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Complementary Medicines in the Management of Cholesterol for Pharmacists Assessment Test HOW TO COMPLETE THE ASSESSMENT You will find the answers to all the questions mostly in this manual. Please attempt all questions and indicate your answer on the SEPARATE ASSESSMENT ANSWER SHEET ONLY. When you have completed all questions, detach the sheet and return it to the address provided. 1. Which of the following group of statements are true I. Cholesterol is not essential for life II. There is no healthy level for cholesterol in the body III. The prevalence of hypercholesterolaemia in Malaysia in 2006 was 53.5% IV. The only way to manage hypercholesterolaemia is to take medication (A) III (B) I,II,IV (C) I,II,III (D) II,III,IV 2. Which complementary medicines have been shown to have positive results compared to statin medication in lowering cholesterol (also as adjunctive therapy)? I. Policosanol II. Fish oil III. Gugulipid IV. Garlic V. Vitamin B3 (A) I, II, III (B) III, IV, V (C) I, II, V (D) II, III, IV 3. Which of the following complementary medicines are not recommended or contraindicated in pregnancy and/or lactation? I. Policosanol II. Lecithin III. Garlic IV. CoQ10 (A) I, II (B) I, II, IV (C) I, III (D) I, III, IV 4. Which of the following statements are TRUE for CoQ10? I. A fat-soluble vitamin-like antioxidant II. CoQ10 levels increases with ageing and exercise III. Reduce the degree of muscle pain (myalgia) associated with statin treatment IV. CoQ10 absorbs best when taken on an empty stomach or before meals V. It is recommended dosage is 100-150mg per day (A) I, II, III (B) II, III, V (C) I, III, IV (D) I, III, V 5. How does globe artichoke work on lowering hypercholesterolaemia? (A) By acting as an antioxidant and therefore it prevents oxidation of LCL-C (B) By increasing HDL-C levels and inhibiting platelet ‘clumping’ (C) (D) By inhibiting HMG-CoA reductase and thereby reducing cholesterol synthesis By promoting bile production and increase bile flow, thus increasing the emulsification of cholesterol into bile salts 6. The following statements are true for lecithin EXCEPT (A) Naturally found in the myelin sheath which forms a protective covering for the nerves (B) Lecithin can be used as an adjunctive therapy with cholesterol-lowering drugs without any adverse effects (C) Higher doses of lecithin (more than the recommended dose) is needed to lower cholesterol effectively (D) It is contraindicated in patients who are on warfarin, aspirin and anti-platelet drugs 7. Which of the following has a drug-herb-vitamin interaction based on its clinical studies? (Also refer to the Complementary Medicine Interaction Guide in this manual) I. Lecithin II. Fish oil III. Garlic IV. Gugulipid V. Vitamin C (A) I, IV, V (B) II, III, IV (C) I, II, III (D) III, IV, V 8. Which of the following statements are TRUE in the treatment of hypercholesterolaemia? I. Dietary and lifestyle changes should be considered and adopted before considering drug therapy in patients without CHD or at high risk of CHD II. Some form of weight reduction by exercising (if necessary) is ideal to achieve optimal weight and help to lower the risk of CHD III. Complementary medicines may be used as an adjunctive therapy with drugs in the treatment of hypercholesterolaemia IV. Smoking and alcohol consumption has a compounding effect on CHD risk (A) II,III,IV (B) I, II, III, IV (C) I, II, III (D) I, II, IV 9. The following are important points that you need to highlight to your patients when taking fish oil EXCEPT (A) To be taken with meals as it absorbs better with a meal that consists of small amounts of fat (B) Fish oil decreases TG & TC levels only in hypercholesterolaemic patients based on clinical trials (C) Can be used safely with other complementary medicines or as an adjunctive therapy with cholesterol-lowering medication (D) Doses above 10gm a day should be suspended 1 week before surgery as it may increase the risk of bleeding associated with surgery 10. Which of the following statement is FALSE? (A) Policosanol has been found to decrease the activity of HMG-CoA reductase and has undergone more than 30 clinical trials over a 15 year period (B) Gugulipid’s active components, guggulsterones and gugulipid has been found to have the ability to reduce cholesterol levels (C) High intake of phytosterols and phytostanols has no effect on the absorption of fatsoluble vitamins & antioxidants (D) Grape seed has been found to prevent damage to cholesterol and lining of the artery by acting as an antioxidant. Complementary Medicines in the Management of Cholesterol for Pharmacists Assessment Answer Sheet Name: _____________________________________ MPS Membership No: ___________ Pharmacy / Institution: _______________________________________________________ Full Address: ______________________________________________________________ _________________________________________________________________________ Tel: __________________________ Fax: ________________________ Email: ________________________ Date: _______________________ Please circle the answer Question Answer 1 A B C D 2 A B C D 3 A B C D 4 A B C D 5 A B C D 6 A B C D 7 A B C D 8 A B C D 9 A B C D 10 A B C D You may send in your answer by returning this sheet to the address/fax below, or via email by stating the question number and answer. Complementary Medicines in the Management of Cholesterol for Pharmacists Malaysian Pharmaceutical Society 5B, Lorong Rahim Kajai 13 Taman Tun Dr Ismail 60000 Kuala Lumpur Fax: 03-77263749 Email: [email protected]