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Prepared: 8 April 2013 Name: Michael H. Lev, M.D. Office Address: Massachusetts General Hospital Gray Bldg 241 H Boston, MA 02114-9657 Home Address: 122 Mill Street Newton Centre, MA, 02459 Work Phone: (617) 724 – 7125 (office) (617) 726 – 8789 (Neurovascular Lab) Work E-mail: [email protected] Work Fax: 617-724-3338 Place of Birth: Brooklyn, N.Y. Education: 1978 H.S. 1982 Sc.B. 1986 M.D. Stuyvesant High School Biophysics with Honors, Magna Cum Laude Seven Year Medical Education Program New York, N.Y. Brown University Brown University Postdoctoral Training: 1983 - 1984 1986 - 1987 1987 - 1989 1990 - 1994 1993 - 1995 1986 - 1989 1990 - 1995 Fulbright Scholar Intern Resident Resident Fellow Clinical Fellow Clinical Fellow Weizmann Institute of Science Medicine Medicine Radiology Neuroradiology Medicine Radiology Rehovot, Israel Boston University Medical Center Boston University Medical Center Massachusetts General Hospital Massachusetts General Hospital Boston University Medical Center Harvard Medical School Boston University School of Medicine Harvard Medical School Harvard Medical School Harvard Medical School Academic Appointments: 1989 - 1990 Clinical Instructor Medicine 1995 - 2001 2001 - 2004 2004 - present Instructor Assistant Professor Associate Professor Radiology Radiology Radiology Hospital Appointments: 1989 - 1990 Staff Physician Acute Medical Service 1995 - 2004 Assistant Physician Radiology 1995 - present 1995 - 2011 1995 - present Associate Physician Staff Radiologist Staff Radiologist Radiology Head and Neck Radiology Neuroradiology Edith Nourse Rogers Memorial Veterans Hospital Massachusetts General Hospital, Massachusetts Eye and Ear Infirmary (MEEI) Massachusetts General Hospital MEEI Massachusetts General Hospital Major Administrative Responsibilities: 1995 - present 1997 - present 1999 - 2001 2000 - present 2004 - present 2011 - present Director of Neuro-CT Director of Emergency Neuroradiology Neuroradiologic Teleradiology Coordinator Director of Radiology Neurovascular Laboratory Co-Director HMS Neuroradiology Weeklong CME Course: Functional MRI & Spectroscopy (annual, fall) Director HMS Intensive Review of Neuroradiology Weekend CME Course (annual, spring) Department of Radiology, Massachusetts General Hospital Department of Radiology, Massachusetts General Hospital Department of Radiology, Massachusetts General Hospital Department of Radiology, Massachusetts General Hospital Department of Radiology, Massachusetts General Hospital and Harvard Medical School (Gonzalez RG, Hirsch JA, Lev MH, Schaefer PW) Department of Radiology, Massachusetts General Hospital and Harvard Medical School (Lev MH, Gonzalez RG) Major Committee Assignments: 1998 - 2009 1999 - 2000 Chairman Education Committee, Biomedical Student Society Co-Chairman Program Committee, Campus Jewish Appeal Member Curriculum Committee Member PACS/ER Neuroradiology Planning Committee Executive Committee Junior Member, Radiology Associates Representative House of Delegates Chairman Membership Committee 2000 - present Member Radiology Resident Selection Committee 2000 - present 2000 Member Neuroradiology Fellow Selection Committee Member Organizing Committee 2001 - 2002 Treasurer ENRS 2001 Member Organizing Committee 2002 - 2008 Co-Director ACR/ASNR Committees for CPT/CMS coding proposals (i) CT Perfusion - with William Dillon, MD, UCSF (ii) CT Angiography- with Gordon Harris, PhD, MGH Vice President and Meeting Organizer ENRS 1979 - 1980 1979 - 1980 1981 - 1985 1997 - 1998 1998 - 1999 2002 - 2003 2003 - 2005 Co-Chairman (with R Latchaw, MD), AHA Publication Subcommittee on Stroke Perfusion Imaging Guidelines Brown University Brown University Brown University Medical School Massachusetts General Hospital Massachusetts General Hospital Massachusetts Medical Society The Eastern Neuroradiological Society Massachusetts General Hospital Massachusetts General Hospital 1st Annual Symposium on CT/MR Brain Perfusion Imaging, Giessen, Germany The Eastern Neuroradiological Society 2nd Annual Symposium on CT/MR Brain Perfusion Imaging, San Francisco, CA American College of Radiology/American Society of Neuroradiology The Eastern Neuroradiological Society American Heart Association 2 2003 Member Organizing Committee 2003 - 2007 2003 - 2004 Member ASNR Task Force on Stroke President ENRS 2004 - present Member, MGH Acute Stroke Quality Task Force (ASQT) Scientific Program Committee Member RSNA / Abstract Reviewer / Annual Meeting Award Judge Member, ASNR Research Committee Member, AMA (representing AAN/ACR) Physician Consortium for Performance Improvement (PCPI), National Committee for Stroke and Stroke Rehabilitation Workgroup 2004 - 2010 2005 - 2011 2006 - present 2006 - 2010 2006 - present 2007 - 2011 2007 2007 - present 2008 - 2011 2008 - 2012 2010 2010 - 2012 Co-director, ACR / ASNR Committee for CPT/CMS coding proposals: CT Perfusion (with Max Wintermark MD) Annual Meeting Abstract Reviewer, ASNR Executive Committee Senior Member, Radiology Associates Member Organizing Committee: Advanced Neuroimaging and Acute Stroke Neuroradiology Fellowship CAQ Oral Board Examiner / Radiology Resident Oral Board Examiner, ABR RSNA Education Exhibits Awards Committee (EEAC) for Neuroradiology STIR “I” (Stroke Imaging Repository Consortium) Steering Committee Member STAIR (Stroke Treatment Academic Industry Roundtable) VIIth Annual Meeting Committee Committee Member, ACR/ASNR/SPR Practice Guidelines for the Performance of Computed Tomography (CT) Perfusion in Neuroradiologic Imaging 2011 - present Member, MGH Stroke Care Redesign Team 2011 - present Member, Stroke Progress Review Group (SPRG), Imaging Committee Member, Radiology Associates Executive Committee Nominating Committee Maintenance of Certification (MOC) Quality Review Board Chair and Primary Author for ASNR Ad Hoc Committee response to NINDS RFI (Request for Information) re Stroke Imaging Priorities PRG Chair and Primary Author for ASNR-ACR Ad Hoc Committee response to Wellpoint RFI re CT Perfusion Imaging Policy STIR “II” (Stroke Imaging Repository Consortium) Working Group Leader STAIR (Stroke Treatment Academic Industry Roundtable) VIIIth Annual Meeting Team Leader (“salvageable brain detection” subgroup) 2012 2012 - present 2012 2012 2012 - present 2013 3rd International Symposium on CT/MR Brain Perfusion Imaging, St. Louis, MO American Society of Neuroradiology The Eastern Neuroradiological Society Massachusetts General Hospital Radiological Society of North America American Society of Neuroradiology American Medical Association (American Academy of Neurology / American College of Radiology); national committee for standardized quality assurance (QA) stroke measures American College of Radiology/American Society of Neuroradiology American Society of Neuroradiology Massachusetts General Hospital NIH Sponsored “Future Directions” R13 Conference (Washington DC) American Board of Radiology Radiological Society of North America National Institute of Neurological Disorders and Stroke, NIH STAIR Consortium American College of Radiology/American Society of Neuroradiology/Society for Pediatric Radiology Partners Healthcare, Massachusetts General Hospital National Institute of Neurological Disorders and Stroke, NIH Massachusetts General Hospital, Department of Radiology Massachusetts General Hospital, Department of Radiology American Society of Neuroradiology American Society of Neuroradiology American College of Radiology National Institute of Neurological Disorders and Stroke, NIH STAIR Consortium 3 Professional Societies: 1986 - present 1990 - present 1990 - present 1992 - present 1993 - present 1995 - present 1997 - present 1998 - present 2000 - present 2002 - present 2007 - present Massachusetts Medical Society American Roentgen Ray Society Radiological Society of North America American Association for the Advancement of Science American Society of Neuroradiology New England Roentgen Ray Society Eastern Neuroradiological Society American Society of Head and Neck Radiology American Heart Association (AHA) Scientific Council in Cardiovascular Radiology Scientific Council in Stroke American College of Radiology Examiner, American Board of Radiology Editorial Boards and Scientific Reviewer: • Ad Hoc Reviewer o o o o o o o o o o o o o o American Journal of Neuroradiology American Journal of Radiology Annals of Neurology Archives of Neurology Cerebrovascular Diseases Journal of Magnetic Resonance Imaging Journal of the Moffitt Cancer Center Journal of Neuroimaging Lancet Neuroradiology Neurosurgery Radiology Skeletal Radiology Stroke (American Heart Association) • Other Editorial Roles 1999 - present 1999 - 2003 Advisory Board Distinguished Scientific Advisor 2000 - present 2007 - 2009 2009 - present Editorial Board Member Deputy Editor Special Consultant Deputy Editor, Special Consultant to the Editor-in-Chief Editorial Board Consultant for Neuroradiology 2009 - present GE Medical Systems: Functional CT Radiological Society of North America Research and Education Foundation American Journal of Neuroradiology Radiology Radiology Neurosurgery Honors and Prizes: 1977 1978 1978 NYC School Science Fair: Naval Science Cruiser Award NYC School Science Fair: Major Award Army Silver Medal and NASA Citation NYC High School Citywide Science Fair; US Navy NYC High School Citywide Science Fair; Top Five International Science and Engineering Fair, Anaheim CA 4 1978 1978 - 1982 1979 - 1981 1979 1979 1981 1982 1982 1983 - 1984 1985 1985 1996 2000 2005 2006 2007 2008 2010 2011 2012 2012 2013 2013 Gold Medal Social Studies, Silver Medals Physics and Mathematics, Championship Math Team Award SEIU Scholarship Award Melba Schub Zinoman Scholarship Award Hartshorn-Hypatia Mathematics Award CRC Award for Chemistry Excellence in Undergraduate Research Baker Fellowship Anatomy Dissection Prosector Fulbright Fellowship to Weizmann Institute of Science Honors in NIH Neurology / Neurosurgery Clinical Elective Honors in Medical Subinternship RSNA Seed Grant Award Margaret and Leonard C. Doubleday Distinguished Lecturer “Partners in Excellence” Award for ASQT membership, MGH Bowditch Prize for ASQT membership, MGH Nominated for 2006 Excellence in Mentoring Award, HMS Elected Fellow of the AHA (FAHA) “Partners in Excellence” Award for CT Dose Committee RSNA “Magna Cum Laude” Award for Education Exhibit (Optimization of Head CT Image Quality at low and sub mSv Radiation Doses) : only 28 awarded of more than 2,100 exhibits AHA ISC Meeting “Top 10% Abstract” Award for “Degree of Clot-related Susceptibility Artifact is an Independent Risk Factor for Parenchymal Hematoma Following Mechanical Thrombectomy” Elected Fellow of the ACR (FACR) “Dale Cooper Lecturer in Neuroradiology”, grand rounds / visiting professor Executive Council on Research (ECOR) Innovative Technologies “Book-of-Achievements” Distinction (1 of 3 from CIMIT for 2013) Stuyvesant High School Graduation, NYC Service Employees International Union B'nai B'rith Hillel Foundation Brown University Brown University Sigma Xi Scientific Research Society Brown University Brown University Program in Medicine Fulbright Scholar National Institutes of Health Brown University Program in Medicine Radiological Society of North America Houston Radiological Society, MD Anderson Cancer Center Acute Stroke Quality Taskforce, Massachusetts General Hospital Acute Stroke Quality Taskforce, Massachusetts General Hospital Harvard Medical School American Heart Association, American Stroke Association CT Radiation Dose Optimization and Standardization Committee, Massachusetts General Hospital Radiological Society of North America (RSNA) Annual Meeting, 2011 American Heart Association International Stroke Conference Annual Meeting 2012, New Orleans, LA American College of Radiology Department of Radiology, Emory University, Atlanta, GA MGH ECOR and Partners Healthcare Center for Integration of Medicine and innovative Technology (CIMIT), Boston, MA 5 Report of Funded and Unfunded Projects Funding Information Current Principal Investigator NIH/NINDS, 1 P50 ~ $8.2 million (total P50, (20% effort) NS051343-01A2 over 5 yrs) “SPOTRIAS I: Special Program of Translational Research in Acute Stroke”; Project 2 - CTP Prediction of Maximal Tissue Salvage and Clinical Improvement in Acute Stroke. Investigators: Lev MH, Koroshetz WJ, Furie K, Singhal A, Harris GJ, et al. Co-investigator, NIH/NINDS, 1 P50 NS051343 ~$2.8 million total 3 yr 2011 - 2013 Co-director Core Imaging Lab budgeted (10% effort) ($917,628 current yr) “SPOTRIAS II: Special Program of Translational Research in Acute Stroke”; Co-director Core Imaging Lab; Co-investigator Project 1 - “MR WITNESS” clinical trial Investigators: Furie K, Schwamm L, Wu O, Lev MH, Harris GJ, et al. 2006-2011 Millennium Pharmaceuticals 2007 - present Neuroimaging consultant for “α4β7 Integrin in Inflammatory Bowel Disease”. Investigators: Parikh A, Provenzale J, Lev MH. ~ $2-4 K / yr Co-principal Investigator General Electric Healthcare ~ $90 K total (20% effort) (i) “CT Perfusion Thresholds in Acute Stroke Triage”; (ii) CT volume shuttle acquisition/time resolved postprocessing; (iii) ASIR (iterative reconstruction) CT evaluation on the HD scanner for neuroimaging; (iv) Spectral CT neuroradiological applications; and (v) multi-center ASIR evaluation for general imaging. Investigators: Lev MH, Sahani D, Pomerantz S 2008 - present NBIB, NIH Subcontract ~ $364 K total through U of Cincinnati (5U54EB007954-04 sub award 005213) “Point-ofcare” Center (POC-CENT) Electrical Impedance Spectroscopy: Technical Development and Clinical Feasibility Trial in Stroke and Hemorrhage Investigators: Lev MH, Schwamm L, Rosenthal E, Bonmassar G. 2010 - 2012 Principal Investigator (3.66% effort) Co-investigator NIH/NINDS, NS075209 (3% effort, unpaid consultant) CTP to Predict Response to Recanalization in Ischemic Stroke Project (CRISP) Principal Investigators: Maarten Lansberg MD PhD, Greg Albers