Download Supplementary Materials

doi: 10.1038/nature06328
SUPPLEMENTARY INFORMATION
SUPPLEMENTARY FIGURE LEGENDS
Figure S1 | Functional characterisation of SNMP fusion proteins. Dose-response curve
for cVA in Or67d neurons of wild-type (Berlin), SNMP mutant (Or67dGAL4/+;SNMP1/SNMP2), SNMP:GFP rescue (Or67d-GAL4/UASSNMP:GFP;SNMP1/SNMP2) and YFP(1):Or83b/SNMP:YFP(2) rescue
(Or67d:GAL4,UAS-YFP(1):Or83b/UAS-SNMP:YFP(2);SNMP1,Or83b2/SNMP2,Or83b1 )
animals. Mean responses are plotted (± s.e.m; wild-type n=47, SNMP mutant n=46,
SNMP:GFP rescue n=20; YFP(1):Or83b/SNMP:YFP(2) rescue n=22; ≤4
sensilla/animal, mixed genders). Wild-type and SNMP:GFP rescue responses to cVA
are not significantly different (ANOVA; p>0.1175). YFP(1):Or83b/SNMP:YFP(2) rescue
responses to cVA are highly significantly different from SNMP mutants and from wildtype (ANOVA; p<0.0001), indicating partial rescue.
Figure S2 | Cell type-specific rescue of SNMP expression. a, Immunostaining for
mCD8:GFP (anti-GFP, green) and LUSH (magenta) in LUSH-GAL4/UAS-mCD8:GFP
animals reveals faithful recapitulation of endogenous expression by the LUSH-GAL4
driver. b, Two-colour RNA in situ hybridisation for SNMP (green) and Or67d (magenta)
in antennal sections of wild-type, Or67d neuron SNMP rescue (Or67d-GAL4/UASSNMP;SNMP1/SNMP2) and support cell SNMP rescue (LUSH-GAL4/UASSNMP;SNMP1/SNMP2) animals.
www.nature.com/nature
1
Corrected response (spikes s-1)
Benton et al., Figure S1
wild-type
SNMP:GFP rescue
120
80
YFP(1):Or83b/SNMP:YFP(2) rescue
40
0
0
0.1
1
10
100
SNMP
-/-
cVA (%)
www.nature.com/nature
2
Benton et al., Figure S2
mCD8:GFP
LUSH protein
SNMP RNA
Or67d RNA
SNMP RNA
Or67d RNA
merge
www.nature.com/nature
SNMP-/- + Support cell rescue
wild-type
b
SNMP-/- + Neuronal rescue
LUSH-GAL4/UAS-mCD8:GFP
a
SNMP RNA
Or67d RNA
3
Table S1: Genes identified in the comparative genomics screen
Gene ID
Gene Name
Predicted function/protein homologies
ODORANT AND GUSTATORY RECEPTORS
CG10609
Or83b
CG17867
Or10a
CG15377
Or22c
CG11767
Or24a
CG13106
Or30a
CG16960
Or33a
CG16961
Or33b
CG5006
Or33c
CG12931
Or45b
CG17584
Or49b
CG12501
Or56a
CG9820
Or59a
CG12526
Or67a
CG14176
Or67b
CG14156
Or67c
CG14157
Or67d
CG17871
Or71a
CG10612
Or83a
CG15581
Or83c
CG11735
Or85b
CG17911
Or85c
CG11742
Or85d
CG17916
Or92a
CG17241
Or94a
CG6679
Or94b
CG13948
Gr21a
CG13787
Gr28a
CG13788
Gr28b
CG18531
Gr2a
CG17213
Gr33a
CG1712
Gr43a
CG33151
Gr59e
CG33150
Gr59f
CG15779
Gr5a
CG13888
Gr61a
CG14979
Gr63a
CG32261
Gr64a
CG32257
Gr64b
CG32255
Gr64f
CG7189
Gr66a
odorant co-receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
odorant receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
gustatory receptor
ODORANT BINDING PROTEINS
CG11748
Obp19a
CG6641
Obp28a
CG12905
Obp46a
CG30067
Obp50a
CG30072
Obp50c
CG30074
Obp50d
CG13939
Obp50e
CG13518
Obp58b
CG13524
Obp58c
CG13517
Obp59a
CG10436
Obp69a
CG8807
Obp76a
CG11421
Obp83a
CG11422
Obp83b
CG1176
Obp84a
CG11732
Obp85a
CG17284
Obp93a
CG14379
CheA87a
CG15242
CheB42a
CG10264
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
odorant binding protein
chemosensory protein family A
chemosensory protein family B
antennal carrier/juvenile hormone binding protein
4
Gene ID
Gene Name
Predicted function/protein homologies
