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International Conference on Systems Biology of Human Disease (SBHD) July 5 ‐ 7, 2017, Heidelberg Alphabetical list of poster presenters Presenting author Abazari, Mohammad Foad Adebiyi, Prof. Ezekiel Adlung, Dr. Lorenz Amberkar, Dr. Sandeep Shankar Appel, Lena Maetani Arazi, Dr. Arnon Banaei‐Esfahani, Amir Batra, Dr. Richa Ben Guebila, Dr. Marouen Bensimon, Ariel Binder, Dr. Marco Bintener, Tamara Bokharaie, Hanieh Breuer, Dr. Marian Colome Tatche, Dr. Maria De Landtsheer, Sebastien Di Ponzio, Chiara Domínguez Hüttinger, Dr. Elisa Dost, Maria Friedmann, Dr. Elfriede Friedrich, Dhana Fröhlich, Benjamin Garcia‐Alonso, Dr. Luz Gunawan, Prof. Rudiyanto Hasenauer, Dr. Jan Hasenauer, Dr. Jan Hass, Helge Huber, Dr. Heinrich Imig, Dirke Jabs, Julia Kallenberger, Dr. Stefan Kallenberger, Dr. Stefan Matthias Kankeu, Cynthia Kazeroonian, Atefeh Kleimeier, Dana Kollek, Prof. Regine Konrath, Fabian Krantz, Dr. Marcus Krause, Linda Kravchenko‐Balasha, Dr. Nataly Kuchen, Dr. Erika Poster number 39 67 45 49 21 47 64 65 41 8 3 36 26 59 5 10 54 11 35 46 16 62 18 52 19 6 15 4 53 34 60 13 50 1 28 42 55 23 37 12 2 Title Investigation of Cisplatin‐, Lead Acetate‐ and Cyclosporine‐induced Nephrotoxicity by Systems Biology Approaches SIGNAL TRANSDUCTION PATHWAYS IMPORTANT FOR THE RBC – PARASITE INTERACTIONS: COMPUTATIONAL AND EXPERIMENTAL INSIGHTS From static information on cellular protein abundance in patient samples to predictions of dynamic proliferation behavior Pan brain region analysis identifies common and differential pathways associated with amyloid‐beta pathology in Alzheimer’s Disease Dynamics of tumor‐reactive lymphocytes in the melanoma mouse model Multi‐dimensional Profiling of Kidney, Blood and Urine in Lupus Nephritis Patients Towards a Comprehensive Model of Oxidative Stress in Mycobacterium tuberculosis Clinical Isolates Transcriptome based classifier for cutaneous T cell lymphoma and dermatitis A fast and parallel implementation enables flux variability analysis for large scale metabolic models Deciphering MET‐dependent modulation of cellular responses to ionizing radiation by quantitative phosphoproteomics Dynamic Modeling of Virus Replication and Cell‐Intrinsic Innate Immune Responses Identification of cancer metabolism rewiring strategies by using constraint‐based modelling and machine‐learning Evaluation of Cancer disease genes and their corresponding drug targets in Protein‐protein interaction Metabolic Reconstruction of the Minimal Cell Single cell genomics and low input epigenomics FALCON: An Efficient Pipeline for the Contextualization of Logical Network Models CYP3A5 expression in PDAC cells results in tumor niches protected from cytotoxic drugs Modelling the complex regulatory interplay between Epithelial‐Mesenchymal‐Transitions and the Microenvironment in Health and Disease A Boolean Model of the Ras/Raf/Mek/Erk pathway Modeling and Simulation of the effectiveness of drugs From transcription factor dynamics to cell fate: p53 nuclear accumulation changes stochastic gene expression of target genes. Quantification of mechanical properties of P.falciparum‐infected hemoglobinopathic erythrocytes: Protection mechanism against severe forms of malaria Transcription factor activities enhance markers of drug response in cancer Bioinformatics Analysis of Human Ageing: From transcriptomics to phenomics Large‐scale mechanistic model predicts drug response of cancer cell lines Parallelisation and high‐performance computing enables statistical inference of multi‐scale models Predicting tumor growth and ligand dependence from mRNA by combining machine learning with mechanistic modeling Signal transduction analysis suggests that a switch in interferon response during infection and infarct can act as regulator of inflammatory signaling Cell population dynamics during apoptotic treatment Resolving drug effects in patient‐derived cancer cells links organoid responses to genome alterations Paradoxical amplification of MAPK and PI3K/Akt signaling activities due