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Meeting on Infection, Immunity, Brain and Cognition Sponsored by the Stanley Medical Research Institute (SMRI) Room 531, Alumni Hall, 4227 Fifth Avenue, Pittsburgh, PA 15213 April 21, 2016 Time 8.00 am – 8.30 8.30 am – 8:45 am 8.45 am – 9:00 am Speaker Topic REGISTRATION AND BREAKFAST David A. Lewis, MD Welcome Thomas Detre Professor and Chair Department of Psychiatry, University of Pittsburgh Julius Friese Tribute to Mr. & Mrs. Stanley Stanley Medical Research Institute Pre-clinical studies/in vitro models. Moderator: Maree Webster, PhD, Executive Director, SMRI 9.00 am – Robert H. Yolken, MD Infections, antibiotic use and psychiatric disorders 9:20 am Theodore and Vada Stanley Distinguished Professor of Neurovirology in Pediatrics, Johns Hopkins Univ. 9.20 am – 9:40 am Vernon B. Carruthers, PhD 9.40 am – 10:00 am Jon Boyle, PhD 10.00 am – 10:20 am Mikhail Pletnikov, MD, PhD 10.20 am 10.40 am 10.40 am – 11:00 am 11.00 am – 11:30 am 11.30 am – 11:50 am Efficacy of novel bumped kinase inhibitors for treating experimental chronic Toxoplasma gondii infection Using comparative parasite models to understand the mechanisms of Toxoplasma virulence and potentially manipulation of host behavior Toxoplasma, dopamine and behavioral alterations Professor of Microbiology and Immunology University of Michigan Associate Professor of Biological Sciences University of Pittsburgh Professor of Psychiatry and Behavioral Sciences Johns Hopkins University BREAK Fred L. Homa, PhD Associate Professor of Microbiology & Molecular Genetics, University of Pittsburgh Sabine Bahn, PhD Nuclear events in the assembly of alpha herpes viruses Microglial activation following exposure to serum from schizophrenia patients Professor of Chemical Engineering and Biotechnology, Cambridge University, UK Immunology. Moderator: Maree Webster, PhD Lisa Ann Borghesi, PhD Murine and human hematopoietic stem cells in Associate Professor of Immunology, inflammation University of Pittsburgh 11.50 am – 12:10 pm Paolo Piazza, PhD Research Assistant Professor of Infectious Diseases and Microbiology, University of Pittsburgh 12.10 pm-1.20 pm. Effective targeting of the persistent HIV-1 during antiretroviral therapy requires priming of naive CD8+ T cells LUNCH (provided) Meeting on Infection, Immunity, Brain and Cognition April 21, 2016 (continued) Time Speaker Topic Clinical studies. Moderator: Caterina Rosano, PhD, University of Pittsburgh 1.20 pm 1.40 pm Ernesto T. A. Marques, Jr., MD, PhD 1.40 pm 2.00 pm Faith Dickerson, PhD, MPH 2.00 pm 2.20 pm Phillip Nielsen, MSc 2.20 pm 2.40 pm Muhammad Ayub, MBBS, MRCPsych, MSc, MD 2.40 pm 3.00 pm Ibtihal Ibrahim Zika virus: An emerging threat Associate Professor of Infectious Diseases and Microbiology, University of Pittsburgh Clinical Professor of Psychiatry University of Maryland & Sheppard Pratt Hospital. Doctoral Fellow, Aarhus University Clinical trials at the Sheppard Pratt Stanley Research Program Neonatal inflammatory markers as risk factors for psychiatric disorders Schizophrenia genetic studies in Pakistan Associate Professor of Psychiatry Queens University, Kingston, Canada Lecturer in Psychiatry, Mansoura University, Egypt 3.00 pm 3.20 pm Pilot studies for treatment of Toxoplasma Gondii infection and cognitive dysfunction in Egypt BREAK iPSC-based models and antiviral drug discovery. Moderator: Sabine Bahn, PhD, Cambridge University 3.20 pmKip Kinchington, PhD iPSC based models for varicella zoster virus 3.40 pm Professor of Ophthalmology, Molecular Genetics infections and Biochemistry, University of Pittsburgh 3.40 pm 4.00 pm Lora McClain, PhD 4.00 pm 4.20 pm Jim McNulty, MSc, PhD 4.20 pm 4.40 pm Mark Schurdak, PhD 4.40 pm 5.00 pm Dino D’Aiuto, PhD Post-Doctoral Fellow, University of Pittsburgh Professor of Chemistry, McMaster University, Canada Visiting Research Associate Professor of Computational and Systems Biology University of Pittsburgh Instructor, Department of Psychiatry, University of Pittsburgh HSV-1 latency models using human iPSC-derived neurons Discovery and development of new antiviral and anti-toxoplasmosis agents Moderate throughput platform for drug discovery using iPSC-derived neurons. Analysis of novel compounds for HSV-1 infections in multiple cells Meeting on Infection, Immunity, Brain and Cognition April 22, 2016 Time Speaker Topic 7.30 am – 8.00 am Breakfast (on location) Epidemiologic and add on studies. Moderator: Vern Carruthers, PhD, University of Michigan 8.00 am 8.30 am Mary Ganguli, MD, PhD 8.30 am 8.50 am Lori Jones-Brando, PhD 8.50 am 9.10 am 9.10 am9.30 am 9.30 am9.50 am 9.50 am10.10 am Professor of Psychiatry, Epidemiology and Neurology, University of Pittsburgh Epidemiological studies in the MonongahelaYoughiogheny (Mon-Yough) valley Antigen-specific responses to HCMV and cognitive decline: Is there a correlation? Johns Hopkins University Clinical studies at Pittsburgh. Moderator: Vern Carruthers, PhD, University of Michigan Daniel J. Buysse, MD Sleep health UPMC Professor of Sleep Medicine Professor of Psychiatry and Clinical and Translational Science University of Pittsburgh Anne Germain, PhD Sleep: A pillar of resilience Associate Professor of Psychiatry, Psychology, and Clinical and Translational Science University of Pittsburgh Martica Hall, PhD Professor of Psychiatry, Psychology, and Clinical and Translational Science University of Pittsburgh Deepinder K. Dhaliwal, MD, L.Ac Professor of Ophthalmology University of Pittsburgh 10.10 am 10.30 am Sleep, Inflammation and Infection: Opportunities for Translational Science Herpes infection of the eye BREAK Novel techniques to facilitate biomedical research. Moderator: Vern Carruthers, PhD, University of Michigan Aaron Smith, PhD Raman Spectroscopy in cell culture methods 10.30 am 10.50 am 10.50 am 11.10 am 11.10- am 12.00 noon Biomedical Scientist ChemImage Corporation Madhavi Ganapathiraju, PhD Department of Biomedical Informatics University of Pittsburgh Novel protein-protein interactions that connect mental disorders, cilia and immunity Closing remarks and Discussion