ODOUR DEGRADING/BIOTRANSFORMATION ENZYMES
CG9452
acid phosphatase
CG12896
AhpC/TSA family peroxidase
CG18516
aldehyde oxidase/xanthine dehydrogenase domains, ferredoxin domain, FAD-binding domain
CG18519
aldehyde oxidase/xanthine dehydrogenase domains, ferredoxin domain, FAD-binding domain
CG4009
animal haem peroxidase
CG30445
aromatic-L-amino acid decarboxylase
CG10339
carboxylesterase
CG9283
carboxylesterase
CG9287
carboxylesterase
CG17148
Esterase P
carboxylesterase
CG1131
alpha-Esterase-10
carboxylesterase, cholinesterase
CG9289
carboxylesterase, coiled coil region
CG1128
alpha-Esterase-9
carboxylesterase/cholinesterase
CG34127
carboxylesterase/lipase
CG1895
Cyp28c1
cytochrome P450
CG6081
Cyp28d2
cytochrome P450
CG12028
Cyp302a1
cytochrome P450
CG6585
Cyp308a1
cytochrome P450
CG14728
Cyp315a1
cytochrome P450
CG8302
Cyp4aa1
cytochrome P450
CG17970
Cyp4ac2
cytochrome P450
CG8859
Cyp6g2
cytochrome P450
CG8457
Cyp6t3
cytochrome P450
CG31674
D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain, NAD binding domain
CG4181
glutathione S-transferase
CG4421
glutathione S-transferase
CG18548
GstD10
glutathione S-transferase
CG6142
GMC oxidoreductase
CG9521
GMC oxidoreductase
CG12398
GMC oxidoreductase domains
CG10357
lipase
CG13282
lipase
CG13562
lipase
CG18258
lipase
CG18641
lipase
CG5665
lipase
CG6472
lipase
CG31684
lipase domains
CG7367
lipase, transmembrane domain
CG4020
male sterility protein domain/fatty acyl reductase
CG13833
short chain dehydrogenase domain
CG5948
superoxide dismutase
CG9432
l(2)01289
thioredoxin-like repeats, coiled coil region, transmembrane domain
CG10178
UDP glycosyltransferase
CG15661
UDP glycosyltransferase
CG30036
UDP glycosyltransferase
CG30037
UDP glycosyltransferase
CG5724
UDP glycosyltransferase
CG5999
UDP glycosyltransferase
CG13270
Ugt36Ba
UDP glycosyltransferase
CG13271
Ugt36Bb
UDP glycosyltransferase
CG11012
Ugt37a1
UDP glycosyltransferase
CG11012
Ugt37a1
UDP glycosyltransferase
CG8652
Ugt37c1
UDP glycosyltransferase
CG6475
UDP glycosyltransferase
TRANSCRIPTION FACTORS
CG7508
atonal
CG15725
CG32121
CG13845
CG32006
CG12632
fd3F
CG1132
fd64A
bHLH domain
BTB domain, Zn fingers
BTB domain, Zn fingers
FLYWCH Zn finger domain
forkhead domain
forkhead domain
forkhead domain
5
Gene ID
Gene Name
Predicted function/protein homologies
CG8333
CG15696
CG2047
CG11294
CG15216
CG10296
CG10488
CG8246
CG3905
CG11966
CG3081
CG9019
CG10309
CG15269
CG17568
CG18555
CG32830
CG4374
CG32120
CG10147
CG3485
HLHmgamma
HLH and Orange domains
homeobox domain
homeobox domain
homeodomain
MYND Zn finger
nuclear hormone receptor Zn finger
Paired and homeobox domains
Paired domain
RING finger
Zn finger
Zn finger
Zn finger, steroid hormone binding domain
Zn fingers
Zn fingers
Zn fingers
Zn fingers
Zn fingers
Zn fingers
Zn fingers
Zn fingers, Zn finger-associated domain
Zn fingers, Zn finger-associated domain
fushi tarazu
eyegone
Pox neuro
suppressor of zeste 2
dissatisfaction
senseless
ION CHANNELS/TRANSPORTERS
CG13490
CG14239
CG15555
CG30181
CG31105
CG4110
pickpocket11
CG14398
pickpocket13
CG8527
pickpocket23
CG4805
pickpocket28
CG11209
pickpocket6
CG6112
pHCl
CG7411
ora transientless
CG17063
innexin 6
CG3536
CG9176
cngl
CG10101
CG10633
CG12624
CG14076
CG15324
CG2657
CG31718
