Download Table S2.

Table S2. Abbreviations of pathway enzymes, their E.C., gene name/numbers and reaction(s) they catalyze.
Abbr.
Enzyme name
E.C.
Gene
Gene
name
number
Reaction(s)
RN
Purine Metabolism
AK
Adenylate kinase
2.7.4.3
adk
MSU_0439
ATP + AMP = 2 ADP
R00127
ASL
Adenylosuccinate lyase
4.3.2.2
purB
MSU_0708
N6-(1,2-dicarboxyethyl) AMP =
R01083
fumarate + AMP
ASS
Adenylosuccinate synthase
6.3.4.4
purA
GTP + IMP + L-aspartate = GDP +
MSU_0292
R01135
phosphate +
N6-(1,2-dicarboxyethyl)-AMP
GK
Guanosine kinase
2.7.1.73
gsk
?
GMPS
Guanosine monophosphate
6.3.5.2
guaA
MSU_0479
synthase
ATP + Guanosine = ADP + GMP
R01228
ATP + xanthosine 5'-phosphate + L-
R01231
glutamine + H2O = AMP +
diphosphate + GMP + L-glutamate
GUK
Guanylate kinase
2.7.4.8
gmk
MSU_0372
ATP + GMP = ADP + GDP
R00332
IK
Inosine kinase
2.7.1.73
gsk
?
ATP + inosine = ADP + IMP
R01131
IMPD
Inosine monophosphate
1.1.1.20
guaB
MSU_0478
5'-phosphate + NAD+ + H2O =
R01130
dehydrogenase
5
xanthosine 5'-phosphate + NADH +
H+
NT5
5'‐nucleotidase
3.1.3.5
ushA
?
5'-ribonucleotide + H2O = a
R07297
ribonucleoside + phosphate
PK
Pyruvate kinase
2.7.1.40
pyk
MSU_0701
phosphoenolpyruvate + dADP =
R01138
pyruvate + dATP
R01858
phosphoenolpyruvate + dGDP =
R00200
pyruvate + dGTP
phosphoenolpyruvate + ADP =
pyruvate + ATP
PNP
Purine‐nucleoside
2.4.2.1
deoD
MSU_0073
D‐ribose 1‐phosphate
phosphorylase
RDR
Ribonucleoside-
adenosine + phosphate = adenine +
1.17.4.1
diphosphate reductase
nrdA
MSU_0309
2'-deoxyribonucleoside diphosphate
nrdF
MSU_0311
+ thioredoxin disulfide + H2O =
R04294
ribonucleoside diphosphate +
thioredoxin
TRX
Thioredoxin-disulfide
reductase
1.8.1.9
trxB
MSU_0480
thioredoxin + NADP+ = thioredoxin
disulfide + NADPH + H+
R02016
Abbr.
Enzyme name
E.C.
Gene
Gene
name
number
upp
MSU_0875
Reaction(s)
RN
Pyrimidine Metabolism
UPRT
Uracil
2.4.2.9
phosphoribosyltransferase
UMP + diphosphate = uracil + 5-
R00966
phospho-alpha-D-ribose 1diphosphate
UMPK
Uridylate kinase
2.7.4.22
pyrH
MSU_0503
ATP + UMP = ADP + UDP
R00158
PK
Pyruvate kinase
2.7.1.40
pyk
MSU_0701
phosphoenolpyruvate + UDP =
R00659
pyruvate + UTP
R02320
phosphoenolpyruvate + dCDP =
R02320
pyruvate + dCTP
phosphoenolpyruvate + dTDP =
pyruvate + dTTP
CTPS
CTP synthase
6.3.4.2
pyrG
MSU_0362
ATP + UTP + NH3 = ADP +
R00571
phosphate + CTP
PFK
6-Phosphofructokinase
2.7.1.11
pfk
MSU_0702
CTP + D-Fructose 6-phosphate =
R00767
CDP + D-Fructose 1,6-bisphosphate
RDR
Ribonucleoside‐
1.17.4.1
diphosphate reductase
nrdA
MSU_0309
2'-deoxyribonucleoside diphosphate
nrdF
MSU_0311
+ thioredoxin disulfide + H2O =
R04294
ribonucleoside diphosphate +
thioredoxin
TRX
Thioredoxin-disulfide
1.8.1.9
trx
MSU_0480
reductase
TPP
Thymidine phosphorylase
thioredoxin + NADP+ = thioredoxin
R02016
disulfide + NADPH + H+
2.4.2.4
deoA
?