to overexpression of CBL ubiquitin ligases Stop‐and‐go in translational regulation: modeling the stochastically fluctuating cellular stress response to virus infection Quantitative Proteomics and Systems Analysis of Cultured H9C2 Cells during Differentiation over Time Dissecting the sources of heterogeneity in T cell kinetics using live cell imaging data A mathematical Model of LPS induced Indoleamine 2,3‐dioxygenase activation along the kynurenine pathway in pigs Meanings and Concepts of Standardization in Systems Medicine Dynamical modelling of DNA damage‐dependent NF‐kB activation Building the knowledge base to understand cellular regulation in health and disease Interface dermatitis is mediated by a type I immune response Understanding cancer phenomena using a thermodynamic‐based approach Two interacting cell‐intrinsic processes explain inheritance and heterogeneity of cell‐cycle lengths International Conference on Systems Biology of Human Disease (SBHD) July 5 ‐ 7, 2017, Heidelberg Alphabetical list of poster presenters Künstner, Axel Kuritz, Karsten Marquez‐Lago, Prof. Tatiana T. Meimandi Parizi, Farzaneh Mir, Jonas Murugan, Rajagopal Ayyanar Neumann, Stefan Opitz, Christiane Poos, Alexandra Maria Raimondi, Dr. Francesco Raimúndez Álvarez, Elba Ramon, Charlotte Anna Marie Rastgou Talemi, Dr. Soheil Ryan, Dr. Colm J. Salopiata, Florian Samal, Dr. Satya Swarup Schweinoch, Darius Sheng, Caibin Sitte, Maren Stiehl, Dr. Thomas Stübler, Sabine Stumpf, Laura Sophia Thedieck, Kathrin Trump, Dr. Saskia Wehler, Pierre Wittig, Dr. Ulrike Worf, Karolina Wu, Guoyu Zipprich, Gideon 27 14 51 63 33 48 40 68 32 38 20 25 44 66 17 24 22 58 61 29 30 69 7 9 56 43 57 31 70 A distinct cutaneous microbiota profile in autoimmune bullous disease patients Reconstructing dynamic processes from high dimensional snap‐shot data Systems Biology of the intestinal microbiota in neurodegenerative disorders Study of lung cancer based on context‐specific genome‐scale metabolic network Data‐driven mathematical modelling of antigen‐stimulus effects on T cell kinetics Clonal evolution of human memory B cell responses A computational model of EGFR receptor trafficking Restricting genome scale metabolic models with expression data reveals novel enriched signatures in glioblastoma Using Mixed Integer Linear Programming to identify regulators of telomerase expression Understanding the functional consequences of protein variation in cancer through integration of structure, interaction and pathway knowledge. Understanding the role of ErbB signaling in resistance to antibody‐based therapies in gastric carcinoma using mechanistic models. Functional metabolic alignment of human and yeast metabolic networks for rare metabolic disorder modeling Mathematical modeling of dengue virus infection and innate immune response A compendium of co‐regulated protein complexes in breast cancer reveals collateral loss events associated with tumor suppressor gene defects The influence of EGF/HGF receptor abundance on therapy resistance in NSCLC cell lines Sensitive parameters and tipping points of biochemical networks needed in precision medicine Mathematical Model for the RIG‐I Pathway Activation by dsRNA Investigating signaling dynamics using knock‐in fluorescent reporters Predicting the influence of combination therapies in signaling networks Relating clonal hierarchies to disease dynamics of acute leukemias Towards a systems biology model for inflammatory bowel disease Mathematical modeling of the A20 feedback mechanism in TNF‐α‐induced signaling pathways A systems study reveals concurrent activation of AMPK and mTOR by amino acids Asthma development in early childhood is associated with epigenetic changes in enhancer regions Engineering optogenetic control of p53 to study the effects of its dynamics on cellular outcome independent of stress SABIO‐RK and SEEK: de.NBI Tools for Systems Biology Projects Finding schizophrenia related pathways Using optogenetics to study the dynamics of TGF‐β signaling pathway OTP – An automation platform for managing NGS data