MD 2011 - 2016 ~ $3 million total 5 yr budgeted DOD, through a Center for ~ $100 K total Integration of Medicine and Innovative Technology (CIMIT) Innovation Grant Electrical Impedance Spectroscopy: An EKG for the Brain?: Portable Battlefield Detection of Acute Traumatic Extra-axial Hematoma Investigators: Lev MH, Schwamm L, Rosenthal E, Borgie R, Kamalian MS, Bonmassar G. 2012 - 2013 Principal Investigator (6.34% effort) 6 Past 1995 - 1996 Investigator SONUS Pharmaceuticals "An investigation of the diagnostic efficiency of echogen contrast-enhanced carotid non-invasive studies in comparison to that of spiral CT angiography" Investigators: Ackerman RH, Gahn G, Candia M, Lev MH, Richardson EP. 1996 - 1997 Principal Investigator Radiological Society of North America Seed Grant Award “Radiation necrosis versus glioma recurrence?: Diagnostic accuracy, surgical utility, and pathophysiological imaging correlates of spin-labeled perfusion MRI” 1996 - 1998 Film Reviewer Sandoz Pharmaceuticals “Human glioma gene therapy trial” Principal Investigator / Imaging Consultant: Sorensen AG. 1997 Investigator Hologram Technology International Spiral CT holography: Neuroradiological Applications Investigators: Lev MH, Farkas J, Gonzalez RG. 1997 - 1999 Investigator 1998 - 2000 Investigator General Electric Medical Systems, CT Division “The clinical utility of spiral CT angiography in acute stroke” Investigators: Gonzalez RG, Lev MH, Hunter GJ, Hamburg LM, Farkas J. Integrated Medical Image Processing Systems (IMIPS), Inc. “Subtraction and co-registration software in CT perfusion imaging of hyperacute stroke” Investigators: Lev MH, Berdichevsky D, Alpert NM, Gonzalez RG, Thangaraj V. 1998 - 2000 Film Reviewer Astra Pharmaceuticals “Acute stroke neuroprotective agent therapy trial” Principal Investigator / Imaging Consultant: Parexel, Goldberg M. 1999 - 2002 Investigator General Electric Medical Systems, CT Division “Multidetector CT cerebral perfusion imaging in acute stroke”. Investigators: Lev MH, Gonzalez RG, Harris GJ, Nichols S. 2000 (summer) Principal Investigator American Heart Association “Comparison of MR diffusion and CT perfusion imaging of hyperacute stroke”. Principal Investigator: Lev MH, student: Tyler M. Berzin, Brown University Program in Medicine. 2000 - 2001 Investigator MD On Line (MDOL), Inc. “Disease pattern recognition modules in neuroimaging”. Investigators: Lev MH, Benjamin M, Dreyer K, Schulze T, Brady T. 7 2001 - 2002 Investigator Nycomed Amersham, Imaging “CT perfusion imaging in patients with acute embolic stroke: predicting final infarct size” Investigators: Lev MH, Hunter GJ, Hamberg L, Gonzalez RG, Harris GJ. 2001 - 2006 Co-Principal Investigator (20% effort) US Army (Department of Defense), DAMD 17-01-10710 “Natural history and treatment response of vestibular schwannomas in NF2 patients” Investigators: Slattery W, Lev MH, Worldcare, Inc., et al. 2002 - 2006 Co-Principal Investigator (20% effort) 2002 (summer) Principal Investigator (~ $3.5 million) NIH Agency for Heatlh Care (~$2 million) Policy and Research (AHCPR), R01 HS1139201A1 “STOP Stroke: Screening Technology and Outcomes Project in Stroke”. Investigators: Koroshetz WJ, Lev MH, Furie K, Gleason S, Gazelle GS, Harris GJ, Gonzalez RG, et al. Pasteur Program, Harvard Medical School “CT perfusion imaging in acute stroke triage” Principal Investigator: Lev MH, student: Nupur Mehta, Harvard University Medical School. 2003 – 2006 Co-Principal Investigator (5% National Neurofibromatosis effort) Foundation “Digital Image Archiving Pilot Project for Patients with NF1 and NF2” Investigators: Harris GJ, Lev MH, Jarimillo D, MacCollin MM, MMS Inc. 2003 – 2005 Film Reviewer ~ $80,000 Proxima Therapeutics and Worldcare Clinical “GliaSite brain tumor brachytherapy MR imaging assessment” Investigators: Lev MH, Bill Dooley. 2004 – 2005 Film Reviewer Novartis and Worldcare Clinical “Neurological assessment in rectal cancer anti-angiogenesis trial” Investigators: Lev MH, Brad Dean. 2006 Film Reviewer Rutland Regional Medical Center, Rutland VT Quality assurance film reviewer for neuroradiology reports Reader: Lev, MH 2006 - 2009 Film Reviewer Serano and Worldcare Clinical “Serano Multiple Sclerosis Trial” Investigators: Pomerantz SR, Romero J, Chen J, Lev MH. 2006 - 2009 Director, Core Imaging Laboratory Vernalis LTD, UK ~ $100 K + 8 V10153-2S-01 Thrombolysis Trial: Core Imaging Laboratory. Site PI: Lev MH, Harris GJ, Alex Sherman, Spinale D, and Demchuk AM (Calgary) 2007 - 2009 Film Reviewer Novartis and Beacon Bioscience “Glivec plus Hydroxurea Progressive Glioblastoma Multiforme Trial” Investigators: Sorensen AG, Rincon S, Copens W, Lev MH. Investigator CoAxia 2007 - 2010 “SafeFlow 24: Safety and Efficacy of NeuroFlo in 8-24 hours Patients” Investigators: Noguiera R, Lev MH, Schwamm L. Investigator General Electric Healthcare 2006 - 2010 “3D-MIP reconstruction of aneurysm CTA with automated bone removal” Investigators: Pomerantz SR, Harris GJ, Lev MH. ~ $50K Investigator General Electric Healthcare ~ $25K 2006 - 2010 “CT Perfusion Thresholds in Acute Stroke Tissue Characterization: Perfusion 4 Software Evaluation” Investigators: Lev MH. Report of Local Teaching and Training Teaching of Students in Courses 1. Brown University / Brown University Program in Medicine 1981 Biochemistry 123 Undergraduate Teaching Assistant 1982 - 1983 Undergraduate Human Physiology 6 Teaching Assistant 1983 Undergraduate Stanley Kaplan DAT Course Course Instructor 1985 Medical Students National Boards Review Course Class Instructor 2. Boston University Medical Center 1987 Introduction to Clinical Medicine Workshop Medical Students Class Instructor 3. Harvard Medical School / Massachusetts General Hospital 1991 - 1999 Clinical Clerkship in Radiology: Ultrasound and Cardiac Radiology Medical Students Instructor Six lectures/yr, 1 hr/lecture, approximately 10 students/lecture 1999 - 2002 Medical Students Fourth Year Comprehensive Exam (OSCE) Faculty Examiner One morning (5 hour) session per year 1999 - 2007 Core Clinical Clerkship in Radiology at MGH (RD500M.3): Neuroradiology (CT, Neurotrauma, MRI, Brain Tumors) Instructor Six 1-hour lectures per year, and approximately 12 students per lecture Medical Students 9 2008 - present Medical Students Core Clinical Clerkship in Radiology at MGH (RD500M.3): Neuroradiology (CT, Neurotrauma, MRI, Brain Tumors) Instructor Twelve 1-hour lectures/year, and approximately 6 students/lecture Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) 1991 - 1997 Residents/Fellows Cardiac, GI, and Neuroradiology: Summer Radiology Minicourse Department of Radiology, Massachusetts General Hospital Lecturer 3-4 lectures per year, 1 hour per lecture, approx. 40 residents/fellows per lecture Residents/Fellows Neuroradiology, Spinal Radiology, and Head & Neck Radiology, Neuroradiology Division Minicourse, Massachusetts General Hospital Lecturer 3-6 lectures/yr, 1 hr/lecture, approx 40 residents/fellows per lecture 1996 - present Residents Radiology Board Review Sessions, Massachusetts General Hospital Instructor 3-6 lectures/yr, 3 hrs/lecture, approximately 10 residents per lecture 1998 - 1999 Residents Radiology Board Review Sessions, Beth Israel - Deaconess Medical Center Instructor 1-2 lectures per year, 3 hours per lecture, approximately 6 residents per lecture 1998 -2007 Residents Radiology Board Review Sessions, Mt. Auburn Hospital Instructor 1-2 lectures per year, 3 hours per lecture, 6 residents per lecture 2000 - 2002 Psychology Graduate Students Harvard Clinical Neuropsychology Course, Massachusetts General Hospital Instructor 2 lectures per year, 2 hours per lecture, approximately 8 clinical psychology students per lecture 2001 - 2007 Residents/Fellows /Staff Neuro / Head and Neck Radiology Lecture Series, Mt. Auburn Hospital 10 lectures per year, 1+ hour per lecture, approx. 20 residents/fellows/staff per lecture 2002 – 2010 (occasional) Residents Radiology Board Review Sessions, BU Medical Center 1996 - present 2004 – present (occasional) Residents/Fellows /Staff Instructor 1-2 lectures per year, 3 hours per lecture, approximately 6 residents per lecture Radiology Board Review Sessions, UMass Medical Center Instructor 1-2 lectures per year, 2 hours per lecture, approximately 10 residents/staff/fellows per lecture 2006 – present (occasional) Residents/Fellows /Staff Neuroimaging Review, Spaulding Rehabilitation Hospital 1994 - present Neuroradiology, Head and Neck Radiology, and Neuro-MRI sCME Course, Harvard University Medical School Course Instructor / 2-4 lectures per year, 20-45 min per lecture, approximately 125-225 Co-Director attendees per lecture Staff 1995 - 2000 Instructor 1 one-hour lecture per year, approximately 35 residents/fellows/staff per lecture MGH Visiting Fellowship Program in MRI, Department of Radiology, Massachusetts General 10 Staff Hospital and Charlestown MRI Center Course Instructor 3-4 lectures per year, 1.5 hours per lecture, approximately 10 attendees per lecture 1995 – present (occasional) Fellows Neuroradiology Division Visiting Fellowship Program, Department of Radiology, Massachusetts General Hospital Mentor duration 4-12 weeks, approximately 1 visiting fellow per year 1997 - 1998 MGH Neuro-MRI Visiting Fellowship Program, Department of Radiology, Massachusetts General Hospital and Charlestown MRI Center Course Instructor 3-4 lectures per year, 1 hour per lecture, approximately 10 attendees per lecture Staff 1997 - 2005 Residents MGH / BWH Radiology Review Course, Partners ealthcare and Harvard Medical School Course Instructor 1-2 lectures per year, 1 hour per lecture, approximately 200 residents/fellows/staff per lecture 2009 - present Residents MGH/BWH “Mock” Radiology Boards Instructor Instructor 5 hours, 10 residents 2010 - 2011 MGH Radiology Technologist Patient Safety Week: “Limiting Radiation Dose in Neuroradiological Head CT Scanning” Lecturer 3 one-hour lectures Staff Report of Regional, National and International Invited Teaching and Presentations Regional March 1989 Medical Grand Rounds; Part 1: Carotid Artery Evaluation Brockton Hospital, MA Lecture, 2 hours April 1989 Medical Grand Rounds; Part 2: Carotid Endarterectomy and Stroke Treatment Brockton Hospital, MA Lecture, 2 hours October 1994 Neurology Grand Rounds; Neurovascular Spiral CT Angiography Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour December 1995 Neurosurgery Grand Rounds; The Role of CT Angiography in the Evaluation of Recurrent Carotid Occlusive Disease Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour March 1996 Case Records of the Massachusetts General Hospital; radiology discussant, New England Journal of Medicine Clinico-pathological Conference Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour April 1996 Neurology Departmental Stroke Rounds; The Clinical Utility of Carotid Artery Spiral CT Angiography Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour September 1996 Lecture, 1 hour Records of the Massachusetts General Hospital; radiology discussant, New England Journal of Medicine Clinicopathological Conference NEJM 11 Etherdome, Massachusetts General Hospital, Boston MA NEJM June 1997 Neurosurgery Grand Rounds; Perfusion MR Imaging of Radiation Necrosis versus Glioma Recurrence Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour September 1997 Brigham and Women’s Hospital Brain Tumor Conference; Functional Imaging of Brain Tumors, Pathology Conference Brigham and Women’s Hospital, MA Lecture, 45 minutes November 1997 Neurosurgery Grand Rounds; Perfusion MRI of Human Brain Tumors: Clinical Applications Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour February 1998 Radiology Grand Rounds; Head and Neck Radiology: The Requisites University of Vermont College of Medicine, Burlington, VT Lecture, 2 hours February 1998 Case Records of the Massachusetts General Hospital radiology discussant, New England Journal of Medicine Clinico-pathological Conference Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour October 1998 CME Course on Brain Tumors; Functional MR Imaging of Human Gliomas Brigham and Womens Hospital (BWH), Harvard Medical School, Boston, MA Lecture, 45 minutes October 1998 CME Update Course on Stroke; Neuroimaging of Carotid Artery Occlusive Disease Brigham and Womens Hospital (BWH), Harvard Medical School, Boston, MA Lecture, 45 minutes March 1999 Radiology Grand Rounds; Head & Neck: The Requisites Mount Auburn Hospital, Cambridge, MA Lecture, 1.5 hours April 1999 Case Records of the Massachusetts General Hospital radiology discussant, New England Journal of Medicine Clinico-pathological Conference Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour October 1999 Case Records of the Massachusetts General Hospital; radiology discussant, New England Journal of Medicine Clinico-pathological Conference Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour October 1999 Lecture, 1 hour American Heart Association Boston Operation Stroke Conference: Strategies for Improving Acute Stroke Therapy; Rapid CT Interpretation in Suspected Stroke NEJM NEJM NEJM Cambridge, MA AHA May 2000 CME Update and Comprehensive Review Course on Stroke; Carotid Disease Diagnostic Techniques: MR, CTA, and Angiography BWH / MGH, Harvard Medical School, Boston MA Lecture, 30 minutes November 2000 Lecture, 45 minutes Educational Symposia, Inc. “MR Contrast Update 2000”; 12 MRI Contrast for the CNS Boston, MA January 2001 Case Records of the Massachusetts General Hospital; radiology discussant, New England Journal of Medicine Clinico-pathological Conference Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour March 2001 Grand Rounds, Functional Brain Imaging of Cognitive Function: the Next Generation Albert Einstein Medical School Kennedy Center for Pediatrics, New York, NY Lecture, 1 hour April 2001 Lecture, 30 minutes 39th Annual Meeting American Society of Neuroradiology “How To” Workshop; CTAC/TP Acute Stroke Boston, MA April 2001 NEJM ASNR, GE Medical Systems 