Thymidine + Orthophosphate =
R01570
Thymine + 2-Deoxy-D-ribose
1-phosphate
TK
Thymidine kinase
2.7.1.21
tdk
MSU_0066
ATP + thymidine = ADP +
R01567
thymidine 5'-phosphate
TMPK
Thymidylate kinase
2.7.4.9
tmk
MSU_0829
2.7.1.15
rbsK
?
ATP + dTMP = ADP + dTDP
R02094
ATP + D-ribose = ADP + D-ribose
R01051
Ribose Metabolism
RIBK
Ribokinase
5-phosphate
PPM
Phosphoglucomutase
5.4.2.2
cpsG
MSU_0035
alpha-D-Ribose 1-phosphate = D-
R01057
Ribose 5-phosphate
PRPPS
Ribose-phosphate
diphosphokinase
2.7.6.1
prs
MSU_0015
ATP + D-ribose 5-phosphate =
AMP + PRPP
R01049
Abbr.
Enzyme name
E.C.
Gene
Gene
name
number
pgiB
MSU_0013
Reaction(s)
RN
D-glucose 6-phosphate = D-fructose
R00771
Glycolysis
PGI
Glucose-6-phosphate
5.3.1.9
isomerase
PFK
6-phosphofructokinase
6-phosphate
2.7.1.11
pfk
MSU_0702
ATP + D-fructose 6-phosphate =
R00756
ADP + D-fructose 1,6-bisphosphate
FBA
Fructose biphosphate
4.1.2.13
fba
MSU_0475
aldolase
D-fructose 1,6-bisphosphate =
R01068
glycerone phosphate + Dglyceraldehyde
TIM
Triose phosphate
5.3.1.1
tim
MSU_0071
isomerase
GAPDH
Glyceraldehyde-3-
D-glyceraldehyde 3-phosphate =
R01015
glycerone phosphate
1.2.1.12
gap
MSU_0835
phosphate dehydrogenase
D-glyceraldehyde 3-phosphate +
R01061
phosphate + NAD+ =
3-phospho-D-glyceroyl phosphate +
NADH + H+
GAPN
NADP-dependent
1.2.1.9
gapN
MSU_0029
D-glyceraldehyde 3-phosphate +
glyceraldehyde
NADP+ + H2O = 3-phospho-D-
dehydrogenase
glycerate +
R01058
NADPH + 2 H+
PGK
Phosphoglycerate kinase
2.7.2.3
pgk
MSU_0072
ATP + 3-phospho-D-glycerate =
R01512
ADP + 3-phospho-D-glyceroyl
phosphate
PGM
Phosphoglycerate mutase
5.4.2.1
gpml
MSU_0072
2-phospho-D-glycerate = 3-
R01518
phospho-D-glycerate
ENO
Enolase
4.2.1.11
eno
MSU_0703
2-phospho-D-glycerate =
R00658
phosphoenolpyruvate + H2O
PYK
Pyruvate kinase
2.7.1.40
pyk
MSU_0701
ADP + phosphoenolpyruvate = ATP
R00200
+ pyruvate
LDH
L-lactate dehydrogenase
1.1.1.27
ldh
MSU_0299
pyruvate + NADH + H+ = lactate +
R00703
NAD+
Lipid metabolism
FBA
Fructose biphosphate
4.1.2.13
fba
MSU_0475
aldolase
D-fructose 1,6-bisphosphate =
R01068
glycerone phosphate + Dglyceraldehyde
ADH
Alcohol dehydrogenase
1.1.1.1
adh
?
glyceraldehyde + NADH + H+ =
glycerol + NAD+
R01041
Abbr.
Enzyme name
E.C.
Gene
Gene
name
number
plsB
?
Reaction(s)
RN
acyl-CoA + sn-glycerol 3-phosphate
R00851
Lipid Metabolism
G3PAT
Glycerol-3-phosphate O-
2.3.1.15
acyltransferase
= CoA + 1-acyl-sn-glycerol
3-phosphate
1aG3AT
1-acyl-sn-glycerol-3-
2.3.1.51
plsC
?
phosphate acyltransferase
acyl-CoA + 1-acyl-sn-glycerol 3-
R02241
phosphate = CoA +
1,2-diacyl-sn-glycerol 3-phosphate
GK
Glycerol kinase
2.7.1.30
glpk
MSU_0290
glycerol + ATP = ADP + glycerol
R00847
3‐phosphate
CDPDG
Phosphatidate
2.7.7.41
cdsA2
cytidylyltransferase
PGP
CDP-diacylglycerol--
MSU_0501
?