CG32704
CG6185
CG7385
CG32975
nAcRalpha-34E
CG10864
CG10369
CG12543
CG32770
CG3367
CG15004
CG12455
CG4587
CG10505
CG11898
CG16700
CG10251
CG14196
CG30345
CG3409
CG6978
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
degenerin/epithelial sodium channel (DEG/ENaC)
GABA receptor, glycine-gated chloride channel
histamine-gated chloride channel
innexin
intracellular cyclic nucleotide activated cation channel
intracellular cyclic nucleotide activated cation channel
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
ionotropic glutamate receptor
nicotinic acetylcholine-activated cation-selective channel
outward rectifier potassium channel
inward rectifier potassium channel
potassium channel
potassium channel
potassium channel
sodium channel auxiliary subunit
voltage-gated calcium channel
voltage-gated calcium channel
ABC transporter domains, ATPase domains
ABC transporter domains, ATPase domains
amino acid transporter
MFS transporter
MFS transporter
MFS transporter
MFS transporter
MFS transporter
6
Gene ID
Gene Name
CG15221
CG15408
CG3285
CG6600
CG8925
CG10183
CG14204
CG16723
CG30471
CG10804
CG33124
CG9657
CG17929
CG6901
CG10006
IMMUNITY
CG10146
CG18372
CG4740
CG7629
CG32924
CG1365
CG1367
CG1878
CG1385
CG5528
CG12813
CG32679
CG1851
CG14928
CG1887
CG31741
CG7000
CG7422
CG3212
CG4099
Predicted function/protein homologies
MFS/sugar transporter
MFS/sugar transporter
MFS/sugar transporter
MFS/sugar transporter
MFS/sugar transporter
NRF domain, transmembrane domains
NRF domain, transmembrane domains
NRF domain, transmembrane domains
NRF domain, transmembrane domains
sodium:neurotransmitter symporter family
sodium:solute symporter family
sodium:solute symporter family
sugar (and other) transporter
sugar (and other) transporter
ZIP Zn transporter
Attacin-A
Attacin-B
Attacin-C
Attacin-D
Cecropin 2
Cecropin A1
Cecropin A2
Cecropin B
Defensin
Toll-9
Ady43A
Sr-CIV
CUTICLE FORMATION/MELANISATION
CG7072
CG8511
CG13675
CG14301
CG15313
CG32036
CG12255
CG15008
CG18348
CG30042
CG30045
CG31876
CG4052
CG6305
CG7076
CG8515
CG9079
CG9290
CG9295
CG2341
Ccp84Ad
CG1331
Ccp84Af
CG13670
CG15007
CG10140
CG14304
CG7548
Gram-negative antibacterial peptide
Gram-negative antibacterial peptide
Gram-negative antibacterial peptide
Gram-negative antibacterial peptide
Gram-positive antibacterial peptide
Gram-positive antibacterial peptide
Gram-positive antibacterial peptide
Gram-positive antibacterial peptide
Gram-positive antibacterial peptide
leucine-rich repeats, transmembrane domain, TIR domain
MD-2-related lipid-recognition domain
SCP domain
adenosine kinase
spatzle-like cysteine-knot cytokine
CD36-related scavenger receptor
CD36-related scavenger receptor
CD36-related scavenger receptor
CD36-related scavenger receptor
Complement Control Protein domains, MAM domain, Somatomedin B-like domain
scavenger receptor class C type I
chitin-binding domain
chitin-binding domain
chitin-binding domain type 2
chitin-binding domain type 2
chitin-binding domain type 2
chitin-binding domain type 2, transmembrane domain
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4
chitin-binding domain type 4, transmembrane domain
chitin-binding domain type 4, transmembrane domain
chitin-binding domains type 2
