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Hyaluronic Acid Binding Protein 2 Is a Novel Regulator of Vascular Integrity by Nurbek Mambetsariev, Tamara Mirzapoiazova, Bolot Mambetsariev, Saad Sammani, Frances E. Lennon, Joe G.N. Garcia, and Patrick A. Singleton Arterioscler Thromb Vasc Biol Volume 30(3):483-490 March 1, 2010 Copyright © American Heart Association, Inc. All rights reserved. Figure 1. Pulmonary endothelial hyaluronic acid binding protein (HABP) 2 expression is regulated by lipopolysaccharide (LPS) and hyaluronan. Nurbek Mambetsariev et al. Arterioscler Thromb Vasc Biol. 2010;30:483-490 Copyright © American Heart Association, Inc. All rights reserved. Figure 2. Differential effects of high-molecular-weight hyaluronan (HMW-HA) and low-molecularweight hyaluronan (LMW-HA) on hyaluronic acid binding protein (HABP) 2 protease activity. Nurbek Mambetsariev et al. Arterioscler Thromb Vasc Biol. 2010;30:483-490 Copyright © American Heart Association, Inc. All rights reserved. Figure 3. PAR receptors regulate hyaluronic acid binding protein (HABP) 2–mediated endothelial barrier disruption. Nurbek Mambetsariev et al. Arterioscler Thromb Vasc Biol. 2010;30:483-490 Copyright © American Heart Association, Inc. All rights reserved. Figure 4. Hyaluronic acid binding protein (HABP) 2–mediated endothelial barrier disruption is regulated by RhoA and Rho kinase (ROCK). Nurbek Mambetsariev et al. Arterioscler Thromb Vasc Biol. 2010;30:483-490 Copyright © American Heart Association, Inc. All rights reserved. Figure 5. Hyaluronic acid binding protein (HABP) 2 regulates vascular permeability in acute lung injury models in vivo. Nurbek Mambetsariev et al. Arterioscler Thromb Vasc Biol. 2010;30:483-490 Copyright © American Heart Association, Inc. All rights reserved.
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