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Adrian Streit, 三月2016
Curriculum Vitae 简历
姓:
Streit
名:
Adrian
出生时间:
1966 年 4 月 30 日
出生地点:
瑞士，伯尔尼
国籍:
瑞士
婚姻状况:
已婚
子女:
一个儿子
家庭住址:
德国
家庭电话:
+49 7472 91 81 400
工作地址:
Max-Planck-Institut für Entwicklungsbilogie
Abteilung Evolutionsbiologie
Spemannstrasse 35
72076 Tübingen, Germany
工作电话:
07071 601 403
电子邮箱:
[email protected]
Brühlhof 6, 72072 Tübingen-Bühl
教育经历:
时间
学历
Burgdorf 文科中学(瑞士)
1979-1985
Matura Type A
伯尔尼大学 (瑞士)
1985-1990
生物硕士
伯尔尼大学 (瑞士)
1990-1994
理学博士
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Adrian Streit, 三月2016
工作经历:
1989-1990
瑞士伯尔尼大学，动物研究所 ，生物学硕士(硕士论文: A 部分:
Sequencing of a mouse histone H3.2 gene. B 部分: Efficiency of 3’ end
processing of different histone pre-mRNAs in vitro).
1990-1994
瑞士伯尔尼大学，动物研究所，博士研究生。导师： Daniel Schümperli
博士，教授 (博士论文: The Role of the Conserved Terminal Hairpin
Structure in Histone mRNA 3’ End Formation).
1994-1997
美国科罗拉多大学，博士后。导师： William B. Wood 博士, 教授。研究
主题：sex determination in the nematode Caenorhabditis elegans.
1997-1999
瑞士苏黎世大学，博士后。导师： Monica Steinmann-Zwicky 博士，教
授。 研究主题：sex determination in the fruit fly Drosophila
melanogaster.
1999-2003
瑞士弗莱堡大学，生物学，研究和教学助理。导师：Fritz Müller 博士，
教授。 研究主题：the early embryonic development of Caenorhaditis
elegans.
2003-
德国马克斯-普朗克学会，图宾根发育生物学研究所，进化生物学系，课
题组负责人。研究课题： the early embryonic development of
Caenorhaditis elegans. Building up and certification of safety level 2
laboratories for work with nematodes of risk group 2. Gradual transition
to work on parasitic nematodes of the genera Strongyloides and
Onchocerca and the reproductive biology of parasitic nematodes of the
genera Strongyloides and Onchocerca.
2005-2012
图宾根大学讲师
2012-
图宾根大学生物系的特聘教授
语言能力:
德语
母语
英语
流利
法语
流利
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Adrian Streit, 三月2016
教学经验:
自 1999 年开始对生物学系和医学院的学生完成定期教学任务。包括瑞士弗莱堡大
学和德国图宾根大学。
发表过的科研论文:
Streit, A., Wang, J., Kang, Y. and Davis, R. E. (2016). Gene Silencing and Sex
Determination by Programmed DNA Elimination in Parasitic Nematodes.
Current Opinion in Microbiology, submitted (invited review).
Streit, A. (2016). Genetics: Modes of Reproduction and Genetic Analysis.
Parasitology, in press (Review, special issue on Strongyloides spp.).
Kulkarni, A., Lightfoot, J. W. and Streit, A. (2016). Germline organization in
Strongyloides nematodes reveals alternative differentiation and regulation
mechanisms. Chromosoma, in press.
Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., Tracey, A.,
Cotton, J. A., Stanley, E. J., Beasley, H., Bennett, H., Brooks, K., Harsha, B.,
Kajitani, R., Kulkarni, A., Harbecke, D., Nagayasu, E., Nichol, S., Ogura, Y.,
Quail, M., Randle, N., Ribeiro, D., Sanchez-Flores, A., Hayashi, T., Itoh, T.,
Denver, D. R., Grant, W., Stoltzfus, J. D., Lok, J. B., Murayama, H., Wastling,
J., Streit, A., Kikuchi, T., Viney, M. E., Matthew Berriman, M. (2016). The
Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes.
Nature Genetics, 48, 299-307.
Kulkarni, A., Holz, A., Rödelsperger, C., Harbecke, D. and Streit, A. (2016).
Differential chromatin amplification and chromosome complements in the
germline of Strongyloididae (Nematoda). Chromosoma, 125, 125-136.
Guo, L., Chang, Z., Dieterich, C. and Streit, A. (2015). A protocol for chemical
mutagenesis in Strongyloides ratti. Experimental Parasitology 158, 2-7
(special issue).
