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Publikationen Martin Fassnacht (Stand Januar 2015) 1. Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M 2015 Mutations in the deubiquitinase gene USP8 cause Cushing's disease. Nat Genet 47:31-38 2. Deutschbein T, Fassnacht M, Weismann D, Reincke M, Mann K, Petersenn S 2015 Treatment of malignant phaeochromocytoma with a combination of cyclophosphamide, vincristine and dacarbazine: own experience and overview of the contemporary literature. Clin Endocrinol (Oxf) 82:84-90 3. Faria AM, Sbiera S, Ribeiro TC, Soares IC, Mariani BM, Freire DS, de Sousa GR, Lerario AM, Ronchi CL, Deutschbein T, Wakamatsu A, Alves VA, Zerbini MC, Mendonca BB, Fragoso MC, Latronico AC, Fassnacht M, Almeida MQ 2014 Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer. Clin Endocrinol (Oxf) 4. Ronchi CL, Sbiera S, Volante M, Steinhauer S, Scott-Wild V, Altieri B, Kroiss M, Bala M, Papotti M, Deutschbein T, Terzolo M, Fassnacht M, Allolio B 2014 CYP2W1 is highly expressed in adrenal glands and is positively associated with the response to mitotane in adrenocortical carcinoma. PLoS One 9:e105855 5. Eisenhofer G, Brown S, Peitzsch M, Pelzel D, Lattke P, Glockner S, Stell A, Prejbisz A, Fassnacht M, Beuschlein F, Januszewicz A, Siegert G, Reichmann H 2014 Levodopa therapy in Parkinson's disease: influence on liquid chromatographic tandem mass spectrometricbased measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine. Ann Clin Biochem 51:38-46 6. Corteville C, Fassnacht M, Bueter M 2014 [Surgery as pluripotent instrument for metabolic disease. What are the mechanisms?]. Chirurg 85:963-968 7. Ronchi CL, Kroiss M, Sbiera S, Deutschbein T, Fassnacht M 2014 EJE prize 2014: current and evolving treatment options in adrenocortical carcinoma: where do we stand and where do we want to go? Eur J Endocrinol 171:R1-R11 8. Di Dalmazi G, Berr CM, Fassnacht M, Beuschlein F, Reincke M 2014 Adrenal function after adrenalectomy for subclinical hypercortisolism and Cushing's syndrome: a systematic review of the literature. J Clin Endocrinol Metab 99:2637-2645 9. Assie G, Letouze E, Fassnacht M, Jouinot A, Luscap W, Barreau O, Omeiri H, Rodriguez S, Perlemoine K, Rene-Corail F, Elarouci N, Sbiera S, Kroiss M, Allolio B, Waldmann J, Quinkler M, Mannelli M, Mantero F, Papathomas T, De Krijger R, Tabarin A, Kerlan V, Baudin E, Tissier F, Dousset B, Groussin L, Amar L, Clauser E, Bertagna X, Ragazzon B, Beuschlein F, Libe R, de Reynies A, Bertherat J 2014 Integrated genomic characterization of adrenocortical carcinoma. Nat Genet 46:607-612 10. Baecher S, Kroiss M, Fassnacht M, Vogeser M 2014 No endogenous ouabain is detectable in human plasma by ultra-sensitive UPLC-MS/MS. Clin Chim Acta 431:87-92 11. Sue M, Martucci V, Frey F, Lenders J, Timmers HJ, Peczkowska M, Prejbisz A, Swantje B, Bornstein SR, Arlt W, Fassnacht M, Beuschlein F, Robledo M, Pacak K, Eisenhofer G 2014 Lack of Utility of SDHB Mutation Testing in Adrenergic Metastatic Phaeochromocytoma. Eur J Endocrinol 12. Weismann D, Peitzsch M, Raida A, Prejbisz A, Gosk M, Riester A, Willenberg HS, Klemm R, Manz G, Deutschbein T, Kroiss M, Darr R, Bidlingmaier M, Januszewicz A, Eisenhofer G, Fassnacht M 2014 Measurements of Plasma Metanephrines by Immunoassay versus LCMS/MS for Diagnosis of Pheochromocytoma. Eur J Endocrinol 13. Heinze B, Herrmann LJ, Fassnacht M, Ronchi CL, Willenberg