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DEAN’S ANATOMY Aishwarya Roy 2. How can [[#|personalized medicine]] lead to more effective treatment ? By looking at the etiology of the disease individually, personalized medicine can lead to an effective treatment. The molecular profile of each individual is different and this could help detect future diseases based on family genetics, age, gender etc. Question: Can personalized medicine increase the chances of discrimination? Matthew [[#|Bowser]] 1. What is your understanding of the term “personalized medicine”? My idea of personalized medicine is a type of medical treatment that is used depending on the certain person and how they react to different medications. Often I have heard about people who take certain pills for anxiety or [[#|depression]] who have to change their medication because it isn't working. I believe personalized medicine is the best way to treat people successfully with all types of illness or disease. Jen Kuang 1. What is your understanding of the term “personalized medicine”? My limited understanding to personalized medicine is that it is made for each individual therefore is a better method of treatment. My question is if personalized medicine can ever become affordable enough that the people who need it but cant afford it can still have access to it? Jessica Gorrell 3. Why do you think “personalized medicine” is particularly relevant to [[#|cancer patients]]? Cancer can occur in a variety of forms with each diagnosis being entirely different from one another. The mass of cells growing in a patient diagnosed with stage 3c breast cancer (for example) could be almost 100% different from a different patient with the same diagnosis. Personalized medicine can help each patient with their individual case, especially when a generalized treatment won’t work for everyone. Pantea Fatemi Ardestani 3. Why do you think “personalized medicine” is particularly relevant to cancer patients? I believe that personalized medicine is relevant to cancer patients because it has to deal, in particular, with an individuals DNA. [[#|Cancer cells]] are specific to the individual patient and in turn, must be personalized to fit the stage and point the patient's in. MEDICAL MINIONS Nina Roxo - My understanding of personalized medicine is a sort of way of treating a certain disease based on individual biological/physiological needs. Personalized medicine can be more effective in disease treatment because instead of giving the same generic prescription to everyone, specific cases are taken into consideration and the treatments are catered to individual need. This could be particularly relevant to patients dealing with cancer because genetically, no two types of cancer are the same, hence "personalized." My questions are, since the genetics of human beings are so similar, by utilizing and discovering more in personalized medicine, can we find more treatment methods that can be put to use by several people instead of a few? Are there certain types of people who will respond better to certain personalized types of medicine? When are generic medicines most effective? What types of disorders are better treated by personalized medicine? Zachary Taylor- Personalized medicine as I understand it is the fairly new practice of setting up a treatment for patients designed specifically for their individual needs. Personalized medicine can be used simply in every day practices such as prescriptions for acne or for ADD. My brother has a specific prescription with a specific dosage and concentration based on his individual needs, it can also be used in cancer research because cancer is a genetic mutation, and that means that not a single case of cancer is the same. I have a few questions regarding the personalized medicine; why do doctors ask about past medical experience? What makes the nature of your genetics different from others diseases? and do common diseases affect others differently just because of their own individual genetics? Jackie Doody - My understanding of personalized medicine is medicine made specifically for a person. Based on various factor such as age, genetic makeup, medical history, and sex, this medicine takes into account all the factors, giving the person the best treatment possible. Personalized medic can lead to a more effective diagnosis and treatment because it understands the person better than just generic medic you can purchase at a pharmacy. The personalized medicine works directly with the conditions of the individual, giving them the help they need. Personalized medicine is very relevant to cancer patients. Based on how bad the cancer is, or on what factors led up to the patient being diagnosed with cancer, research can be done to see what can help the individual the most. Personalized medicine in the world of cancer treatment becomes more effective, fighting against the type of cancer the patient is diagnosed with in a more direct way, made to treat only that patient. A personalized diagnosis of cancer in order to create the personalized medicine may not be what most doctors want to do (it will take a lot of effort and research) however, I believe it would help greatly with the treatment of cancer. My question is, how much will the procedure of diagnosing and producing the personalized medicine cost? Also, does personalized medicine have to be personalized for each individual, or could it be a bit broader, being personalized for