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Patel, Vyomesh
BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Vyomesh Patel
Staff Scientist
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Brighton Polytechnic, England
University of Bristol, England
University of Bristol, England
Oral and Pharyngeal Cancer Branch
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
B.Sc.
Ph.D.
Post Doctoral
Post Doctoral
1986
1993
1993
1995
Pharmacology
Oral Cancer
Oral Cancer
Oral Cancer
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment,
experience,and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles, all
authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to this application
A.
Personal Statement
The major goal of this proposal is to design and test nano-devices for point-of-care use for the ultralow detection of relevant biomarkers associated with oral cancer development and progression. In
this regard, I have a strong interest in improving our understanding of oral cancer pathogenesis, and
also how this information can lead to improved diagnosis, prognosis and, treatment options. Included
in this, I have laid the ground-work for the use of technology to drive some of these research
interests, for instance by applying mass spectrometry in a recent study, likely to represent a technical
breakthrough, on the proteomic analysis of paraffin embedded oral cancer tissues, we were able to
indentify several protein of interest and some are likely to be of clinical importance. Among many
candidates, DSG3 have the potential to identify primary tumors that may have progressed, and the
detection of this protein in lymph-nodes of oral cancer patients may help, for instance, in the choice
of treatment option. In addition, my recent interests have focused on applying nano-technology to
oral cancer. I have been involved in a collaboration developing carbon-nanotubes as carriers for the
targeted delivery of anticancer drugs to the tumors. As a result of these previous experiences from
my collaborations with both my extra and intra-mural colleges, I am aware of the importance of
frequent communication among project members and of constructing a realistic research plan,
timeline, and budget. The current application builds logically on my prior work and interests. Finally,
oral cancer is associated with a poor prognosis, with a 5-year survival that has changed little, and
this in part is due to the lack of early detection and, the availability of validated biomarkers to follow
patients at risk. Thus, the goals of this proposal would be a useful addition at point-of-care for
diagnostic and prognostic application.
B. Positions and Honors
Positions and Employment
2001-present Staff Scientist, Oral and Pharyngeal Cancer Branch,
National Institute of Dental and Craniofacial Research, NIH, Bethesda, USA
Honors
2008
National Institute of Dental Research, Special Act Award
2006
National Institute of Dental Research, Performance Award
2004
National Institute of Dental Research, Special Act or Service Award
C. Selected peer-reviewed publications (Publications selected from 78 peer-reviewed publications).
1.
Prime S.S., Matthews J.B., Patel V., Game S.M., Donnelly M., Stone A., Paterson I.C., Sandy J.,
Yeudall W.A. TGF-ß receptor regulation mediates the response to exogenous ligand but is
independent of the degree of cellular differentiation in human oral keratinocytes. Int J Cancer 56:1,
1994.
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Patel V., Senderowicz A.M., Pinto D.J., Igishi T., Sausville E.A. and Gutkind J.S. Flavopiridol, a novel
cdk inhibitor surpresses the growth of carcinomas of the head and neck by inducing apoptosis. J.
Clin. Invest 9: 1674, 1998.
Leethanakul C., Patel V., Gillespie J., Pallante M., Ensley J.F., Liotta L.A., Emmert-Buck M., Gutkind
J.S. Distinct pattern of expression of differentiation and growth-related genes in squamous cell
carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA
arrays. Oncogene 19:3220, 2000.
Patel V., Lahusen T., Sy T., Sausville E.A., Gutkind J.S., Senderowicz A.M. Perifosine, a Novel
Alkylphospholipid Induces p21WAF1 Expression in Squamous Carcinoma Cells Through a p53Independent Pathway Leading to Loss in Cdk Activity and Cell Cycle Arrest. Cancer Res 62:1401,
2002.
Patel V., Lahusen T., Leethanakul C., Igishi T., Kremer M., Quintanilla-Martinez L., Ensley J.F.,
Sausville E.A., Gutkind J.S., and Senderowicz A.M.. Antitumor Activity of UCN-01 in Carcinomas of
the Head and Neck Is Associated with Altered Expression of Cyclin D3 and p27[KIP1] Clin Cancer
Res. 8:3549, 2002.
Sodhi A., Montaner S., Patel V., Román J.G., Li Y., Sausville E.A., Sawai E.T., Gutkind J.S. Akt plays
a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G proteincoupled receptor. Proc. Natl. Acad. Sci., 101:4821, 2004.
