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MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus by Nicholas J. Leeper, and John P. Cooke Circulation Volume 123(3):236-238 January 25, 2011 Copyright © American Heart Association, Inc. All rights reserved. Metabolic alterations in diabetes mellitus increase the generation of microRNA (miRNA) 503. miRNA503 causes translational repression or degradation of mRNAs that encode proteins needed for the endothelial processes required for angiogenesis. Nicholas J. Leeper, and John P. Cooke Circulation. 2011;123:236-238 Copyright © American Heart Association, Inc. All rights reserved.