39th Annual Meeting of the American Society of Neuroradiology; GE Medical Systems Advanced Analysis Workshop: CT Perfusion Imaging Lecture, 1 hour Boston MA GE Medical Systems November 2001 Annual MR/CT Review Course; Advanced CT Imaging of Hyperacute Stroke Brigham and Women’s Hospital, Boston, MA Lecture, 30 minutes January 2002 1-hour lecture and 45 minute film panel NERRS CT Angiographic Imaging of Acute Stroke, New England Roentgen Ray Society Boston, MA February 2002 Neuroradiology Grand Rounds, CTA and CTP Applications Brigham and Women’s Hospital Neuroradiology Division, Boston, MA Lecture, 1 hour April 2002 Lecture, 30 minutes Medical Imaging: Techniques and Applications; 3D Neurovascular Imaging with MSCT Boston, MA May 2002 Case Records of the Massachusetts General Hospital radiology discussant, New England Journal of Medicine Clinico-pathological Conference Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour October 2002 2 hour film review and 1 hour lecture Grand Rounds; Functional CT Imaging of Acute Stroke NEJM North Shore University Medical Center, Manhasset, NY December 2002 Weekly Brain-Map Seminar: CT Perfusion Imaging in Acute Stroke – Technical Considerations and Clinical Impact Athinoula A. Martinos Center for Biomedical Imaging, MGH; Boston MA Lecture, 1 hour December 2002 Lecture, 4 hours “CT/MR Head to Toe” Annual Radiology Review Course; Practical Functional Imaging of Acute Stroke, Screening Evaluation of Carotid Artery Occlusive Disease, and Multislice CT Pearls and Pitfalls New York University, New York, NY 13 July 2003 Grand Rounds; Advanced Imaging Techniques in Brain Tumor Assessment (to be rescheduled) The Cleveland Clinic Brain Tumor Institute, Cleveland, OH Lecture, 2 hours October 2003 Hospital of the University of Pennsylvania, Grand Rounds: Acute Stroke Imaging 1 hour film review and 1 hour lecture 16th Annual Meeting of the Eastern Neuroradiological Society; Advanced CT Imaging of Acute Stroke Lecture, 30 minutes Philadelphia, PA August 2004 Boston, MA October 2004 ENRS New England Roentgen Ray Society, CT Angiographic Imaging of Acute Stroke 1-hour lecture and 45 minute film panel NERRS American Roentgen Ray Society, Practical Applications in Diagnostic Imaging Seminar; Acute Stroke CTA Two 1-hour workshops Boston, MA October 2004 Boston, MA ARRS May 2005 Grand Rounds; (i) Advanced CT Imaging of Acute Stroke and (ii) Comprehensive Head and Neck Imaging Review, Mineola, LI Winthrop Hospital, Minneola, Long Island, NY Lecture, 3 hours January 2006 Columbia University, Grand Rounds CTP Two 1.5-hour board reviews and one 1-hour lecture Neurovascular Rounds: Imaging Update in Acute Stroke Boston University Lecture, 1.5 hours New York, NY February 2006 Boston, MA April 2006 Boston University Hartford Hospital, Grand Rounds Two 1-hour lectures and two 1hour board reviews CT Perfusion of Acute Stroke; Connecticut Statewide Neurology Meeting (invited) Lecture, 30 minutes Protocol Development Expert Meeting for GE Scanners, Bracco Diagnostics Two 4-hour and one 2-hour group sessions Bracco Pharmaceuticals SCBT/MDCT Meeting, Westin Harbor Hotel; “MDCT of Acute Stroke” and “MDCT of Carotid Occlusive Disease” Lecture, 1 hour Hartford, CT June 2006 Hartford, CT July 2006 New York, NY September 2006 Boston, MA January 2007 MGH Neurology Grand Rounds, Advanced CT/MR Stroke Triage: From Clinical Trials to Standard of Care? Etherdome, Massachusetts General Hospital, Boston MA Lecture, 1 hour March 2007 Lecture, 15 minutes MGH Vascular Summit, “Carotid US, CT, or MR: How Do I Choose?” Etherdome, Massachusetts General Hospital, Boston MA 14 April 2007 SPOTRIAS Annual Meeting, “CTP Imaging Project Summary” Lecture, 30 minutes Eastern Neuroradiological Society 19th Annual Meeting Speaker, Moderator, and Executive Committee ENRS MDCT: A Practical Approach, SCBCT-MR 5th Annual Symposium; Stroke CTA/CTP Acquisition, Post Processing, Interpretation Presentation, 30 minutes New York NY August 2007 Stowe, VT September 2008 Boston, MA SCBBCT October 2008 BWH CT-MRI CME Review Course; “Advanced CT and MR Imaging in Patient Selection for Thrombolytic Therapy” Brigham and Women’s Hospital, Boston, MA Presentation, 30 minutes October 2009 BWH CT-MRI CME Review Course; “Advanced Imaging in Patient Selection for Thrombolytic Therapy” Presentation, 45 minutes Allegheny Hospital Medical Center, Radiology/Neurology Grand Rounds: Advanced Imaging of Acute Stroke for Patient Triage Three 1-hour board reviews and two 1-hour lectures New England Roentgen Ray Society; Neuroradiology Case Discussion Session Moderator one 45 minute film panel Boston, MA November 2009 Pittsburgh, PA March 2010 Boston, MA April 2010 NERRS SPOTRIAS Annual Meeting, “CTP Imaging Project Summary: IMPACT” Boston, MA April 2010 Lecture, 25 minutes SPOTRIAS Maine Medical Center Grand Rounds: Advanced CT and MR Imaging of Acute Stroke for Patient Treatment Selection One 2-hour lecture, and one 4hour general resident review Portland, ME April 2010 27th Annual Princeton Conference on Cerebrovascular Disease (invited) Boston, MA Stony Brook Medical Center (SUNY), Grand Rounds: Differential Diagnosis of Spinal Cord Lesions Port Jefferson, Long Island, NY May 2010 May 2010 One 1-hour lecture and one 1hour board review LI Radiological Society / Nassau County Medical Center Grand Rounds: CTP Imaging of Acute Stroke – Radiation Dose and Clinical Optimization One 1-hour lecture and one 1hour board review Case Records of the Massachusetts General Hospital radiology discussant, New England Journal of Medicine Lecture, 1 hour Long Island, NY May 2011 15 Clinico-pathological Conference on “Coalescent Mastoiditis” Etherdome, Massachusetts General Hospital, Boston MA October 2011 MGH-Webster Foundation, International Symposium on Radiation Dose in CT; “Head and Neck: Current Radiation Dose Issues and Protocols” Boston, MA February 2012 New England Roentgen Ray Society Keynote Address; “Advanced CT Imaging of Acute Stroke – Current Paradigms”; and Film Panel Discussant Lecture, 45 minutes and Film Panel Discussant, 30 min NERRS MGH Vascular Center Grand Rounds Speaker: “Advanced Neuroimaging Pearls for Clinicians” Boston, MA September 2012 Lecture, 15 minutes ISRC Boston, MA March 2012 NEJM Lecture, 45 minutes MGH Vascular Center MGH Vascular Center Harvard CME Course: “Carotid Artery – From Evidence to Rhetoric”; imaging lecture Boston, MA Lecture, 25 minutes Harvard CME Vascular Conference National May 1998 36th Annual Meeting American Society of Neuroradiology “How To” Workshop; Spiral CT Imaging of Acute Stroke Philadelphia, PA July 1998 Lecture, 2 hours ASNR, GE Medical Systems Cuban Medical Convention; Inflammatory Disease of the Sinonasal Cavities Lecture, 1.5 hours 99th Annual Meeting of the American Roentgen Ray Society, New Issues Forum; CT Angiography of Hyperacute Stroke Lecture, 45 minutes Miami, FL May 1999 New Orleans, LA May 1999 ARRS 37th Annual Meeting of the American Society of Neuroradiology “How To” Workshop; Spiral CT Imaging of Neurovascular Disease and Hyperacute Stroke Lecture, 2 hours San Diego, CA ASNR, GE Medical Systems January 2000 Radiology Grand Rounds; CTA of Hyperacute Stroke: Pearls and Pitfalls Jefferson University Medical Center, Philadelphia, PA Lecture, 1 hour March 2000 Houston Radiological Society Meeting and Grand Rounds of MD Anderson Cancer Center; CT and MR Perfusion Imaging of Stroke and Brain Tumors Lecture, 3 hours 38th Annual Meeting of the American Society of Neuroradiology (Special Focus Session on Stroke); Spiral CT Angiographic and Perfusion Imaging of Hyperacute Stroke Lecture, 30 minutes Houston, TX April 2000 16 Atlanta, GA April 2000 ASNR 38th Annual Meeting of the American Society of Neuroradiology “How To” Workshop; Hyperacute Stroke: CT Perfusion Imaging Atlanta, GA April 2000 ASNR, GE Medical Systems American Academy of Neurology Annual Meeting; CT Perfusion of Hyperacute Stroke: The Next Generation San Diego, CA December 2000 Lecture, 30 minutes Seminar, 2 hours AAN Stroke 2001: New Directions, New Hope presented by Neurological Institute of New Jersey; The MRI toolbox: Advanced MR Imaging in Stroke 45 minutes “Clinical Essentials of Spiral CT”; CT Angiography of Stroke, Head, and Neck Three 45 minute and one 1/2 hour lectures Institute for Advanced Medical Education, Inc. 101st Annual Meeting of the American Roentgen Ray Society, Multidetector Helical CT Forum; CT Angiography/CT Perfusion Imaging of Acute Stroke Lecture, 45 minutes Newark, NJ March 2001 New Orleans, LA May 2001 Seattle, WA March 2002 ARRS 2nd Annual Symposium on CT/MR Brain Perfusion; CT in Acute Ischemia – Methods/Indications (invited) Lecture, 30 minutes 40th Annual Meeting of the American Society of Neuroradiology; Advanced Clinical Imaging Seminar: CT Perfusion Imaging – Practice and Pitfalls Lecture, 20 minutes San Francisco, CA May 2002 Vancouver, Canada June 2002 ASNR 4th Annual Stanford University International Symposium on Multidetector Row CT; CTA/CTP of Stroke and Carotid Occlusive Disease (invited) Lecture, 40 minutes San Francisco, CA MDCT November 2002 Annual Citywide Neuroradiology Rounds at the Mallinckrodt Institute; Perfusion CT: Theory and Practice Made Simple Mallinckrodt Institute, St. Louis MO Lecture, 1 hour January 2003 Neuro-Oncology 2003: Current Concepts: Advanced Imaging Techniques in Neuro-Oncology The Cleveland Clinic Brain Tumor Institute, Orlando, FL Lecture, 20 minutes February 2003 Lecture, 1 hour American Heart Association 28th International Conference on Stroke and Cerebral Circulation; CT Perfusion Imaging Techniques and Treatment Triage in Acute Stroke Phoenix, AZ August 2003 AHA ISC The Eastern Neuroradiological Society 15th Annual Meeting Speaker, Moderator, and Meeting Organizer 17 Historic Williamsburg, VA ENRS December 2003 Lecture, 1 hour Neuroradiology Case Review Course, 88th Scientific Assembly and Annual Meeting of the Radiological Society of North America; Spine Imaging Review Chicago, IL May 2004 RSNA Neurofibromatosis II Investigators Meeting (DAMD 17-011-0710) Aspen, CO June 2004 DOD Sponsor 42nd Annual Meeting of the American Society of Neuroradiology; Advanced Clinical Imaging Seminar: Perfusion Imaging in Clinical Practice – CT versus MRI? Seattle, Washington December 2004 89th Scientific Assembly and Annual Meeting of the Radiological Society of North America; (i) Invited Review Poster Presentation on Cerebral CT Perfusion Imaging: Pearls and Pitfalls, and (ii) Neuroradiology Scientific Session Multi-Hance Expert Meeting, Bracco Diagnostics One 5-hour and one 3-hour group sessions Bracco Diagnostics Annual Meeting of American Academy of Neurosurgery; Advanced Tumor Imaging: Pearls and Pitfalls Lecture, 15 minutes New Orleans, LA May 2005 AANS MDCT: A Practical Approach Symposium; Neuro MDCT/Carotid CTA/Stroke CTA St Louis, MO June 2005 Moderator, 1 hour session RSNA Las Vegas, Nevada April 2005 Lecture, 20 minutes ASNR Chicago, IL April 2005 Lecture, 2 hours Lecture, 1 hour Society of Computed Body Tomography and Magnetic Imaging Neurofibromatosis II Investigators Meeting (DAMD 17-011-0710) Aspen, CO Lecture, 1 hour DOD Sponsor September 2005 Philadelphia, PA Isovue CT Contrast Advisory Group Meeting, Bracco Two 4-hour group sessions Bracco Diagnostics November 2005 90th Scientific Assembly and Annual Meeting of the Radiological Society of North America; “Functional Imaging of Brain Tumors: Con”; Neuroradiology Controversies Course Lecture, 45 minutes Chicago, IL February 2006 RSNA American Heart Association 31st International Stroke Conference; Advanced CT Imaging Seminar Kissimmee, FL March 2006 Las Vegas, NV Lecture, 30 minutes AHA ISC Educational Symposia on MDCT Imaging Three 45 minute lectures 18 April 2006 44th Annual Meeting of the American Society of Neuroradiology; Neuroradiology Research Foundation Seminar: CT Perfusion San Diego, CA July 2006 ASNR, GE Medical Systems Medical Advisory Board Meeting Presentation: “State-ofthe-art Stroke Imaging”, Co-Axia One 30-minute presentation, one-day scientific session Co-Axia New Developments in Helical CT scanning, GE Healthcare Medical Advisory Board Lecture, 30 minutes Seattle, WA October 2006 Two 30 minute lectures Milwaukee, WI GE Medical Advisory Board November 2006 Milwaukee, WI Dual Energy CT, GE Healthcare Medical Advisory Board Lecture, 1 hour GE Medical Advisory Board November 2006 91st Scientific Assembly and Annual Meeting of the Radiological Society of North America (1) Imaging Symposium: Imaging and Interventions in the Aging Patient: Advanced Neuroimaging for Stroke Prevention and Management (2) Emergency Radiology Series: Using MR Angiography to Screen for Blunt Carotid and Vertebral Artery Injuries (3) Neuroradiology/ Head and Neck: Neuroradiology Keynote Speaker: Advanced Stroke Imaging- From Clinical Trials to Standard of Care? Two 2-3 hour Refresher Course sessions, and moderator/keynote speaker “Stroke Imaging Triage”, one 1.5 hour Stroke scientific session Chicago, IL April 2007 RSNA Paion-Forrest Labs / GE CT Perfusion in Stroke Triage Medical Advisory Board Meeting 8-hour meeting, one 1 hour presentation 59th Annual Meeting, American Academy of Neurology; Imaging Evaluation in Acute Stroke and Selection of Patients for Therapy Lecture, 45 minutes San Francisco CA April 2007 Boston, MA June 2007 AAN 9th Annual Stanford University International Symposium on Multidetector Row CT Scanning San Francisco CA June 2007 Lecture, 40 minutes MDCT 45th Annual Meeting of the American Society of Neuroradiology; “How To” Workshop (GE Medical Systems): CT Perfusion Imaging in Acute Stroke Chicago IL Lecture, 30 minutes ASNR, GE Healthcare July 2007 Minneapolis MN Medical Advisory Board Meeting, Co-Axia Presentation, 30 minutes Co-Axia September 2007 Advanced Neuroimaging and Acute Stroke: NIH Sponsored Future Directions “R13” Conference Organizing committee, 30-min lecture, chair of 2-hr workshop 12th Annual Spiral/Helical CT 2007: National Symposium one 40-min, one 