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Download Whole Organism Chemical Screens to Identify Modulators
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Whole Organism Chemical Screens to Identify Modulators of FGF Signaling Michael Tsang Dept. of Developmental Biology University of Pittsburgh Presented by GTC, a conference production company • (626) 256-6405 • www.gtcbio.com Whole Organism Chemical Screens to Identify Modulators of FGF Signaling Michael Tsang PhD Dept. of Developmental Biology University of Pittsburgh Zebrafish •Vertebrate Rapid development and •rela5vely short genera5on 5me Developmental studies available •from 5me of fer5liza5on •Transparent embryo Evolu5onarily conserved •genome embryos can be screened in •mul5well plates Zebrafish embryo development is very rapid 8-Cell (2hrs post fertilization) L D 24hpf A P R V What can we learn from fish development that relates to human embryogenesis Wnts, FGFs, TGF-ßs, Hh, Notch, VEGF, RA etc...... Current Chemical Screening Models • Yeast/Cell Culture • C. elegans • Drosophila • zebrafish • Mouse $$ $/$$ $ Relevance In vitro Throughput • $ $$ $$$$ Fibroblast Growth Factors and their role in development and disease •Family of 22 genes •Regulate cellular proliferation, survival and differentiation •Required for embryogenesis •Human genetic disease, Apert and Pfeiffers syndrome (craniofacial deformities) a result of FGF receptor mutations •Upregulated in Cancers •Important for Wound healing and repair •Important for Regeneration of organs and tissues (teeth) ATTENTION! The entire presentation will be provided to registered attendees only at the conference! To view the rest of this exciting presentation and many more please register for the conference at www.gtcbio.com
