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Isolation and Identification of Hematopoietic Stem Cell– Stimulating Substances From Kampo (Japanese Herbal) Medicine, Juzen-Taiho-To by Hiroko Hisha, Haruki Yamada, Masumi H. Sakurai, Hiroaki Kiyohara, Yongan Li, Cheng-ze Yu, Norito Takemoto, Hideki Kawamura, Katsunori Yamaura, Seiichi Shinohara, Yasuhiro Komatsu, Masaki Aburada, and Susumu Ikehara Blood Volume 90(3):1022-1030 August 1, 1997 ©1997 by American Society of Hematology Purification of TJ-48. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology Increases in GM-CFC colony counts and size in the presence of F-1. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology HPLC pattern of subfraction (E-5) of TJ-48. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology Chemical structure of fatty acids. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology Stimulation of HSC proliferation by standard fatty acids. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology Enhancement of surface molecule expression on MS-5 by linolenic acid. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology Cobblestone colonies of P-HSCs cultured with nontreated MS-5 (left) or MS-5 pre-incubated with 5 μg/mL of linolenic acid (right) for 6 weeks. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology Experimental protocol of oleic acid administration into MMC-treated mice. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology Effect of oleic acid on CFU-S recovery after MMC injection. Hiroko Hisha et al. Blood 1997;90:1022-1030 ©1997 by American Society of Hematology