45-min, and two 20-min lectures Washington DC October 2007 19 Las Vegas NV November 2007 92nd Scientific Assembly and Annual Meeting of the Radiological Society of North America (1) refresher course faculty, “Emergency Radiology: MR Angiography Screening for Neurovascular Injury” (2) moderator/organizer, Special Focus Session: Controversies in Acute Stroke, “Vulnerable Plaque” Chicago IL April 2008 RSNA SPOTRIAS Annual Meeting, “CTP Imaging Project Summary” Lecture, 1 hour; multiple discussion panels NIH 46th Annual Meeting of the American Society of Neuroradiology; “How To” Workshop (GE Medical Systems): CT Perfusion Imaging in Acute Stroke Triage and Roundtable Discussion of Emergency Neuroradiology One 30-min lecture and one 2hr panel discussion Los Angeles CA May 2008 New Orleans LA July 2008 ASNR/GE Medical Systems Medical Advisory Board Meeting, Neuroflo device trial (“Sentis”) Lecture, 1 hour; multiple discussion panels Co-Axia 93rd Scientific Assembly and Annual Meeting of the Radiological Society of North America; refresher course faculty, “Emergency Radiology: Head Trauma” Lecture, 30 minutes Sundance, Utah November 2008 Two 30-min lectures in two 90min sessions Chicago IL RSNA December 2008 “National Diagnostic Imaging Symposium” CME Course Advanced Imaging Triage of Acute Stroke and Vulnerable Plaque Imaging for Stroke Prevention Loma Linda University, Orlando, FL Lecture, 30 minutes May 2009 SPOTRIAS Annual Meeting, “CTP Imaging Project Summary” Lecture, 20 minutes; multiple discussion panels NIH General Electric Medical Advisory Board on Adaptive Statistical Iterative Reconstruction (ASIR) Techniques for CT Scanning One-day workshop Washington DC July 2009 Milwaukee, WI November 2009 GE Healthcare 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America; refresher course faculty, “Radiation Dose Issues in Neuroradiology” Chicago IL September 2010 Lecture, 30 minutes RSNA STAIR Committee VIIth Annual Meeting; “Advanced CT and MR Imaging for Acute IA Thrombolysis Triage” Lecture, 30 minutes 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America; refresher course faculty, “Radiation Dose Issues in Neuroradiology” Lecture, 30 minutes Washington, DC November 2010 Chicago IL RSNA 20 February 2011 American Heart Association International Stroke Conference (AHA ISC) Satellite Symposium (Genentech sponsored), “Ischemic Stroke: Contemporary Strategies to Maximize Reperfusion with Advanced CT Imaging” Los Angeles CA May 2011 Lecture / Discussion Panel, 30 min / 2 hrs AHA/ISC Combined Neurology/Radiology Grand Rounds: “New Paradigms in Acute Stroke Imaging”, Mayo Clinic Lecture / Q&A, 60 minutes The Eastern Neuroradiological Society 23th Annual Meeting: CTA/CTP for Acute Stroke Triage Lecture, 30 minutes; Discussion Panel, 15 minutes ENRS 4th Annual Meeting of the Society of Vascular and Interventional Neurology; CT Perfusion as a Selection Tool for Thrombolysis Triage in Acute Stroke Lecture, 20 minutes; Discussion Panel, 15 minutes Rochester MN September 2011 Chatham MA October 2011 Ft Lauderdale FL March 2012 SVIN Advisory Board meeting for the NIH/NBIB funded “Pointof-Care Center “ Program Project Grant; lecture on “Electrical Impedance Spectroscopy” (EIS) Cincinnati, OH April 2012 “POC-CENT”, U of Cincinnati 50th Annual Meeting of the American Society of Neuroradiology: “Acute Stroke Imaging: What if DWI is Unavailable?” NY, NY October 2012 Philadelphia, PA Nov 2012 Grand rounds, visiting professor, “Advanced Stroke Imaging”, Thomas Jefferson University Hospital Rescheduled for May 2013 due to Hurricane “Sandy” Lecture 1 hour, resident case review 2 hours Visiting Professor Grand rounds, visiting professor, “Advanced Stroke Imaging”, University of Massachusetts Medical Center (UMass) Lecture 1 hour, resident case review 2 hours Visiting Professor 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America; refresher course faculty, “Advanced Imaging of Ischemic Stroke” Chicago, IL May 2013 San Diego, CA Lecture, 20 min; Discussion panel, 5 minutes RSNA “Dale Cooper Lecturer in Neuroradiology”, grand rounds / visiting professor, Emory University Dept of Radiology Lecture 1 hour, resident case review 2 hours Visiting Professor 51st Annual Meeting of the American Society of Neuroradiology, Research Foundation of the ASNR Special Session: “Advanced Acute Stroke Imaging: DWI and Perfusion” Lecture, 25 minutes; Discussion Panel, 15 minutes Atlanta, GA April 2012 Lecture, 20 minutes; Discussion Panel, 5 minutes ASNR Worcester, MA Nov 2012 Lecture, 30 minutes; Discussion Panel, / Workshops 6 hours ASNR 21 International October 1996 VIII International Workshop of the MR Angio Club: “Advances in 3D Vascular Imaging”; CTA head & neck Lecture, 2.5 hours International Society for Magnetic Resonance in Medicine: Sixth Scientific Meeting and Exhibition; Clinical Applications of Perfusion MR Imaging Lecture 1 hour Rome, Italy April 1998 Sydney, Australia January 1999 ISMRM MR ‘99 Eighth International MRI Symposium: MR in the New Millennium; Functional MRI - An Update Lecture, 30 minutes Garmisch, Germany February 1999 “Radionights” Lecture Series; Current Concepts in Acute Stroke Imaging Radiology Dept. Klinikum Innenstadt, LMU Muenchen, Germany Lecture, 2 hours May 1999 Lecture, 45 minutes International Society for Magnetic Resonance in Medicine: Seventh Scientific Meeting and Exhibition; Perfusion MR Imaging: Clinical Applications Philadelphia, PA ISMRM July 1999 25th Annual Meeting of the Brazilian College of Radiology; Neurovascular Applications of Perfusion MRI and CT Angiographic Imaging Rio de Janeiro, Brazil Lecture, 3 hours August 1999 Lecture, 45 minutes Annual Meeting of the Eastern Neuroradiological Society; Advanced Head and Neck Imaging: Case Review Montreal, Canada June 2000 ENRS 2nd Annual Stanford University International Symposium on Multidetector Row CT; Hyperacute Stroke San Francisco, CA October 2000 Lecture, 30 minutes MDCT 1st Annual Symposium on CT/MR Brain Perfusion Imaging; Advanced MR and CT Techniques in Stroke Triage Lecture, 1.5 hours Moderator, 2 sessions 1st International Multi-slice CT Conference, GE Medical Systems; Clinical Neuroradiologic Applications of Multidetector CT Angiography Lecture, 2 hours 3rd Annual Stanford University International Symposium on Multidetector Row CT; CTA/CTP of Stroke and Carotid Occlusive Disease Lecture, 40 minutes 2001 Annual Meeting of the Dutch Society of Radiology; New Developments in the Functional CT Evaluation of 45 minute plenary session Giessen, Germany March 2001 Dalian, China June 2001 San Francisco, CA September 2001 22 Acute Stroke (canceled due to WTC attacks) Ermelo, Netherlands October 2001 2001 Annual Meeting of the Brazilian College of Radiology; Neurovascular Applications of Perfusion MRI and CT Angiographic Imaging (canceled due to WTC attacks) Lecture, 4 hours New Frontiers in Stroke Meeting, Trans-Canadian Stroke Panel; CTA/CTP Methods and Applications Moderator and two 30-minute lectures 11th Annual Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine; Perfusion Imaging: MR versus CT (canceled due to SARS) Lecture, 30 minutes Curitiba, Brazil November 2001 Toronto, Canada May 2003 Toronto, Canada October 2003 ISMRM 3rd International Symposium on CT/MR Brain Perfusion; CT/CTA/CTP Clinical Utility, and MR Permeability of Brain Tumors: Beyond First Pass Techniques Lecture, 1 hour Neuroimaging Seminar; 1st Scientific Meeting (to be rescheduled) Lecture, 1 hour Sixth Asian-Australasian Federation of Interventional and Therapeutic Neuroradiology (AAFITN); Functional Neuroimaging in Patient Triage Lecture, 1.5 hours St. Louis, MO October 2003 Santiago Chile March 2004 Bangkok, Thailand May 2004 AAFITN Annual Meeting of the Swedish Neurological Society; Modern Applications of CTA/CTP in Stroke (invited) Lecture, 30 minutes Stockholm, Sweden June 2004 5th World Stroke Conference; Stroke CT Perfusion (invited) Vancouver, Canada Lecture, 30 minutes September 2004 Acute Stroke Imaging, Grand Rounds, University of Ottawa Medical Center Lecture, 3 hours November 2004 Rome, Italy Siemens MDCT Protocol Development Expert Meeting Two 4-hour group sessions Bracco Pharmaceuticals October 2005 Las Vegas, NV Global Symposium on Clinical High Field MRI Lecture, 45 minutes Stanford University November 2005 Taipei, Taiwan 4th Annual Meeting of Asian Society for Neuro-Oncology Keynote Address, 1 hour June 2006 8th Annual Stanford University International Symposium on Multidetector Row CT: Neurovascular MDCT Five 9-minute lectures Ottawa, Canada San Francisco, CA MDCT 23 September 2006 International Workshop on NF2: State of the Art; “Imaging of Neurofibromatosis Type II in Clinical Trials” Lecture, 30 minutes International Stroke Conference (AHA ISC) / Vernalis Satellite Session, “Essentials of CT/CTA for Thrombolysis Triage: Tricks, Pearls, Pitfalls” imaging tutorial Lecture, 1 hour Paris, France February 2007 San Francisco CA American Heart Association September 2007 Irish National “Thrombolyis Day” Stroke Conference; Mismatch Imaging for Stroke Treatment Triage Royal College, Dublin Ireland Lecture, 1 hour October 2007 One-week testing of prototype scanner with phantom / patient experiments General Electric Medical Advisory Board on Dual Energy CT Imaging Rabin Medical Center, Tel Aviv, Israel January 2008 61st Annual Conference of the Indian Radiological and Imaging Association Five 30-minute review/research lectures on neuro-imaging IRIA 12th Asian Oceanian Congress of Radiology: Cerebrovascular Imaging Lecture, 2 hours Bangalore, India October 2008 Seoul, Korea May 2010 AOCR 12th Annual Stanford University International Symposium on Multi-detector Row CT Scanning Six 10 minute lectures, 60 minutes ISCT 13th Annual Stanford University International Symposium on Multi-detector Row CT Scanning Three 10 minute lectures, 30 minutes; Neuroimaging Session Moderator, 2.5 hours ISCT Combined Neurology/Radiology Grand Rounds: “New Paradigms in Acute Stroke Imaging”, University of Calgary Lecture, 1 hour; Resident Conference, 1 hour Combined Neurology/Radiology Grand Rounds: “New Paradigms in Acute Stroke Imaging”, University of Toronto Lecture, 1 hour; Resident Conference, 1 hour 14th Annual Stanford University International Symposium on Multi-detector Row CT Scanning Three 10 minute lectures, 30 minutes; Neuroimaging Session Moderator, 2.5 hours ISCT Madrid-MIT M+ Vision Consortium invited speaker: “Unmet Needs in Advanced Neuroimaging” Two 1.5 hour lectures Stroke Treatment Academic Industry Research Roundtable (STAIR), Meeting VIII, team leader representing STIR (stroke imaging repository) group 1.5 day group workshops San Francisco, CA June 2011 San Francisco, CA November 2011 Calgary, Canada April 2012 Toronto, Canada June 2012 San Francisco, CA July 2012 Madrid, Spain March 2013 24 Washington DC June 2013 Washington DC STAIR 14th Annual Stanford University International Symposium on Multi-detector Row CT Scanning Three 10 minute lectures, 30 minutes; Neuroimaging Session Moderator, 2.5 hours ISCT 25 Report of Clinical Activities and Innovations A. Licensure and Certification: 1987 1988 1989 1994 1996 - 2009 1998 - 2004 1999 - 2005 2007 - 2009 2009 - National Board of Medical Examiners Certification Massachusetts Medical License American Board of Internal Medicine (ABIM) Certification American Board of Radiology (ABR) Certification ABR Certificate of Added Qualification (CAQ) in Neuroradiology New York State Medical License Maine Medical License Rhode Island Medical License ABR MOC Re-certification of Added Qualification (CAQ) in Neuroradiology B. Practice Activities and Clinical Innovations: 1995 1996 - 1997 1998 - 2000 - 2004 2007 2008 - 2009 2009 - 2010 - Established the accuracy and clinical utility of CT angiography (CTA) for the diagnosis and characterization of acute neurovascular disorders, such as stroke and carotid artery dissection. Pilot studies demonstrating the feasibility and potential added clinical value of MR perfusion imaging (MRP) for: (i) brain tumor angiogenesis, staging, and outcome prediction; and (ii) acute stroke diagnosis and treatment. Pioneered the use of CTA-source images in patient selection for thrombolytic stroke therapies. Numerous peer reviewed publications, reviews, edited textbooks, case reports, chapters, and invited lectures that developed, defined, and communicated the roles of innovative physiological imaging techniques in the management of diverse, clinically important neurological and head & neck disorders, such as parotid gland tumors, neurofibromatosis type II, schwannomatosis, atrial myxoma brain emboli, cerebral schistosomiasis, and inflammatory amyloid angiopathy. Established the accuracy and clinical utility of CT perfusion imaging (CTP) for the diagnosis and characterization of cerebral ischemic and neoplastic disorders; Determined optimal digital image display parameters for acute stroke detection using unenhanced head CT scanning. Early efforts at technical optimization and radiation dose reduction for routine head CT scans, most recently involving novel iterative reconstruction and dual energy scanning techniques. Introduced and helped to validate the CTA “spot sign” – an important predictor of hematoma expansion for patients with acute intracranial hemorrhage. Introduced and championed pilot studies of a promising, novel portable device for the detection and monitoring of stroke, hemorrhage, and traumatic brain injury - "Electrical Impedance Spectroscopy” - effectively an "EKG for the brain", developed at the MGH-MRI center. Introduced a novel CTA imaging marker for vulnerable internal carotid artery plaque. Successfully challenged the accepted paradigm regarding the optimal metric for determining admission infarct size using CTP datasets acquired and post-processed with “current generation” scanner platforms (specifically, recommending the use of “flow” rather than “volume” maps). Pioneered a novel “atlas-based” toolkit for brain structure-function correlation with CTP/MRI. C. Report of Technological and other Scientific Innovations: Patents Pending “System and Method Employing the Stochastic Gabor function and Dual Energy Pulses for Electrical Impedance Spectroscopy (EIS)” MGH 511-21816.01, Provisional application filed 8/26/12 Giorgio Bonmassar, Eric S Rosenthal, Michael H Lev 26 Report of Scholarship I. Peer Reviewed Major Publications: A1. Research Investigations 1. Sorensen AG, Buonanno FS, Gonzalez RG, Schwamm LH, Lev MH, Huang-Hellinger FR, Reeese TG, Weisskoff RM, Davis TL, Suwanwela N, Can U, Moreira JA, Copen WA, Look RB, Finklestein SP, Rosen BR, Koroshetz WJ. Hyperacute Stroke: Evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging. Radiology 1996; 199(2):391-401. 