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Gingival swelling could be caused by... Edema due to inflammation Intake of anti-epileptic medications Monocytic leukemic cell infiltration All of the above None of the above A decrease in organ size (atrophy) may be a result of each of the following, EXCEPT... lack of innervation reduction of blood supply aging hypoplasia reduction of hormonal stimulation Dystrophic calcification is.... associated with an elevated serum calcium level commonly observed in the lungs, stomach and small intestine frequently associated with renal impairment generally seen in foci of degeneration and necrosis observed in tissues which normally secrete acid The presence of squamous epithelium in the lower trachea of a 42-year-old female with a history of smoking is called..... Dysplasia Aplasia Anaplasia Hyperplasia Metaplasia In apoptosis, the caspase serves to..... crosslink the proteins dissolve the cytoskeleton puncture the cell membrane recognize a virally-infected cell tear up the DNA at every 110 base pairs During autolysis, loss of cellular basophilia is due to... An increase in glycogen A decrease in glycogen A decrease in nucleoproteins An increase in nucleoproteins An increase in water A 27-year-old man has multiple, irregular lightly pigmented 1 to 5 cm macular (flat) skin lesions scattered on the skin of his trunk and extremities. He also has multiple firm, non-tender 0.5 to 1 cm dermal nodules. He has scoliosis. He develops an astrocytoma of the left parietal lobe. No other family members are similarly affected. Which of the following is the most likely genetic basis for his condition? Heterozygous LDL receptor mutation Germ line mutation in FBN-1 gene Spontaneous new NF-1 mutation Two acquired abnormal genes that encode type I procollagen Homozygosity for a mutation leading to increased GM2 ganglioside in lysosomes Carbon tetrachloride (CCl4) produces predominantly a... dose-related hepatocellular damage fatty infitration of the liver hypersensitivity reaction cholestatic reaction hemolytic reaction In apoptosis, the caspase serves to..... crosslink the proteins dissolve the cytoskeleton puncture the cell membrane recognize a virally-infected cell tear up the DNA at every 110 base pairs Which of the following would LEAST likely directly lead to anoxic cell injury? Carbon monoxide poisoning Cyanide poisoning Drowning Hemorrhagic shock Hypoglycemia A 44-year-old man has a total serum bilirubin of 1.0 mg/dL, albumin 3.1 g/dL, alkaline phosphatase 45 U/L, aspartate aminotransferase 77 U/L, and alanine aminotransferase of 55 U/L. On physical examination, his liver span is increased. An abdominal CT scan reveals marked hepatomegaly and the liver shows decreased attenuation in relation to the spleen. Based upon these findings and the microscopic appearance shown here, which of the following conditions is most likely to have led to these findings: Septicemia with Pseudommonas aeruginosa Congestive heart failure Chronic alcoholism Metastatic adenocarcinoma Generalized atherosclerosis A cranial epidural abscess is usually mirrored in the cerebrospinal fluid by... increased cells elevated protein decreased protein elevated glucose no change in cells, protein or glucose A lymph node involved in antibody formation in response to a stimulus will morphologically exhibit... sinus hyperplasia paracortical proliferation follicular hyperplasia atrophic changes no change An acquired decrease in the size of a normally developed tissue or organ is.... hypoplasia neoplasia metaplasia atrophy aplasia Glycogen storage diseases include which of the following, except ? hexoseaminidase A deficiency (Tay-Sachs disease) acid maltase deficiency (Pompe's disease) debrancher enzyme deficiency, Cori disease muscle phosphorylase deficiency (McArdle's disease) glucose-6-phosphatase (G6Pase) deficiency (Von Gierke's disease) Metastatic calcification is a complication of: Hypoparathyroidism Decrease in blood calcium levels Osteomalacia and vitamin D deficiency Chronic renal failure Hemosiderosis Which one of the following best describes the phenomenon of epithelial dysplasia? An increase in epithelial thickness due to an increase in the number of cells An increase in epithelial thickness due to an increase in cell volume A decrease in epithelial thickness due to a decrease in number of dividing cells An