HS, Quinkler M, Reisch N, Zink M, Allolio B, Hahner S 2014 Less common genotype variants of TP53 polymorphisms are associated with poor outcome in adult patients with adrenocortical carcinoma. Eur J Endocrinol 170:707-717 14. Berruti A, Fassnacht M, Haak H, Else T, Baudin E, Sperone P, Kroiss M, Kerkhofs T, Williams AR, Ardito A, Leboulleux S, Volante M, Deutschbein T, Feelders R, Ronchi C, Grisanti S, Gelderblom H, Porpiglia F, Papotti M, Hammer GD, Allolio B, Terzolo M 2014 Prognostic role of overt hypercortisolism in completely operated patients with adrenocortical cancer. Eur Urol 65:832-838 15. Weismann D, Liu D, Bergen T, Peitzsch M, Raida A, Wagner M, Fassnacht M, Weidemann F, Allolio B 2014 Hypertension and hypertensive cardiomyopathy in patients with a relapsefree history of phaeochromocytoma. Clin Endocrinol (Oxf) 16. Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullie M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M 2014 Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. J Clin Endocrinol Metab 99:E2093-2100 17. Beuschlein F, Fassnacht M, Assie G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, RizkRabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B 2014 Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. N Engl J Med 370:10191028 18. Fenske WK, Christ-Crain M, Horning A, Simet J, Szinnai G, Fassnacht M, Rutishauser J, Bichet DG, Stork S, Allolio B 2014 A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. J Am Soc Nephrol 25:2376-2383 19. Hahner S, Spinnler C, Fassnacht M, Burger-Stritt S, Lang K, Milovanovic D, Beuschlein F, Willenberg HS, Quinkler M, Allolio B 2014 High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency - a prospective study. J Clin Endocrinol Metab:jc20143191 20. Drechsler C, Schneider A, Gutjahr-Lengsfeld L, Kroiss M, Carrero JJ, Krane V, Allolio B, Wanner C, Fassnacht M 2014 Thyroid function, cardiovascular events, and mortality in diabetic hemodialysis patients. Am J Kidney Dis 63:988-996 21. Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ 2014 PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit. Nat Commun 5:5680 22. Jurowich CF, Seyfried F, Miras AD, Bueter M, Deckelmann J, Fassnacht M, Germer CT, Thalheimer A 2014 Does bariatric surgery change olfactory perception? Results of the early postoperative course. Int J Colorectal Dis 29:253-260 23. Fassnacht M, Kroiss M, Allolio B 2013 Update in adrenocortical carcinoma. J Clin Endocrinol Metab 98:4551-4564 24. Kerkhofs TM, Baudin E, Terzolo M, Allolio B, Chadarevian R, Mueller HH, Skogseid B, Leboulleux S, Mantero F, Haak HR, Fassnacht M 2013 Comparison of two mitotane starting dose regimens in patients with advanced adrenocortical carcinoma. J Clin Endocrinol Metab 98:4759-4767 25. Verburg FA, Reiners C, Grelle I, Barth H, Fassnacht M, Luster M 2013 Calcium stimulated calcitonin measurement: a procedural proposal. Exp Clin Endocrinol Diabetes 121:318-320 26. Jurowich C, Fassnacht M, Kroiss M, Deutschbein T, Germer CT, Reibetanz J 2013 Is there a role for laparoscopic adrenalectomy in patients with suspected adrenocortical carcinoma? A critical appraisal of the literature. Horm Metab Res 45:130-136 27. Frey A, Kroiss M, Berliner D, Seifert M, Allolio B, Guder G, Ertl G, Angermann CE, Stork S, Fassnacht M 2013 Prognostic impact of subclinical thyroid dysfunction in heart failure. Int J Cardiol 168:300-305 28. Weismann