2. Brown JH, Lustrin ES, Lev MH, Ogilvy CS, Taveras JM. Characterization of intracranial aneurysms using CT angiography. AJR 1997; 169(3):889-893. 3. Lev MH, Kulke SF, Sorensen AG, Boxerman JL, Brady TJ, Rosen BR, Buchbinder BR, Weisskoff RM. Contrast to noise ratio in functional MRI of relative cerebral blood volume mapping with sprodiamide injection. JMRI 1997; 7(3): 523-527. 4. Hunter GJ, Hamburg LM, Ponzo JA, Huang-Hellinger FR, Morris PP, Rabinov J, Farkas J, Lev MH, Schaefer PW, Ogilvy CS, Schwamm L, Buonanno FS, Koroshetz WJ, Wolf GL, Gonzalez RG. Rapid assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with 3D functional computed tomography: early clinical results. AJNR 1998; 19(1):29-37. 5. Lev MH, Khanduja K, Morris PP, Curtin HD. Parotid pleomorphic adenomas: Delayed CT enhancement. AJNR 1998; 19(10):1835-1839. 6. Gahn G, Ackerman RH, Candia MR, Barrett KM, Lev MH, Huang AY. Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: preliminary results. J Ultrasound Med 1999; 18(2):101-108. 7. Ostergaard L, Hochberg FH, Rabinov J, Sorensen AG, Lev MH, Kim L, Weisskoff RM, Gonzalez RG, Gyldensted C, Rosen BR. Early changes measured by MRI in cerebral blood flow, blood volume, and blood brain-barrier permeability following dexamethasone treatment in patients with brain tumors. J Neurosurg 1999; 90(2):300-305. 8. Brown JH, Lustrin ES, Lev MH, Ogilvy CS, Taveras JM. Reduction of aneurysm clip artifacts on CT angiograms: A technical note. AJNR 1999; 20(4):694-696. 9. Lev MH, Schaefer PW. Subarachnoid gadolinium enhancement mimicking subarachnoid hemorrhage on FLAIR MR images [Peer reviewed viewbox article]. AJR 1999; 173(5):1414-1415. 10. Lev MH, Farkas J, Gemmete JJ, Hossain ST, Hunter GJ, Koroshetz WJ, Gonzalez RG. Acute stroke: improved nonenhanced CT detection - Benefits of soft-copy interpretation by using variable window width and center level settings. Radiology 1999; 213(1):150-155. 11. Fitzek MM, Thornton AF, Rabinov JD, Lev MH, Pardo FS, Munzenrider JF, Okunieff P, Bussiere M, Braun I, Hochberg FH, Hedley-Whyte ET, Liebsch NJ, Harsh GR 4th. Accelerated fractionated proton/photon irradiation to 90-cobalt gray equivalent (CGE) for glioblastoma multiforme: results of a phase II prospective trial. J Neurosurg 1999; 91(2):251-60. 12. Sorensen AG, Patel S, Harmath C, Bridges S, Synnott J, Sievers A, Yoon YH, Lee EJ, Yang MC, Lewis RF, Harris GJ, Lev MH, Schaefer PW, Buchbinder BR, Barest G, Yamada K, Ponzo J, Kwon HY, Gemmete J, Farkas J, Tievsky AL, Ziegler RB, Salhus MRC, Weisskoff R. Comparison of diameter and perimeter methods for tumor volume calculation. J Clin Oncol 2001; 19:551-557. 27 13. Lev MH, Farkas J, Rodriguez VR, Schwamm LH, Hunter GJ, Putman CM, Rordorf GA, Buonanno F, Budzik R, Koroshetz WJ, Gonzalez RG. CT angiography in the rapid triage of patients with hyperacute stroke: Accuracy in the detection of large vessel thrombus. JCAT 2001;25(4):520-8. 14. Fitzek MM, Thornton AF, Harsh G, Rabinov JD, Munzenrider JE, Lev MH, Anzukiewicz M, Bussiere M, Hedley-Whyte ET, Hochberg FH, Pardo FS. Dose-escalation with proton/photon irradiation for daumasduport lower grade glioma: Results of an institutional phase I/II trial. Int J Radiation Oncology Biol Phys 2001;51:131-137. 15. Lev MH, Segal AZ, Farkas J, Hossain ST, Putman C, Hunter GJ, Budzik R, Harris GJ, Buonanno FS, Ezzedine M, Chang Y, Koroshetz WJ, Gonzalez RG, Schwamm LH. Utility of Perfusion Weighted CT Imaging in Acute MCA Stroke Treated with Intra-arterial Thrombolysis: Prediction of Final Infarct Volume and Clinical Outcome. Stroke 2001:32;2021-2028. 16. Gleason S, Furie KL, Lev MH, O’Donnell J, McMahon PM, Beinfeld MT, Halpern E, Mullins M, Harris G, Koroshetz WJ, Gazelle GS. Potential influence of acute CT on inpatient costs in patients with ischemic stroke. Academic Radiology 2001;8:955-964. 17. Alpert NM, Berdichevsky D, Levin Z, Thangaraj V, Gonzalez RG, Lev MH. Performance evaluation of an automated system for registration and post-processing of CT scans. JCAT 2001; 25(5):747-752. 18. Eastwood JD, Lev MH, Azhari T, Lee TY, Barboriak DP, Delong DM, Fitzek C, Herzau M, Wintermark M, Meuli R, Brazier D, Provenzale JM. CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke. Radiology 2002; 222(1):227-36. 19. Ezzeddine MA, Lev MH*, McDonald CT, Rordorf G, Oliveira-Filho J, Aksoy F, Farkas J, Segal AZ, Gonzalez RG, Koroshetz WJ. CT angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke. Stroke 2002:33(4);959-966. 20. Mullins ME, Lev MH *, Schellingerhout D, Koroshetz WJ, Gonzalez RG. Influence of the availability of clinical history on the noncontrast CT detection of acute stroke. AJR 2002;179(1);223-228. 21. Romero JM, Lev MH*, Chan ST, Connelly MM, Curiel RC, Jackson AE, Gonzalez RG, Ackerman RH. Sonography of neurovascular occlusive disease: interpretive pearls and pitfalls. Radiographics 2002; 22:1165-1176. 22. Schellingerhout D, Lev MH, Baaga RJ, Rincon S, Berdichevsky D, Thangaraj V, Gonzalez RG, Alpert NM. Co-registration of head CT comparison studies: assessment of clinical utility. Academic Radiology 2003 Mar; 10:242–248. 23. Nguyen-Huynh MN, Lev MH, Rordorf G. Spontaneous recanalization of internal carotid artery occlusion**. Stroke 2003 Apr; 34:1032-1034. 24. Slattery WH 3rd, Fisher LM, Yoon G, Sorensen G, Lev MH. Magnetic resonance imaging scanner reliability for measuring changes in vestibular schwannoma size. Otol Neurotol. 2003 Jul;(4):666-70; discussion 670-1. 25. Lev MH, Romero JM, Goodman DNF, Bagga R, Kim HY, Clerk NA, Ackerman RH, Gonzalez RG. Total occlusion versus hairline residual lumen of the internal carotid arteries: Accuracy of single-row detector helical CT angiography. AJNR 2003 Jun; 24(6):1123-9. 26. Eastwood JD, Lev MH, Wintermark M, Fitzek C, Barboriak DP, Delong DM, Lee TY, Azhari T, Herzau M, Chilukuri VR, Provenzale JM. Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke. AJNR 2003 Oct; 24(9):1869-1875. 27. Greer DM, Koroshetz WJ, Cullen S, Gonzalez RG, Lev MH. MRI improves detection of intracerebral hemorrhage over CT following intra-arterial thrombolysis. Stroke 2004; 35:491-495. 28 28. Lev MH, Ozsunar Y, Henson JW, Barest GD, Harsh GR, Fitzek MM, Chiocca EA, Rabinov JD, Rosen BR, Hochberg FH, Schaefer PW, Gonzalez RG. Glial tumor grading and outcome prediction using dynamic spinecho MR susceptibility mapping compared to conventional contrast enhanced MRI: confounding effect of elevated relative cerebral blood volume of oligodendrogliomas. AJNR 2004 Feb; 25:214-221. 29. Mullins ME, Lev MH*, Bove P, O’Reilly CE, Saini S, Rhea JT, Thrall J, Hunter GJ, Hamberg LM, Gonzalez, RG. Comparison of image quality between conventional and low-dose unenhanced head CT. AJNR 2004 Apr;25(4):533-8. 30. Henson JW, Nogueira RG, Covarrubias DJ, Gonzalez RG, Lev MH. Gadolinium contrast CT angiography of the circle of Willis and neck. AJNR 2004 Jun-Jul;25(6):969-72. 31. Sanelli PC, Lev MH, Eastwood JD, Gonzalez RG, Lee TY. The Effect of Varying User-Selected Input Parameters on Quantitative Values in CT Perfusion Maps. Acad Radiol. 2004 Oct;11(10):1085-92. 32. Coutts SB, Lev MH, Eliasziw M, Roccatagliata L, Hill MD, Schwamm LH, Pexman JH, Koroshetz WJ, Hudon ME, Buchan AM, Gonzalez RG, Demchuk AM. ASPECTS on CTA source images versus unenhanced CT: added value in predicting final infarct extent and clinical outcome. Stroke. 2004 Nov;35(11):2472-6. 33. Sims JR, Rordorf G, Smith EE, Koroshetz WJ, Lev MH, Buonanno F, Schwamm LH. Arterial Occlusion Revealed by CT Angiography Predicts NIH Stroke Score and Acute Outcomes after IV tPA Treatment. AJNR Am J Neuroradiol. 2005 Feb;26(2):246-51. 34. MacCollin M, Chiocca EA, Evans DG, Friedman JM, Horvitz R, Jaramillo D, Lev M, Mautner VF, Niimura M, Plotkin SR, Sang CN, Stemmer-Rachamimov A, Roach ES. Diagnostic criteria for schwannomatosis. Neurology. 2005 Jun 14;64(11):1838-45. 35. Slattery WH, Lev MH, Fisher LM, Connell SS, Iqbal Z, Go JL. MRI Evaluation of Neurofibromatosis 2 Patients: A Standardized Approach for Accuracy in Interpretation. Otol Neurotol. 2005 Jul;26(4):733-740. 36. Schwamm LH, Rosenthal ES, Swap CJ, Rosand J, Rordorf G, Buonanno FS, Vangel MG, Koroshetz WJ, Lev MH. Hypoattenuation on CT angiographic source images predicts risk of intracerebral hemorrhage and outcome after intra-arterial reperfusion therapy. AJNR Am J Neuroradiol. 2005 Aug;26(7):1798-803. 37. Mullins ME, Barest GD, Schaefer PW, Hochberg FH, Gonzalez RG, Lev MH. Radiation necrosis versus glioma recurrence: conventional MR imaging clues to diagnosis. AJNR Am J Neuroradiol. 2005 Sep;26(8):1967-72. 38. Mullins ME, Lev MH, Schellingerhout D, Gonzalez RG, Schaefer PW. Intracranial Hemorrhage Complicating Acute Stroke: How Common Is Hemorrhagic Stroke on Initial Head CT Scan and How Often Is Initial Clinical Diagnosis of Acute Stroke Eventually Confirmed? AJNR Am J Neuroradiol. 2005 Oct;26(9):2207-12. 39. Schaefer PW, Roccatagliata L, Ledezma C, Hoh B, Schwamm LH, Koroshetz W, Gonzalez RG, Lev MH. First-Pass Quantitative CT Perfusion Identifies Thresholds for Salvageable Penumbra in Acute Stroke Patients Treated with Intra-arterial Therapy. AJNR Am J Neuroradiol. 2006 Jan;27(1):20-5. 40. Ulmer S, Braga TA, Barker FG, Lev MH, Gonzalez RG, Henson JW. Clinical and radiographic features of peritumoral infarction following resection of glioblastoma. Neurology 2006;67:1668–1670. 41. Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, Lev MH, Rosand J. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology 2007;68: 2007 Mar 20;68(12):889-94. 29 42. Kinnecom C, Lev MH, Wendell L, Smith EE, Rosand J, Frosch MP, Greenberg SM. Course of cerebral amyloid angiopathy-related inflammation. Neurology. 2007 Apr 24;68(17):1411-6. 43. Camargo ES, Furie KL, Singhal AB, Roccatagliata L, Cunnane ME, Halpern EF, Harris GJ, Simth WS, Gonzalez RG, Koroshetz WJ, Lev MH. Acute brain infarct: CT angiographic source images versus nonenhanced CT scans for detection and delineation. Radiology. 2007; Aug;244(2):541-8. 44. Fisher LM, Doherty JK, Lev MH, Slattery WH 3rd. Distribution of nonvestibular cranial nerve schwannomas in neurofibromatosis 2. Otol Neurotol. 2007 Dec;28(8):1083-90. 45. Torres F, He J, Yeh IB, Schwamm LH, Lev MH, Schaefer PW, González RG. An Acute Ischemic Stroke Classification Instrument That Includes CT or MR Angiography: The Boston Acute Stroke Imaging Scale.AJNR Am J Neuroradiol. 2008 Jun;29(6):1111-7. 46. Rosenthal ES, Schwamm LH, Roccatagliata L, Coutts SB, Demchuk AM, Schaefer PW, Gonzalez RG, Hill MD, Halpern EF, Lev MH. Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based "Benefit of Recanalization" Model. AJNR Am J Neuroradiol. 2008 Sep;29(8):1471-5. 47. Schaefer PW, Yoo AJ, Bell D, Barak ER, Romero JM, Nogueira RG, Lev MH, Schwamm LH, Gonzalez RG, Hirsch JA. CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy. Stroke. 2008 Nov;39(11):3107-9. 48. Schaefer PW, Barak ER, Kamalian S, Gharai LR, Schwamm L, Gonzalez RG, Lev MH. Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke. CT and MR Perfusion Imaging Are Strongly Correlated When Sufficient Brain Volume Is Imaged. Stroke 2008 Nov;39(11):2986-92. 49. Furtado AD, Smith WS, Koroshetz W, Dillon WP, Furie KL, Lev MH, Vittinghoff E, Schaeffer S, Biagini T, Hazarika O, Wintermark M. Perfusion CT Imaging Follows Clinical Severity in Left Hemispheric Strokes. Eur Neurol. 2008;60(5):244-52. 50. Harris GJ, Plotkin SR, Maccollin M, Bhat S, Urban T, Lev MH, Slattery WH. Three-dimensional volumetrics for tracking vestibular schwannoma growth in neurofibromatosis type II. Neurosurgery. 2008 Jun;62(6):1314-9; discussion 1319-20. 51. Nogueira RG, Lev MH, Roccatagliata L, Hirsch JA, Gonzalez RG, Ogilvy CS,Halpern EF, Rordorf GA, Rabinov JD, Pryor JC. Intra-Arterial Nicardipine Infusion Improves CT Perfusion-Measured Cerebral Blood Flow in Patients with Subarachnoid Hemorrhage-Induced Vasospasm. AJNR Am J Neuroradiol. 2009 Jan;30(1):160-4. 52. Goldmakher GV, Camargo EC, Furie KL, Singhal AB, Roccatagliata L, Halpern EF, Chou MJ, Biagini T, Smith WS, Harris GJ, Dillon WP, Gonzalez RG, Koroshetz WJ, Lev MH. Hyperdense Basilar Artery Sign on Unenhanced CT Predicts Thrombus and Outcome in Acute Posterior Circulation Stroke. Stroke. 2009 Jan;40(1):134-9. 53. Babiarz LS, Romero JM, Murphy EK, Brobeck B, Schaefer PW, Gonzalez RG, Lev MH*. ContrastEnhanced MR Angiography Is Not More Accurate Than Unenhanced 2D Time-of-Flight MR Angiography for Determining >=70% Internal Carotid Artery Stenosis. AJNR Am J Neuroradiol. 2009 Apr;30(4):761-8. 54. Romero JM, Babiarz LS, Forero NP, Murphy EK, Schaefer PW, Gonzalez RG, Lev MH. Arterial Wall Enhancement Overlying Carotid Plaque on CT Angiography Correlates With Symptoms in Patients With High Grade Stenosis. Stroke. 2009 May;40(5):1894-6. 55. Arsava EM, Rahman R, Rosand J, Lu J, Smith EE, Rost NS, Singhal AB, Lev MH, Furie KL, Koroshetz WJ, Sorensen AG, Ay H. Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke. Neurology. 2009 Apr 21;72(16):1403-10. 30 56. Oleinik A, Romero JM, Schwab K, Lev MH, Jhawar N, Delgado Almandoz JE, Smith EE, Greenberg SM, Rosand J, Goldstein JN. CT Angiography for Intracerebral Hemorrhage Does Not Increase Risk of Acute Nephropathy. Stroke. 2009 Jul;40(7):2393-7. 