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Supplemental Table 1 Genes upregulated in cell lines, prostate cancer tissues expressing AR-Vs
[modified from Hornberg et al (2011) PloS One 6(4): e19059; Hu et al (2012) Cancer Res
72(14): 3457-62; “Other Aliases”, “Description”, and “Function” from PubMed Gene,
http://www.ncbi.nlm.nih.gov/gene]
Genes
CDCA5
Other
Aliases
SORORIN
BIRC5
Survivin
BUB1
BUB1A
KPNA2
IPOA1
KNTC1
ROD
BUB1B
SSK1;
MAD3L
CDC25B
RP51009E24.3
MAD2L2
MAD2B
CENPE
CENP-E
ESPL1
ESP1;
separase
KIF2C
KNSL6
NEK2
NEK2A
CIT
CRIK
KIF22
KID; KNSL4
CCNA2
CCN1; CCNA
ZWINT
HZwint-1
Description
Function
cell division cycle associated 5
baculovirual IAP repeat
inhibitor of apoptosis
containing 5
budding uninhibited by
benzimidazoles 1 homolog
spindle checkpoint function
(yeast)
karyopherin alpha 2 (RAG
import of proteins into nucleus
cohort 1, importin alpha 1)
involved in proper chromosome
kinetochore associated 1
segregation during cell division
budding uninhibited by
benzimidazoles 1 homolog
spindle checkpoint function
beta (yeast)
cell division cycle 25 homolog
activates CDK1/CDC2
B (S. pombe)
MAD2 mitotic arrest
mitotic spindle assembly checkpoint
deficient-like 2 (yeast)
accumulates in G2 phase of cell
centromere protein E, 312
cycle; responsible for mammalian
kDa
chromosome movement and/or
spindle elongation
extra spindle pole bodies
initates final separation of sister
homolog 1 (S. cerevisiae)
chromatids
microtubule-dependent molecular
kinesin family member 2C
motor involved in anaphase
chrosmosome segregation
NIMA (never in mitosis gene
localized to centrosome and reaches
a)-related kinase 2
maximal levels in late G2 phase
localized to central spindle and
citron (rho-interacting,
midbody, functions to promote
serine/threonin kinase 21)
efficient cytokinesis
role in metaphase chromosome
kinesin family member 22
alignment and maintenance
activates CDC2 or CDK2 kinases to
cyclin A2
promote G1/S and G2/M transitions
ZW10 interactor
localizes to prophase kinetochores,
remains on kinetochore until late
anaphase
TPX2
DIL-2
KIF15
HKLP2
MAD2L1
MAD2
PKMYT1
MYT1
UBE2C
UBCH10
PLK1
PLK
NUSAP1
LNP; ANKT
ETV4
PEA3
FABP5
E-FABP
HES6
HES-6
UGT2B17
UDPGT2B17
AR
DHTR
BARD1
BARD-1
CDK1
CDC2
TOP2A
TOP2; TP2A
CDC20
CDC20A
TPX2, micotubule-associated,
homolog (Xenopus laevis)
kinesin family member 15
MAD2 mitotic arrest
mitotic spindle assembly checkpoint
deficient-like 1 (yeast)
protein kinase, membrane
negatively regulates G2/M transition
associated tyrosine/threonine
of cell cycle
1
member of E2 ubiquitin-conjugating
enzyme family, required for
ubiquitin-conjugating enzyme destruction of mitotic cyclins and
E2C
progression of cell cycle
polo-like kinase 1
nucleolar and spindle
role in spindle microtubule
associated protein 1
organization
ets variant 4
fatty acid binding protein 5
may play role in fatty acid uptake,
(psoriasis-associated)
transport, and metabolism
basic helix-loop-helix transcription
hairy and enhancer of split 6
repressor that regulates cell
(Drosophila)
differentiation
involved in glucuronidation, an
UDP glucuronosyltransferase
intermediate step in the metabolism
2 family. polypeptide B17
of steroids
steroid-hormone activated
transcription factor; stimulates
androgen receptor
transcription of androgen
responsive genes
interacts with N-terminal region of
BRCA1 associated RING
BRCA1, may be target of oncogenic
domain 1
mutations
cyclin-dependent kinase 1,
essential for G1/S and G2/M
cell division cycle 2
transitions
involved in chromosome
condensation, chromatid
topoisomerase (DNA) II alpha
separation, and relief of torsional
170kDa
stress that occurs during DNA
transcription and replication
required for two microtubulecell division cycle 20 homolog
dependent processes: nuclear
(S. cerevisiae)
movement prior to anaphase and
chromosome separation
SLC7A5
CD98
solute carrier family 7 (amino
acid transporter light chain, L
system), member 5
E2F2
E2F-2
E2F transcription factor 2
binds specifically to pRB in cell-cycle
dependent manner; controls cell
cycle
MCM7
CDC47;
MCM2
minichromosome
maintenance complex
component 7
essential for initiation of eukaryotic
genomic replication
CCNB2
HsT17299
cyclin B2
HSPB1
HSP27
heat shock 27kDa protein 1
TTK
PYT
TTK protein kinase
E2F5
E2F-5
E2F transcription factor 5,
p130-binding
MCM2
BM28;
CCNL1
minichromosome
maintenance complex
component 2
MYC
c-MYC
v-myc myelocytomatosis viral
oncogene homolog (avian)
NCAPG
CAP-G
non-SMC condensin I
complex, subunit G
BCL2L12
BCL2L12
BCL2-like 12 (proline rich)
cyclin B2 is primarily associated with
the Golgi region and also binds to
transforming growth factor beta RII
and thus cyclin B2/cdc2 may play a
key role in transforming growth
factor beta-mediated cell cycle
control
involved in stress resistance and
actin organization
essential for chromosome alignment
at the centromere during mitosis
and is required for
centrosome;tumorigenesis may
occur when this protein fails to
degrade and produces excess
centrosomes resulting in aberrant
mitotic spindles duplication
control of cell cycle; this protein and
E2F4 interact with tumor suppressor
proteins p130 and p107, but not
with pRB
involved in the initiation of
eukaryotic genome replication
transcription factor that regulates
cell cycle progression, apoptosis and
cellular transformation gene targets
encodes a subunit of the condensin
complex, which is responsible for
the condensation and stabilization
of chromosomes during mitosis and
meiosis
member of BCL-2 family, which act
as anti- or pro-apoptotic regulators;
this protein contains a Bcl-2
homology domain 2 (BH2); the
function of this gene has not yet
been determined
MELK
HPK38
MCM4
NKCD
TUBB
TUBB1
maternal embryonic leucine
zipper kinase
minichromosome
maintenance complex
component 4
tubulin, beta class
RECQL4
RECQ4
RecQ protein-like 4
MTDH
LYRIC
metadherin
STMN1
Lag, SMN
stathmin 1/oncoprotein 18
EXO1
HEX1
exonuclease 1
TUBA1B
K-ALPHA-1
tubulin, alpha 1b
UHRF1
Np95
ubiquitin-like with PHD and
ring finger domains 1
KIF20A
RAB6KIFL
kinesin family member 20A
ORC6
ORC6L
PTPRF
LAR
initiation of eukaryotic genome
replication
a DNA helicase, which unwinds
double-stranded DNA into singlestranded DNAs; may modulate
chromosome segregation
prevents assembly and promotes
disassembly of microtubules
encodes a protein with 5' to 3'
exonuclease activity as well as an
RNase H activity
an E3 ubiquitin ligase; plays a major
role in the G1/S transition by
regulating topoisomerase II alpha
and retinoblastoma gene
expression, and functions in the
p53-dependent DNA damage
checkpoint
part of the origin recognition
complex (ORC), it binds specifically
to origins of replication and serves
as a platform for the assembly of
additional initiation factors such as
origin recognition complex.
Cdc6 and Mcm proteins; gene
subunit 6 like (yeast)
silencing studies with small
interfering RNA demonstrated that
this protein plays an essential role in
coordinating chromosome
replication and segregation with
cytokinesis
protein tyrosine phosphatase, functions in the regulation of
receptor type, F
RAD21
HR21
RAD21 homolog (S. pombe)
HIST1H4C H4FG
histone cluster 1, H4c
HSPE1
HSP10
heat shock 10kDa protein 1
(chaperonin 10)
PBK
SPK
PDZ binding kinase
epithelial cell-cell contacts at
adherents junctions and in the
control of beta-catenin signaling
highly regulated association of this
protein with mitotic chromatin
specifically at the centromere region
suggests its role in sister chromatid
cohesion in mitotic cells
this gene is intronless and encodes a
member of the histone H4 family;
transcripts from this gene lack polyA
tails but instead contain a
palindromic termination element
gene encodes a major heat shock
protein which functions as a
chaperonin
encodes a serine/threonine kinase
related to the dual specific mitogenactivated protein kinase kinase
(MAPKK) family; this mitotic kinase
may be involved in the activation of
lymphoid cells and support
testicular functions, with a
suggested role in the process of
spermatogenesis