Download Anti-MHC Class I Monomorphic monoclonal antibody, clone DWT33

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Anti-MHC Class I Monomorphic monoclonal antibody, clone DWT33 [FITC]
Cat.No: DCABY-172
Lot. No. (See product label)
PRODUCT INFORMATION
Specificity
Mouse anti Horse MHC Class I Monomorphic antibody, clone DWT33 recognizes monomorphic
equine MHC Class I and was classified at the International Equine Leucocyte Antigen Workshop.
Immunogen
Equine leucocytes
Isotype
IgG2a
Source/Host
Mouse
Species Reactivity
Horse
Clone
DWT33
Conjugate
FITC
Applications
Flow Cytometry
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Procedure
Conjugated Antibodies
Format
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Size
100 μg
Buffer
Phosphate buffered saline.
Storage
Store at +4°C for one month or at -20°C for longer.This product should be stored undiluted.Storage in
frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the
antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Background
Introduction
MHC Class I molecules play a central role in the immune system by presenting peptides derived from
the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha
chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at
varying levels. MHC Class I molecules are expressed on most nucleated cells where they present
endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T
cells. Fibroblasts or neurons however only show a low level of antigen.
Keywords
A 28; A 9; Antigen presenting molecule; Aw 24; Aw 68; CLASS I HISTOCOMPATIBILITY ANTIGEN;
H2 K1; H2K; HLA A; HLA class I histocompatibility antigen A 1 alpha chain; HLA class I
histocompatibility antigen A 11 alpha chain; HLA class I histocompatibility antigen A 2 alpha chain;
HLA class I histocompatibility antigen A 24 alpha chain; HLA class I histocompatibility antigen A 3
alpha chain; HLA class I histocompatibility antigen A 30 alpha chain; HLA class I histocompatibility
antigen A 32 alpha chain; HLA class I histocompatibility antigen A 68 alpha chain; HLAA; Leukocyte
antigen class I A; Major histocompatibility complex class I A; MHC class I antigen A 1; MHC class I
antigen A*11; MHC class I antigen A*2; MHC class I antigen A*24; MHC class I antigen A*3; MHC
class I antigen A*30; MHC class I antigen A*32; MHC class I antigen A*68; MHC class I antigen HLA A
heavy chain; MHC class I heavy chain H2 K
Antigen Gene Information
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
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References
1. Lunn, D.P. et al. (1998) Report of the Second Equine Leucocyte Antigen Workshop, Squaw valley,
California, July 1995. Vet Immunol Immunopathol. 62:101-143.
2. Mérant, C. et al. (2009) Young foal and adult horse monocyte-derived dendritic cells differ by their
degree of phenotypic maturity.
Vet Immunol Immunopathol. 131:1-8.
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
2
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