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Supplemental Table 1: List of analytes, cycle information and test methodology endocrine and special chemistry tests for the Canadian Health Measures Survey, Cycle 1 (2007-2009) and Cycle 2 (2009-2011). Cycle 1 Tests Apolipoprote in A1 (ApoA1) Apolipoprote in B (ApoB) Ferritin Instrume nt Tube Type SST Blood/Uri ne B Instrume nt Vitros 5,1 FS Method Immunoturbidimetric/spectrophoto metry (polyclonal antibodies) WHO-IFCC RR SP101 SST B Vitros 5,1 FS Immunoturbidimetric/spectrophoto metry SST B WHO-IFCC RR SP3-08 WHO 2nd IS 80/578 Immulite 2000 Glycated hemoglobin A1c (HbA1c) EDTA whole blood B Vitros 5,1 FS Immunoturbidimetric, End-point / spectrophotometry (anti-HbA1c antibody, polyhapten) Vitros 5,1 FS High sensitivity Creactive protein (HsCRP) SST B Vitros 5,1 FS Immunoturbidimetric, Two-point rate / spectrophotometry (monoclonal antibodies) Vitros 5,1 FS Homocystein e (Hcy) EDTA plasm a SST B Vitros 5,1 FS Enzymatic / reflectance spectrophotometry B Centaur XP Two-site sandwich immunoassay using direct chemiluminescent technology Insulin Cycle 2 Method Solid phase twosite chemiluminescence immunometric assay Immunoturbidimet ric, End-point / spectrophotometry (anti-HbA1c antibody, polyhapten) Immunoturbidimet ric, Two-point rate / spectrophotometry (monoclonal antibodies) Traceability IFCC Reference Method ERM-DA470 Reference Material NIST SRM® 1955 Immulite 2000 Solid phase twosite chemiluminescent immunometric Immulite: WHO NIBSC 1st IRP 66/304 Centaur XP: WHO Parathyroid hormone SST B Red blood cell folate EDTA B Immulite 2000 by DPC Competitive immunoassay using direct chemiluminescent technology Immulite 2000 Serum Folate SST B Immulite 2000 by DPC Competitive immunoassay using direct chemiluminescent technology Immulite 2000 U Vitros 5,1 FS Polymer / surfactant immunochemical reaction then turbidimetric spectrophotometry Vitros 5,1 FS Urine Albumin Liaison / Diasorin assay Direct competitive chemiluminescence immunoassay Solid phase, competitive chemiluminescent enzyme assay involving an automated alkaline denaturation procedure Solid phase, competitive chemiluminescent enzyme assay involving an automated alkaline denaturation procedure Immunoturbidimet ric, Blanked Endpoint / spectrophotometry (polyclonal antibodies) 1st IRP 66/304 In-house preparation of synthetic human PTH (1-84) An internal standard manufactured using qualified materials and measurement procedures An internal standard manufactured using qualified materials and measurement procedures BAMIRMM-LGC (Bundesanstalt für Materialforschung und prüfung/Institute for Reference ethods and Materials/Laborat ory of the Government Chemist) ERMDA470 Reference Material Vitamin B12 SST B Immulite 2000 by DPC Competitive chemiluminescence immunoassay Immulite 2000 Competitive chemiluminescence immunoassay Vitamin D [(25-OH)] plasma EDTA plasm a B DiasorinLiaison Competitive chemiluminescence immunoassay Liaison / Diasorin Competitive chemiluminescence immunoassay An internal standard manufactured using qualified materials and measurement procedures Iisotope dilution liquid chromatography mass spectrometry (IDLC-MS) reference method procedure (RMP) from Ghent University. This RMP is further traceable to NIST SRM 2972
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