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Adrian Streit, 三月2016 Curriculum Vitae 简历 姓: Streit 名: Adrian 出生时间: 1966 年 4 月 30 日 出生地点: 瑞士,伯尔尼 国籍: 瑞士 婚姻状况: 已婚 子女: 一个儿子 家庭住址: 德国 家庭电话: +49 7472 91 81 400 工作地址: Max-Planck-Institut für Entwicklungsbilogie Abteilung Evolutionsbiologie Spemannstrasse 35 72076 Tübingen, Germany 工作电话: 07071 601 403 电子邮箱: [email protected] Brühlhof 6, 72072 Tübingen-Bühl 教育经历: 时间 学历 Burgdorf 文科中学(瑞士) 1979-1985 Matura Type A 伯尔尼大学 (瑞士) 1985-1990 生物硕士 伯尔尼大学 (瑞士) 1990-1994 理学博士 1 Adrian Streit, 三月2016 工作经历: 1989-1990 瑞士伯尔尼大学,动物研究所 ,生物学硕士(硕士论文: A 部分: Sequencing of a mouse histone H3.2 gene. B 部分: Efficiency of 3’ end processing of different histone pre-mRNAs in vitro). 1990-1994 瑞士伯尔尼大学,动物研究所,博士研究生。导师: Daniel Schümperli 博士,教授 (博士论文: The Role of the Conserved Terminal Hairpin Structure in Histone mRNA 3’ End Formation). 1994-1997 美国科罗拉多大学,博士后。导师: William B. Wood 博士, 教授。研究 主题:sex determination in the nematode Caenorhabditis elegans. 1997-1999 瑞士苏黎世大学,博士后。导师: Monica Steinmann-Zwicky 博士,教 授。 研究主题:sex determination in the fruit fly Drosophila melanogaster. 1999-2003 瑞士弗莱堡大学,生物学,研究和教学助理。导师:Fritz Müller 博士, 教授。 研究主题:the early embryonic development of Caenorhaditis elegans. 2003- 德国马克斯-普朗克学会,图宾根发育生物学研究所,进化生物学系,课 题组负责人。研究课题: the early embryonic development of Caenorhaditis elegans. Building up and certification of safety level 2 laboratories for work with nematodes of risk group 2. Gradual transition to work on parasitic nematodes of the genera Strongyloides and Onchocerca and the reproductive biology of parasitic nematodes of the genera Strongyloides and Onchocerca. 2005-2012 图宾根大学讲师 2012- 图宾根大学生物系的特聘教授 语言能力: 德语 母语 英语 流利 法语 流利 2 Adrian Streit, 三月2016 教学经验: 自 1999 年开始对生物学系和医学院的学生完成定期教学任务。包括瑞士弗莱堡大 学和德国图宾根大学。 发表过的科研论文: Streit, A., Wang, J., Kang, Y. and Davis, R. E. (2016). Gene Silencing and Sex Determination by Programmed DNA Elimination in Parasitic Nematodes. Current Opinion in Microbiology, submitted (invited review). Streit, A. (2016). Genetics: Modes of Reproduction and Genetic Analysis. Parasitology, in press (Review, special issue on Strongyloides spp.). Kulkarni, A., Lightfoot, J. W. and Streit, A. (2016). Germline organization in Strongyloides nematodes reveals alternative differentiation and regulation mechanisms. Chromosoma, in press. Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., Tracey, A., Cotton, J. A., Stanley, E. J., Beasley, H., Bennett, H., Brooks, K., Harsha, B., Kajitani, R., Kulkarni, A., Harbecke, D., Nagayasu, E., Nichol, S., Ogura, Y., Quail, M., Randle, N., Ribeiro, D., Sanchez-Flores, A., Hayashi, T., Itoh, T., Denver, D. R., Grant, W., Stoltzfus, J. D., Lok, J. B., Murayama, H., Wastling, J., Streit, A., Kikuchi, T., Viney, M. E., Matthew Berriman, M. (2016). The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes. Nature Genetics, 48, 299-307. Kulkarni, A., Holz, A., Rödelsperger, C., Harbecke, D. and Streit, A. (2016). Differential chromatin amplification and chromosome complements in the germline of Strongyloididae (Nematoda). Chromosoma, 125, 125-136. Guo, L., Chang, Z., Dieterich, C. and Streit, A. (2015). A protocol for chemical mutagenesis in Strongyloides ratti. Experimental Parasitology 158, 2-7 (special issue). Witte, H., Moreno, E., Rödelsperger, C., Kim, J. S., Kim, J. S., Streit, A. and Sommer, R. J. (2015). Gene inactivation using the CRISPR/Cas9 system in the nematode Pristionchus pacificus. Development Genes and Evolution 225, 