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Protein*
Organism
Regulatory Function †
Regulatory
role
Category‡
References
AarP (P43463)
Providencia
stuartii
Regulation of 2'-N-acetyltransferase, capable of
acetylating both peptidoglycan and certain
aminoglycoside antibiotics
Activator
S
Macinga et al
1995
Ada (P06134)
Escherichia
coli
Repair of alkylated guanine in DNA by
stoichiometrically transferring the alkyl group at
the O-6 position to a cysteine residue in the
enzyme.
Activator
S
Nakabeppu et
al 1985
AdaA
(P19219)
Bacillus subtilis
Methylphosphotriester-DNA alkyltransferase is
one of two genes required for the adaptive
response of bacteria to alkylating agents
Activator
S
Morohoshi et
al. 1990
AdiY (P33234)
E. coli
Regulation of the arginine decarboxylase system.
Activator
A-R
Gallegos et al
1997
AggR
(P43464)
E. coli
Regulator of aggregative adherence fimbria I
expression in enteroaggregative E. coli.
Activator
V
Munson et al
2001
AppY
(P05052)
E. coli
Induces the synthesis of acid phosphatase (appA)
and several other polypeptides (such as appBC)
during the deceleration phase of growth.
Activator,
Repressor
A-R
Gallegos et al
1997
AraC
(P0A9E0)
E. coli
Regulation of the expression of a regulon
involved in the transport and catabolism of Larabinose. It regulates initiation of transcription of
the araBAD operon.
Activator;
Repressor
M-C
Schleif 2003
CafR (P26950)
Yersinia pestis
Regulator of the expression of the F1 operon for
capsule synthesis
Activator
V
Friedlander et
al 1995,
Munson et al
2001
CfaD (P25393)
E. coli
Activator of the CFA/I adhesin (cfaA) gene of
enterotoxigenic E. coli
Activator
V
Karlyshev et
al 1992
CsvR (P43460)
E. coli
Activator of the fimbrial gene in enterotoxigenic
E. coli
Activator
V
Munson et al
2001
EnvY (P10805)
E. coli
Influences the temperature-dependent expression
of several envelope proteins, most notably the
porins ompF and ompC and the lambda receptor,
lamB.
Activator
A-R
Lundrigan et
al 1989
EutR (P36547)
E. coli,
Activates the transcription of the ethanolamine
operon.
Activator
M-C
Troup et al
1994.
S. typhimurium
ExsA (P26993)
Pseudomonas
aeruginosa
Activator of exoenzyme S synthesis above a low
basal level.
Activator
V
Frank and
Iglewski
1991
FapR (P23774)
E. coli
Positive regulator of the expression of the 987P
operon for the fimbrial protein in enterotoxigenic
E. coli.
Activator
V
Klaasen and
de Graaf
1990
FeaR (Q47129)
E. coli
Positive regulator of tynA/maoA and feaB/padA,
the genes for 2-phenylethylamine catabolism.
Activator
M-N
Yamashita et
al 1996
GadW
(P63201)
E. coli K12
Depending on the conditions (growth phase and
medium), acts as a positive or negative regulator
of gadA and gadBC.
Activator
A-R
Ma et al 2002
GadX
(Q9EYV5)
E. coli
O127:H6
Regulates the expression of genes involved in acid
resistance.
Activator;
Repressor
A-R
Ma et al 2002
HilD (P41782)
S. typhimurium
HilD protein is involved in the expression of the
HilA gene, which is encoded on Salmonella
pathogenicity island 1 (SPI-1).
Activator
V
Schechter et
al 1999.
HrpB (P31778)
Ralstonia
solanacearum
Positive regulation of hypersensitive response
genes involved in plant pathogenicity.
Activator
V
Genin et al
1992.
InvF (P69343)
S typhimurium
Required for the expression of several genes
encoding type III secretion system SPI-1 effector
proteins.
Activator
V
Kaniga et al
1994.
LacR (O33813)
Staphylococcus
xylosus
Transcriptional regulator of the lacPH genes for
lactose utilization.
Activator
M-C
LcrF (P28808)
Y. pestis
Activator of the thermally regulated virulent yopE
gene.
Activator
V
Bassias and
Brueckner
1998
Goguen et al
1992.
LumQ
(Q51872)
Photobacterium
leiognathi
Probable transcriptional regulator of riboflavin
synthesis genes.
MarA
(P0ACH5)
E. coli K12
Transcriptional activator of genes involved in the
multiple antibiotic resistance (Mar) phenotype.
MelR
(P0ACH8)
E. coli K12
MmsR
(P28809)
M-G
Lin et al
1995.
Activator
S
Rhee et al
1998
Transcription regulator for the expression of the
melAB operon for the melibiose catabolism.
Activator
M-C
Webster et al
1987.
P. aeruginosa.
Regulatory protein for the mmsAB operon for the
valine catabolism.
Activator
M-G
Steele et al
1992.
MsmR
(Q00753)
Streptococcus
mutans
Regulatory protein for the msm operon for
multiple sugar metabolism.
Activator
M-C
Russell et al
1992.
MxiE
(P0A2S7)
S. flexneri
Necessary for the secretion of ipa invasins.
Activator
V
Allaoui et al
1993.
