Download Curriculum Vitae

Olivia Claire Hibbitt
Date of Birth: 17 December 1978
Email: [email protected]
Nationality: New Zealander
Telephone: 02 9036 3034
Employment History
June 2010 – Present
Centre for Vascular Research
University of Sydney
Post-doctoral research fellow
February 2005 – June 2010
Department of Physiology Anatomy
and Genetics, University of Oxford
Senior Post-doctoral research fellow
April 2002 – December 2004
Department of Pharmacology
University of Oxford
Research Assistant/Doctoral Student
January 2001 – March 2002
University College London
Department of Physiology
Research Assistant
Education
2005 DPhil (Reproductive Physiology)
Worcester College and the Department of Pharmacology, Oxford, United
Kingdom
2000 BSc Honours (Anatomy and Structural Biology)
First Class
University of Otago, Dunedin, New Zealand
1996 ‘A’ Bursary
Tauhara College, Taupo, New Zealand
Awards
2009
2008
2007
2007
2006
2004
2004
2004
American Society for Gene Therapy prize travel award
Awarded a poster presentation prize, British Society for Gene Therapy
Recipient of a 2007 exceptional merit award (Oxford University)
American Society for Gene therapy prize travel award
Finalist, 2006 Daily Telegraph Science Writer awards.
Recipient of 2004 exceptional merit award (Oxford University)
Placed in top 10 of the Wellcome Trust/New Scientist Essay competition
Presented at the Promega Young Scientist of the Year prize Session at the Society
for Experimental Biology Annual Main Meeting
2000 Best 4th year presentation, International Post-graduate Conference, University of
Otago, Dunedin, NZ
Successful funding applications
2011-2013 PROJECT GRANT Site-specific integration of functional genomic loci:
Applications in gene therapy Dr Jim Vadolas, Dr Richard Wade-Martins and Dr Olivia
Hibbitt AU$431,172 NHMRC 1009989 (CIC)
2010-2012 PROJECT GRANT Novel molecular strategies to treat familial
hypercholesterolaemia by modulation of low density lipoprotein receptor expression, Dr
Richard Wade-Martins, Professor Keith Channon, Dr Angela Russell and Dr Olivia
Hibbitt. £159,810 British Heart Foundation (Chief Investigator)
2009 PROJECT GRANT Optimising delivery and expression of the low density
lipoprotein receptor under physiological regulation for gene therapy of familial
hypercholesterolaemia. Dr Richard Wade-Martins, Professor Keith Channon and Olivia
Hibbitt. £78,315 British Heart Foundation (Chief Investigator, named researcher)
2009 PROJECT GRANT High-throughput screening for compounds that will enhance
expression from the Low Density Lipoprotein receptor using a novel genomic DNA based
luciferase assay. Dr Olivia Hibbit and Dr Richard Wade-Martins £50,000 Oxford/BHF
centre of research excellence small award. (Chief Investigator)
2008 PROJECT GRANT Optimising delivery and expression of the low density
lipoprotein receptor under physiological regulation for gene therapy of familial
hypercholesterolaemia. Dr Richard Wade-Martins, Professor Keith Channon and Olivia
Hibbitt. £57,000 British Heart Foundation (Chief Investigator, named researcher)
2008 Oxford University Bridging support scheme Dr Olivia Hibbitt £7,000 (Chief
Investigator)
2002-2004 Doctoral Training award, Department of Pharmacology, University of
Oxford £20,000
Professional Memberships
British Society for Gene Therapy
American Society for Gene Therapy
Work related experience
Medical Foundation Building (Sydney) First Aid Officer 2010
University of Oxford spokesperson on animal research 2007-10
Senior Doctoral Teaching Associate 2008-10
Departmental Committee 2008-10: Elected post-doctoral member of the Department of
Physiology Anatomy and Genetics Departmental committee.
Home Office animal training modules 1-5:
Deputy Licence holder
UK government Science and Engineering ambassadors scheme 2007-2010
Invited Seminars
March 2010
February 2010
September 2007
January 2007
Regulated Genes and drugs; novel approaches to enhancing gene
therapy for familial hypercholesterolaemia. Oxford Gene Therapy
Network Seminar Series
‘High-throughput cell-based assay to identify novel cholesterollowering compounds’ Vice Chancellors Forum on Drug Discovery,
Oxford, UK
‘Novel
Approaches
for
the
treatment
of
Familial
Hypercholesterolaemia’ Oxford Gene Therapy Network Seminar
series.
