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Seizures and Epilepsy PRESENTED BY GERRY BROPHY Training in Care Solutions The brain is made up of billions of neurons, or nerve cells. These are the electrically charged units that, as they communicate with each other, organize electrical energy to make the brain work. A neuron has three parts— a cell body, an axon, and dendrites. The enzymes and genetic material which directs the neuron are contained in the cell body. The cell body is surrounded by thin, branch-like projections, or dendrites. The axon is a long, thin, tail-like extension from the cell body, insulated by a sheath of myelin. It carries an electrical charge to the axon terminal, where it activates the release of neurotransmitting chemicals. A. Primary Generalized Seizure B. Partial Seizure C. Partial Seizure with Secondary Generalization Definitions: Clinical An epileptic seizure : is an intermittent stereotypical, usually unprovoked, disturbance of consciousness, behaviour, emotion, motor function or sensation that on clinical grounds results from cortical neuronal discharge Epilepsy is a condition in which seizures recur, usually spontaneously Definition of Epilepsy by cause Idiopathic Symptomatic Drugs Alcohol Birth Trauma Brain Tumour CVA (stroke) Infection How Many People Have Epilepsy? Epilepsy is the most serious neurological disorder affecting people of all ages. It is believed that, as an absolute minimum, 0.5% of the population have Epilepsy, this equates to 1 person in every 200, (350,000 people). 20% of children, onset being before the age of 5 years. 30% are sufferers between the ages of 6 and 25 years 50% the onset is after the age of 25. What causes seizures to happen In most people with epilepsy, seizures are spontaneous events without a clear cause? However, in a few people, seizures can also be triggered by specific stimuli such as flashing lights of certain frequencies. Lack of sleep exhaustion, boredom, anxiety, abrupt stopping of anti-epileptic medication, to much alcohol, recreational drugs, computer screens and games and also a bang to the head or accident can all cause them. What types of seizures do you know? Classification of Seizures Partial-onset seizures Simple partial Complex partial Secondary generalised tonic-clonic Classification of Seizures cond. Generalised-onset seizures Typical absence Atypical absence Myoclonic Atonic Primary generalised tonic-clonic Clonic Tonic Partial-onset seizures Commence at any age Usually have an aura which reflects seizure origin and initial spread. Awareness may be retained (simple partial), partially preserved or lost (complex partial) Can be secondary generalised tonic clonic Common patterns e.g. clustering Generalised-onset Seizures Childhood, adolescence, young adults No warning Abrupt loss of consciousness (except myoclonus) Occur in normal e.g. typical absence or diffusely abnormal brain e.g. tonic drop attacks Common pattern; soon after wakening Seizures involving altered consciousness or behaviour Simple partial seizures Twitching, numbness, sweating, dizziness or nausea; disturbances to hearing, vision, smell or taste; a strong sense of deja vu. Complex partial seizures Plucking at clothes. Smacking lips. Swallowing repeatedly or wandering around. The person is not aware of their surroundings or of what they are doing. Atonic seizures Sudden loss of muscle control Causing the person to fall to the ground. Recovery is quick. Tonic-clonic Seizures Can be primary or secondary generalised Distinction has implications for management Myoclonic seizures Brief forceful jerks which can affect the whole body or just part of it. The jerking could be severe enough to make the person fall. Absence seizures The person may appear to be daydreaming or switching off. They are momentarily unconscious and totally unaware of what is happening around them. Diagnoses of Epilepsy Blood tests. These are done to check the general health of the person and help exclude a metabolic cause for the epilepsy. CAT scan or MRI scan These help to exclude structural cause for the epilepsy and seizures. EEC (Electroencephalogram) This test measures the electrical activity of the surface of the brain at the time of the test. Prevalence of epilepsy in people with Learning Disability Up to 30% of people with LD have epilepsy About 30% of people with epilepsy have LD More common in people with severe to profound LD 50%+ Current antiepileptic drugs Phenobarbitone 1912 Primidone 1952 Carbamazepine 1963 Clonazepam 1974 Vigabatrin 1989 Gabapentin 1993 Topiramate 1995 Oxcarbazepine 2000 Pregabalin 2004 Phenytoin 1938 Ethosuximide 1960 Sod. Valproate 1974 Clobazam 1982 Lamotrigine 1991 Piracetam 1993 Tiagabine 1998 Levetiracetam 2000 Zonisamide 2005 A Common Sense Approach Issues Specific to Learning Disability Communication Care situation Co-morbidity Communication People with Learning Disabilities are more likely than the general population to have communication difficulties. This can make information gathering and history taking difficult. Communication Various reasons: • “Physical” e.g. dysarthria due to cerebral palsy, deafness, cleft palate. • “Psychological” e.g. specific deficits due to autism, mute due to anxiety/ depression. • “Pathological” e.g. due to the severity of intellectual impairment – i.e. lacks ability to understand and communicate. Communication May have no verbal communication, but may communicate through: • Signing – e.g. Makaton • Pointing – e.g. to word cards • Picture boards / communication passports • Gesture • Carers • Facial expression • Behaviour So don’t make assumptions - ask! Communication May have verbal communication but : • Do not properly understand questions • Cannot adequately describe symptoms • Cannot understand concept of time • Cannot see this as important/ relevant • Wishes to avoid talking about epilepsy • Finds talking about other subjects more interesting Carers Clients now find themselves