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Impaired Pial Arteriolar Reactivity to Hypercapnia During Hyperammonemia Depends on Glutamine Synthesis by Takahiko Hirata, Raymond C. Koehler, Tetsu Kawaguchi, Saul W. Brusilow, and Richard J. Traystman Stroke Volume 27(4):729-736 April 1, 1996 Copyright © American Heart Association, Inc. All rights reserved. Pial arteriole diameter (mean±SE) as a percent of baseline during the 6-hour infusion period of NaAcetate or NH4Acetate under normocapnic conditions. Takahiko Hirata et al. Stroke. 1996;27:729-736 Copyright © American Heart Association, Inc. All rights reserved. Percent change in pial arteriole diameter (mean±SE) during 10 minutes of hypercapnia before infusion of sodium acetate or ammonium acetate but after treatment with vehicle, MSO, or BSO (baseline response) and during 10 minutes of hypercapnia at 6 hours of salt infusion in the same rats. Takahiko Hirata et al. Stroke. 1996;27:729-736 Copyright © American Heart Association, Inc. All rights reserved. CBF and cerebral vascular resistance (mean±SE) during normocapnia and 10 minutes of hypercapnia at 6 hours of sodium acetate or ammonium acetate in groups pretreated with vehicle, MSO, or BSO. *P<.05 from normocapnia by paired t test; †P<.05 from hypercapnic value in sodium acetate group with corresponding pretreatment by Newman-Keuls test; and #P<.05 from hypercapnic values in MSO+ammonium acetate group by Newman-Keuls test. Takahiko Hirata et al. Stroke. 1996;27:729-736 Copyright © American Heart Association, Inc. All rights reserved. Blood flow (mean±SE) to cerebellum, diencephalon, midbrain, and combined medulla and pons during normocapnia and 10 minutes of hypercapnia at 6 hours of sodium acetate or ammonium acetate in groups pretreated with vehicle, MSO, or BSO. *P<.05 from normocapnia by paired t test; †P<.05 from hypercapnic value in sodium acetate group with corresponding pretreatment by Newman-Keuls test; and #P<.05 from hypercapnic values in MSO+ammonium acetate group by Newman-Keuls test. Takahiko Hirata et al. Stroke. 1996;27:729-736 Copyright © American Heart Association, Inc. All rights reserved.