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Additional file 5. Gene Ontologies for the genes from cluster 4. GO ID term Number of genes Cellular component nucleoplasm cytoplasmic vesicle cytoplasmic membrane-bounded vesicle vesicle membrane-bounded vesicle nuclear lumen organelle lumen membrane-enclosed lumen melanosome pigment granule intracellular organelle lumen cytosol nucleoplasm part cell projection membrane membrane raft plasma membrane cell fraction basolateral plasma membrane cell projection Cajal body lateral plasma membrane 12 11 10 11 10 13 15 15 4 4 14 13 7 3 4 19 10 4 8 2 2 Biological Process protein kinase cascade response to osmotic stress response to abiotic stimulus intracellular signaling cascade response to organic substance response to endogenous stimulus actin cytoskeleton organization actin filament-based process purine nucleotide catabolic process response to hormone stimulus cytoskeleton organization positive regulation of transport nucleotide catabolic process in utero embryonic development cellular response to hormone stimulus positive regulation of cell projection organization regulation of cell cycle nucleobase, nucleoside, nucleotide and nucleic acid catabolic process nucleobase, nucleoside and nucleotide catabolic process intracellular transport lipopolysaccharide-mediated signaling pathway response to exogenous dsRNA nitrogen compound catabolic process hyperosmotic response regulation of cell size heterocycle catabolic process detection of mechanical stimulus 8 4 8 12 12 9 5 5 3 8 6 5 3 5 4 3 5 3 3 7 2 2 3 2 4 3 2 Molecular Function metal ion binding cation binding ion binding transition metal ion binding 31 31 31 22 protein complex binding insulin receptor binding zinc ion binding ATP binding adenyl ribonucleotide binding enzyme binding profilin binding adenyl nucleotide binding DNA binding purine nucleoside binding nucleoside binding purine ribonucleotide binding ribonucleotide binding protein domain specific binding mannosyltransferase activity purine nucleotide binding oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor nucleotide binding 6 3 17 15 15 8 2 15 15 15 15 16 16 6 2 16 2 18