chitin-binding peritrophin A domain, coiled coil region
insect cuticle protein
7
Gene ID
CG8541
CG8543
CG3757
CG17044
CG13804
PROTEASES
CG18188
CG11843
CG12256
CG12951
CG13744
CG14760
CG14892
CG16997
CG17404
CG32523
CG3739
CG3916
CG5255
CG6298
CG6865
CG7432
CG7996
CG9564
CG30371
CG30375
CG10663
CG10280
CG10129
CG13748
CG15369
CG7219
CG12807
CG30047
CG30049
CG33012
CG33013
SIGNALLING
CG13692
CG31118
CG18747
CG16976
CG5559
CG11573
CG15819
CG14387
CG15178
CG12796
CG13579
CG16726
CG16766
CG18208
CG30340
CG31351
CG31645
CG32547
CG33696
CG4187
CG4313
CG4395
CG7994
CG8007
CG8784
Gene Name
Predicted function/protein homologies
yellow
yellow-e2
yellow-g2
insect cuticle protein
insect cuticle protein
major royal jelly protein domain
major royal jelly protein domain
major royal jelly protein domain
Damm
snake
Try29F
nudel
Spn28D
Spn85f
RabX4
Discoidin domain receptor
caspase
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease
serine protease, CUB domain
serine protease, CUB domain
serine protease, thrombospondin type I repeats
Zn-dependent metalloprotease, transmembrane domain
serine protease
BPTI/Kunitz family serine protease inhibitor
cystatin-like domain
serpin
serpin
peptidase family M20/M28, transmembrane domains
peptidase family M20/M28, transmembrane domains
peptidase family M20/M28, transmembrane domains
peptidase family M20/M28, transmembrane domains
ARF GTPase activator-related
small GTPase
arrestin domains
C2 domain
C2 domains, transmembrane domain
collagen-activated transmembrane receptor protein tyrosine kinase
DOCK-like GEF domain
EF hand
EF hands
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
8
Gene ID
Gene Name
Predicted function/protein homologies
CG17061
CG31350
CG6515
CG10738
CG14877
CG5719
CG14885
CG31469
CG3216
CG14163
CG3277
CG14714
CG40204
CG15405
CG8519
CG7991
CG12102
CG15664
CG12933
CG4969
CG18646
CG4910
CG10342
CG18243
CG15284
methuselah-like 10
Octb3R
Takr86C
GPCR?
GPCR
GPCR
guanylate cyclase
guanylate cyclase
guanylate cyclase
guanylate cyclase
low molecular weight phosphatase family
Natriuretic peptide receptor C (receptor guanylate cyclase)
protein kinase domain
protein tyrosine kinase
protein tyrosine phosphatase
Ras association (RalGDS/AF-6) domain
Ras GEF domain
Ras GTPase
SH3 domain
small GTPase
small GTPase
small GTPase regulator-related, coiled coil regions
wingless-related
Rap/Ran-GAP domain, BTB domain
neuropeptide hormone
neuropeptide hormone
protein tyrosine phosphatase
cysteine-knot cytokine
Gyc-89Da
Rgk3
Wnt6
Ccap
npf
Ptp52F
partner of burs
PROTEIN-PROTEIN INTERACTION
CG31062
sidestep
CG5423
robo3
CG13207
nompA
CG16827
alphaPS4
CG5372
alphaPS5
CG7527
CadN2
CG6118
CG11072
CG4509
CG13165
CG13272
CG13924
CG13966
CG15720
CG17009
CG30175
CG32397
CG6026
CG7031
CG13800
CG15415
CG17443
CG6108
CG6793
CG18648
cp309
CG12958
CG14890
CG13136
CG13310
CG7179
CG30264
CG11101
pawn
CG1567
C901
CG33955
CG13913
CG31832
CG9593
CG14964
Ig and Ig-like domains, FN3 domain, transmembrane domain
Ig and Ig-like domains, FN3 domains, transmembrane domain
PAN domains, ZP domains, transmembrane domain
integrin alpha subunit
integrin alpha subunit
neural cadherin
BTB domain
BTB/POZ domain
cadherin repeats, transmembrane domain, coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil region
