Download SDC 2 Demographic and clinical characteristics of 22 documented

13
SDC 2 Demographic and clinical characteristics of 22 documented cases of neonatal melioidosis sorted by year of publication
Ca
Country,
Se
Onset
GA
BW
Mode of
se
year
x
(days)
(wee
(g)
transmiss
1
US,
M
19714
2
Thailand,
2 (37
ks)
ion
Term 2,977
NA†
h)
M
14
33
1,230
HCAI
Clinical features
Thailand,
F
14
32
1,370
HCAI
19888
4
Thailand,
19888
F
IAB
32
1,340
NA
Treatment and duration
Outcome
of antibiotics therapy
Poor feeding,
- B. pseudomallei
- Surgery at 3 h after
Died (119 h
lethargy, fever,
sepsis and meningitis
birth
after birth)
jaundice,
- Depressed right
- Polymyxin B
grunting
frontal skull fracture.
(parenterally and
- Pneumonia
intrathecally), 9 h
- B. pseudomallei and
- Cefotaxime and
Klebsiella sepsis
gentamicin, 14 d
RD, apnea,
- B. pseudomallei
- Ceftazidime, 20 d
Recovered
lethargy
sepsis, sterile CSF
Asymptomatic
- B. pseudomallei
- Penicillin and
Recovered
sepsis
gentamicin, 10 d
Asymptomatic
19888
3
Diagnosis
Recovered
14
5
Thailand,
M
IAB
19888
Prete
1,330
NA
Severe RD
rm
- B. pseudomallei
- Penicillin and
Died (20 h
sepsis
gentamicin, 20 h
after birth)
- Cefotaxime, 4 h
Died (9th date
- Respiratory distress
syndrome
6
Thailand,
M
5
19888
Prete
1,600
HCAI
Apnea
rm
- B. pseudomallei
meningitis and
of life)
Candida sepsis
- Pneumonia
7
8
Malaysia, M
2 (30
19933
h)
Malaysia, M
19987
10
Term 3,400
Term 3,200
HCAI
CAI
RD, lethargy,
- B. pseudomallei and
- Penicillin and
Died (5th date
poor feeding
Acinetobacter sepsis
gentamicin, 1 d then
of life)
and diffuse
- Septic shock and
- Ticarcillin and
macular rash
bronchopneumonia
gentamicin, 2 d
RD, fever,
- B. pseudomallei
- Cloxacillin and
Died (20 h
cough, lethargy,
sepsis
gentamicin
after
poor feeding
- Septic shock,
bronchopneumonia
admission)
15
9
Malaysia, M
8
Term 3,600
CAI
19987
10
Netherla
F
2
32
1,850
Transmit
Fever,
- B. pseudomallei
- Cefotaxime and
irritability,
sepsis and meningitis
gentamicin, then
tachypnea,
- Pneumonia and
- Ceftazidime, 3 weeks
convulsion
omphalitis
RD, sepsis
- B. pseudomallei
- Ceftazidime, 8 weeks
nds,
ted from
sepsis and pneumonia
then
20011
mother-
- Right lung abscess
- Amoxicillin-
to-child‡
11
Australia, M
2
37
3,020
20049
12-
Thailand,
19
200410
20
Malaysia, F
20052
NA NA
8
NA
NA
Term 2,700
Recovered
Recovered
clavulanate, 6 weeks
Transmit
Fever,
- B. pseudomallei
- Ampicillin and
Died (5th date
ted from
tachypnea,
sepsis
gentamicin
of life)
mother-
bradycardia,
- Septic shock and
to-child§
hypotension
respiratory failure
NA
Fever (100%),
- B. pseudomallei
NA
All died
peritonitis (2/8)
sepsis
Fever, RD,
- B. pseudomallei
- Cefotaxime (200
Died (30th
vomiting,
sepsis and pneumonia
mg/kg/day) and
date of life)
CAI
16
lethargy, poor
- Acute Respiratory
piperacillin (200
feeding, pale,
distress syndrome
mg/kg/day), 2 d then
hypotension
- Ceftazidime 50
mg/kg/dose q 12 h
21
India,
F
IAB
35
1,900
NA*
20095
Fever, grunting,
- B. pseudomallei
- Ceftriaxone and
tachypnea,
sepsis
gentamicin, 1 d then
lethargy, poor
- Bronchopneumonia
- Ceftazidime and
peripheral
vancomycin, 10 d then
perfusion
amoxicillin-
Recovered
clavulanate, 2 weeks
22
Thailand,
20116
M
21
Term 2,500
CAI
Fever,
- B. pseudomallei and
- Cloxacillin (200
Died (27th
hematemesis,
methicillin-susceptible
mg/kg/day), 6 d
date of life)
melena,
Staphylococcus aureus
lethargy, seizure sepsis
- Septic shock
17
CAI indicates community-acquired infection; F, Female; HCAI, healthcare-associated infection; IAB, immediately after birth; M, male; NA, not
available; RD, respiratory distress
†
Cultures of the mother's urogenital tract were negative for B. pseudomallei. The father had recent military service in Vietnam, but he had no
contact with the infant. The maternal grandmother had diabetes mellitus.
‡
Placental microabscesses, on prednisone due to ulcerative colitis and had vacation to Thailand. Cervical culture showed B. pseudomallei with
both IgG and IgM enzyme immunoassay were reactive
§
Mastitis at 2nd date before delivery, B. pseudomallei total antibody titer of 1/160 by indirect hemagglutination inhibition with both IgG and IgM
enzyme immunoassay were reactive
*Vaginal swab of the mother or environmental samples from the NICU were not recovered B. pseudomallei