57. Schaefer PW, Mui K, Kamalian S, Nogueira RG, Gonzalez RG, Lev MH. Avoiding "Pseudo-Reversibility" of CT-CBV Infarct Core Lesions in Acute Stroke Patients After Thrombolytic Therapy. The Need for Algorithmically "Delay-Corrected" CT Perfusion Map Postprocessing Software. Stroke. 2009 Aug;40(8):2875-8. 58. Sims JR, Gharai LR, Schaefer PW, Vangel M, Rosenthal ES, Lev MH, Schwamm LH. ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology. 2009 Jun 16;72(24):2104-10. 59. Delgado Almandoz JE, Yoo AJ, Stone MJ, Schaefer PW, Goldstein JN, Rosand J, Oleinik A, Lev MH, Gonzalez RG, Romero JM. Systematic Characterization of the Computed Tomography Angiography Spot Sign in Primary Intracerebral Hemorrhage Identifies Patients at Highest Risk for Hematoma Expansion. The Spot Sign Score. Stroke. 2009 Sep;40(9):2994-3000. 60. Maas MB, Furie KL, Lev MH, Ay H, Singhal AB, Greer DM, Harris GJ, Halpern E, Koroshetz WJ, Smith WS. National Institutes of Health Stroke Scale Score Is Poorly Predictive of Proximal Occlusion in Acute Cerebral Ischemia. Stroke. 2009 Sep;40(9):2988-93. 61. Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, Harris GJ, Halpern E, Kemmling A, Koroshetz WJ, Furie KL. Collateral Vessels on CT Angiography Predict Outcome in Acute Ischemic Stroke. Stroke. 2009 Sep;40(9):3001-5. 62. Fisher LM, Doherty JK, Lev MH, Slattery WH. Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium. Otol Neurotol. 2009 Sep;30(6):835-41. 63. Smith WS, Lev MH, English JD, Camargo EC, Chou M, Johnston SC, Gonzalez G, Schaefer PW, Dillon WP, Koroshetz WJ, Furie KL. Significance of Large Vessel Intracranial Occlusion Causing Acute Ischemic Stroke and TIA. Stroke. 2009 Dec;40(12):3834-40. 64. Wei SC & Ulmer S (co 1st authors), Lev MH*, Pomerantz SR, González RG, Henson JW*. Value of Coronal Reformations in the CT Evaluation of Acute Head Trauma. AJNR Am J Neuroradiol. 2010 Feb 31(2):334339. 65. Sheth KN, Cushing TA, Wendell L, Lev MH, Romero JM, Schwab K, Smith EE, Greenberg SM, Rosand J, Goldstein JN. Comparison of Hematoma Shape and Volume Estimates in Warfarin Versus Non-WarfarinRelated Intracerebral Hemorrhage. Neurocrit Care. 2010 Feb;12(1):30-4. 66. Delgado Almandoz JE, Yoo AJ, Stone MJ, Schaefer PW, Oleinik A, Brouwers HB, Goldstein JN, Rosand J, Lev MH, Gonzalez RG, Romero JM. The Spot Sign Score in Primary Intracerebral Hemorrhage Identifies Patients at Highest Risk of In-Hospital Mortality and Poor Outcome Among Survivors. Stroke. 2010 Jan;41(1):54-60. 67. Delgado Almandoz JE, Schaefer PW, Kelly HR, Lev MH, Gonzalez RG, Romero JM. Multidetector CT Angiography in the Evaluation of Acute Blunt Head and Neck Trauma: A Proposed Acute Craniocervical Trauma Scoring System. Radiology. 2010 Jan;254(1):236-44. 68. Lima FO, Lev MH, Levy RA, Silva GS, Ebril M, de Camargo EC, Pomerantz S, Singhal AB, Greer DM, Ay H, González RG, Koroshetz WJ, Smith WS, Furie KL. Functional Contrast-Enhanced CT For Evaluation of Acute Ischemic Stroke Does Not Increase the Risk of Contrast-Induced Nephropathy. AJNR Am J Neuroradiol. 2010 May;31(5):817-21. 31 69. Ozsunar Y, Mullins ME, Kwong K, Hochberg FH, Ament C, Schaefer PW, Gonzalez RG, Lev MH. Glioma Recurrence Versus Radiation Necrosis? A Pilot Comparison of Arterial Spin-Labeled, Dynamic Susceptibility Contrast Enhanced MRI, and FDG-PET Imaging. Acad Radiol. 2010 Mar;17(3):282-90. 70. Kennedy DN, Haselgrove C, Makris N, Goldin DM, Lev MH, Caplan D, Caviness VS. WebParc: a tool for analysis of the topography and volume of stroke from MRI. Med Biol Eng Comput. 2010 Mar;48(3):215-28. 71. Silva GS, Lima FO, Camargo EC, Smith WS, Singhal AB, Greer DM, Ay H, Lev MH, Harris GJ, Halpern EF, Sonni S, Koroshetz W, Furie KL. Wake-Up Stroke: Clinical and Neuroimaging Characteristics. Cerebrovasc Dis. 2010 Jan 30;29(4):336-342. 72. Ferreira RM, Lev MH*, Goldmakher GV, Kamalian S, Schaefer PW, Furie KL, Gonzalez RG, Sanelli PC. Arterial input function placement for accurate CT perfusion map construction in acute stroke. AJR Am J Roentgenol. 2010 May;194(5):1330-6. 73. Delgado Almandoz JE, Kelly HR, Schaefer PW, Lev MH, Gonzalez RG, Romero JM. Prevalence of traumatic dural venous sinus thrombosis in high-risk acute blunt head trauma patients evaluated with multidetector CT venography. Radiology. 2010 May;255(2):570-7. 74. Bonmassar G, Iwaki S, Gregory Goldmakher GV, Angelonea LM, Belliveau JW, Lev MH. On the Measurement of Electrical Impedance Spectroscopy (EIS) of the Human Head. International Journal of Bioelectromagnetism. 2010 Jan 1;12(1):32-46. 75. Payabvash S, Kamalian S, Fung S, Wang Y, Passanese J, Kamalian S, Souza LC, Kemmling A, Harris GJ, Halpern EF, González RG, Furie KL, Lev MH. Predicting Language Improvement in Acute Stroke Patients Presenting with Aphasia: A Multivariate Logistic Model Using Location-Weighted Atlas-Based Analysis of Admission CT Perfusion Scans. AJNR Am J Neuroradiol. 2010 Oct;31(9):1661-8. 76. Delgado Almandoz JE, Schaefer PW, Goldstein JN, Rosand J, Lev MH, González RG, Romero JM. Practical Scoring System for the Identification of Patients with Intracerebral Hemorrhage at Highest Risk of Harboring an Underlying Vascular Etiology: The Secondary Intracerebral Hemorrhage Score. AJNR Am J Neuroradiol. 2010 Oct;31(9):1653-60. 77. Silva GS, Lima FO, Camargo EC, Smith WS, Lev MH, Harris GJ, Halpern EF, Koroshetz W, Furie KL. Gender Differences in Outcomes after Ischemic Stroke: Role of Ischemic Lesion Volume and Intracranial Large-Artery Occlusion. Cerebrovasc Dis. 2010 Aug 24;30(5):470-475. 78. Lima FO, Furie KL, Silva GS, Lev MH, Camargo EC, Singhal AB, Harris GJ, Halpern EF, Koroshetz WJ, Smith WS, Yoo AJ, Nogueira RG. The Pattern of Leptomeningeal Collaterals on CT Angiography Is a Strong Predictor of Long-Term Functional Outcome in Stroke Patients With Large Vessel Intracranial Occlusion. Stroke. 2010 Oct;41(10):2316-22. 79. Poisson SN, Nguyen-Huynh MN, Johnston SC, Furie KL, Lev MH, Smith WS. Intracranial Large Vessel Occlusion as a Predictor of Decline in Functional Status After Transient Ischemic Attack. Stroke. 2011 Jan;42(1):44-7. 80. Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, Harris GJ, Halpern EF, Koroshetz WJ, Furie KL. The Prognosis for Aphasia in Stroke. J Stroke Cerebrovasc Dis. 2012 Jul;21(5):350-7. 81. Delgado Almandoz JE, Su HS, Schaefer PW, Goldstein JN, Pomerantz SR, Lev MH, Gonzalez RG, Romero JM. Frequency of Adequate Contrast Opacification of the Major Intracranial Venous Structures with CT Angiography in the Setting of Intracerebral Hemorrhage: Comparison of 16- and 64-Section CT Angiography Techniques. AJNR Am J Neuroradiol. 2011 May;32(5):839-45. 32 82. Jamshidi S, Kandiah PA, Singhal AB, Resnick JB, Furie KL, Borczuk P, Parry BA, Lev M, Koroshetz WJ, Chang Y, Nagurney JT. Clinical Predictors of Significant Findings on Head Computed Tomographic Angiography. J Emerg Med. 2011 Apr;40(4):469-75. 83. Payabvash S, Souza L, Wang Y, Schaefer PW, Furie KL, Halpern EF, Gonzalez RG, Lev MH. Regional Ischemic Vulnerability of the Brain to Hypoperfusion: The Need for Location Specific Computed Tomography Perfusion Thresholds in Acute Stroke Patients. Stroke 2011 May;42(5):1255-60. 84. Kamalian S, Kamalian S, Maas MB, Goldmacher GV, Payabvash S, Akbar A, Schaefer PW, Furie KL, Gonzalez RG, Lev MH. CT Cerebral Blood Flow Maps Optimally Correlate With Admission DiffusionWeighted Imaging in Acute Stroke but Thresholds Vary by Postprocessing Platform. Stroke. 2011 Jul;42(7):1923-8. 85. Yoo AJ, Hu R, Hakimelahi R, Lev MH, Nogueira RG, Hirsch JA, González RG, Schaefer PW. CT Angiography Source Images Acquired with a Fast-Acquisition Protocol Overestimate Infarct Core on Diffusion Weighted Images in Acute Ischemic Stroke. J Neuroimaging. 2011 Aug 17 [Epub ahead of print]. 86. Souza LCS, Payabvash S, Wang Y, Kamalian S, Schaefer P, Gonzalez RG, Furie KL, Lev MH. Admission CTP is an Independent Predictor of Hemorrhagic Transformation (HT) in Acute Stroke, with Similar Accuracy to DWI. Cerebrovascular Diseases. 2011;33(1):8-15. 87. Delgado Almandoz JE, Kelly HR, Schaefer PW, Brouwers HB, Yoo AJ, Stone MJ, Goldstein JN, Rosand J, Lev MH, Gonzalez RG, Romero JM. CT angiography spot sign predicts in-hospital mortality in patients with secondary intracerebral hemorrhage. J Neurointerv Surg. 2012 Nov 1;4(6):442-7. 88. Pulli B, Schaefer PW, Hakimelahi R, Chaudhry ZA, Lev MH, Hirsch JA, González RG, Yoo AJ. Acute Ischemic Stroke: Infarct Core Estimation on CT Angiography Source Images Depends on CT Angiography Protocol. Radiology. 2012 Feb;262(2):593-604. 89. Kamalian S, Kamalian S, Konstas AA, Maas MB, Payabvash S, Pomerantz SR, Schaefer PW, Furie KL, González RG, Lev MH. CT Perfusion Mean Transit Time Maps Optimally Distinguish Benign Oligemia from True "At-Risk" Ischemic Penumbra, but Thresholds Vary by Postprocessing Technique. AJNR Am J Neuroradiol. 2012 Mar;33(3):545-9. 90. Rapalino O, Kamalian MS, Kamalian S, Payabvash S, Souza LCS, Zhang D, Joshi M, Sahani DV, Lev MH, Pomerantz SR. Cranial CT with Adaptive Statistical Iterative Reconstruction (ASIR): Improved Image Quality with Concomitant Radiation Dose Reduction. AJNR Am J Neuroradiol. 2012 Apr;33(4):609-15. 91. González RG, Lev MH*, Goldmacher GV, Smith WS, Payabvash S, Harris GJ, Halpern EF, Koroshetz WJ, Camargo EC, Dillon WP, Furie KL. Improved Outcome Prediction using CT Angiography in Addition to Standard Ischemic Stroke Assessment: Results from the STOPStroke Study. PLoS One. 2012;7(1):e30352. Epub 2012 Jan 20. 92. Souza LC*, Yoo AJ*, Chaudry ZA, Payabvash S, Kemmling A, Schaefer, PW, Hirsch JA, Furie KL, Gonzalez RG, Nogueira RG, Lev MH. Malignant CTA Collateral Profile is Highly Specific for Large Admission DWI Infarct Core and Poor Outcome in Acute Stroke. AJNR Am J Neuroradiol. 2012 Aug;33(7):1331-6. 93. Yoo AJ, Chaudhry ZA, Nogueira RG, Lev MH, Schaefer PW, Schwamm LH, Hirsch JA, González RG. Infarct Volume Is a Pivotal Biomarker After Intra-Arterial Stroke Therapy. Stroke. 2012 May;43(5):1323-30. 94. Payabvash S, Souza L, Kamalian S, Wang Y, Passanese J, Kamalian S, Fung S, Halpern EF, Schaefer PW, Gonzalez RG, Furie KL, Lev MH. Location-weighted CTP analysis predicts early motor improvement in stroke: A preliminary study. Neurology. 2012 Jun 5;78(23):1853-9. 33 95. Hakimelahi R, Yoo AJ, He J, Schwamm LH, Lev MH, Schaefer PW, González RG. Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke. BMC Neurol. 2012 Nov 5;12:132. 96. Pomerantz SR, Kamalian S, Zhang D, Gupta R, Rapalino O, Sahani DV, Lev MH. Virtual monochromatic reconstruction of dual-energy unenhanced head CT at 65–75 keV maximizes image quality compared with conventional polychromatic CT. Radiology. 2013 Jan;266(1):318-25. 97. Bonmassar G, Iacono MI, Lev MH. Dual energy pulses for Electrical Impedance Spectroscopy with the stochastic Gabor function. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:138-41. 98. Romero JM, Kelly HR, Delgado Almandoz JE, Hernandez-Siman J, Passanese JC, Lev MH, González RG. Contrast Extravasation on CT Angiography Predicts Hematoma Expansion and Mortality in Acute Traumatic Subdural Hemorrhage. AJNR Am J Neuroradiol. 2013 Feb 28. [Epub ahead of print] 99. Kidwell CS, Jahan R, Gornbein J, Alger JR, Nenov V, Ajani Z, Feng L, Meyer BC, Olson S, Schwamm LH, Yoo AJ, Marshall RS, Meyers PM, Yavagal DR, Wintermark M, Guzy J, Starkman S, Saver JL; MR RESCUE Investigators. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013 Mar 7;368(10):914-23. Collaborators: includes Lev M 100. Lau AY, Wong KS, Lev M, Furie K, Smith W, Kim AS. Burden of Intracranial Steno-Occlusive Lesions on Initial Computed Tomography Angiography Predicts Poor Outcome in Patients With Acute Stroke. Stroke. 2013 Mar 19. [Epub ahead of print] * Corresponding or co-first author ** Cover article A2. Research Publications from the STIR / VISTA Steering Committee 1. Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, Kim JS, Breuer L, Singer OC, Warach S, Christensen S, Treszl A, Forkert ND, Galinovic I, Rosenkranz M, Engelhorn T, Köhrmann M, Endres M, Kang DW, Dousset V, Sorensen AG, Liebeskind DS, Fiebach JB, Fiehler J, Gerloff C; STIR and VISTA Imaging Investigators. DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol. 2011 Nov;10(11):978-86. Appendix: STIR and VISTA Imaging Steering Committee includes Michael Lev. 2. Ali M, Bath P, Brady M, Davis S, Diener HC, Donnan G, Fisher M, Hacke W, Hanley DF, Luby M, Tsivgoulis G, Wahlgren N, Warach S, Lees KR; VISTA Steering Committees. Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses. Int J Stroke. 2012 Feb;7(2):133-8. Appendix: STIR and VISTA Imaging Steering Committee includes Michael Lev. 3. Cheng B, Brinkmann M, Forkert ND, Treszl A, Ebinger M, Köhrmann M, Wu O, Kang DW, Liebeskind DS, Tourdias T, Singer OC, Christensen S, Luby M, Warach S, Fiehler J, Fiebach JB, Gerloff C, Thomalla G; STIR and VISTA Imaging Investigators. Quantitative measurements of relative fluid-attenuated inversion recovery (FLAIR) signal intensities in acute stroke for the prediction of time from symptom onset. J Cereb Blood Flow Metab. 2013 Jan;33(1):76-84. Appendix: STIR and VISTA Imaging Steering Committee includes Michael Lev. 4. Ali M, Hazelton C, Lyden P, Pollock A, Brady M; VISTA Collaboration. Recovery from poststroke visual impairment: evidence from a clinical trials resource. Neurorehabil Neural Repair. 2013 Feb;27(2):133-41. Appendix: STIR and VISTA Imaging Steering Committee includes Michael Lev. B. Other Peer Reviewed Publications 34 National Guidelines and Recommendations: 1A. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. Stroke 2008 May;39(5):1621-8. 1B. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. AJNR Am J Neuroradiol. 2008 May;29(5):e23-30. 2. Latchaw RE, Alberts MJ, Lev MH, Connors JJ, Harbaugh RE, Higashida RT, Hobson R, Kidwell CS, Koroshetz WJ, Mathews V, Villablanca P, Warach S, Walters B; on behalf of the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, and the Interdisciplinary Council on Peripheral Vascular Disease. Recommendations for Imaging of Acute Ischemic Stroke. A Scientific Statement From the American Heart Association. Stroke. 