Witte, H., Moreno, E., Rödelsperger, C., Kim, J. S., Kim, J. S., Streit, A. and Sommer,
R. J. (2015). Gene inactivation using the CRISPR/Cas9 system in the
nematode Pristionchus pacificus. Development Genes and Evolution 225, 5562.
Hildebrandt, J. C., Eisenbarth, A., Renz, A. and Streit, A. (2014). Reproductive
biology of Onchocerca ochengi, a nodule forming filarial nematode in zebu
cattle. Veterinary Parasitology 205, 318-329..
Streit, A. (2014). How to become a parasite without sex chromosomes: a hypothesis
for the evolution of Strogyloides sp. and related nematodes. Parasitology 141,
1244-1254 (Review).
Schär, F., Guo. L., Streit, A., Khieu, V., Sinuon, M., Marti, H. and Odermatt, P.
(2014). Strongyloides stercoralis genotypes in humans in Cambodia.
Parasitology inernational, 63, 533-536.
Rödelsperger, C. and Streit, A. (2013). Komplexität im Kleinen - NematodenGenome im Vergleich. BIOspektrum 06.13, 606-610. (in German)
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Adrian Streit, 三月2016
Kulkarni, A., Dyka, A., Nemetschke, L., Grant, W. N. and Streit, A. (2013).
Parastrongyloides trichosuri suggests that XX/XO sex determination is
ancestral in Strongyloididae (Nematode). Parasitology 140, 1822-1830.
Eisenbarth, A., Ekale, D., Hildebrandt, J. C., Achukwi, M. D, Streit, A. and Renz, A.
(2013). Molecular evidence of ‘Siisa form’, a new genotype related to
Onchocerca ochengi in cattle from North Cameroon. Acta Tropica 127, 261265.
Rödelsperger, C., Streit, A. and Sommer, R. J. (2013). Structure, function and
evolution of the nematode genome. In: eLS. John Wiley & Sons Ltd,
Chichester. http://www.els.net/ DOI: 10.1002/9780470015902.a0024603
(Review).
Streit, A. (2012). Silencing by throwing away: a role for chromatin diminution.
Developmental Cell 23, 918-919 (Preview).
Hildebrandt, J. C., Eisenbarth, A., Renz, A. and Streit, A. (2012). Single worm
genotyping demonstrates that Onchocerca ochengi females simultaneously
produce progeny sired by different males. Parasitology Research 111, 22172221.
Sommer, R. J. and Streit, A. (2011). Comparative Genetics and Genomics of
Nematodes: Genome Structure, Development and Lifestyle. Annual Review of
Genetics 45, 1-20 (Review).
Nemetschke, L., Eberhardt, A. G., Hertzberg, H. and Streit, A. (2010). Genetics,
chromatin diminution and sex chromosome evolution in the parasitic
nematode genus Strongyloides. Current Biology 20, 1687-1696.
Streit, A. and Sommer, R. J. (2010). Genetics: Random expression goes binary
Nature, 463, 891-892 (News and Views).
Nemetschke, L., Eberhardt, A. G., Viney, M. E. and Streit, A. (2010). A genetic map
of the animal-parasitic nematode Strongyloides ratti. Molecular and
Biochemical Parasitiology 169, 124-127.
Wegewitz, V., Schulenburg, H. and Streit, A. (2009). Do males facilitate the spread
of novel phenotypes within populations of the androdioecious nematode
Caenorhabditis elegans? Journal of Nematology, 41, 247-254.
Minasaki, R., Puoti, A. and Streit, A. (2009). The DEAD-box protein MEL-46 is
required in the germ line of the nematode Caenorhabditis elegans. BMC
Developmental Biology 9, 35
Ogawa, A., Streit, A., Antebi, A. and Sommer, R. J. (2009). A conserved endocrine
mechanism controls the formation of dauer and infective larvae in nematodes.
Current Biology 19, 67-71.
Eberhardt, A. G., Mayer, W. E., Bonfoh, B. and Streit, A. (2008). The Strongyloides
(Nematoda) of sheep and the predominant Strongyloides of cattle form at least
two different, genetically isolated populations. Veterinary Parasitology 157, 8999.
Wegewitz, V., Schulenburg, H. and Streit, A. (2008) Experimental insight into the
proximate causes of male persistence variation among two strains of the
androdioecious Caenorhabditis elegans (Nematoda). BMC Ecology 8, 12.
