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2009 PDR GUIDE TO DRUG INTERACTIONS, SIDE EFFECTS AND INDICATIONS FOR TINNITUS As listed in the 2009 Physicians’ Desk Reference Companion Guide When taken at recommended dosages, the following prescription and over-the-counter drugs have caused tinnitus in a small percentage of patients. Note: These drugs were not specifically tested on people who already had tinnitus. More information about these listed drugs can be found in the 2009 Physicians’ Desk Reference (PDR). PDR page numbers follow the drug names on this list. A Abelcet Injection……………………………………………..……. Accutane Capsules……………………………..……………..….. Aceon Tablets (2 mg, 4 mg, 8 mg) (1.5%)….…………. Actiq (1% or greater)…………..………………….….…..……. Aggrenox Capsules (less than 1%)……………………..….. cAgrylin Capsules (1% - 5%)…………………………..……. Alferon N Injection (one patient)…………………..………… Aloxi Injection (less than 1%)…………………………………. Ambien Tablets (infrequent)……………………...…………… Ambien CR Tablets (infrequent to 1%)……………………. Amerge Tablets (infrequent)…………………………...….…. cAnaprox Tablets (3% - 9%)……………………...…..……. cAnaprox DS Tablets (3% - 9%)…………….…….….…… Anzemet Injection (infrequently)………………………..…… Anzemet Tablets (infrequently)……………………….……... Aricept Tablets (infrequent)………………………….………... Aricept ODT Tablets (infrequent)…………………………….. Asacol Delayed-Release Tablets……………………….…..… Atacand HCT (0.5% or greater)………….…………………… Atripla Tablets………………………………………………………. Atrovent Nasal Spray 0.06% (less than 1%) ………..... Avelox (less than 0.1%) ………………………………………… Axert Tablets (rare)…………………..…………………..……. B Bayer Aspirin ……………………………………..………………… Biaxin/Biaxin XL…………………………………………….…….… Bicillin C-R Injectable Suspension…………………………… Bicillin L-A Injection ………………………………………………. C Campral Tablets (infrequent)……………………………….. Capastat Sulfate for Injection……………………………….. Carbatrol Capsules………..…………………………….…….…. Cardene I.V. (rare) ………………………………………..……. Cardizem LA Extended Release Tablets (less than 2%) …………………………………… Celebrex Capsules (0.1% - 1.9%)…………….…….…...… Celexa (infrequent)……………………………….…….……..... cCellCept Capsules (3% to less than 20%)……………. cCellCept Intravenous (3% to less than 20%)………… cCellCept Oral Suspension (3% to less than 20%)…. cCellCept Tablets (3% to less than 20%)………………. Chantix Tablets (infrequent)………………………………….. Cialis Tablets (less than 2%)…………………………………… Cipro I.V. (1% or less)………………………………..………... Cipro (less than 1%) ……………………………………………. Cipro XR Tablets ………………..……………………………..…. Clinoril Tablets (greater than 1%)……….……….………... Combigan Ophthalmic Solution ……………………………… Copaxone for Injection (at least 2%)……………………… Coreg Tablets (greater than 0.1% - 1%)………..…..….. Coreg CR Extended-Release Capsules (0.1% to less than or equal to 1%) ………………….. Cosopt Sterile Ophthalmic Solution………………….……... Cozaar Tablets (less than 1%) ………………………….….. Cubicin…………………………………………………….……....…. Cuprimine Capsules ………………………………………………. Cymbalta Delayed-Release Capsules (Infrequent)…….. 1134 2607 3038 959 819 3017 1726 1059 2692 2696 1301 2632 2632 2701 2704 1062 1062 2579 642 938 836 2803 2431 750 411 1775 1777 1158 1791 3019 1093 421 2979 1160 2622 2622 2622 2622 2511 1792 2817 2810 2823 1962 553 3110 1387 1393 1969 1973 995 1986 1801 D Dapsone Tablets USP………………………………..…….…… Demadex Injection….……....…….…….…………………….. Demadex Tablets ……………………………………………….. cDepakote ER Tablets (greater than 1% - 7%)……. Diovan HCT Tablets (greater than 0.2%)…………….….. Doxil Injection (less than 1%)…………………….……..….. E cEC-Naprosyn Delayed-Release Tablets (3%-9%)…… Edecrin…………………………………………………………….…. Effexor XR Extended-Release Tablets (frequent)…….. Eldepryl Capsules……………………………………………..….. Elmiron Capsules (less than or equal to 1%)……..….… cEmend Capsules (3.7%)………………………………..….. cEmend for Injection (3.7%) ………………………………. Emsam Transdermal System (frequent)…………………. Engerix-B Vaccine….