people of most of the same categories? Finally, will we be able to discover personalized medication that completely defeats the illness, or will the illness come back, proving the medicine was not as well prescribed for the individual as thought? Aleksandra Sabov- Personalized medicine is healthcare created custom for a person based on their medical history, allergies, genetics and other various factors. This is done to make a patients journey to wellness a pleasant one. Personalized medicine can lead to a more effective diagnosis by using medicine that is best for that patient. Not every treatment option will work, so by looking at the genetic code of the person, the most optimal treatment plan can be used. This is especially important in cancer patients because when someone has cancer, they have a rapid growth of cells and depending on what type of cancer it is, certain genes are activated and vice versa. If doctors can figure out what exactly is causing the cancer, then they can try to develop drugs to inhibit the receptors and stop the cancer growth. Then the patient can go on a clinical trial and such. This may become routine for all cancer patients in the near future to increase the number of survivors and try everything that can possible be done to help the patient. I do have a question however, since all these new drugs will be coming out, who will be funding this and how will the patients pay for all of these new drugs? Crista Chavez - Personalized medicine from my understanding is personally tailoring patient care and treatments based on the individual’s genome in order to see improvement in the patients’ health and lifestyle. We all may be human, but we are not the same, so each individual body and cell can react differently in each patient. Personalized medicine is extremely important in cancer patients because while cancer is categorized by types it will never be nor react the same in every patient’s body. I am interested in the history of how personalized medicine came about? And what are the newer forms of personalized medicine? DETAA James Burgess - My understanding of personalized medicine is that it involves tailored treatments of diseases made specifically for individual patients based on how their genetic makeup reacts to their illness. My questions involving personalized medicine are, can personalized treatment of specific individuals be used to find new treatments of more generalized populaces? If so, how does that happen? Will personalized medicine allow medical experts to anticipate mutations of diseases in the future? How will the discovery of genes that lead to risks of disease affect the future treatment of diseases? Will medical professionals be able to one day edit a person’s genetic code to reduce the risk of disease or even make a person immune? What are the moral and ethical implications of the ability to alter a person’s genetic makeup? How would that differ (or does it) from eugenics? With personalized medicine being seen as the future of modern medicine, what are the main challenges that need to be overcome before genetic evaluation becomes "mainstream"? How can primary care physicians integrate genetics into regular care? What stops them from being able to now? Burooj Mushtaq - To me, the term “personalized medicine” is medicine that is prescribed to a certain individual because it takes into account every symptom and possible condition the person may have and then puts those into consideration when treating whatever it is meant to treat. It is medicine for a particular genetic make-up. “Personalized medicine” is most likely particularly relevant to cancer patients because of the nature of the disease itself and treatments are extremely effective in at least targeting the cancer and attempting to treat it. Some questions I personally have consist of asking how exactly the medicine becomes personalized, and how expensive it is to create them – also why personalized medicine is not a more common practice in the world. Mohamad Alnaal - Personalized medicine, as I understand it, is medicine that is made for a specific person and not a specific disease. This medicine is based on the genetic makeup of a certain individual so that it is made to work with a specific person and not a specific disease. Of course this medicine will help cure or treat specific diseases but the medicine is not the same for every individual. The medicine is different based on a specific individuals genetic makeup so that it is made to work for that specific person. This specific medicine may not work the same for another individual and that is where the term "personalized" comes into play. Animan Randhawa- Personalized medicine, from what I've understood is the use of genomic information to guide an individual person's treatment. While it is a very promising field of healthcare, the first question that came to mind was the cost that would be involved in such a treatment and how it can be reduced to provide healthcare to every person in need.Also,what is the error percentage involved in a sensitive area like genomics? Another issue of concern is privacy. What steps can be taken to ensure the privacy of patients, especially with identity theft on the rise. How can we be sure that information will not be misused? What are the risks involved in personalized medicine? DOUBLE X 1. What is your understanding of the term “personalized medicine”? Personalized medicine is medication made specifically