coiled coil regions
coiled coil regions
coiled coil regions
coiled coil regions
coiled coil regions
coiled coil regions
coiled-coil regions
collagen triple helix repeat, coiled coil region
CUB domain
CUB domain
CUB domain
DPY30 domain, ankyrin repeats
EGF repeat, transmembrane domain
EGF repeats
EGF repeats, Laminin G domains
FH3 domain, coiled coil domain
Fibrinogen-related domain
Fibrinogen-related domain
fibronectin type 3 domains, Ig domains, coiled coil region
9
Gene ID
CG7504
CG11620
CG4814
CG14469
CG12557
CG10134
CG14249
CG14678
CG7166
CG13672
CG1504
CG4054
CG8561
CG4977
CG1804
CG11136
CG14747
CG15617
CG32131
CG6688
CG9587
CG14168
CG15803
CG14515
CG13289
CG8647
CG12594
CG15042
CG31755
CG13648
CG17211
CG13074
CG14285
CG33227
CG30188
CG14010
CG4950
CG15431
CG30164
Gene Name
dpr12
dpr13
beat-Va
beat-VII
kekkon-2
kekkon-6
MISCELLANEOUS
CG32136
Tsp68C
CG17330
jhamt
CG9048
Vm26Aa
CG9046
Vm26Ab
CG16874
Vm32E
CG9271
Vm34Ca
CG13658
CG13659
CG31104
CG31370
CG31380
CG31436
CG31975
CG9259
CG9497
CG17928
CG6660
CG17028
CG32637
CG12654
CG12092
NPC1b
CG15534
CG14934
CG30360
Predicted function/protein homologies
forkhead associated domain, coiled coil region
HEAT repeats
Ig and Ig-like domains
Ig C-2 domain
Ig C-2 domain
Ig domain
Ig domain
Ig domains
Ig-like and Ig domains, FN3 domain
Ig-like domain
leucine-rich repeats
leucine-rich repeats
leucine-rich repeats
leucine-rich repeats, Ig domain
leucine-rich repeats, Ig domain, transmembrane domain
leucine-rich repeats, transmembrane domain
PAN domain
PDZ domain
PDZ domain
PDZ domain
PDZ domain
PDZ domain, coiled coil region
PDZ domains
Reeler domain
SH2 domain
thrombospondin N-terminal-like domain
thrombospondin type 1 repeat, Laminin G domain
Tudor domain
Tudor domain, coiled coil region
VWC domains
VWC domains
WD40 repeats
WD40 repeats
CUB domain, LDL receptor class A domain, transmembrane domain
Ig and Ig-like domains, FN3 domain, transmembrane domain
Ig-like and Ig domains, transmembrane domain
leucine-rich repeats, transmembrane domain
transmembrane domain, coiled coil region
transmembrane domains, coiled coil region
tetraspanin
juvenile hormone acid methyltransferase
vitelline membrane protein
vitelline membrane protein
vitelline membrane protein
vitelline membrane protein
choline kinase
choline kinase
choline kinase
choline kinase
choline kinase
choline kinase
choline kinase
choline kinase
choline kinase
cytochrome b5-like heme/steroid binding domain, transmembrane domain, fatty acid desaturase
GNS1/SUR4 family long chain fatty acid elongase
inositol monophosphatase
LDL receptor class A domain
LDL receptor class A domains
Patched-related
sphingomyelin phosphodiesterase, Saposin B domain
alpha-amylase domain (inactive)
alpha-amylase domain (inactive)
10
Gene ID
CG11159
CG7900
CG8834
CG31766
CG30274
CG10546
CG31636
CG13078
CG14120
CG15531
CG12560
CG40305
CG40317
CG14259
CG14661
CG15497
CG17189
CG8945
CG4312
CG5097
CG33192
CG10584
CG15831
CG1961
CG4787
CG9642
CG11231
CG11260
CG13011
CG2022
CG15585
CG15593
CG15596
CG31561
CG14925
CG8644
CG15538
CG15590
CG15591
CG13209
CG5922
CG16734
CG13613
CG13614
CG14115
CG14826
CG14829
CG17781
CG17782
CG14116
CG18669
CG14455
CG14456
CG14458
CG12516
CG17758
CG11693
CG13492
CG13942