…………………………………………….. Equerto Extented-Release Capsules………………….……. Evoxac Capsules (less than 1%)……………………………. Exelon Capsules (frequent)……………………………………. Exelon Oral Solution (frequent)……………………………… Exelon Patch (infrequent)…………………………………..… Exforge Tablets (greater than 0.1% but less than 1%) ……………. 1746 2630 2630 423 2216 2378 2632 698 3195 3052 2435 1992 1999 905 1409 3174 1013 2229 2233 2233 2238 F cFabrazyme for Intravenous Infusion (8%) …………. Fansidar Tablets…………………………………………………… Flumadine (0.3 to 1%) …………………………………………. Frova Tablest (frequent)………………………………………… Furosemide Tablets ……………………………………………… 1241 2636 1167 1111 2186 G Gabitril Tablets (frequent)……………………………………... Gantrisin Pediatric Suspension………………………………. Gengraf Capsules (1% to less than 3%)………………… Geodon Capsules (infrequent)………………………....…… Gleevec Tablets (infrequent)……………………..…………. 973 2638 435 2520 2255 I Imitrex Nasal Spray ……………………………………………. Indocin (greater 1%)…………….…………….……………… cIntron A for Injection (less than 5%)…………………… 1470 2024 2859 K Kaletra (less than 2%)……………………………….………… 452 L Lamictal (1.1%)……………………………………………….…… Levaquin…………………………………….………………………… Levaquin in 5% Dextrose Injection………………………… Levitra Tablets (less than 2%)……………………………… Lexapro Oral Suspension (frequent)……………………… Lexapro Tablets (frequent)…………………………………… Lidoderm Patch…………………………………………………… Lipitor Tablets (less than 2%)………………………………… Lunesta Tablets (infrequent)…………………………………. Lyrica Capsules (greater than or equal to 1%)………… 1488 2416 2416 2876 1174 1174 1114 2501 2994 2527 M Marinol Capsules (less than 1%)………………………………….. Maxalt Tablets (infrequent)…………………………………………. Maxalt-MLT Oral Disintegrating Tablets (infrequent) ………… Meridia Capsules…………………………………………………………… Miacalcin Nasal Spray (less than 1%)..…………………………… Micardis Tablets (more than 0.3%)….…………….……..……….. Micardis HCT Tablets…………………………………….….….……….. Mirapex Tablets (greater than or equal to 1%)……………….. Mobic Oral Suspension (less than 2%) …………………………… Mobic Tablets (less than 2%)……………….…………….…..…….. Mustargen for Injection (infrequent)………………….……….….. 3163 2056 2056 475 2274 852 854 857 863 863 2492 N Nadolol Tablets (1 to 5 of 1000 patients) ….………….…… cNalfon Capsules (4.5%)...…………………………..…….…… Namenda (infrequent)…..………………….……………………... cNaprosyn Suspension (3% to 9%) ………………………….. cNaprosyn Tablets (3% to 9%)………………………………. Neoral Oral Solution (1% to less than 3%) ………………. Neoral Soft Geletin Capsules (1% to less than 3%)……. Neupro Transdermal System ……………………………………….. Nexavar Tablets (uncommon) …………………………….…… Nexium Delayed-Release Capsules (less than 1%) ……… Nexium I.V. (less than 1%)……………………………………… Nexium Delayed-Release Oral Suspension (less than 1%)… Noroxin Tablets………………………………………………….. Norvir (less than 2%) …………………………………………….… 2192 2508 1180 2632 2632 2280 2280 3149 784 645 652 645 2069 489 O Orthoclone OKT3 Sterile Solution …….…..……………….…… OxyContin Tablets (less than 1%) …………………………. … 2387 2589 P Parnate Tablets…………………………………..……………….…… Paxil (frequent)………………………………………………………… Paxil CR Controlled-Release Tablets (frequent)……….…… Pepcid Tablets(infrequent)………………………………………….. Pepto-Bismol Original Liquid, Maximum Strength Liquid, Original and Cherry Tablets, Chewable Tablets and Easy-To Swallow Caplets………………………………… Percocet Tablets……………………………………………………….. Percodan Tablets………………………………………………………. Pletal Tablets (less than 2%)……..……………..………………. Primaxin I.M. …….…..…….…..……………………..………..……. Primaxin I.V. (less than 0.2%)……………………..………..….. Prinivil Tablets (0.3% to 1.0%)…….……………….………..…. Prinzide Tablets (0.3% to 1%) ……..………..…….….…….... Pristiq Extended-Release Tablets (1% to 2%)……………… cPrograf Capsules and Injections (3% to 15%)………….. Protonix Delayed-Release Oral Suspension (less than 1%)… Protonix Delayed-Release Tablets (less than 1%)… Protonix I.V. (less than 1%) ……….………………………...