2.7.8.5
pgsA
MSU_0466
CTP + phosphatidate = diphosphate
R01799
+ CDP-diacylglycerol
CDP-diacylglycerol + sn-glycerol 3-
glycerol-3-phosphate 3-
phosphate = CMP +
phosphatidyltransferase
3(3-sn-phosphatidyl)-sn-glycerol 1-
R01801
phosphate
PGPB
Phosphatidyl
3.1.3.27
pgpA
?
glycerophosphatase
phosphatidylglycerophosphate +
R02029
H2O = phosphatidylglycerol +
phosphate
CLS/PD
Cardiolipin synthase
2.7.8.-
cls
MSU_0014
2 Phosphatidylglycerol =
R07390
Cardiolipin + Glycerol
CK
Choline kinase
2.7.1.32
licA
MSU_0492
ATP + choline = ADP + O-
R01021
phosphocholine
CPCT
Choline-phosphate
2.7.7.15
pct
cytidylyltransferase
GPDH
Glycerol‐3‐phosphate
1.1.99.5
gpsA
MSU_0351
CTP + choline phosphate =
(?)
diphosphate + CDP-choline
MSU_0539
(?)
dehydrogenase
R01890
glycerol 3‐phosphate + NAD+ =
glycerone phosphate + NADH + H+
Nicotinate metabolism
PNCB
Nicotinate
2.4.2.11
pncB
phosphorybosyltransferase
MSU_0347
nicotinate +
MSU_0348
5-phospho-alpha-D-ribose 1-
R01724
diphosphate = nicotinate Dribonucleotide + diphosphate
NADD
Nicotinate-nucleotide
adenylyltransferase
2.7.7.18
nadD
MSU_0351
ATP + nicotinate ribonucleotide =
diphosphate + deamido-NAD+
R03005
Abbr.
Enzyme name
E.C.
Gene
Gene
name
number
metK
MSU_0082
Reaction(s)
RN
Amino acid metabolism
MAT
methionine
2.5.1.6
adenosyltransferase
DCM
DNA (cytosine‐5‐)‐
ATP + L-methionine + H2O =
R00177
phosphate + PPi +SAM
2.1.1.37
hpaII
MSU_0397
M
methyltransferase
SAM + DNA = S-adenosyl-L-
R00380
homocysteine + DNA
containing 5-methylcytosine
SAMT
S-adenosyl-L-methionine-
2.1.1.12
mraW
MSU_0409
S-adenosyl-L-methionine + L-
dependent
methionine = S-adenosyl-L-
methyltransferase
homocysteine +
R00649
S-methyl-L-methionine
TRMD
tRNA (guanine-N(7)-)-
2.1.1.33
trmD
MSU_0450
methyltransferase
S-adenosyl-L-methionine + tRNA =
R00600
S-adenosyl-L-homocysteine +
tRNA
containing N7-methylguanine
TRMU
tRNA (5-
2.1.1.61
trmU
MSU_0305
S-adenosyl-L-methionine + tRNA =
methylaminomethyl-2-
S-adenosyl-L-homocysteine +
thiouridylate)-
tRNA
methyltransferase
containing 5-methylaminomethyl-2-
R00601
thiouridylate
AHC
adenosylhomocysteinase
3.3.1.1
ahcy
?
S-adenosyl-L-homocysteine + H2O
R00192
= L-homocysteine + adenosine
GAT
aspartyl/glutamyl-
6.3.5.6
gatA
MSU_0487
ATP + L-glutamyl-tRNA(Gln/Asn)
R04212
tRNA(Asn/Gln)
6.3.5.7
gatB
MSU_0787
+ L-glutamine = ADP + phosphate
R03905
gatC
MSU_0486
+ L-glutaminyl-tRNA(Gln/Asn) +
amidotransferase
L-glutamate
atRNA
Aminoacyl-tRNA
synthases
6.1.1.-
Several
ATP + amino acid + tRNA = AMP
genes
+ diphosphate + aminoacyl-tRNA