irregular proliferation and maturation of cells throughout the layers of the epithelium Absence of epithelium because of lack of cell proliferation An increase in the number of cells normally present in an organ or tissue is termed... inflammation hypertrophy metaplasia hyperplasia dysplasia A 21-year-old woman has bilaterally diminished hearing . Audiometry confirms a conduction hearing loss. She has had several rib fractures, a right femoral fracture, and a left humeral fracture, as well as a left wrist fracture over the past 8 years. Her dentist notes deformities of multiple teeth, but no caries. The sclerae of her eyes demonstrate a faint slate-blue colour. A biochemical defect in formation of which of the following is most likely to produce these findings? Fibrinogen Collagen Keratin Hyaluronic acid Elastin Fibronectin Dermatan sulfate In the picture attached the effect is predominantly....... anaplasia dysplasia hyperplasia hypertrophy metaplasia When many cells undergo necrosis at once, a definable patern of necrosis is produced. From the following pictures select the sequence of necroses which corresponds to the order of the pictures. a. A.Caseous necrosis B. liquefactive necrosis C.coagulative necrosis D.fat necrosis b. A.fat necrosis B.liquefactive necrosis C.Coagulative necrosis D.Caseous necrosis c. A.fat necrosis B. Liquefactive necrosis C.Caseous necrosis D.Coagulative necrosis d. A.Caseous necrosis B.Coagulative Necrosis C.Liquefactive necrosis D.Fat necrosis The myocardium of a 53-year-old male who is suffering from a heart attack from coronary occlusion has an irreversible injury when... Glycogen is depleted Cytoplasmic sodium increases Nuclei undergo karyorrhexis Intracellular pH diminishes Blebs form on cell membranes At autopsy the patient's myocardium with H&E stain showed no evidence of ischemic changes, but there was diffuse intersitital fibrosis. Iron stain of the myocardium (see attached histopathology) suggests that he most likley had each of the following EXCEPT.... decreased liver function decreased serum ferritin diabetes mellitus increased brown pigment in the heart muscle fibers increased pressure in the portal vein The enzyme defect in phenylketonuria is a deficiency in a/an.... oxidase hydroxylase decarboxylase transaminase phosphorylase A 59-year-old female had a cerebral infarction. Months later, a CT scan shows a cystic area in her cerebral cortex. The CT finding is a consequence of resolution from....... Liquefactive necrosis Atrophy Coagulative necrosis Caseous necrosis Apoptosis Each of the following is an example of hyperplasia EXCEPT ... enlargement of one kidney after surgical removal of the other kidney changes in the thyroid gland in response to increased demand for thyroid hormone changes in breast tissue during pregnancy enlargement of lymph nodes during a viral infection enlargement of skeletal muscles after weight training Hemosiderin: Stored primarily in the brain Accumulates in atrophic organs in old people Hemoglobin derived pigment devoid of iron Brownish pigment Effects of carbon tetrachloride on the liver includes.. fatty change damage to cell membranes by free radicals both neither With regard to thromboemboli, which statement is incorrect? Occurs most frequently in the coronary arteries Prolonged bedrest is one of the most common predisposing conditions Commomnly originates in arteries Are not lethal unless there is extensive infarction Each of the following is an example of hyperplasia EXCEPT ... enlargement of one kidney after surgical removal of the other kidney changes in the thyroid gland in response to increased demand for thyroid hormone changes in breast tissue during pregnancy enlargement of lymph nodes during a viral infection enlargement of skeletal muscles after weight training Each of the following is an example of apoptosis EXCEPT ....... Deletion of autoreactive T cells from the thymus Destruction of hepatocytes in chronic hepatitis Elimination of epithelial cells from the gastrointestinal tract Remodeling of embryonic hand to form fingers Stroke caused by thrombosis of middle cerebral artery In which of the following situations is metaplasia most likely to have occurred? Tanning of the skin following sunlight exposure Lactation following pregnancy Vitamin A deficiency Acute myocardial infarction Urinary obstruction from an enlarged prostate