2009 Nov;40(11):3646-78. 3. Albers GW, Goldstein LB, Hess DC, Wechsler LR, Furie KL, Gorelick PB, Hurn P, Liebeskind DS, Nogueira RG, Saver JL; for the STAIR VII Consortium. Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies. Stroke. 2011 Sep;42(9):2645-2650. Appendix: STAIR VII writing committee members included Michael H Lev. Case Reports: 1. Chew FS, Lev MH. Polyethylene osteolysis. Radiology Pathology Conference of the Massachusetts General Hospital. AJR 1992; 159(6): 1254. 2. Lev MH, Blickman JG. Extragonadal yolk sac tumor: Sonographic and CT findings. AJR 1993; 160(2): 370-371. 3. Lev MH, Chew FS. Transitional cell carcinoma. Radiology Pathology Conference of the Massachusetts General Hospital. AJR 1993; 160(1): 74. 4. Batchelor TT, Platten M, Palmer-Toy DE, Hunter GJ, Lev MH, Dalmau J, Hochberg FH. Chorea as a paraneoplastic complication of Hodgkin’s disease. Journal of Neuro-oncology 1998; 36(2):185-190. 5. Eskey CJ, Lev MH *, Tatter SB, Gonzalez RG. Cerebral CT venography in surgical planning for a tentorial meningioma. JCAT 1998; 22(4):530-532. 6. Abdelaziz OS, Ogilvy CS, Lev MH. Is there a potential role for hyoid bone compression in the pathogenesis of carotid artery stenosis? Surgical Neurology 1999; 51(6):650-653. 7. Hwang BJ, Connelly MM, Lev MH *. Distinctive MR imaging appearance of hemorrhagic cerebral aneurysms associated with atrial myxoma. AJR 2001; 177(4):925-927. 8. Sanelli PC, Lev MH, Gonzalez RG, Schaefer PW. Unique linear and nodular MR enhancement pattern in schistosomiasis of the central nervous system: report of three patients. AJR 2001;177(6):1471-1474. 9. Lee JW, M Houtchens, Hochberg F, Price B, Lev MH, Cunnane M, Pfannl R, MacCollin M. Glioblastoma multiforme presenting as bilateral internal auditory canal tumors. Journal of Neurology. J Neurol. 2006 Apr;253(4):522-4. 35 10. Thomas SH, Schwamm LH, Lev MH. Case records of the Massachusetts General Hospital. Case 16-2006. A 72-year-old woman admitted to the emergency department because of a sudden change in mental status. N Engl J Med. 2006 May 25;354(21):2263-71. 11. Laposata M, Van Cott EM, Lev MH. Case records of the Massachusetts General Hospital. Case 1-2007. A 40-year-old woman with epistaxis, hematemesis, and altered mental status. N Engl J Med. 2007 Jan 11;356(2):174-82. 12. Stankovic KM, Eskandar E, El Khoury JB, Lev MH, Sadow PM. Case records of the Massachusetts General Hospital. Case 2-2013. A 20-year-old man with recurrent ear pain, fever, and headache. N Engl J Med. 2013 Jan 17;368(3):267-77. * Corresponding author II. Other Peer and Non Peer Reviewed Major Publications: Letters, Commentaries, and Editorials: 1. Lev MH. The Oath [letter]. Hospital Practice (Office Edition) 1990; 25(6):13. 2. Brown JH, Lustrin ES, Lev MH, Taveras JM. CT angiography of the circle of Willis: Is spiral technology always necessary? [letter]. AJNR 1997; 18(9):1794-1795. 3. Lev MH, Rhea JT, Bramson RT. Avoidance of variability and error in radiology [invited comment]. Lancet 1999; 354(9175):272. 4. Lev MH, Ackerman RH. Infarct fogging may explain “reversible” ischemia determined by xenon-enhanced CT [letter]. AJNR 1999; 20(10):2023. 5. Lev MH. Diffusion weighted MRI of multiple sclerosis: added clinical value, or just another pretty face? [invited editorial]. AJNR 2000; 21(5):805-808. 6. Lev MH, Farkas J, Gemmete JJ, Hossain ST, Hunter GJ, Koroshetz WJ, Gonzalez RG. Acute stroke: How to improve CT detection and avoid errors in radiology [invited letter]. Radiology 2000; 216(3):920-921. 7. Lev MH, Grant PE. MEG functional imaging: The next generation? [invited editorial]. AJNR 2000; 21(8):1369-1370. 8. Quencer RM, Bowen BC, Castillo M, Falcone S, Fischbein NJ, Lev MH, Mukherji S, Palasis S, Strother C. Meeting summary: Thirty-Ninth Annual Meeting of the American Society of Neuroradiology. AJNR 2001; 22(10):1978-1982. 9. Lev MH. Gliomatosis cerebri has normal relative blood volume: Really!? Who cares? Should you? [invited editorial]. AJNR 2002; 23(3):345-346. 10. Koroshetz WJ, Lev MH. Contrast computed tomography scan in acute stroke: "You can't always get what you want but you get what you need" [invited editorial]. Ann Neurol 2002; 51(4):415-6. 11. Lev MH. CT/MR perfusion imaging and alphabet soup: an appeal for standardized nomenclature [invited editorial]. AJNR 2002; 23(5):746-747. 12. Lev MH, Koroshetz WJ, Schwamm LH, Gonzalez RG. CT or MRI for Imaging Patients with Acute Stroke: Visualization of "Tissue at Risk"? [letter]. Stroke 2002 Dec; 33(12):2736-7. 36 13. Lev MH. CT versus MR for acute stroke imaging: is the "obvious" choice necessarily the correct one? [invited editorial]. AJNR 2003 Nov-Dec;24(10):1930-1. 14. Lev MH, Romero JM, Gonzalez RG. Flow voids in time-of-flight MR angiography of carotid artery stenosis? It depends on the TE! [letter] AJNR 2003 Nov-Dec;24(10):2120. 15. Lev MH. Stroke I: overview and current clinical practice [introduction]. Neuroimaging Clin N Am. 2005 May;15(2):xv-xvi. 16. Lev MH. Stroke II: Imaging Techniques and Future Directions [introduction]. Neuroimaging Clin N Am. 2005 Aug;15(3):xv-xvi. 17. Lev MH, Vedolin L. Permeability versus cerebral blood volume measurement in brain tumor evaluation: comparative clinical value and advice to authors [editorial]. AJNR Am J Neuroradiol. 2006 Feb;27(2):418-9. 18. Lev MH, Gonzalez RG, Schaefer PW, Koroshetz WJ, Dillon WP, Wintermark M. Cerebral Blood Flow Thresholds in Acute Stroke Triage [letter]. Stroke 2006. Sep;37(9):2202. 19. Lev MH. CT/NIHSS Mismatch for Detection of Salvageable Brain in Acute Stroke Triage Beyond the 3Hour Time Window. Overrated or Undervalued? [letter]. Stroke 2007. Jul;38(7):2028-9. 20. Murai Y, Ikeda Y, Teramoto A, Goldstein JN, Greenberg SM, Smith EE, Lev MH, Rosand J. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage [letter]. Neurology. 2007 Aug 7;69(6):617; author reply 617. 21. Bankier AA, Levine D, Sheiman RG, Lev MH, Kressel HY. Redundant publications in Radiology: shades of gray in a seemingly black-and-white issue [editorial by the Radiology Editorial Board]. Radiology. 2008 Jun;247(3):605-7. 22. Lev MH. Regarding "Symptomatic acute occlusion of the internal carotid artery: Reappraisal of urgent vascular reconstruction based on current stroke imaging" [letter]. J Vasc Surg. 2008 Oct;48(4):1068; author reply 1069. 23. Wintermark M, Lev MH. FDA Investigates the Safety of Brain Perfusion CT. AJNR. Am J Neuroradiol. 2010 Jan;31(1):2-3. Epub 2009 Nov 5. 24. Konstas A, Lev MH. CT perfusion imaging of acute stroke: the need for arrival time, delay insensitive, and standardized postprocessing algorithms? Radiology. 2010 Jan;254(1):22-5. 25. Lev MH. Acute Stroke Imaging: What Is Sufficient for Triage to Endovascular Therapies? AJNR Am J Neuroradiol. 2012 May;33(5):790-2. 26. Lev MH. Perfusion Imaging of Acute Stroke: Its Role in Current and Future Clinical Practice. Radiology 2013 Jan;266(1):22-7. 27. González RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR, Larvie M, Hirsch JA, Gupta R. The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. J Neurointerv Surg. 2013 Mar 14. [Epub ahead of print] Textbook Chapters: 1. Schaefer PW, Lev MH, Buchbinder BR, Gonzalez RG. Clinical applications of functional MRI. In: Taveras JM, Ferrucci JT, eds. Radiology: Diagnosis, Imaging, Intervention. Philadelphia: Lippincott 1997; Chapter 33A. 37 2. Lev MH, Silverman PM, Curtin HD. The larynx. In: Husband JE, Reznek RH, eds. Imaging in Oncology.** Oxford: Isis Medical 1998; 457-479. 3. Lev MH, Curtin HD. Larynx. In: Gentry LR, ed. Normal Anatomy of the Head and Neck: Neuroimaging Clinics of North America. WB Saunders 1998; 8(1):235-256. 4. Lev MH, Rosen BR. Clinical applications of intracranial perfusion MR imaging. In: Heiserman JE, ed. Fast Scan and Echo Planar MR Imaging: Neuroimaging Clinics of North America. WB Saunders 1999; 9(2):309331. 5. Lev S, Lev MH. Cystic lesions. In: Weber AL, ed. Radiological Evaluation of the Neck: Radiological Clinics of North America. WB Saunders 2000; 38(5):1013-1027. 6. Lev S, Lev MH. Neck masses and lymph node pathology. In: Taveras JM, Ferrucci JT, eds. Radiology: Diagnosis, Imaging, Intervention. Philadelphia: Lippincott 2000 (update); chapter 83. 7. Lev MH, Hunter GJ, Hamberg LM, Gonzalez RG. Computed tomography angiography and perfusion imaging of acute stroke. In: Fisher M, Bogousslavsky J, eds. Current review of cerebrovascular disease, fourth edition. Philadelphia: Current Medicine Inc. 2001; 93-99. 8. Sahani D, Lev MH, Kubaska S, Kalva S, Saini S. Magnetic resonance imaging in oncology. In: Bettman M et al, eds. Diagnostic imaging and image-guided intervention. London: Macmillan. 2001. 9. Askoy FG, Lev MH *. Dynamic contrast-enhanced brain perfusion imaging: techniques and clinical applications. In: Drayer BP,ed. Neuroimaging Clinics of North America. Philadelphia: WB Saunders August 2001; 11(3):485-500. 10. Hunter GJ, Hamberg LM, Lev MH, Gonzalez RG. Computed tomography angiography and perfusion imaging of acute stroke. In: Pinsky MR, ed. Cerebral Blood Flow: Mechanisms of Ischemia, Diagnosis, and Therapy. Berlin: Springer. 2002;165-178. 11. Sasson JP, Abdelrahman NG, Aquino S, Lev MH*. Trachea: Anatomy and Pathology. In: Som PM, Curtin HD, eds. Head and Neck Imaging, fourth edition. St. Louis: Mosby. 2002; 1700-1726. 12. Lev MH, Gonzalez RG. CT Angiography and CT Perfusion Imaging. In: Mazziotta JC and Toga AW, eds. Brain Mapping: The Methods, second edition. San Diego: Academic Press. 2002; 427-484. 13. Ackerman RH, Romero JM, Lev MH. Ultrasonography of the extracranial carotid arteries. In: Latchaw RE, Kucharczyk J, Moseley ME, eds: Imaging of the Nervous System. Philadelphia, Elsevier. 2005; 421-438. 14. Romero JM, Ackerman RH, Dault NA, Lev MH. Noninvasive evaluation of carotid artery stenosis: indications, strategies, and accuracy. In: Lev MH, ed: Neuroimaging Clin N Am. 2005 May;15(2):351-65. 15. Schaefer PW, Copen WA, Lev MH, Gonzalez RG. Diffusion-weighted imaging in acute stroke. In: Lev, MH, ed: Neuroimaging Clin N Am. 2005 Aug;15(3):503-30. 16. Shetty SK, Lev MH. CT Perfusion in Acute Stroke. In: Lev, MH, ed: Neuroimaging Clin N Am. 2005 Aug;15(3):481-501. 17. Schaefer PW, Copen WA, Lev MH, Gonzalez RG. Diffusion-weighted imaging in acute stroke. Magn Reson Imaging Clin N Am. 2006 May;14(2):141-68. 18. Pomerantz SR, Lev MH. Neurovascular Computed Tomography Angiography. In: Gilman S, ed; Neurobiology of Disease. Burlington MA, Elsevier Academic Press. 2007; 801-820. 38 19. Copen WA, Lev MH. Neuroimaging of the acute stroke patient. In: Greer DM, ed; Acute Ischemic Stroke: An Evidence-Based Approach. Hoboken NJ, John Wiley and Sons. 2007; 3-37. 20. Shetty SK, Lev MH. Computed Tomography in acute stroke. In: Torbey MT and Selim MH, eds; The Stroke Book. New York NY, Cambridge University Press. 2007; 95-114. 21. Vossough A, Lev MH. CNS Infarction. In: Newton HB and Jolesz FA, eds; Handbook of Neuro-Oncology Neuroimaging. New York NY, Elsevier / Academic Press. 2008;74-83. 22. Röther J, Pomerantz SR, Kucinski T, Lev MH. Chapter 50, Imaging intra- and extracranial vessels: computed tomography angiography and magnetic resonance angiography. Handb Clin Neurol. 2008;94:1021-38. 23. Delgado Almandoz JE, Romero JM, Pomerantz SR, Lev MH. Computed Tomography Angiography of the Carotid and Cerebral Circulation. Radiol Clin North Am. 2010 Mar;48(2):265-281. 24. Rapalino O, Kamalian S, Gupta R, Phan C, Pomerantz S, Romero J, Joshi M, Lev MH. Neurological Applications. In: Johnson TRC, Fink C, Schonberg SO, Reiser MF, eds; Dual Energy CT in Clinical Practice. Heidelberg, Springer. 2011;128-140. 25. Gupta R, Mani S, Mehndiratta A, Pomerantz S, and Lev MH. Multidetector Computed Tomography as a Problem-Solving Tool in Neuroradiology. In: Law M, Som PM, Naidich TP, eds; Problem Solving in Neuroradiology. Philadelphia PA, Elsevier / Saunders. 2011:3-61. 26. Konstas AA, Wintermark M, Lev MH. CT Perfusion Imaging in Acute Stroke. In: Schaefer PS, ed; Neuroimaging Clin N Am. 2011 May;21(2):215-38. 27. Yoo A, Lev MH. Neurovascular Imaging of the Acute Stroke Patient. In: Barrett K and Meschia J, eds; Neurology in Practice: “Stroke”. Wiley-Blackwell, 2012, in submission. 28. Johnson J, Lev MH. Advanced CT Imaging of Acute Stroke. In: Torbey MT and Selim MH, eds; The Stroke Book: 2nd Edition. Cambridge University Press, 2012, in submission. * Corresponding author ** First prizewinner for multi-authored textbooks, Society of Authors Medical Book Awards (London), December 1999 Edited Textbooks/Collections: 1. Lev MH, ed. Neuroimaging Clinic of North America: Stroke, Volume I. Philadelphia: Elsevier Saunders 2005; May 15(2). 2. Lev MH, ed. Neuroimaging Clinic of North America: Stroke, Volume II. Philadelphia: Elsevier Saunders 2005; Aug 15(3). 3. Gonzalez RG, Hirsch JA, Koroshetz WJ, Lev MH, Schaefer PW, eds. Acute Ischemic Stroke: Imaging and Intervention, 1st edition. Heidelberg: Springer 2006; Jan. 4A. Forbes K, Lev MH, Shetty S, Heiserman J, eds. Q&A Color Review of Neuroimaging. New York: Manson Publishing (Cambridge, UK Edition) 2008; April. 4B. Lev MH, Forbes K, Shetty S, Heiserman J, eds. Q&A Color Review of Neuroimaging. New York: Thieme Publishing (NY, US Edition) 2008; April. 39 4C. Forbes K, Lev MH, Shetty S, Heiserman J, eds. Q&A Color Review of Neuroimaging. New York: Manson Publishing (Cambridge, RUSSIAN LANGUAGE Edition) 2010; June. 5. Wintermark M, Lev MH. Radiation Dose in Neuroradiology CT Protocols. AJNR Special Collections (Am J Neuroradiol). 2009 Nov 5. 6. Gonzalez RG, Hirsch JA, Lev MH, Schaefer PW, Schwamm LH, eds. Acute Ischemic Stroke: Imaging and Intervention, 2nd edition. Heidelberg: Springer 2011. 7. Lev MH editor and Kamalian SM, contributor. “Radiology Select: Stroke”. Radiology (journal) Special Collection (solicited by the Radiological Society of North America [RSNA] for CME and SAM credits, RSNA.ORG/RADIOLOGYSELECT). July 2012. Reviews and Educationally Relevant Publications: 1. Lev MH. Magnetic resonance in medicine, Ed. by Peter A Rinck. [book review]. Academic Radiology 1995; 2(10):934. 