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Adrian Streit, 三月2016
Streit, A. (2008). Reproduction in Strongyloides (Nematoda): a life between sex and
parthenogenesis. Parasitology 135, 285-294 (Review).
Eberhardt, A. G., Mayer, W. E. and Streit, A. (2007). The free-living generation of the
nematode Strongyloides papillosus undergoes sexual reproduction.
International Journal for Parasitology 37, 989-1000.
Minasaki, R. and Streit, A. (2007). mel-47, a novel protein required for early cell
divisions in the nematode Caenorhabditis elegans. Molecular Genetics and
Genomics 277, 315-328.
Takacs-Vellai, K., Vellai, T., Puoti, A., Passannante, M., Wicky, C., Streit, A., Kovacs,
A. L. and Müller, F. (2005). Inactivation of the autophagy gene bec-1 triggers
apoptotic cell death in C. elegans. Current Biology 15, 1513-1517.
Stoyanov, C. N., Fleischmann, M., Suzuki, Y., Tapparel, N., Gautron, F., Streit, A.,
Wood, W. B. and Müller, F. (2003). Expression of the C. elegans labial
Orthologue ceh-13 during Male Tail Morphogenesis. Developmental Biology
259, 137-149.
Streit, A., Kohler, R., Marty, T., Belfiore, M., Takacs-Vellai, K., Maria-Alessandra
Vigano, M. A., Schnabel, R., Affolter, M. and Müller, F. (2002). Conserved
regulation of the C. elegans labial/ Hox1 gene ceh-13. Developmental Biology
242, 96-108.
Streit, A., Bernasconi, L., Sergeev, P. and Steinmann-Zwicky, M. (2002). mgm1, the
earliest sex-specific germline marker in Drosophila reflects the expression of
the gene esg in male stem cells. International Journal of Developmental
Biology 46, 159-166.
Sergeev, P., Streit, A., Heller, A. and Steinmann-Zwicky, M. (2001). The Drosophila
dorsoventral determinant pipe contains ten copies of a variable exon
homologous to mamalian heparan sulfate 2-sulfotransferase. Developmental
Dynamics 220, 122-132.
Streit, A., Li, W., Robertson, B., Schein, J., Kamal, I. H., Marra, M. and Wood, W. B.
(1999). Homologs of the Caenorhabditis elegans masculinizing gene her-1 in
Caenorhabditis briggsae and the filarial parasite Brugia malayi. Genetics 152,
1573-1584.
Li, W., Streit, A., Robertson, B. and Wood, W. B. (1999). Evidence for multiple
promoter elements orchestrating male-specific regulation of the her-1 gene in
C. elegans. Genetics 152, 237-248.
Wood, W. B., Streit, A. and Li, W. (1997). Dosage compensation: X-repress yourself.
Current Biology 7, R227-R230 (Dispatch).
Spycher, C., Streit, A., Stefanovic, B., Albrecht, D., Wittop Koning, T. H. and
Schümperli, D. (1994). 3' end processing of mouse histone pre-mRNA:
evidence for additional base-pairing between U7 snRNA and pre-mRNA.
Nucleic Acids Research 22, 4023-4030.
Streit, A., Wittop Koning, T., Soldati, D., Melin, L. and Schümperli, D. (1993).
Variable effects of the conserved RNA hairpin element upon 3' end processing
of histone pre-mRNA in vitro. Nucleic Acids Research 21, 1569-1575.
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Adrian Streit, 三月2016
Melin, L., Soldati, D., Mital, R., Streit, A. and Schümperli, D. (1992). Biochemical
demonstration of complex formation of histone pre-mRNA with U7 small
nuclear ribonucleoprotein and hairpin binding factors. EMBO Journal 11, 691697.
Gruber, A., Streit, A., Reist, M., Benninger, P., Böhni, R. and Schümperli, D.
(1990). Structure of a mouse histone-encoding gene cluster. Gene 95,
303-304.
参与评审的科研杂志：
Acta Tropica, BioEssays, BMC Biology, BMC Developmental Biology, BMC
Evolutionary Biology, BMC Genetics, BMC Genomics, BMC Research Notes, Current
Genomics, Developmental Cell, EvoDevo, Experimental Parasitology, FEBS Journal,
Genetica, Genome, Infection Genetics and Evolution, International Journal for
Parasitology, Journal of Helmintology, Journal of Medicinal Chemistry, Journal of
Nematology, Mobile Genetic Elements, Molecular and Cellular Proteomics,
Nematology, Nematology Monographs and Perspectives (vol. 11), Parasite
Immunology, Parasitology, PLOS Neglected Tropical Diseases, PLOS Pathogens,
Science, Transactions of the Royal Society of Tropical Medicine and Hygiene,
Trends in Parasitology, WormBook, Zoological Science.