5562. Hildebrandt, J. C., Eisenbarth, A., Renz, A. and Streit, A. (2014). Reproductive biology of Onchocerca ochengi, a nodule forming filarial nematode in zebu cattle. Veterinary Parasitology 205, 318-329.. Streit, A. (2014). How to become a parasite without sex chromosomes: a hypothesis for the evolution of Strogyloides sp. and related nematodes. Parasitology 141, 1244-1254 (Review). Schär, F., Guo. L., Streit, A., Khieu, V., Sinuon, M., Marti, H. and Odermatt, P. (2014). Strongyloides stercoralis genotypes in humans in Cambodia. Parasitology inernational, 63, 533-536. Rödelsperger, C. and Streit, A. (2013). Komplexität im Kleinen - NematodenGenome im Vergleich. BIOspektrum 06.13, 606-610. (in German) 3 Adrian Streit, 三月2016 Kulkarni, A., Dyka, A., Nemetschke, L., Grant, W. N. and Streit, A. (2013). Parastrongyloides trichosuri suggests that XX/XO sex determination is ancestral in Strongyloididae (Nematode). Parasitology 140, 1822-1830. Eisenbarth, A., Ekale, D., Hildebrandt, J. C., Achukwi, M. D, Streit, A. and Renz, A. (2013). Molecular evidence of ‘Siisa form’, a new genotype related to Onchocerca ochengi in cattle from North Cameroon. Acta Tropica 127, 261265. Rödelsperger, C., Streit, A. and Sommer, R. J. (2013). Structure, function and evolution of the nematode genome. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net/ DOI: 10.1002/9780470015902.a0024603 (Review). Streit, A. (2012). Silencing by throwing away: a role for chromatin diminution. Developmental Cell 23, 918-919 (Preview). Hildebrandt, J. C., Eisenbarth, A., Renz, A. and Streit, A. (2012). Single worm genotyping demonstrates that Onchocerca ochengi females simultaneously produce progeny sired by different males. Parasitology Research 111, 22172221. Sommer, R. J. and Streit, A. (2011). Comparative Genetics and Genomics of Nematodes: Genome Structure, Development and Lifestyle. Annual Review of Genetics 45, 1-20 (Review). Nemetschke, L., Eberhardt, A. G., Hertzberg, H. and Streit, A. (2010). Genetics, chromatin diminution and sex chromosome evolution in the parasitic nematode genus Strongyloides. Current Biology 20, 1687-1696. Streit, A. and Sommer, R. J. (2010). Genetics: Random expression goes binary Nature, 463, 891-892 (News and Views). Nemetschke, L., Eberhardt, A. G., Viney, M. E. and Streit, A. (2010). A genetic map of the animal-parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitiology 169, 124-127. Wegewitz, V., Schulenburg, H. and Streit, A. (2009). Do males facilitate the spread of novel phenotypes within populations of the androdioecious nematode Caenorhabditis elegans? Journal of Nematology, 41, 247-254. Minasaki, R., Puoti, A. and Streit, A. (2009). The DEAD-box protein MEL-46 is required in the germ line of the nematode Caenorhabditis elegans. BMC Developmental Biology 9, 35 Ogawa, A., Streit, A., Antebi, A. and Sommer, R. J. (2009). A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes. Current Biology 19, 67-71. Eberhardt, A. G., Mayer, W. E., Bonfoh, B. and Streit, A. (2008). The Strongyloides (Nematoda) of sheep and the predominant Strongyloides of cattle form at least two different, genetically isolated populations. Veterinary Parasitology 157, 8999. Wegewitz, V., Schulenburg, H. and Streit, A. (2008) Experimental insight into the proximate causes of male persistence variation among two strains of the androdioecious Caenorhabditis elegans (Nematoda). BMC Ecology 8, 12. 