for one person to treat the type of illness or disease they have. It is created by looking into the person's genetic make up (DNA) and the specific type of illness or disease they have. I think this is the best way to treat someone because considering it is created for their specific needs, this will probably the most effective way to treat that illness or disease. Amanda LaFlamme 2. How can personalized medicine lead to more effective diagnosis and/or treatment? Despite having 99.99% of identical genes, everyone's body is slightly different, and therefore reacts to medication differently. Personalized medicine allows a mediation to be produced and provided a person with a personal treatment based on their genome to treat a specific illness or disease. Resulting question: How is personalized medication created? What part of the genome must we focus on in order to treat chronic diseases such as cancer? Alexis Dusio 3. Why do you think “personalized medicine” is particularly relevant to cancer patients? Although cancer is defined as the uncontrolled growth of abnormal cells in the body, it is an extremely broad disease encompassing many different forms. Every person who is diagnosed with cancer experiences the disease differently, which is why personalized medicine is especially important for them. Cancer can have many causes and pathways, so it is important to realize that it is impossible all patients will respond well to the same form of treatment. Resulting Question: How many different causes of cancerous cell growth can there be for one specific form of the disease, such as skin cancer? Marcela Orjuela 4. What are some existing examples of personalized medicine approaches in cancer treatment? How effective are they in improving patient outcomes? A great example of personalized medicine is a drug named Herclon, used to treat certain breast cancer patients. The drug is only applied to patients after a series of test to determine if they need it. Although the cancer these patients have is breast cancer, using these methods they are getting a more thorough and accurate treatment by specifically targeting the problem within their unique genetic makeup. Resulting Question: What needs to be done to utilize more drugs that are specific not only to a certain cancer but to a certain condition within the cancer? THE FALCONS Rachel LoBalboPersonalized medicine is medication that is formed and created for a specific person and their needs based on their genetic makeup. This is useful because it will usual cause the medication to work quicker when comparable with your DNA. Other things used to find what is necessary for personalized medicine may be medical history, gender and a family medical history. Amir ManiAn example of personalized medicine being utilized in cancer patients is the BRCA1 and BRCA2 genetic test for breast cancer. The BRCA1 and BRCA2 tests are very effective at revealing the chances of a patient to form breast cancer in their lifetimes by analyzing their genetic information. My question is in regards to the financial impact of these kinds of personalized medicine. From prior knowledge, I know companies can patent genetic tests and charge obscene sums of money for it. So I’m wondering if laws will be passed to curb the costs of personalized medicine and prevent companies from patenting our genome. Jesse Ngandjuy 3. Why do you think “personalized medicine” is particularly relevant to cancer patients? I believe that personalized medicine approaches in cancer treatment because people have different genes and the medicine is made and adjusted in a way that will fit their needs. Nicholas Russo1)What is your understanding of the term “personalized medicine”? -Personalized medicine is the idea of being able to match a pharmaceutical to the precise and individual biological needs of an individual patient. This would mean that treatment would be most effective for the patient to whom this treatment was introduced. 2) How can personalized medicine lead to more effective diagnosis and/or treatment? -This is because with precision medicine physicians are able to look at genetics in order to determine the conditions to which an individual is susceptible. These defective genes can be targeted and repaired making the treatment directly match the needs of a patient rather then being generic for everyone. 3) Why do you think “personalized medicine” is particularly relevant to cancer patients? -Because the genes that predispose that individual to certain cancers can be targeted with precision medicine and repaired, therefore curing the disease. 4) What are some existing examples of personalized medicine approaches in cancer treatment? How effective are they in improving patient outcomes? -Defective genes that have been found to be tied to cancer are targeted, they are injected with the healthy form of that gene and then display the functions of the normal gene. This would reverse the effects of cancer completely. 5) What techniques are utilized to develop a personalized diagnosis for cancer patients? Can you envision such techniques occurring routinely for every patient in the foreseeable future? -We currently are using methods of testing and locating defective genes and repairing them by physically replacing them. The process is not as efficient as it can be tight now, it takes time and for troughs who don’t have time to lose it could be fatal. I see it being used routinely though not in the very near future.