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Supplemental information 2 A. Structural based prediction Sequence based prediction Unknown Interaction Protein A Unknown Interaction Protein B Sequence protein B Sequence protein A Protein A Protein B Protein A Protein B Assignment of domains by Threading Orthologue information (BLAST) Domain of protein A Domain of protein B Protein A' Known domain interactions Hypothesis Protein B' Hypothesis Protein A Interaction Protein B Interaction according to Interaction databases (Netpro) Supplemental information 2 B. 1 2 3