Download during 10 minutes of hypercapnia before infusion of sodium acetate

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Impaired Pial Arteriolar Reactivity to Hypercapnia During
Hyperammonemia Depends on Glutamine Synthesis
by Takahiko Hirata, Raymond C. Koehler, Tetsu Kawaguchi, Saul W. Brusilow, and
Richard J. Traystman
Stroke
Volume 27(4):729-736
April 1, 1996
Copyright © American Heart Association, Inc. All rights reserved.
Pial arteriole diameter (mean±SE) as a percent of baseline during the 6-hour infusion period of
NaAcetate or NH4Acetate under normocapnic conditions.
Takahiko Hirata et al. Stroke. 1996;27:729-736
Copyright © American Heart Association, Inc. All rights reserved.
Percent change in pial arteriole diameter (mean±SE) during 10 minutes of hypercapnia before
infusion of sodium acetate or ammonium acetate but after treatment with vehicle, MSO, or BSO
(baseline response) and during 10 minutes of hypercapnia at 6 hours of salt infusion in the same
rats.
Takahiko Hirata et al. Stroke. 1996;27:729-736
Copyright © American Heart Association, Inc. All rights reserved.
CBF and cerebral vascular resistance (mean±SE) during normocapnia and 10 minutes of
hypercapnia at 6 hours of sodium acetate or ammonium acetate in groups pretreated with
vehicle, MSO, or BSO. *P<.05 from normocapnia by paired t test; †P<.05 from hypercapnic value
in sodium acetate group with corresponding pretreatment by Newman-Keuls test; and #P<.05
from hypercapnic values in MSO+ammonium acetate group by Newman-Keuls test.
Takahiko Hirata et al. Stroke. 1996;27:729-736
Copyright © American Heart Association, Inc. All rights reserved.
Blood flow (mean±SE) to cerebellum, diencephalon, midbrain, and combined medulla and pons
during normocapnia and 10 minutes of hypercapnia at 6 hours of sodium acetate or ammonium
acetate in groups pretreated with vehicle, MSO, or BSO. *P<.05 from normocapnia by paired t
test; †P<.05 from hypercapnic value in sodium acetate group with corresponding pretreatment
by Newman-Keuls test; and #P<.05 from hypercapnic values in MSO+ammonium acetate group
by Newman-Keuls test.
Takahiko Hirata et al. Stroke. 1996;27:729-736
Copyright © American Heart Association, Inc. All rights reserved.
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