D, Pelka T, Bender G, Jurowich C, Fassnacht M, Thalheimer A, Allolio B 2013 Bariatric surgery for morbid obesity in craniopharyngioma. Clin Endocrinol (Oxf) 78:385-390 29. Terzolo M, Baudin AE, Ardito A, Kroiss M, Leboulleux S, Daffara F, Perotti P, Feelders RA, deVries JH, Zaggia B, De Francia S, Volante M, Haak HR, Allolio B, Al Ghuzlan A, Fassnacht M, Berruti A 2013 Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adjuvantly following radical resection. Eur J Endocrinol 169:263-270 30. Sbiera S, Kroiss M, Thamm T, Beyer M, Majidi F, Kuehner D, Wobser M, Becker JC, Adam P, Ronchi C, Allolio B, Fassnacht M 2013 Survivin in adrenocortical tumors - pathophysiological implications and therapeutic potential. Horm Metab Res 45:137-146 31. Hahner S, Kreissl MC, Fassnacht M, Haenscheid H, Bock S, Verburg FA, Knoedler P, Lang K, Reiners C, Buck AK, Allolio B, Schirbel A 2013 Functional characterization of adrenal lesions using [123I]IMTO-SPECT/CT. J Clin Endocrinol Metab 98:1508-1518 32. Chortis V, Taylor AE, Schneider P, Tomlinson JW, Hughes BA, O'Neil DM, Libe R, Allolio B, Bertagna X, Bertherat J, Beuschlein F, Fassnacht M, Karavitaki N, Mannelli M, Mantero F, Opocher G, Porfiri E, Quinkler M, Sherlock M, Terzolo M, Nightingale P, Shackleton CH, Stewart PM, Hahner S, Arlt W 2013 Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5alpha-reductase, explaining the need for personalized glucocorticoid and androgen replacement. J Clin Endocrinol Metab 98:161-171 33. Ronchi CL, Sbiera S, Leich E, Henzel K, Rosenwald A, Allolio B, Fassnacht M 2013 Single nucleotide polymorphism array profiling of adrenocortical tumors--evidence for an adenoma carcinoma sequence? PLoS One 8:e73959 34. Drechsler C, Ritz E, Tomaschitz A, Pilz S, Schonfeld S, Blouin K, Bidlingmaier M, Hammer F, Krane V, Marz W, Allolio B, Fassnacht M, Wanner C 2013 Aldosterone and cortisol affect the risk of sudden cardiac death in haemodialysis patients. Eur Heart J 34:578-587 35. Erdogan I, Deutschbein T, Jurowich C, Kroiss M, Ronchi C, Quinkler M, Waldmann J, Willenberg HS, Beuschlein F, Fottner C, Klose S, Heidemeier A, Brix D, Fenske W, Hahner S, Reibetanz J, Allolio B, Fassnacht M, German Adrenocortical Carcinoma Study G 2013 The role of surgery in the management of recurrent adrenocortical carcinoma. J Clin Endocrinol Metab 98:181-191 36. Peitzsch M, Pelzel D, Glockner S, Prejbisz A, Fassnacht M, Beuschlein F, Januszewicz A, Siegert G, Eisenhofer G 2013 Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites. Clin Chim Acta 418:50-58 37. Reibetanz J, Jurowich C, Allolio B, Fassnacht M, Fassnacht M 2013 Reply to letter: "regional lymphadenectomy for adrenocortical carcinoma". Ann Surg 257:e15 38. Kreissl MC, Schirbel A, Fassnacht M, Haenscheid H, Verburg FA, Bock S, Saeger W, Knoedler P, Reiners C, Buck AK, Allolio B, Hahner S 2013 [(1)(2)(3)I]Iodometomidate imaging in adrenocortical carcinoma. J Clin Endocrinol Metab 98:2755-2764 39. Volante M, Terzolo M, Fassnacht M, Rapa I, Germano A, Sbiera S, Daffara F, Sperone P, Scagliotti G, Allolio B, Papotti M, Berruti A 2012 Ribonucleotide reductase large subunit (RRM1) gene expression may predict efficacy of adjuvant mitotane in adrenocortical cancer. Clin Cancer Res 18:3452-3461 40. Amar L, Fassnacht M, Gimenez-Roqueplo AP, Januszewicz A, Prejbisz A, Timmers H, Plouin PF 2012 Long-term postoperative follow-up in patients with