Amornphimoltham P., Sriuranpong V., Patel V., Benavides F., Conti C.J., Sauk J., Sausville E.A.,
Molinolo A.A., Gutkind J.S., Persistent activation of the Akt pathway in head and neck squamous cell
carcinoma: a potential target for UCN-01, Clin. Cancer Research, 10:4029, 2004.
Sriuranpong V., Mutirangura A., Gillespie J.W., Patel V., Amornphimoltham P., Molinolo A.A.,
Kerekhanjanarong V., Supanakorn S., Supiyaphun P., Rangdaeng S., Voravud N., Gutkind J.S.
Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and
cDNA microarrays. Clin. Cancer Research, 10:4944, 2004.
Baker H., Patel V., Molinolo A.A., Myers J.N., El-Naggar A.K., Gutkind J.S., Hancock W.S. Proteomewide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and
tandem mass-spectrometry, Oral Oncology, 41:183, 2005.
Amornphimoltham P., Patel V., Sodhi A., Nikitakis N., Sauk J., Sausville E.A., Molinolo A.A., Gutkind
J.S. mTOR, a Novel Molecular Target in Squamous Cell Carcinomas of the Head and Neck. Cancer
Res 65:9961, 2005.
Yu X., Munge B., Patel V., Jensen G., Bhirde A., Gong J.D., Kim S., Gillespie J., Gutkind J.S.,
Papadimitrakopoulos F., Rusling J.F. Carbon nanotube amplification strategies for highly sensitive
immunosensing of cancer biomarkers in serum and tissue. J. Amer. Chem. Soc., 128:1119, 2006.
Castilho R.M., Squarize C.H., Patel V., Millar S.E., Zheng Y., Molinolo A., and Gutkind J.S.
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene, 26:
5078, 2007.
Gavard J., Patel V., and Gutkind J.S. Angiopoietin-1 prevents VEGF-induced endothelial permeability
by sequestering Src through mDia. Dev Cell, 14: 25, 2008.
Patel V., Hood B.L., Molinolo A.A., Lee N.H., Conrads T.P., Krizman D.B., Veenstra T.D., and Gutkind
J.S. Proteomic analysis of laser-captured paraffin embedded tissues: A molecular portrait of head
and neck cancer progression. Clin Cancer Res, 14: 1002, 2008.
Amornphimoltham P., Leelahavanichkul K., Molinolo A.A., Patel V., and Gutkind J.S. Inhibition of
mTOR by Rapamycin is Sufficient to Promote the Regression of Carcinogen-Induced Skin Tumor
Lesions. Clin Cancer Res, 14: 8094-8101, 2008.
Czerninski R., Amornphimoltham P., Patel V., Molinolo A.A., and Gutkind J.S. Targeting mTOR by
Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model. Cancer
Res Chemo Prev, 2: 27-36, 2009.
Bhirde A.A., Patel V., Gavard J., Zhang G., Sousa A.A., Masedunskas A., Leapman R.D., Weigert R.,
Gutkind J.S., and Rusling J.F. Targeted killing of cancer cells in vivo and in vitro with EGF-directed
carbon nanotube-based drug delivery. ACS Nano, 3: 307-316, 2009.
Mani V., Chikkaveeraiah B.V., Patel V., Gutkind J.S, and Rusling J.F. Ultrasensitive immunosensor for
cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle
amplification. ACS Nano, 3: 585-594, 2009.
Patel, Vyomesh
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Munge B.S., Krause C.E., Malhotra R., Patel V., Gutkind J.S., and Rusling J.F. Electrochemical
immunosensors for Interleukin-6: Comparison of carbon nanotube forest and gold nanoparticle
platforms. Electrochemistry Communication, 11: 1009-1012, 2009.
Chikkaveeraiah B.V., Bhirde A., Malhotra R., Patel V., Gutkind J.S., and Rusling J.F. Single-wall
carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for
prostate cancer. Anal Chem, 81: 9129-9134, 2009.
Malhotra R., Patel V., Vaqué J.P., Gutkind J.S., Rusling J.F. Ultrasensitive electrochemical
immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel
amplification, 82: 3118-3123, 2010.
D. Research Support
Intramural Program, National Institute of Dental and Craniofacial Research