in a variety of care settings: Family home Their own homes – with professional support - from minimal to 24 hours Shared tenancies Group homes Nursing Homes Continuing NHS Care Private Care Homes Epilepsy Care Plans These should include: Contact details for all involved Details of Medication Summary of Seizure Types Annual/ monthly Seizure Charts Rescue Medication protocol An epilepsy history A section to record any contact the patient has with GP/ hospital/ nurse, etc Carers - Training Carers need to be trained in the following areas: Epilepsy Awareness Administration of Rescue medication Rectal diazepam Buccal Midazolam First Aid and Basic Life Support Moving and Handling But also may need to be individualised for specific patients/ circumstances Co-morbidity - Physical Genetic conditions predisposing to physical illness • Downs Syndrome - hypothyroidism, leukaemia, heart defects, diabetes • Tuberous Sclerosis - kidney and cerebral tumours Physical condition of which LD is a feature • Cerebral Palsy – scoliosis, prone to urinary or respiratory infections • Encephalitis – epilepsy Developmental disorders of which physical disorder is a feature • Autism - epilepsy Co-morbidity - Difficulties Investigations: May not tolerate investigations (or presumed they will not tolerate investigations) May have non specific abnormal results (associated with aetiology of Learning Disability but not necessarily of seizures) Consent issues – MCA 2005 Co-morbidity - Difficulties Medications: Drug interactions Side effects • • AEDs - Cognitive/ Behavioural/ Physical Psychotropics - lower seizure threshold Compliance Consent Formulations • PEG feeding, swallowing problems Practical difficulties in LD and epilepsy Diagnostic difficulties Difficulties getting accurate information from carers Lack of carer education / experience of epilepsy Mistaking stereotypes with seizure activity Client tolerance of investigations Non Epileptic Attack Disorder (NEAD) Management Difficulties Increased rates of side-effects Patients may not be able to report side effects Other behaviours and psychiatric disorder may be masked by high levels of sedation Informed consent about care plan may be impossible Medical Emergencies Status Epilepticus or Recurrent seizures (i.e. more than 2/3 without apparent recovery in-between) Unusually prolonged seizure (Depends upon individual) Not responding to Stesolid (Rectal valium) Not known to have epilepsy Medical Emergencies Cluster of seizures without signs of stopping (Recurrent seizures with recovery period between). Suspected serious secondary injury (e.g. from fall during tonic stage). You are concerned and need further advice . Remember - if in doubt do too much rather than too little EMERGENCY FIRST AID Tonic-Clonic seizures The person loses consciousness, the body stiffens, then falls to the ground. This is followed by jerking movements. A blue tinge around the mouth is likely. This is due to irregular breathing. Loss of bladder and/or bowel control may occur. After a minute or two the jerking movements should stop and consciousness may slowly return. First Aid Don’t panic . Once a seizure has started there is nothing you can do to stop it. If you can get to the person quickly enough try to gently lower them to the ground. Remember to look after your back and if the person is writhing violently it may be best to stand away and let the person fall. If you get injured you will be of no use to the person having a seizure. Make a note of the time. First Aid Once the person is on the floor try to loosen any clothing such as belts, ties buttons etc. This is to ensure an adequate blood and oxygen flow. Do not restrain the person in any way. The violent contractions of the muscles could results in bone breakage. If possible remove any objects that could cause further injury to the person. Move chairs and tables out of the way as well as knives and forks. First Aid Try to put something soft under their head to prevent any head injuries e.g. cushions or blankets or even your coat. Never put anything in the mouth or try to remove the tongue from between the teeth. If they are going to bite their tongue or lips they will have already done so. When the seizure has finished. Check the airway and breathing, put the person gently in the recovery position. First Aid After the seizure the person may simply fall asleep where they are. They may be confused and dazed but will almost certainly want to sleep. Stay with the person and accompany them to their bed or the nearest sofa. Let the person sleep and check on them regularly. Record the seizure. Don't... Restrain the person Put anything in the person’s mouth Try to move the person unless they are in danger Give the person anything to eat or drink until they are fully recovered Attempt to bring them round Call for an ambulance if... You know it is the person’s first seizure The seizure continues for more than five minutes One tonic-clonic seizure follows another without the person regaining consciousness between seizures The person is injured during the seizure You believe the person needs urgent medical attention Recording a seizure. There is no agreed standard for the recording of epileptic seizures. Partial seizures .i.e. absences may be difficult to spot and therefore record accurately. Generalised seizures are easier to record but activity before the seizure took place may be of greater importance in identifying and preventing triggers than other details. Recording a seizure If someone has regular seizures it maybe possible to break the recording down. For example first try to identify what time of day the seizures are most likely to occur .i.e. their duration. Then concentrate on what the person is doing immediately preceding a seizure to try and establish if there are obvious triggers. Finally concentrate on what actually takes place during the seizure. For example; colour changes, movements, breathing, and condition after the seizure.