apparently benign pheochromocytoma and paraganglioma. Horm Metab Res 44:385-389 41. Ronchi CL, Leich E, Sbiera S, Weismann D, Rosenwald A, Allolio B, Fassnacht M 2012 Single nucleotide polymorphism microarray analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways. Neoplasia 14:206-218 42. Hammer GD, Fassnacht M, Lalli E 2012 Adrenal cancer: scientific advances. Mol Cell Endocrinol 351:1 43. Kroiss M, Quinkler M, Johanssen S, van Erp NP, Lankheet N, Pollinger A, Laubner K, Strasburger CJ, Hahner S, Muller HH, Allolio B, Fassnacht M 2012 Sunitinib in refractory adrenocortical carcinoma: a phase II, single-arm, open-label trial. J Clin Endocrinol Metab 97:3495-3503 44. Ronchi CL, Sbiera S, Leich E, Tissier F, Steinhauer S, Deutschbein T, Fassnacht M, Allolio B 2012 Low SGK1 expression in human adrenocortical tumors is associated with ACTHindependent glucocorticoid secretion and poor prognosis. J Clin Endocrinol Metab 97:E2251-2260 45. Hahner S, Kreissl MC, Fassnacht M, Haenscheid H, Knoedler P, Lang K, Buck AK, Reiners C, Allolio B, Schirbel A 2012 [131I]iodometomidate for targeted radionuclide therapy of advanced adrenocortical carcinoma. J Clin Endocrinol Metab 97:914-922 46. Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, Welin S, Schade-Brittinger C, Lacroix A, Jarzab B, Sorbye H, Torpy DJ, Stepan V, Schteingart DE, Arlt W, Kroiss M, Leboulleux S, Sperone P, Sundin A, Hermsen I, Hahner S, Willenberg HS, Tabarin A, Quinkler M, de la Fouchardiere C, Schlumberger M, Mantero F, Weismann D, Beuschlein F, Gelderblom H, Wilmink H, Sender M, Edgerly M, Kenn W, Fojo T, Muller HH, Skogseid B, Group F-AS 2012 Combination chemotherapy in advanced adrenocortical carcinoma. N Engl J Med 366:2189-2197 47. Reibetanz J, Kroiss M, Deutschbein T, Fenske W, Gasser M, Jurowich C, Germer CT, Allolio B, Fassnacht M 2012 [German adrenocortical carcinoma registry. Surgical therapy results and follow-up treatment]. Chirurg 83:528-535 48. Herrmann LJ, Heinze B, Fassnacht M, Willenberg HS, Quinkler M, Reisch N, Zink M, Allolio B, Hahner S 2012 TP53 germline mutations in adult patients with adrenocortical carcinoma. J Clin Endocrinol Metab 97:E476-485 49. Reibetanz J, Jurowich C, Erdogan I, Nies C, Rayes N, Dralle H, Behrend M, Allolio B, Fassnacht M, German ACCsg 2012 Impact of lymphadenectomy on the oncologic outcome of patients with adrenocortical carcinoma. Ann Surg 255:363-369 50. Waldmann J, Patsalis N, Fendrich V, Langer P, Saeger W, Chaloupka B, Ramaswamy A, Fassnacht M, Bartsch DK, Slater EP 2012 Clinical impact of TP53 alterations in adrenocortical carcinomas. Langenbecks Arch Surg 397:209-216 51. Schirpenbach C, Hoppert T, Aleksic I, Neumann HP, Hahner S, Fassnacht M, Allolio B 2012 [A 47-year-old patient with paroxysmal arterial hypertension and gastric tumors]. Internist (Berl) 53:1119-1124 52. Berruti A, Baudin E, Gelderblom H, Haak HR, Porpiglia F, Fassnacht M, Pentheroudakis G, Group EGW 2012 Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23 Suppl 7:vii131-138 53. Couture C, Saveanu A, Barlier A, Carel JC, Fassnacht M, Fluck CE, Houang M, Maes M, PhanHug F, Enjalbert A, Drouin J, Brue T, Vallette S 2012 Phenotypic homogeneity and genotypic variability in a large series of congenital isolated ACTH-deficiency patients with TPIT gene mutations. J Clin Endocrinol Metab 97:E486-495 54. Hermsen IG, Fassnacht M, Terzolo M, Houterman S, den Hartigh J, