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Abridged CV:
Name:
Prof SF (Sarel) Malan
Rank:
Professor
Telnr:
018 299 2266
E-mail:
[email protected]
Qualifications:
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Experience (teaching and otherwise):
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Research area:
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BPharm
MSc
DTE
PhD
Academic Pharmacy intern / PU for CHE - 1986 – 1987
Logistic Officer / Pharmacist / South African Defence Force 1988 – 1989
Academic assistant / PU for CHE - 1990 – 1991
Lecturer – Full-time temporary / PU for CHE - 1991 – 1993
Lecturer – Permanent / PU for CHE - 1994 – 1997
Senior Lecturer / PU for CHE - 1998 – 2002
Visiting Scientist / Vrije Universiteit, Amsterdam, Netherlands
- 2000 – 2001
Associate Professor / PU for CHE - 2003 – 2004
Visiting Professor / LPTC, Bordeaux I University, France 2004
Professor / NWU - 2005 Drug design and molecular modelling – novel entities with
ion channel or neuroprotective activity, and pro-drugs.
Influence of chemical structure and conformation on
physicochemical properties and membrane permeability of
drugs.
W.J. GELDENHUYS, S.F. MALAN, J. R. BLOOMQUIST,
A.P. MARCHAND, AND C.J. VAN DER SCHYF. 2005.
Pharmacology and Structure-activity Relationships of
Bioactive Polycyclic Cage Compounds: A Focus on
Pentacycloundecane Derivatives. Medicinal Research
Reviews, 25(1):21-48.
DE VILLIERS, M.M., VAN EEDEN, C.M., MALAN, S.F.,
DEVARAKONDA, B., LIEBENBERG, W. & KOLLING, W.M.
2005. The relationship between surface adsorption and the
hydrolysis of amitraz in anionic surfactant solutions. Journal
of environmental science and health, Part B - Pesticides,
food contaminants, and agricultural wastes, 40(2):215-231.
K. DU TOIT, E.E. ELGORASHI, S.F. MALAN, S.E.
DREWES, J. VAN STADEN, N.R. CROUCH AND D.A.
MULHOLLAND. 2005. Anti-inflammatory activity and QSAR
studies of compounds isolated from Hyacinthaceae species
and Tachiadenus longiflorus Griseb.. Bioorganic and
Medicinal Chemistry, 13(7):2561-2568.
H.E. BADENHORST, D.S. MAHARAJ, S.F. MALAN, S.
DAYA AND S. VAN DYK. 2005. Histamine 3 Receptor
antagonists reduce superoxide anion generation and lipid
peroxidation in rat brain homogenates. Journal of Pharmacy
and Pharmacology, 57:781-785
E.E. ELGORASHI, S.F. MALAN, G.I. STAFFORD AND J.
VAN STADEN. 2006. Quantitative structure-activity
relationship studies on acetylcholinestrase enzyme inhibitory
effects of Amaryllidaceae alkaloids. South African Journal
of Botany, 72(2):224-231.
Current projects:
Collaborations:
 E. GROBLER, A. GROBLER, C.J. VAN DER SCHYF AND
S.F. MALAN. 2006. Effect of polycyclic cage amines on the
transmembrane potential of neuronal cells. Bioorganic and
Medicinal Chemistry, 14(4):1176-1181.
 N. VLOK, S.F. MALAN, J.J. BERGH, N. CASTAGNOLI JR.
AND J.P. PETZER. 2006. Inhibition of Monoamine Oxidase
B by Analogues of the Adenosine A2A Receptor Antagonist
(E)-8-(3-chlorostyryl)caffeine (CSC). Bioorganic and
Medicinal Chemistry, 14(10):3512-3521.
 MALAN S.F. 2006. From a cage to a model – From the
heart to the brain: Novel concepts in neuroprotection (ISBN
1-86822-509-7). Inaugural lecture. North-West University,
Potchefstroom. 16 p.
 W. J. GELDENHUYS, S. F. MALAN, J. R. BLOOMQUIST
AND C. J. VAN DER SCHYF. 2007. Structure-activity
Relationships of Pentacycloundecylamines at the N-MethylD-Aspartate Receptor. Bioorganic and Medicinal Chemistry,
15(3):1525-1532
 D. VAN DEN BERG, K.R. ZOELLNER, M.O. OGUNROMBI,
S.F. MALAN, G. TERRE’BLANCHE, N. CASTAGNOLI JR.,
J.J. BERGH, AND J.P. PETZER. 2007. Inhibition of
Monoamine Oxidase B by Selected Benzimidazole and
Caffeine Analogues. Bioorganic and Medicinal Chemistry,
15(11):3692-3702
 W.J. GELDENHUYS, M. HAYES, S.F. MALAN, C.J. VAN
DER SCHYF AND D.D. ALLEN. 2007. Receptor Surface
Models in the Classroom: Introducing Molecular Modeling to
Students in a 3D World. Journal of Chemical Education,
84(6):979-982.
 K. DU TOIT, E.E. ELGORASHI, S.F. MALAN, S.E.
DREWES, J. VAN STADEN, N.R. CROUCH AND D.A.
MULHOLLAND. 2007. Antibacterial activity and QSAR of
homoisoflavanones isolated from six Hyacinthaceae
species. South African Journal of Botany, 73(2):236-241.
 M.O. OGUNROMBI, S.F. MALAN, G. TERRE’BLANCHE, N.
CASTAGNOLI, JR., J.J. BERGH, AND J.P. PETZER. 2007.
Neurotoxicity Studies with the Monoamine oxidase B
substrate 1-Methyl-3-Phenyl-3-Pyrroline. Life Sciences,
81(2007):458-467
 Drug design and molecular modelling – novel entities with
ion channel or neuroprotective activity, and pro-drugs.
 Influence of chemical structure and conformation on
physicochemical properties and membrane permeability of
drugs.
 Executive Committee of the Academy of Pharmaceutical
Sciences.
 Executive Committee of the Pharmaceutical Society of South
Africa.
 Expert committee of the Medicines Control Council,
Pharmaceutical/Bioavailability and Analytical.
 Standards Generating Body (SGB) for Pharmacy.
 NRF Advisory Panel – Pharmaceutical and Biomedical
Technology.
 WHO International Non-proprietary Name (INN) Expert
Panel.