Download Androphy NIH bio Dec 2010

BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Androphy, Elliot J.
Professor and Chair of Dermatology
eRA COMMONS USER NAME
eandrox10
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
Brandeis University, Waltham, MA
University of Rochester, Rochester, NY
University of Pittsburgh, Pittsburgh, PA
National Cancer Institute / NIH
A.B.
M.D.
YEAR(s)
1975-79
1979-80
1980-82
1982-86
FIELD OF STUDY
Chemistry
Medicine
Dermatology
Virology
A. Personal Statement
We investigate the genetics and molecular pathogenesis of spinal muscular atrophy (SMA), and have
conducted high throughput screens to identify a treatment for SMA in collaboration with the Laboratory of Drug
Discovery in Neurodegeneration, the Genomics Institute of the Novartis Foundation/The Scripps Research
Institute, and NIH Chemical Genomics Center. We investigate the functions of the SMN protein with emphasis
on its potential role in axonal transport. My lab also investigates the oncogenic functions of papillomavirus E6
and the transcription/replication functions of E2. We are developing small molecule inhibitors of E6 using
structure-based and chemical diversity library screening approaches.
B. Positions and Honors
1982-86
1986-97
Fellow, Laboratory of Cellular Oncology, National Cancer Institute (with Douglas Lowy, M.D.)
Assistant/Associate Professor, Dept. of Dermatology, New England Medical Center
Assistant/Associate Professor, Dept. of Molecular Biology and Microbiology, Tufts University
1990-94
American Cancer Society Faculty Research Award
1997-10/01 Professor and Vice Chair, Dept. of Dermatology, Tufts-New England Medical Center
2001-2010 Barbara & Nathan Greenberg Chair in Biomedical Science
Professor & Vice Chair for Research, Dept. of Medicine, Univ. of Massachusetts Medical School
2001-2009 Director MD/PhD Program, Univ. of Massachusetts Medical School
2010 - Kampen-Norins Professor and Chair, Dept. of Dermatology, Indiana University School of Medicine
Other Experience and Professional Memberships
1992-2002 Associate Editor, Journal of Investigative Dermatology
1997-2001 Member, Experimental Virology Study Section, NIH
2000Editorial Board, Journal of Virology
C. Select peer-reviewed publications (from total of 110)
1. Lorson C.L., Strasswimmer J., Yao J-M., Baleja J.D., Hahnen E., Wirth B., Thanh L., Burghes A.H.M. and
Androphy E.J. SMN oligomerization defect correlates with spinal muscular atrophy severity. Nature
Genetics 19: 63-66, 1998.
2. Lorson C.L. and Androphy E.J. The domain encoded by exon 2 of the survival motor neuron protein
mediates nucleic acid binding. Hum. Mol. Genet. 7: 1269-1275, 1998.
3. Strasswimmer J., Lorson C.L., Breiding D.E., Chen J.J., Le T., Burghes A.H.M. and Androphy E.J.
Identification of survival motor neuron as a transcriptional activator-binding protein. Hum. Mol. Genet. 8:
1219-1226, 1999
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4. Lorson C.L., Hahnen E., Androphy E.J., and Wirth B. A single nucleotide in exon 7 of the SMN gene
regulates splicing and is responsible for spinal muscular atrophy. Proc. Natl. Acad. Sci. 96: 6307-6311,
1999.
5. Monani, U. R., Lorson C.L., Parsons D.W., Androphy E.J., Prior T.W., Burghes A.H.M., and McPherson
J.D. A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the
copy gene SMN2. Hum. Mol. Genet. 8: 1177-1183, 1999.
6. Lorson C.L. and Androphy E.J. An exonic enhancer is required for inclusion of an essential exon in the
SMA-determining gene SMN. Hum. Mol. Genet. 9: 259-265, 2000
7. Singh, NN, Androphy, EJ and Singh, RN. In vivo selection reveals features of combinatorial control that
defines a critical exon in the spinal muscular atrophy genes. RNA 10:1291-1305, 2004.
8. Singh NK, Singh NN, Androphy EJ and Singh RN. Splicing of a critical exon of Survival Motor Neuron
genes is regulated by a silencer element located in its last intron. Mol Cell Biol 26: 1333-1346, 2006.
9. Baleja JB, Cherry J, Gao H, Liu Z, Nicklaus M, Voigt JH, Chen JJ, and Androphy EJ. Identification of
papillomavirus inhibitors based on three-dimension structures of E6-interacting proteins. Antiviral Res
72:49-59, 2006
10. Parish JL, Bean AM, Park RB, and Androphy EJ. ChlR1 is required for loading papillomavirus E2 onto
mitotic chromosomes and viral genome maintenance. Molec Cell 24:867-876, 2006
11. Kumar AR, Naidu S, Wang X, Imbalzano A, Androphy EJ. Interaction of papillomavirus E2 protein with the
chromatin remodeling Brm complex leads to enhanced transcriptional activation. J Virol 81: 2213-20, 2007
12. Sekaric P, Shamanin VA, Luo J, and Androphy EJ. hADA3 regulates p14ARF-induced p53 acetylation and
senescence. Oncogene 26: 6261-6268, 2007.
13. Shamanin VA, Sekaric P, and Androphy EJ. hAda3 degradation by papillomavirus 16 E6 correlates with
abrogation of p14ARF-p53 pathway and efficient immortalization of human mammary epithelial cells. J
Virol 82: 3912-20, 2008.
14. Naidu SR, Love IM, Imbalzano AN, Grossman SR and Androphy EJ. The SWI/SNF chromatin remodeling
subunit BRG1 regulates p53. Oncogene 28:2492-2501, 2009.
15. Melanson SM and Androphy EJ. Topography of bovine papillomavirus E2 protein on the viral genome
during cell cycle. Virology 393: 258-64, 2009.
D. RESEARCH SUPPORT
ONGOING RESEARCH SUPPORT IN PAPILLOMAVIRUS
R01 CA107394-06 Androphy (PI)
Functions of human papillomavirus E6
5/01/10 - 4/30/15
R01 CA58376-17
Androphy (PI)
Control of papillomavirus expression and transformation.
9/24/1993 - 5/31/2012
R01 CA119904-03 Androphy (PI)
Small molecule inhibitors of oncogenic human papillomavirus
1/15/2008 - 12/31/2011
R21 NS064349-01 Androphy (PI)
8/01/2009 - 7/31/2011
Testing Compounds that Increase SMN levels for Efficacy in Mouse Models of SMA
R01 HD 064850-01 Androphy (PI)
9/01/10 - 8/31/13
Cooperative lead development program for the treatment of spinal muscular atrophy
Muscular Dystrophy Association USA
Vesicular transport factor interacts with SMN and the pathogenesis of SMA
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