‘Amplicons a World of Possibility’ Department of Molecular
Medicine and Pathology, School of Medical Sciences, University
of Auckland, New Zealand.
Research Publications
Hibbitt, O.C., Agkatsev, S., Owen, C., Seymour, L., Channon, K., Wade-Martins, R.,
(2010) Targeted knockdown of HMG CoA reductase leads to increased transgene
expression from genomic LDLR mini-gene vectors in vitro and in vivo. Submitted Gene
Therapy August 2010
Hibbitt, O.C., Wade-Martins, R., Gene Therapy for Familial Hypercholesterolaemia:
how close are we? Review, submission September 2010
Hibbitt, O.C., Wade-Martins, R., High capacity extrachromosomal gene expression
vectors. Invited Book Chapter (in press). Methods in Molecular Biology.
Hibbitt, O.C., McNeil, E., Lufino, M., Seymour, L., Channon, K. M., Wade-Martins, R.,
(2010) Efficient in vivo physiological regulation and long-term expression of the low
density lipoprotein receptor transgene by genomic DNA mini gene constructs. Molecular
Therapy 18, 317-26 (Epub 2009 Oct 27).
Hibbitt, O.C., Harbottle, R.P., Waddington, S.N., Bursill, C.A., Channon, K.M., WadeMartins, R., (2007) Delivery and long-term expression of a 135 kb LDLR genomic DNA
locus in vivo by hydrodynamic tail vein injection. Journal of Gene Medicine 9, 488-97
Hibbitt, O.C., Wade-Martins, R., (2006) Delivery of large genomic DNA inserts >100
kb using HSV-1 amplicons. Current Gene Therapy 6, 325-36
Hibbitt, O.C, Coward, K., Kubota, K., Prathalingham, N., Holt, W., Kohri, K.,
Parrington, J., (2005) In vivo gene transfer by electroporation allows expression of a
fluorescent transgene in hamster testis and epididymal sperm and has no adverse effects
upon testicular integrity or sperm quality. Biology of Reproduction 74, 95-101
Bursill CA, McNeill E, Wang L , Hibbitt OC, Wade-Martins R,Paterson DJ , Greaves
DR, Channon KM., (2009) Lentiviral Gene Transfer to Reduce Atherosclerosis
Progression by Long-term CC-Chemokine Inhibition. Gene Therapy 16, 93-102 (Epub
2008 Sep 18)
Parrington J, Coward K, Hibbitt O, Kubota H, Young C, McIlhinney J, Jones O., (2007)
In vivo gene transfer into the testis by electroporation and viral infection--a novel way to
study testis and sperm function. Soc Reprod Fertil Suppl. 65, 469-74
Coward, K., Kubota, K., Hibbitt, O., McIlhinney, N., Kohri, K., Parrington, J., (2006)
Expression of a fluorescent recombinant form of sperm protein PLCzeta in mouse
epididymal sperm by in vivo gene transfer into the testis. Fertility & Sterility 85 suppl. 1,
1281-89
Coward, K., Ponting, C.P., Chang, H-Y., Hibbitt, O., Savolainen, P., Jones, K.T.,
Parrington, J., (2005) Phospholipase C zeta; the trigger of egg activation in mammals, is
present in a non-mammalian species. Reproduction 130, 157-63.
Coward, K., Owen, H., Poustka, A.J., Hibbitt, O., Tunwell, R., Kubota, H., Swann, K.,
Parrington, J., (2004) Cloning of a novel phospholipase C-δ isoform from pacific purple
sea urchin (Strongylocentrotus purpuratus) gametes and its expression during early
embryonic development. Biochem. Biophys. Res. Comm. 313, 894-901
Coward, K., Campos-Mendoza, A., Larman, M., Hibbitt, O., McAndrew, B., Bromage,
N., Parrington, J., (2003) Teleost fish spermatozoa contain a cytosolic protein factor that
induces calcium release in sea urchin egg homogenates and triggers calcium oscillations
when injected into mouse oocytes. Biochem. Biophys. Res. Comm. 305, 299-304
Coward, K., Bromage, N.R., Hibbitt, O., Parrington, J., (2002) Gamete physiology,
fertilization and egg activation in teleost fish. Reviews in Fish Biology & Fisheries 12,
33-58.