参加会议（有口头演讲的）:
30. 06. 2005
University of Pennsylvania, Philadelphia, U.S.A.
05. 07. 2005
University of Tübingen (Inst. of Cell Biology)
01.12. 2005
University of Tübingen (Tropical Institute)
01.06. 2006
University of Tübingen (Inst. of Evolution and Ecology)
27. 03. 2007
University of Fribourg, Switzerland
30. 06. 2007
16th international C. elegans Meeting Los Angeles, U.S.A.
07. 07. 2007
University of Pennsylvania, Philadelphia, U.S.A.
07. 03. 2008
23rd Annual Meeting of the German Society for Parasitology,
Hamburg.
31. 03. 2008
European C. elegans Meeting, Carmona, Spain.
12. 06. 2008
University of Leeds, United Kingdom
12. 09. 2008
Conference "Molecular and Cellular Biology of Helminth
Parasites V", Hydra, Greece.
03. 12. 2008
University of Zürich, Switzerland
23. 02. 2009
University of Berne, Switzerland
17. 03. 2010
24th Annual Meeting of the German Society for Parasitology,
Düsseldorf
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Adrian Streit, 三月2016
06. 06. 2010
Evolutionary Biology of Caenorhabditis and Other Nematodes
Conference, Hinxton, U.K. (invited speaker)
08. 07. 2010
University of Tübingen (Inst. of Human Genetics)
16. 08. 2010
International Congress of Parasitology (ICOPA) XII, Melbourne,
Australia (invited speaker)
16. 09. 2011
Annual Conference of the German Genetics Society, Würtzburg
16. 03. 2012
25th Annual Meeting of the German Society for Parasitology,
Heidelberg
04. 04. 2012
Evolution
of
Caenorhabditis
and
Conference, Cold Spring Harbor, U.S.A.
08. 05. 2012
LeadNet meeting, symposium "The evolution of systems",
Berlin (invited speaker)
21. 06. 2012
University of Tübingen (Tropical Institute)
03. 09. 2012
Conference "Molecular and Cellular Biology of Helminth
Parasites VII", Hydra, Greece.
20. 09. 2012
Huazhong Agricultural University, Wuhan, China
21. 03. 2013
German Nematode Meeting, LMU Munich, Germany
04. 11. 2013
University of Tübingen (EvE)
11. 04. 2014
University of Nice Sophia Antipolis, France
16. 07. 2014
ParaTrop Meeting, Zürich, Switzerland
11. 08. 2014
International Congress of Parasitology (ICOPA) XIII, Mexico City,
Mexico (invited speaker)
13. 08. 2014
International Congress of Parasitology (ICOPA) XIII, Mexico City,
Mexico (talk selected from abstracts)
13. 08. 2014
International Congress of Parasitology (ICOPA) XIII, Mexico City,
Mexico (talk selected from abstracts)
11. 03. 2016
27th Annual Meeting of the German Society for Parasitology,
Göttingen
09. 06. 2016
Retirement Symposium Prof. D. Schümperli, Berne, Switzerland
Other
Nematodes
额外基金:
German Research Foundation Grant AOBJ:602317 (2013, in response to
German African Cooperation Projects in Infectology, 4th Call) project partner.
Total amount granted (not including overhead): Euro 360'150.-- plus 1 postdoc
24 months and 1 PhD student for 12 months.
Amount for project partner Streit: Euro 30'000.
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Adrian Streit, 三月2016
附注: 德国马克斯普朗克学会所属的马克斯普朗克研究所是高度自我基金资助的科研研
究所，经费非常充足。因此，最主要的公共科研基金，德国国家科研基金
(DFG)，不对马普协会的终身研究人员提供科研经费，除非是与其他科研单位的
特别合作项目。
组织会议:
14. 06 - 17. 06. 2014
Evolutionary Biology of Caenorhabditis and other
Nematodes, Welcome Trust Conference, Cambridge, England.
30. 03. - 02. 04. 2016
Evolutionary Biology of Caenorhabditis and other
Nematodes, Cold Spring Harbor Symposium, Cold Spring Harbor, USA.
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