OruR (P72171)
P. aeruginosa
Activates the ornithine acetyltransferase related
genes.
Activator
M-N
Hebert and
Houghton
1997
PchR (P40883)
P. aeruginosa
Regulator of the genes for pyochelin and
ferripyochelin receptors.
Activator
M-G
PerA (P43459)
E. coli O127
Involved in regulation of bfp genes for the
biosynthesis of a type IV pilus in
enteropathogenic E. coli. Activates indirectly the
LEE pathogenicity island.
Activator
V
Reimmann et
al 1998,
Heinrichs and
Poole 1996
GomezDuarte and
Kaper 1995
PocR (Q05587)
S. typhimurium
Positive regulatory protein of cobalamin
biosynthesis.
Activator
M-G
Chen et al
1994.
PqrA (Q52620)
Proteus
vulgaris
Probably confers multidrug resistance in a way
similar to that of the SoxS and MarA genes.
Activator
S
Ishida et al
1995.
RafR (P43465)
Pediococcus
pentosaceus
Involved in the regulation of the raffinose-operon.
Activator
M-C
Gallegos et al
1997.
RamA
(P55922)
Enterobacter
cloacae
Probable transcriptional activator that confers a
multidrug-resistance phenotype
Activator
S
Komatsu et al
1990.
RhaR (P09378)
E coli K12
It activates expression of the rhaSR operon in
response to L-rhamnose.
Activator
M-C
Tobin and
Schleif 1987
RhaS (P09377)
E. coli K12
Activates expression of the rhaBAD and rhaT
operons. Induced by RhaR in response to Lrhamnose.
Activator
M-C
Tobin and
Schleif 1987
RhrA
(Q9Z3Q6)
Rhizobium
meliloti
Transcriptional activator of the rhizobactin
regulon
Activator
M-G
Lynch et al
2001.
Rns (P16114 )
E. coli
Required for the expression of the CS1 and CS2
adhesins of enterotoxigenic E. coli.
Activator
V
Munson et al
2001. Porter
et al 1998
Rob (P0ACI0 )
E. coli K12
Rob regulates antibiotic resistance, organic
solvent tolerance and heavy-metal resistance.
Activator
S
Kwon et al
2000
SirC (Q8Z4A6)
S. typhi
Regulator of the expression of the invasionassociated type III secretion system encoded
within SPI-1.
Activator
V
Gallegos et al
1997
SoxS
(P0A9E2)
E. coli K12
Transcriptional activator of the superoxide
response regulon
Activator
S
Pomposiello,
et al 2001
TcpN (P29492)
Vibrio cholerae
Regulatory protein of the tcp and ctx virulence
genes
Activator
V
TetD (P28816)
E. coli
Transposon Tn10 regulatory protein. Part of the
mar/sox/rob regulon.
Activator
S
Ogierman
and Manning
1992.
Griffith et al
2005
ThcR (P43462)
Rhodococcus
erythropolis
Probably involved in the positive regulation of the
thc operon for the degradation of the
thiocarbamate herbicide EPTC.
Activator
M-G
Nagy et al
1995
UreR (P32326)
E. coli K12
Positive regulator of the expression of the urease
operon.
Activator
M-N
D'Orazio and
Collins 1993
VirF (P0A2T1)
S. flexneri
Primary regulator of plasmid-encoded virulence
genes. Activates the transcription of icsA (virG)
and virB.
Activator
V
Adler et al
1989.
VirF (P13225)
Y.
enterocolitica
Transcriptional activator of the thermallyregulated virulent yopE gene.
Activator
V
Porter et al
1998
XylR
(P0ACI3)
E. coli K12
Regulatory protein for the xylBAFGHR operon.
Activator
M-C
Gallegos et al
1997
XylS (P07859)
P. putida
Regulatory protein of the xylXYZLTEGFJQKIH
operon required for the degradation of toluene, mand p-xylene.
Activator
M-C
Spooner et al
1986
Xys1 (Q04710)
P. putida
Regulatory protein of the TOL plasmid pWW53
meta-1 and meta-2 p-toluato
Activator
M-C
Assinder et al
1993
Xys2 (Q05092)
P. putida
xylDLEGF operon transcriptional activator 2
Activator
M-C
Assinder et al
1992.
Xys3 (Q05335)
P. putida
xylDLEGF operon transcriptional activator 3
Activator
M-C
Freiberg et al
1997.
Xys4 (Q04713)
P. putida
xylDLEGF operon transcriptional activator 4
Activator
M-C
Freiberg et al
1997.
Y4Fk (P55449)
Rhizobium sp
Acts in the complex cascade regulation of the
nodD3 gene.
Activator
M-G
Quirk et al
1994.
YbbB
(P40408)
B. subtilis
Contains one iron siderophore/cobalamin
periplasmic-binding domain
Unknown
M-G
Barbeyron et
al 1994.
YcgK
(P43461)
Alteromonas
carrageenovora
Regulates the structural cgkA gene encoding
kappa-carrageenase
Activator
M-N
Barbeyron et
al 1994.
YdeO
(P76135)
E. coli K12
Induces the expression of gadE and mdtEF.
Regulates the expression of other genes involved
in acid resistance.
Activator
A-R
Ma 2004
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