Conference Proceedings
Hibbitt, O.C., Agkatsev, S., Owen, C., Seymour, L., Channon, K., Wade-Martins, R.,
(2010) Targeted knockdown of HMG CoA reductase leads to increased transgene
expression from genomic LDLR mini-gene vectors in vitro and in vivo. American Society
for Gene Therapy Annual Meeting 2010 Washington DC, May 2010. Oral Presentation,
Hibbitt, O.C., Agkatsev, S., Owen, C., Seymour, L., Channon, K., Wade-Martins, R.,
(2010) Targeted gene knockdown of HMG CoA reductase increases transgene expression
from genomic DNA LDLR mini-gene vectors in vitro and in vivo. British Society for
Gene Therapy annual meeting March, 2010 Oral presentation
Hibbitt, O.C., Seymour, L., Channon, K., Wade-Martins, R., (2009) Physiological
regulation and long term expression of the low density lipoprotein receptor transgene in
vivo from genomic DNA mini-gene constructs. American Society for Gene Therapy
Annual Meeting 2009 San Diego, June 2009. Oral Presentation, abstract travel award.
Hibbitt, O.C., Seymour, L., Channon, K., Wade-Martins, R., (2009) Long term
expression and physiological regulation of the low density lipoprotein receptor transgene
in vivo from mini-gene, genomic DNA hybrid constructs. British Society for Gene
Therapy annual meeting April, 2009 Oral presentation
Hibbitt, O.C., Carroll, F., Seymour, L., Channon, K., Wade-Martins, R., (2008)
Physiologically-regulated low density lipoprotein receptor (LDLR) expression vectors for
the treatment of familial hypercholesterolaemia British Society for Gene Therapy annual
meeting 2008 Herriot Watt University, Edinburgh 9-11th April 2008 Presentation prize
Hibbitt, O.C., Harbottle, R., Waddington, S.N., Bursill, C.A., Coutelle, C., Channon,
K.M., Wade-Martins, R., (2007) Efficient delivery and long-term expression of a 135 kb
LDLR genomic DNA locus in vivo following hydrodynamic tail vein injection. American
Society for Gene Therapy Annual Meeting 2007 Seattle, USA 31st May – 3rd June 2007.
Oral presentation Abstract travel award.
Hibbitt, O.C., Bursill, C.A., Waddington, S.N., Channon, K.M., Wade-Martins, R.,
(2006) Delivery and expression of a 135 kb human LDLR DNA genomic locus in mice
by hydrodynamic tail vein injection of a BAC expression vector. British Society for Gene
Therapy annual meeting 2006, Imperial College, London 28-30th March 2006
Hibbitt, O.C., Coward, K., Kubota, H., Parrington, J., (2004) Glowing gonads: Use of an
in vivo approach to investigate the novel signalling protein PLCzeta and its role at
fertilisation. Society for Experimental Biology annual main meeting 2004, Heriot-Watt
University, Edinburgh 29th March 3rd April 2004, Selected for Promega Young
Scientist Award Session
Lufino, M., Hibbitt, O.C., Wade-Martins, R., (2007) Long-term regulated functional
complementation
of
LDLR
deficiency
in
cells
using iBAC-SMAR-LDLR, a novel infectious genomic DNA episomal vector. American
Society for Gene Therapy Annual Meeting 2007 Seattle, USA 31st May – 3rd June 2007.
Lufino, M., Hibbitt, O.C., Wade-Martins, R., (2007) Regulated functional
complementation
of
low-density
lipoprotein
receptor
deficiency in cells by an episomal SMAR vector carrying a 135-kb LDLR
genomic locus. British Society for Gene Therapy annual meeting 2007, Warwick
University, Coventry 19-21st March 2007. Winner, prize for best Abstract/oral
presentation.
Parrington, J., Coward, K., Hibbitt, O., Kubota, et. al., In vivo gene transfer into the
testis by electroporation and viral infection - A novel way to study testis and sperm
function. 10th International Symposium on Spermatology Madrid, 17th-22nd September
2006
Coward, K., Hibbitt, O., et. al.,(2005). In vivo gene transfer by electroporation allows
long-lived, high level expression of transgenes in hamster testis with no adverse effects
upon testicular integrity or sperm quality. Fertility 2005. Joint Meeting of the British
Andrology Society, British Fertility Society, and the Society for Reproduction and
Fertility. University of Warwick, Coventry, UK. 3 – 6th April 2005. Winner of Prize for
Best Abstract/Talk
Parrington, J., Coward K., and Hibbitt, O., The spark of life – how calcium kickstarts
development of the embryo. Society for Experimental Biology annual main meeting
2003, Southampton , 31 March 4th April 2003