…. Proventil HFA Inhalation Aerosol (less than 3%)….…….. Prozac Weekly Capsules (frequent)………………………………. Prozac Pulvules and Liquid (frequent)…..……….…………… Pylera Capsules……………………………………………………….. (Continued on next page) Please consult with your physician before making any changes in medication. AMERICAN TINNITUS ASSOCIATION P.O. Box 5 • Portland, OR 97207-0005 • 503-248-9985 • 800-634-8978 [email protected] • www.ata.org 1532 1535 1544 2075 2564 1127 1130 2481 2080 2083 2087 2092 3247 622 3254 3254 3257 2914 1852 1852 714 2009 PDR GUIDE TO DRUG INTERACTIONS, SIDE EFFECTS AND INDICATIONS FOR TINNITUS As listed in the 2009 Physicians’ Desk Reference Companion Guide When taken at recommended dosages, the following prescription and over-the-counter drugs have caused tinnitus in a small percentage of patients. Note: These drugs were not specifically tested on people who already had tinnitus. More information about these listed drugs can be found in the 2009 Physicians’ Desk Reference (PDR). PDR page numbers follow the drug names on this list. R Recombivax HB (less than 1%)……….……………….………… Requip Tablets (infrequent)……...….…………………………… Romazicon Injection (less than 1%) …………………………… Rythmol Tablets (less than 1% to 2%)……………………… Rythmol SR Capsules ……………………..………………….…….. S St. Joseph 81 mg Aspirin Chewable and Enteric Coated Tablets …………………………….…….. Salagen Tablets (1% to 2%)……………………………………… Sandimmune (2% or less) …………………………………….….. Solodyn Extended Release Tablets (2%) ……………………. cSoriatane Capsules (less than 1% to 10%)...………...... Sular Extended-Release Tablets (less than or equal or 1%)…………………………………. Sustiva Capsules (less than 2%)…….…………….……………. Sustiva Tablets (less than 2%) …………………………………. Symbyax Capsules (frequent)…..……………………………….. 2107 1561 2646 1586 1590 1903 1082 2296 1938 3062 2975 930 930 1871 T Tarka Tablets (less frequent)………….……………………. Teveten Tablets (less than 1%)……………………..……. Teveten HCT Tablets (less than 1%) …………………….. Timoptic Sterile Ophthalmic Solution……………………… Timoptic in Ocudose…………………………………………… Timoptic-XE Sterile Ophthalmic Gel Forming Solution………………………….…. Toprol-XL Tablets……………….…..…………………..…….. Treximet Tablets…………………………………………………. Tricor Tablets ……………………………………………………. cTrisenox Injection (5%)….………………………………… Twinrix Vaccine………………………………………..……… 511 515 517 2121 2124 2125 666 1616 520 986 1628 U Ultram ER Extended-Release Tablets (1% to greater than 5%)…………………………………. 2428 V Venlaflaxine Hydrochloride Tablets (2%)…………………. Vicoprofen Tablets (less than 3%)…………….…….….... cVoltaren Tablets (1% to 10%)…..………….…….…….. cVoltaren-XR Tablets (1% to 10%)……….……….….…. 2199 533 2334 2337 W Wellbutrin Tablets…….…..………………..…………….……. cWellbutrin SR Sustained-Release Tablets (5% to 6%) …………………………………………… cWellbutrin XL Extended-Release Tablets (3% to 6%)………………..…………..……………. X Xifaxan Tablets (less than 2%) ……………………………. cXyrem Oral Solution (5.9%)……………………………….. Z Zomig Tablets (infrequent) ………………………………… Zomig Nasal Spray (infrequent)……….……………………. Zomig-ZMT Tablets ….……….…………………….…..…….. Zonegran Capsules (frequent)………………………….….. Zosyn for Injection (1% or less)……………….………..... Zyban Sustained-Release Tablets (1%)….……….…..…. Zyprexa Tablets (infrequent)……………………………….. Zyprexa ZYDIS Orally Disintegrating Tablets (infrequent) …………………………………………. Zyrtec Chewable Tablets (less than 2%)……………….. Zyrtec Syrup (less than 2%)…………………………………. Zyrtec Tablets (less than 2%)…..…………………………. Zyrtec-D 12 Hour Extended Relief Tablets (less than 2%) …..…….………………………….. Please consult with your physician before making any changes in medication. ( Described in PDR for Nonprescription Drugs) (Incidence data in parenthesis : c 3% or more) AMERICAN TINNITUS ASSOCIATION P.O. Box 5 • Portland, OR 97207-0005 • 503-248-9985 • 800-634-8978 [email protected] • www.ata.org 1648 1653 1659 2682 1766 694 689 694 1089 3284 1692 1883 1883 1920 1920 1920 1923