CG15564
CG15712
CG14394
CG10017
CG11000
CG13040
Gene Name
Ance-3
metallothionein B
metallothionein C
metallothionein D
osiris 1
osiris 10
osiris 11
osiris 16
osiris 21
osiris 22
osiris 23
osiris 5
osiris 8
Predicted function/protein homologies
Alpha-lactalbumin/lysozyme C domain (inactive)
amidase
AMP-binding ligase
angiotensin converting enzyme
ATP:guanido phosphotransferase, C-terminal catalytic domain
CRAL/TRIO domain
CRAL/TRIO domain
cytochrome b-561/ferric reductase transmembrane domain
DNA/RNA non-specific endonuclease domains
fatty acid desaturase, transmembrane domain
GCN5-related N-acetyl transferase
glycosyltransferase family 10/fucosyltransferase
helicase
juvenile hormone binding protein domain
juvenile hormone binding protein domain
juvenile hormone binding protein domain
juvenile hormone binding protein domain
metallocarboxypeptidase
metallothionein family 5 domain
metallothionein family 5 domain
metallothionein family 5 domain
methyltransferase
myosin ATPase
phosphodiesterase domain, 5’-nucleotidase domain
RNA recognition motif
SET domain, coiled coil region
similar to reverse transcriptase
similarity to integrase/ribonuclease H
MARVEL domain
Mpv17/PMP22 domain, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
DUF1676, transmembrane domain
PAC domain, transmembrane domain
periplasmic binding protein, transmembrane domain
4-helical cytokine domain
DM4/DM12 domain
DM4/DM12 domain
DM4/DM12 domain
DM4/DM12 domain
DM4/DM12 domain
DM4/DM12 domain
DM4/DM12 domain
DM4/DM12 domains
DM4/DM12 domains
DM8 domain
DM8 domain
DM8 domains
DUF1487 domain
DUF270 domain
DUF745 domain
DUF753 domains
Extensin domain
Extensin-2 domain
insect allergen related repeats
Ninjurin domain
OAR domain
PH domain
Retinin C domain
11
Gene ID
Gene Name
Predicted function/protein homologies
CG13041
CG13042
CG13044
CG13056
CG13059
CG13060
CG13062
CG13063
Retinin C domain
Retinin C domain
Retinin C domain
Retinin C domain
Retinin C domain
Retinin C domain
Retinin C domain
Retinin C domain
NOVEL
CG12420
CG12994
CG13069
CG13129
CG13210
CG13300
CG14082
CG14274
CG14312
CG14949
CG15654
CG15673
CG15674
CG17776
CG18294
CG18679
CG30053
CG31900
CG32225
CG32234
CG13047
CG13068
CG13566
CG13576
CG13674
CG14096
CG14160
CG14223
CG14984
CG15449
CG15888
CG18635
CG18676
CG32213
CG32214
CG32939
CG33968
CG9760
CG32208
CG1113
CG11928
CG12524
CG12811
CG12820
CG12836
CG12851
CG1295
CG12964
CG13128
CG13134
CG13203
CG13323
CG13324
CG13373
CG13407
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domain
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
transmembrane domains
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
825-Oak
12
Gene ID
Gene Name
CG13408
CG13461
CG13462
CG13484
CG13588
CG13722
CG13814
CG13857
CG13881
CG13882
CG13936
CG13980
CG14095
CG14318
CG14331
CG14365
CG14497
CG14659
CG14770
CG14973
CG15055
CG15082
CG15125
CG15199
CG15202
CG15311
CG15412
CG15453
CG15649
CG15660
CG15729
CG15867
CG15894
CG15908
CG16800
CG17127
CG17275
CG17368
CG30127
CG30380
CG31051
CG31664
CG31841
CG31959
CG32037
CG32242
CG32537
CG32554
CG40075
CG40081
CG40225
CG5572
CG6362
CG7709
CG7796
CG9965
www.nature.com/nature
Predicted function/protein homologies
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
13
13