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Tessa Bergsbaken, Ph.D. Instructor, Department of Pathology and Laboratory Medicine Center for Immunity and Inflammation Rutgers New Jersey Medical School Work address: Rutgers New Jersey Medical School Department of Pathology and Laboratory Medicine Center for Immunity and Inflammation 205 South Orange Ave. Cancer Center, G-1210 Newark, NJ 07103 T: 973-972-7933 E: [email protected] Home address: Jersey City, NJ Academic Postitions 2017- Rutgers New Jersey Medical School, Newark, NJ Instructor, Department of Pathology and Laboratory Medicine Center for Immunity and Inflammation Education & Training 2009-2016 Postdoctoral Fellow, Immunology University of Washington, Seattle, WA Advisor: Michael Bevan Research topic: Differentiation and maintenance of tissue-resident memory CD8+ T cells 2002-2008 Ph.D., Microbiology Tessa Bergsbaken, Ph.D. University of Washington, Seattle, WA Advisor: Brad Cookson Dissertation title: Caspase-1 activation and pyroptosis during the innate immune 1998-2002 response to bacterial infection B.S., Medical Microbiology and Immunology University of Wisconsin, Madison,WI Publications Peer reviewed journal articles: -T Bergsbaken, MJ Bevan, PJ Fink. Local inflammatory cues regulate differentiation and persistence of tissue-resident memory CD8+ T cells. Cell Rep. 2017 Apr 4; 19(1):114-124. -KA Deets, AM Berkley, T Bergsbaken, PJ Fink. Cutting Edge: Enhanced clonal burst size corrects an otherwise defective memory response by CD8+ recent thymic emigrants. J Immunol. 2016 Mar 15; 196(6):2450-2455. -T Bergsbaken and MJ Bevan. Cutting Edge: Caspase-11 limits the response of CD8+ T cells to low abundance and low affinity antigens. J Immunol. 2015 July 1; 195(1):41-45. -T Bergsbaken and MJ Bevan. Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection. Nat Immunol. 2015 Apr;16(4):406-414. -AS Woodward-Davis, T Bergsbaken, MA Delaney, and MJ Bevan. Dermal-resident versus recruited γδ T cell response to cutaneous vaccinia virus infection. J Immunol. 2015 Mar 1; 194(5):2260-2267. -T Bergsbaken, SL Fink, AB den Hartigh, WP Loomis, and BT Cookson. Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation. J Immunol. 2011 Sep 1; 187(5):2748-54. 2 Tessa Bergsbaken, Ph.D. -BL Deatherage, JC Lara, T Bergsbaken, SL Barrett, S Lara, BT Cookson. Biogenesis of bacterial membrane vesicles. Mol Microbiol. 2009 Jun; 72(6):1395-1407. -SL Fink, T Bergsbaken, and BT Cookson. Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci. 2008 Mar 18; 105(11):4312-7. -T Bergsbaken and BT Cookson. Macrophage activation redirects Yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis. PLoS Pathog. 2007 Nov; 3(11):e161. -LA Cummings, WD Wilkerson, T Bergsbaken, BT Cookson. In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted. Mol Microbiol. 2006 Aug; 61(3):795-809. -WW Lathem, T Bergsbaken, and RA Welch. Potentiation of C1 esterase inhibitor by StcE, a metalloprotease secreted by Escherichia coli O157:H7. J Exp Med. 2004 Apr 19; 199(8):1077-87. -WW Lathem, T Bergsbaken, SE Witowski, NT Perna, and RA Welch. Acquisition of StcE, a C1 esterase inhibitor-specific metalloprotease, during the evolution of Escherichia coli O157:H7. J Infect Dis. 2003 Jun 15; 187(12):1907-14. Review articles: -T Bergsbaken and BT Cookson. Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation. J Leukoc Biol. 2009 Nov; 86: 1153-1158. -T Bergsbaken and BT Cookson. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009 Feb; 7(2):99-109. Presentations 3 Tessa Bergsbaken, Ph.D. -T Bergsbaken, MJ Bevan, and PJ Fink. Intestinal inflammation drives differentiation of tissue-resident memory CD8+ T cell populations. The American Association of Immunologists Annual Meeting, 2016. (selected oral presentation) -T Bergsbaken and MJ Bevan. Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection. Midwinter Conference of Immunologists, 2015. (selected oral presentation) -T Bergsbaken and MJ Bevan.Caspase-11 Regulates the Expansion of CD8+ T Cells. Cancer Research Institute - Cancer Immunotherapy Symposium, 2013. -T Bergsbaken and MJ Bevan. Visualizing the intestinal CD8+ T cell response. Cancer Research Institute - Cancer Immunotherapy Symposium, 2012. -T Bergsbaken and MJ Bevan. Caspase-1 activation in CD8+ T cells. Regional Centers of Excellence National Meeting, 2012. -T Bergsbaken and MJ Bevan. Caspase-1 activation in CD8+ T cells. Cancer Research Institute - Cancer Immunotherapy Symposium, 2011. -T Bergsbaken and BT Cookson. Coordinated host responses during pyroptosis: lysosome exocytosis and inflammatory cytokine maturation. General Meeting - American Society for Microbiology, 2008. -T Bergsbaken and BT Cookson. Macrophage activation redirects Yersinia-infected host cell death from apoptosis to caspase-dependent pyroptosis. FASEB Conference on Microbial Pathogenesis, 2007. (selected oral presentation) -T Bergsbaken and BT Cookson. TLR stimulation redirects Yersinia-infected host cell death from apoptosis to pyroptosis. Gordon Conference on Microbial Toxins and Pathogenicity, 2006. 4 Tessa Bergsbaken, Ph.D. -T Bergsbaken and BT Cookson. Yersinia pseudotuberculosis-induced macrophage death occurs by two distinct pathways. General Meeting - American Society for Microbiology, 2004. Teaching & Service Teaching: -Guest Lecturer - University of Washington, 2006/2008. Medical Bacteriology, MICROM 443. -Teaching Assistant - University of Washington, General Microbiology/General Microbiology Laboratory, MICROM 301/302. -Teaching Assistant – University of Washington, 2003. Introductory Biology: Molecular, Cellular and Developmental Biology Lecture/Laboratory, BIOL 200. 5 Tessa Bergsbaken, Ph.D. Service: -Graduate Student Retreat Organizer - University of Washington, 2006-2007. -Microbiology Departmental Retreat Organizer - University of Washington, 2008. Fellowships & Awards -Trainee Abstract Award - The American Association of Immunologists, 2016. -Irvington Institute Fellowship - Cancer Research Institute, 2011-2014. -Developmental Immunology Post-Doctoral Traineeship - University of Washington, 2010. -Helen Raiboff Whiteley Fellowship - University of Washington, 2008. -Cellular and Molecular Biology Training Grant - University of Washington, 2003-2007 6