4 Adrian Streit, 三月2016 Streit, A. (2008). Reproduction in Strongyloides (Nematoda): a life between sex and parthenogenesis. Parasitology 135, 285-294 (Review). Eberhardt, A. G., Mayer, W. E. and Streit, A. (2007). The free-living generation of the nematode Strongyloides papillosus undergoes sexual reproduction. International Journal for Parasitology 37, 989-1000. Minasaki, R. and Streit, A. (2007). mel-47, a novel protein required for early cell divisions in the nematode Caenorhabditis elegans. Molecular Genetics and Genomics 277, 315-328. Takacs-Vellai, K., Vellai, T., Puoti, A., Passannante, M., Wicky, C., Streit, A., Kovacs, A. L. and Müller, F. (2005). Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Current Biology 15, 1513-1517. Stoyanov, C. N., Fleischmann, M., Suzuki, Y., Tapparel, N., Gautron, F., Streit, A., Wood, W. B. and Müller, F. (2003). Expression of the C. elegans labial Orthologue ceh-13 during Male Tail Morphogenesis. Developmental Biology 259, 137-149. Streit, A., Kohler, R., Marty, T., Belfiore, M., Takacs-Vellai, K., Maria-Alessandra Vigano, M. A., Schnabel, R., Affolter, M. and Müller, F. (2002). Conserved regulation of the C. elegans labial/ Hox1 gene ceh-13. Developmental Biology 242, 96-108. Streit, A., Bernasconi, L., Sergeev, P. and Steinmann-Zwicky, M. (2002). mgm1, the earliest sex-specific germline marker in Drosophila reflects the expression of the gene esg in male stem cells. International Journal of Developmental Biology 46, 159-166. Sergeev, P., Streit, A., Heller, A. and Steinmann-Zwicky, M. (2001). The Drosophila dorsoventral determinant pipe contains ten copies of a variable exon homologous to mamalian heparan sulfate 2-sulfotransferase. Developmental Dynamics 220, 122-132. Streit, A., Li, W., Robertson, B., Schein, J., Kamal, I. H., Marra, M. and Wood, W. B. (1999). Homologs of the Caenorhabditis elegans masculinizing gene her-1 in Caenorhabditis briggsae and the filarial parasite Brugia malayi. Genetics 152, 1573-1584. Li, W., Streit, A., Robertson, B. and Wood, W. B. (1999). Evidence for multiple promoter elements orchestrating male-specific regulation of the her-1 gene in C. elegans. Genetics 152, 237-248. Wood, W. B., Streit, A. and Li, W. (1997). Dosage compensation: X-repress yourself. Current Biology 7, R227-R230 (Dispatch). Spycher, C., Streit, A., Stefanovic, B., Albrecht, D., Wittop Koning, T. H. and Schümperli, D. (1994). 3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA. Nucleic Acids Research 22, 4023-4030. Streit, A., Wittop Koning, T., Soldati, D., Melin, L. and Schümperli, D. (1993). Variable effects of the conserved RNA hairpin element upon 3' end processing of histone pre-mRNA in vitro. Nucleic Acids Research 21, 1569-1575. 5 Adrian Streit, 三月2016 Melin, L., Soldati, D., Mital, R., Streit, A. and Schümperli, D. (1992). Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factors. EMBO Journal 11, 691697. Gruber, A., Streit, A., Reist, M., Benninger, P., Böhni, R. and Schümperli, D. (1990). Structure of a mouse histone-encoding gene cluster. Gene 95, 303-304. 参与评审的科研杂志: Acta Tropica, BioEssays, BMC Biology, BMC Developmental Biology, BMC Evolutionary Biology, BMC Genetics, BMC Genomics, BMC Research Notes, Current Genomics, Developmental Cell, EvoDevo, Experimental Parasitology, FEBS Journal, Genetica, Genome, Infection Genetics and Evolution, International Journal for Parasitology, Journal of Helmintology, Journal of Medicinal Chemistry, Journal of Nematology, Mobile Genetic Elements, Molecular and Cellular Proteomics, Nematology, Nematology Monographs and Perspectives (vol. 11), Parasite Immunology, Parasitology, PLOS Neglected Tropical Diseases, PLOS Pathogens, Science, Transactions of the Royal Society of Tropical Medicine and Hygiene, Trends in Parasitology, WormBook, Zoological Science. 