Magnetic Resonance in Medicine
2012
ARCS Scholar, Achievement Rewards for College Scientists
2012
School of Biological and Health Systems Engineering Fellowship, Arizona State University
2007
Cum Laude (BSE), Arizona State University
2006
Membership, Alpha Etu Mu Honors Society
2002
Arizona State University Leadership Scholar, Arizona State University
C. CONTRIBUTION TO SCIENCE
1. During my time as a doctoral student, my colleagues and I developed an injectable magnetic resonance
imaging probe to non-invasively measure diabetes-related microstructural and functional changes in the
kidney and liver. The resultant publications from these efforts show that the MRI probe can be used to
measure glomerular number and size in rodent and human kidneys - measurements which directly report on
the deleterious effects of diabetic nephropathy on renal function but have, until now, been impossible to
measure without resection and destruction of the kidney. We have also published a study which shows that
the MRI probe can be used to detect pathologic microstructural changes to the hepatic sinusoid which are
caused by non-alcoholic steatohepatitis - a lethal complication of type 2 diabetes. These studies resulted in
project funding through the NIDDK-sponsored Diabetic Complications Consortium. These MRI-based
techniques are a promising platform for studying the effects of diabetes on the kidney and liver and,
potentially, for detecting of kidney and liver damage earlier than the current clinical standards.
a. Beeman SC, Zhang M, Gubhaju L, Wu T, Bertram JF, et al. Measuring glomerular number and size in
perfused kidneys using MRI. Am J Physiol Renal Physiol. 2011 Jun;300(6):F1454-7.
b. Beeman SC, Cullen-McEwen LA, Puelles VG, Zhang M, Wu T, et al. MRI-based glomerular morphology
and pathology in whole human kidneys. Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1381-90.
c.
Bennett KM, Bertram JF, Beeman SC, Gretz N. The emerging role of MRI in quantitative renal glomerular
morphology. Am J Physiol Renal Physiol. 2013 May 15;304(10):F1252-7.
d. Beeman SC, Mandarino LJ, Georges JF, Bennett KM. Cationized ferritin as a magnetic resonance
imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis. Magn
Reson Med. 2013 Feb 6;70(6):1728-1738
2. While at Washington University in Saint Louis, I focused on measuring brain perfusion and absolute tissue
oxygen content with magnetic resonance (MR) techniques (imaging and spectroscopy). My colleagues and
I published a paper describing a MR technique that is sensitive to tissue oxygenation and can report on and
discern pathologies with divergent tissue oxygenation states (E.g., cancer and radiation necrosis). We have
also published on brain perfusion in vascular diseases characterized by elastin deficiency. I have since turned
my attention to developing a MR technique to detect adipose tissue hypoxia (a major common pathway to
insulin resistance and type 2 diabetes). We have collected promising preliminary data that show that MRmeasured R1 is directly proportional to the concentration of O2 dissolved in the lipid of adipose tissue. A noninvasive MR tool which is sensitive to adipose oxygenation would be useful in exploring the hypoxia-driven
pathogenesis of insulin resistance and type 2 diabetes.
a) Beeman SC, Shui YB, Perez-Torres CJ, Engelbach JA, Ackerman JHH, Garbow JR. O2-Sensitive MRI
Distinguishes Brain Tumor vs. Radiation Necrosis in Murine Models. Magn Res Med. 2016 Jun
75(6):2442-7.
b) Knutsen RH, Beeman SC, Broekelmann T, Kovacs A, Danback J, Watson A, Garbow JR, Shoykhet M,
Kozel BA. Minoxidil rescues elastin mediated vasculopathy and improves cerebral blood flow. J Clin
Invest. (in review)
3. My colleagues and I have published on the toxicity of MRI-visible probes and the efforts to improve their
detectability and minimize required doses. Thus far, we have shown that cationic MRI-probes used to detect
kidney and liver dysfunction (described above) are not toxic to the kidney and liver at MRI-detectable doses.
This publication was an important step towards clinical translation of an MRI-probe which may have an impact
on how diabetes-related complications are studied and managed. We have also contributed substantially to
efforts to improve the detectability of these particles and the physiologic structures which they target. The
publications from these efforts show that: (i) chemical modification of the metallic core of cationic MRI-visible
probes can render them ~100-times more detectable (i.e., only 1/100 of the standard dose is required to
detect them in vivo) and (ii) that specialized hardware can be developed/implemented to improve MRI spatial
resolution and detection of kidney glomeruli.
a. Beeman SC, Georges JF, Bennett KM. Toxicity, biodistribution, and ex vivo MRI detection of
intravenously injected cationized ferritin. Magn Reson Med. 2013 Mar 1;69(3):853-61.