2. Lev MH, Whitman GJ. Surviving (and enjoying) RSNA: Some hints for residents and first-time attendees. Applied Radiology 1995; 24(11):30. 3. Lev MH, Groblewski JC, Shortsleeve CM, Curtin HD. Imaging of the sinonasal cavities - inflammatory disease including osteomeatal complex. Applied Radiology 1998; 27:20-30. 4. Lev MH, Hochberg F. Perfusion MR imaging as an end-point to assess brain tumor response to new therapies. Cancer Control: Journal of the Moffitt Cancer Center 1998; 5(2):19-27. 5. Lev MH, Farkas J. CTA in the diagnosis and triage of hyperacute stroke. General Electric Medical Systems CT Case Studies, HiSpeed. 1999. 6. Curtin HD, Lev MH, Sakai O. Head and Neck Imaging: A Regional Approach. MGH CD ROM eCases Series. 1999; Login Brothers, Chicago. 7. Lev MH, Guha-Thakurta N, Gonzalez RG. Emergency Neuroradiology. MGH CD ROM eCases Series. 1999; Login Brothers, Chicago. 8. Lev MH, Nichols SJ. Lightspeed CTA: the complete, 60 second, single bolus neurovascular workup. General Electric Medical Systems CT Case Studies, HiSpeed. 1999. 9. Lev MH, Nichols SJ. Computed tomographic angiography and computed tomographic perfusion imaging of hyperacute stroke. Topics in Magnetic Resonance Imaging; October 2001; 11(5):273-287. 10. Berzin TM, Lev MH *, Gonzalez RG. CT offers early view of hyperacute stroke. Diagnostic Imaging, December 2000 (Special supplement - “advanced CT”); 11-14. 11. Askoy FG, Lev MH *. Dynamic contrast-enhanced brain perfusion imaging: techniques and clinical applications. Semin Ultrasound CT MR. December 2000; 21(6):426-477. 12. Ussery EK, Sanelli PC, Gonzalez RG, Lev MH*. Advanced CT imaging in the evaluation and triage of acute stroke patients. Applied Radiology 2002; February:18-22. 13. Symons SP, Cullen SP, Buonanno F, Gonzalez RG, Lev MH*. Noncontrast conventional computed tomography in the evaluation of acute stroke. Semin Roentgenol. 2002 Jul;37(3):185-91. 40 14. Cullen SP, Symons SP, Hunter G, Hamberg L, Koroshetz W, Gonzalez RG, Lev MH*. Dynamic contrastenhanced computed tomography of acute ischemic stroke: CTA and CTP. Semin Roentgenol. 2002 Jul;37(3):192-205. 15. Guimaraes AR, Ackerman RH, Romero JM, Lev MH*. Multislice CT offers new options for imaging carotid artery stenosis. Diagnostic Imaging 2002 Jul: 70-75. 16. Eastwood JD, Lev MH, Provenzale JM. Perfusion CT with iodinated contrast material. AJR 2003 Jan; 180:312. 17. Covarrubias DJ, Rosen BR, Lev MH. Dynamic magnetic resonance perfusion imaging of brain tumors. The Oncologist 2004; 9(5):528-537. 18. Morgan JA, Ackerman RH, Romero JM, Lev MH*. Non-invasive imaging evaluation of carotid artery occlusive disease. Applied Radiology 2004. 19. Yoo AJ, Murphy EK, Lev MH. Consultations in Computed Tomography CME Series: Neurovascular Applications of CTA – Stroke, Carotid Occlusive Disease, and Beyond. CMP Healthcare Media Group, Nov 2005. 20. Vu D, Lev MH. Noncontrast CT in acute stroke. Semin Ultrasound CT MR. 2005 Dec;26(6):380-6. 21. Wesolowski JR, Lev MH. CT: history, technology, and clinical aspects. Semin Ultrasound CT MR. 2005 Dec;26(6):376-9. 22. Pomerantz SR, Harris GJ, Desai HJ, Lev MH. Computed tomography angiography and computed tomography perfusion in ischemic stroke: A step-by-step approach to image acquisition and threedimensional postprocessing. Semin Ultrasound CT MR. 2006 Jun;27(3):243-70. 23. Seidenwurm D, Turski P, Barr J, Connors J, Lev M, Mukherji S, Russell E. Performance measures in neuroradiology. AJNR Am J Neuroradiol. 2007 Sep;28(8):1435-8. Review. 24. Miller JC, Lev MH, Schwamm LH, Thrall JH, Lee SI. Functional CT and MR imaging for evaluation of acute stroke. J Am Coll Radiol. 2008 Jan;5(1):67-70. 25. Jaff MR, Goldmakher GV, Lev MH, Romero JM. Imaging of the carotid arteries: the role of duplex ultrasonography, magnetic resonance arteriography, and computerized tomographic arteriography. Vasc Med. 2008 Nov;13(4):281-92. 26. Konstas AA, Goldmakher GV, Lee TY, Lev MH. Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis. AJNR Am J Neuroradiol. 2009 Apr;30(4):662-8. 27. Konstas AA, Goldmakher GV, Lee TY, Lev MH. Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 2: Technical Implementations. AJNR Am J Neuroradiol. 2009 May;30(5):885-92. 28. Wintermark M, Rowley HA, Lev MH. Acute stroke triage to intravenous thrombolysis and other therapies with advanced CT or MR imaging: Pro CT. Radiology. 2009 Jun;251(3):619-26. 29. Lima F, Goldmakher G, Lev M, Furie K. Computed tomography. Front Neurol Neurosci. 2009;25:193-6. * Corresponding author Proceedings of Meetings: 41 Dr. Lev has published over 210 abstracts at medical/scientific meetings from 1989 through 2012 (not all listed): 99. Kemmling, A, Kamalian S, Iqbal S, Lev MH. Thrombus Location Matters: Infarct Growth in Acute Proximal Middle Cerebral Artery. Proceedings of the 47th Annual Meeting of the American Society of Neuroradiology, Vancouver, Canada 2009. 100. Kemmling A, Haselgrove C, Makris N, Kamalian, S, Kennedy DN, Caviness VS, Lev MH. Infarct Growth in Acute Proximal Middle Cerebral Artery Occlusion Depends on Pattern of Acute Infarct Core. Proceedings of the 47th Annual Meeting of the American Society of Neuroradiology, Vancouver, Canada 2009. 101. Silva GS, Lima F, Camargo EC, Singhal AB, Greer DM, Ay H, Halpern EF, Smith WS, Lev MH, Koroshetz W, Furie KL. Starting IV t-PA Infusions for Acute Ischemic Stroke at Community Hospitals prior to Transfer to a Regional Stroke Center is Feasible and Safe. Proceedings of the American Heart Association International Stroke Conference, New Orleans LA, 2009. 102. Kemmling A, Haselgrove C, Makris N, Kamalian S, Hodge S, Kennedy DN, Caviness VS, Lev MH. AUTOASPECTS: Validation Of Automated Alberta Stroke Program Early CT Score In Acute Stroke DWI Images Using Brain Parcellation Software WebParc. Proceedings of the American Heart Association International Stroke Conference, New Orleans LA, 2009. 103. Souza, L. SC, Payabvash, S, Furie, KL, Gonzalez, R, Lev, MH. Admission Diffusion-Weighted Imaging and Clinical Data Predict Acute Stroke Patients’ Discharge Condition. Proceedings of the 48th Annual Meeting of the American Society of Neuroradiology Boston, MA 2010. 104. Payabvash, S, Kamalian, S, Wang, Y, Fung, S, Kamalian, S, Souza, LSC, Furie, KL,Gonzalez, R, Lev, MH. Mechanism of Visual Field Defect in Patients with Anterior Circulation Stroke: A Diffusion-Weighted Imaging and CT Perfusion-Based Study. Poster presented at Proceedings of the 48th Annual Meeting of the American Society of Neuroradiology Boston, MA 2010. 105. Schaefer, PW, Kamalian, S, Kamalian, S, Wang, B, Yoo, A, Gonzalez, RG, Lev, MH. Infarct Core Size Greater than 58 cc on CT Cerebral Blood Flow Maps Is Highly Correlated with Poor Outcome. Poster presented at Proceedings of the 48th Annual Meeting of the American Society of Neuroradiology Boston, MA 2010. 106. Ishak, C, Cardoza, S, Lev, M, Bartynski, WS, Emmer, B, Lev, S. CT Radiation Dose Made Easy: A Guide for Healthcare Providers and Patients. Electronic Scientific Exhibit at Proceedings of the 48th Annual Meeting of the American Society of Neuroradiology Boston, MA 2010. 107. Payabvash S, Souza LC, Schaefer PW, Furie KL, Gonzalez RG, Lev MH. Percent “Lower Insular Ribbon Infarction” (LIRI) on Admission DWI Is a Stronger Predictor of Discharge Clinical Improvement in Acute Stroke than Admission Core Infarct Volume, ASPECT Score, or CTA Occlusion. 96th RSNA meeting (Radiological Society of North America), Chicago, Il, 2010. 108. Souza LM, Payabvash S, Esfahani SA, Gonzalez RG, Lev MH, Nogueira R. Admission DWI Infarct Volume May Be A Stronger Predictor of Clinical Outcome than The Presence of Proximal Arterial Occlusion in Acute Stroke Patients Undergoing Reperfusion Therapy. Stroke. 2011;42(3):e235-236. International Stroke Conference 2011, Los Angeles, CA, February 2011 109. Nogueira RG, Kemmling A, Souza LM, Payabvash S, Yoo AJ, Lev MH. Clinical-Diffusion Mismatch Better Discriminates Infarct Growth than MTT-DWI Mismatch in Patients with MCA-M1 Occlusion and Limited Infarct Core. Stroke. 2011;42(3):e235. International Stroke Conference 2011, Los Angeles, CA, February 2011 110. Souza LC, Lev MH, Franceschi AM, Gonzalez RG, Schaefer PW. Thresholded CT Perfusion Maps Can Accurately Determine Infarct Core when Diffusion-Weighted Imaging is Unavailable, and Have Similar 42 Specificity in Identifying Patients Unlikely to Benefit from Thrombolysis. Proceedings of the 49th Annual Meeting of the American Society of Neuroradiology Seattle, WA 2011. 111. Florin LA, Atkinson WL, Kamalian MS, Pomerantz SR, Lev MH, Romero JM. Comparison of Reformatted Thin Slice NCCT Images with Thick Slices in the Detection of Posterior Fossa Lesions: Are More and Thinner Slices Always Better? Proceedings of the 49th Annual Meeting of the American Society of Neuroradiology Seattle, WA 2011. 112. Souza LC, Lev MH, Franceschi AM, Gonzalez RG, Schaefer PW. Thresholded CTP Maps Can Accurately Determine Infarct Core when DWI is Unavailable, and Have Similar Specificity in Identifying Patients Unlikely to Benefit from Thrombolysis. 97th RSNA meeting (Radiological Society of North America), Chicago, Il, 2011. 113. Kamalian SM, Lev MH, Zhang D, Gonzalez RG, Sahani DV, Pomerantz SR Achieving Standard Diagnostic Quality Head CT at Sub-Millisievert (mSv) Doses: A Multifaceted Approach Optimizing all Available Scan Acquisition Parameters, Post-Processing Options, and Scan Review Presets. 97th RSNA meeting (Radiological Society of North America), Chicago, Il, 2011. * Corresponding author ** Cum Laude Citation 43 Narrative: Clinical Expertise and Innovation Pathway The unifying theme of my academic achievements has been the advancement and dissemination of novel methods for imaging brain structure and function in general – and the neurovascular system in particular – not only through equal parts clinical excellence and translation research, but also through teaching at the local, national, and international levels. I have been internationally recognized as a leader in developing, defining, and communicating the roles of innovative physiological imaging techniques in the management of diverse, clinically important neurological disorders including stroke, cancer, and traumatic brain injury. My numerous peer reviewed publications, reviews, edited textbooks, chapters, and invited lectures - establishing CT angiography (CTA) and perfusion (CTP) imaging as convenient, low cost alternatives to MRI - have significantly influenced the triage of stroke and brain tumor patients worldwide. Indeed, many of my high-impact first and senior authored papers of the past 14 years – some highlighted by journal editorials and the lay press - have pioneered the emergency use of CT/CTA/CTP in patient selection for thrombolytic stroke therapies (“Peer reviewed major references” section of CV, refs 10, 15, 19, 25, 39, 43, 61, 63) , potentially shifted the accepted paradigm regarding the optimal metric for determining admission infarct size using CTP (48, 57, 83, 84, 86), and set the agenda for imaging studies of brain tumor angiogenesis, staging, and outcome prediction (3, 28, 37). Together with colleagues in other disciplines from the US and abroad, my Neurovascular Lab research group has been among the first to highlight unique imaging features of a common parotid gland tumor (5), report an important pitfall in the MRI detection of subarachnoid hemorrhage (9), advance routine 3D post-processing of large CT/MRI datasets (17, 31, 50, 64), explore the influence of clinical history availability on the accuracy of head CT interpretation (20) , pilot efforts in head CT radiation dose reduction (29, 87, “edited textbooks” ref 5), characterize CNS schistosomiasis (“Case reports” ref 8) , schwannomatosis (34), atrial myxoma emboli (“Case reports” ref 7), and amyloid angiopathy-related inflammation (42) , introduce a novel CTA marker for vulnerable carotid plaque (54), describe the CTA “spot sign” – an important predictor of intracranial hematoma expansion (41, 59, 66), and develop tools for brain structure-function correlation with CTP/MRI (75, 83, 89). My research has been well funded by government, foundations, and industry; including recent NIH/DOD support to develop a promising portable device for the detection of brain hemorrhage - "Electrical Impedance Spectroscopy” - effectively an "EKG for the brain", invented at the MGH-MRI center (74). These efforts have been enhanced by leadership on many national committees, notably the AHA perfusion imaging guidelines committee (“National guidelines” ref 2), the AMA Physician Consortium for Performance Improvement (PCPI) Stroke/Stroke Rehab Workgroup, as an organizer of the NIH Stroke Roadmap consortium (“National guidelines” ref 1A/B), as a Past-President of the Eastern Neuroradiological Society, and recently on the NINDS Stroke Progress Review Group (SPRG) for imaging. I am an elected Fellow of both the American Heart Association and the American College of Radiology. Locally, I have received “Partners in Excellence” and “Nathaniel Bowditch” awards for service on the MGH Acute Stroke Quality Taskforce (ASQT) and CT Radiation Dose Optimization teams. I served as Deputy Editor for neuroimaging of the pre-eminent, flagship journal of the Radiological Society of North America, Radiology, from 2007 through 2009, continuing as Special Consultant Deputy Editor, and have been on the editorial board of the American Journal of Neuroradiology since 2000. I also serve as an oral examiner for the American Board of Radiology. Perhaps most importantly - as I hope my CV conveys - I am passionate about teaching and mentoring at all levels, culminating in my Spring 2011 launching (with my mentor, Dr. Gonzalez) of a new, very well received Harvard CME course, “Intensive Review of Neuroradiology”. 44
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