参加会议(有口头演讲的): 30. 06. 2005 University of Pennsylvania, Philadelphia, U.S.A. 05. 07. 2005 University of Tübingen (Inst. of Cell Biology) 01.12. 2005 University of Tübingen (Tropical Institute) 01.06. 2006 University of Tübingen (Inst. of Evolution and Ecology) 27. 03. 2007 University of Fribourg, Switzerland 30. 06. 2007 16th international C. elegans Meeting Los Angeles, U.S.A. 07. 07. 2007 University of Pennsylvania, Philadelphia, U.S.A. 07. 03. 2008 23rd Annual Meeting of the German Society for Parasitology, Hamburg. 31. 03. 2008 European C. elegans Meeting, Carmona, Spain. 12. 06. 2008 University of Leeds, United Kingdom 12. 09. 2008 Conference "Molecular and Cellular Biology of Helminth Parasites V", Hydra, Greece. 03. 12. 2008 University of Zürich, Switzerland 23. 02. 2009 University of Berne, Switzerland 17. 03. 2010 24th Annual Meeting of the German Society for Parasitology, Düsseldorf 6 Adrian Streit, 三月2016 06. 06. 2010 Evolutionary Biology of Caenorhabditis and Other Nematodes Conference, Hinxton, U.K. (invited speaker) 08. 07. 2010 University of Tübingen (Inst. of Human Genetics) 16. 08. 2010 International Congress of Parasitology (ICOPA) XII, Melbourne, Australia (invited speaker) 16. 09. 2011 Annual Conference of the German Genetics Society, Würtzburg 16. 03. 2012 25th Annual Meeting of the German Society for Parasitology, Heidelberg 04. 04. 2012 Evolution of Caenorhabditis and Conference, Cold Spring Harbor, U.S.A. 08. 05. 2012 LeadNet meeting, symposium "The evolution of systems", Berlin (invited speaker) 21. 06. 2012 University of Tübingen (Tropical Institute) 03. 09. 2012 Conference "Molecular and Cellular Biology of Helminth Parasites VII", Hydra, Greece. 20. 09. 2012 Huazhong Agricultural University, Wuhan, China 21. 03. 2013 German Nematode Meeting, LMU Munich, Germany 04. 11. 2013 University of Tübingen (EvE) 11. 04. 2014 University of Nice Sophia Antipolis, France 16. 07. 2014 ParaTrop Meeting, Zürich, Switzerland 11. 08. 2014 International Congress of Parasitology (ICOPA) XIII, Mexico City, Mexico (invited speaker) 13. 08. 2014 International Congress of Parasitology (ICOPA) XIII, Mexico City, Mexico (talk selected from abstracts) 13. 08. 2014 International Congress of Parasitology (ICOPA) XIII, Mexico City, Mexico (talk selected from abstracts) 11. 03. 2016 27th Annual Meeting of the German Society for Parasitology, Göttingen 09. 06. 2016 Retirement Symposium Prof. D. Schümperli, Berne, Switzerland Other Nematodes 额外基金: German Research Foundation Grant AOBJ:602317 (2013, in response to German African Cooperation Projects in Infectology, 4th Call) project partner. Total amount granted (not including overhead): Euro 360'150.-- plus 1 postdoc 24 months and 1 PhD student for 12 months. Amount for project partner Streit: Euro 30'000. 7 Adrian Streit, 三月2016 附注: 德国马克斯普朗克学会所属的马克斯普朗克研究所是高度自我基金资助的科研研 究所,经费非常充足。因此,最主要的公共科研基金,德国国家科研基金 (DFG),不对马普协会的终身研究人员提供科研经费,除非是与其他科研单位的 特别合作项目。 组织会议: 14. 06 - 17. 06. 2014 Evolutionary Biology of Caenorhabditis and other Nematodes, Welcome Trust Conference, Cambridge, England. 30. 03. - 02. 04. 2016 Evolutionary Biology of Caenorhabditis and other Nematodes, Cold Spring Harbor Symposium, Cold Spring Harbor, USA. 8