b. Qian C, Yu X, Chen DY, Dodd S, Bouraoud N, Pothayee N, Chen Y, Beeman SC, et.al. Wireless
amplified nuclear MR detector (WAND) for high-spatial-resolution MR imaging of internal organs:
preclinical demonstration in a rodent model. Radiology. 2013 Jul;268(1):228-36.
c. Clavijo Jordan MV, Beeman SC, Baldelomar EJ, Bennett KM. Disruptive chemical doping in a ferritinbased iron oxide nanoparticle to decrease r2 and enhance detection with T1-weighted MRI. Contrast
Media Mol Imaging. 2014 Sep-Oct;9(5):323-32.
d. Clavijo-Jordan V, Kodibagkar VD, Beeman SC, Hann BD, Bennett KM. Principles and emerging
applications of nanomagnetic materials in medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol.
2012 Jul-Aug;4(4):345-65.
4
At the Barrow Neurological Institute I worked with a team of neurologist and neurosurgeons to measure the
effects of surgery and epilepsy on brain structures using MRI and image processing techniques. We
measured changes in brain cortical thickness caused by the rigors of neurosurgery and used a similar
technique to measure brain white matter changes in children with hypothalamic hamartomas. Publication on
the collateral effects of deep-brain surgery on healthy cortex may be useful in improving surgical planning
and approach for deep-brain surgery. Publication on white matter differences in children with hypothalamic
hamartomas may inform on the little-understood pathogenesis of the disease.
a. Little AS, Liu S, Beeman S, Sankar T, Preul MC, et al. Brain retraction and thickness of cerebral
neocortex: an automated technique for detecting retraction-induced anatomic changes using magnetic
resonance imaging. Neurosurgery. 2010 Sep;67(3 Suppl Operative):ons277-82; discussion ons282.
b. Losey TE, Beeman SC, Ng YT, Kerrigan JF, Baxter LC. White matter density is increased in patients with
hypothalamic hamartoma and multiple seizure types. Epilepsy Res. 2011 Feb;93(2-3):212-5.
Complete list of published works:
http://www.ncbi.nlm.nih.gov/sites/myncbi/scott.beeman.1/bibliography/46530516/public/?sort=date&direction=ascending.
D. RESEARCH SUPPORT
Ongoing Research Support
K01 1K01DK109119-01, NIH/NIDDK
2016/04/01-2021/03/31
SC Beeman (PI)
MR Adipose-O2 quantification and the Hypoxia-Driven Insulin Resistance Hypothesis
This project seeks to: (i) develop methodology to non-invasively quantify in vivo adipose oxygen partial pressure
(pO2) with magnetic resonance, (ii) longitudinally characterize the adipose pO2 profile during pathogenic adipose
expansion, and (iii) demonstrate the efficacy of exercise in restoring hypoxic adipose tissue to normoxia in
humans.
Past Projects
R01 CA155365, NIH/NCI
2011/08/12-2016/05/31
JR Garbow (PI)
Imaging Biomarkers for Radiation-Induced Necrosis
The overarching goal of this preclinical research proposal is to identify mechanisms by which radiation-induced
tissue damage can be prevented or mitigated through therapeutic interventions. Specifically, the proposal seeks
to demonstrate that DWI (ADC) and DCE (Ktrans) MRI protocols can quantitatively and non-invasively document
the efficacy of SB415286, an inhibitor of glycogen synthase kinase 3β (GSK-3β), as a neuroprotectant, and
bevacizumab (Avastin), a vascular endothelial growth factor (VEGF) inhibitor, as a mitigator of radiation necrosis.
Scott Beeman serves as postdoctoral research associate on this project.
P30 CA91842, NIH/NCI
2010/07/01-2015/06/30
TJ Eberlein (PI)
Cancer Center Support Grant
The Alvin J. Siteman Cancer Center of Barnes-Jewish Hospital and Washington University School of Medicine
is a multidisciplinary comprehensive cancer research facility. Scott Beeman serves as a postdoctoral research
associate in the Center's Small-Animal Cancer Imaging Shared Resource.
CH-II-2015-482 Children’s Discovery Institute
2015/02/01– 2018/01/31
BA Kozel (PI)
Effect of Elastin Insufficiency on Brain Development and Cognition
Vascular stiffness is independently associated with progressive cognitive impairment and dementia in aging
adults, but little is known about the effects of early-onset/congenital vascular stiffness. Elastin insufficiency
causes early onset large vessel stiffness, in addition to hypertension and stenosis. This proposal leverages the
findings obtainable from mice and humans with elastin insufficiency to test the novel hypothesis that early onset
vascular stiffness may affect brain development and cognitive abilities.