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Guidelines for the Use and Application of Rodent End Point Score-sheet The accompanying score sheet is designed as a basic or generic scoring system for the scoring of rodents. The sheets are designed to make the scoring system as objective as possible and list the cardinal clinical signs that are observable and measurable and should be used as a starting point for any invasive procedure. Score sheets should be created specifically for each scientific procedure. Additional criteria must be added to each scoresheet to reflect the possible clinical outcomes and complications of the technique. As an example, techniques associated with the kidney should include criteria for kidney function (urine output, renal enzymes) together with criteria designed to score septicaemia (temp, hydration, white cell counts). A few examples are given below: Liver Abdominal pain Liver enzymes Jaundice Tumours Size of cutaneous tumours (max 1cm3) Spread of metastasis (imaging, muscle wasting) Ulceration or abscessation of tumour Further Reading Humane Endpoints for Animals Used in Biomedical Research and Testing (2000) ILAR Journal V41(2) http://www.olis.oecd.org/olis/2000doc.nsf/4f7adc214b91a685c12569fa005d0ee7/c125692700623b74c12569 bb005aa3d5/$FILE/00087372.pdf Recognition and Alleviation of Distress in Laboratory Animals (2008) Committee on Recognition and Alleviation of Distress in Laboratory Animals, National Research Council ISBN: 0-309-10818-7, 132 pages, http://www.nap.edu/catalog/11931.html Olfert ED, Goodson DL (2000) Humane endpoints for infectious disease animal models ILAR J 41:99-104 Paster EV, Villines KA, Dickman DL (2004) Endpoints for mouse abdominal tumour models: refinement of current criteria. Comp Med 59:234-241. Ray MA.; Johnston NA.; Verhulst ST, Rita A.and Toth LA. (2010) Identification of Markers for Imminent Death in Mice used in Longevity and Aging Research JAASLAS 49:3 282-288(7)