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Transcript 
Evidence That Outwardly Rectifying Cl− Channels Underlie
Volume-Regulated Cl− Currents in Heart
by Dayue Duan, Joseph R. Hume, and Stanley Nattel
Circulation Research
Volume 80(1):103-113
January 1, 1997
Copyright © American Heart Association, Inc. All rights reserved.
Cell-attached patch-clamp recordings of single-channel currents in rabbit atrial cells.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Dependence of unitary channel current on pipette anion and cation concentrations.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Examples of single-channel currents and kinetic analysis of open and closed dwell times at
RP−40 mV under isotonic conditions.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Recordings from a patch that failed to show single-channel activity under isotonic conditions
(left) but showed typical outwardly rectifying currents after the induction of hypotonic cell
swelling (right).
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Effect of hypotonic cell swelling on channel activity recorded at RP−40 mV in a cell-attached
patch in the presence of 108 mmol/L [Cl−]p.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Comparison of properties of ORCCs recorded under isotonic (Isot.) and hypotonic (Hypot.)
conditions.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Examples of single-channel currents and kinetic analysis of open and closed dwell times at
RP−40 mV under hypotonic conditions.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Effects of tamoxifen on ORCCs activated by cell swelling.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
Effects of tamoxifen on volume-regulated Cl− currents.
Dayue Duan et al. Circ Res. 1997;80:103-113
Copyright © American Heart Association, Inc. All rights reserved.
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