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1 2 3 4 5 6 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Neurotransmitter Nerve impulse Neuron Target cells (a) Nervous system Endocrine cells Target cells Hormone in bloodstream (b) Endocrine system 7 8 9 10 11 12 13 14 15 16 17 18 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Hydrophilic Receptor in Target hormone plasma cell membrane Transport protein Secondmessenger activation Free hormones Bound hormone Hydrophobic hormone Receptor in nucleus Tissue fluid Blood 19 20 21 22 23 24 25 26 27 28 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Telencephalon of brain Future hypothalamus Neurohypophyseal bud Hypophyseal pouch Pharynx Tongue Future thyroid gland Mouth (a) 4 weeks Hypothalamus Hypothalamus Optic chiasm Neurohypophyseal bud Pituitary stalk Posterior lobe Hypophyseal pouch Anterior lobe Sphenoid bone Pharynx Pharynx (b) 8 weeks (c) 16 weeks 29 30 31