Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Biostability • Material response towards the body • • Chemical degradation Mechanical property degradation Biodurability • The aim is that the useful duration of the prosthesis exceeds the life expectancy of the patient. IN PRACTICE, THIS RARELY HAPPENS In practice • Design to meet the need for which the organ had to be replaced. • This requires a collaboration between the physician (who knows the needs) and the scientist/engineer (who knows materials science and biology). Knee ligament Knee ligament • Primary objective • • To restore appropriate function of the knee joint. Improvements • • • Wear Lack of regeneration The targeted customers Knee ligament Cardiac valves Cardiac valves • Primary objective • • To regulate blood exit out of the heart. Improvements • Compromise between cardiac valve hemocompatibility, its expected duration and patient’s life expectancy. Cardiovascular system repair Veine Artère Intima (cellules endothéliales) Valvules Limitante élastique Élastine interne (élastine) Média (cellules musculaires) Limitante élastique externe (élastine) Adventice (tissu conjonctif fibreux) Endovascular prostheses Endovascular prostheses Endovascular prostheses • Primary objectives • • • Recovery of the diameter of arteries after stenosis or aneurism Decrease in hospitalization costs Improvements • • • Hemocompatibility Mettallic ion leaching Mechanical property loss Prosthesis selection depends on pathology Synthetic arterial prostheses • Primary objective • • To reestablish blood flow in one direction Improvements • • • • Hemocompatibility Healing Blood flow through the prothesis wall Biological molecule adsorption Synthetic arterial prostheses Structure de l’artère 17 Biodegradable scaffolds Dacron (PET) >6mm 15µm Materials Science and Engineering C, in press Macromolecular Rapid Communication DOI 10.1002/marc.201300609 Polymer Degradation and Stability, 2012; 97: 1520-1526. J. Biomed. Mater. Res.-Appl. Biomater., 2010, 93B, 531-543. Acta Biomaterialia, 2009, 5, 2416-2428. Cell-Material interaction BAECs on textile (60X) Cell nuclei stained in blue with DAPI Actin filaments stained in red with rhodaminphalloidin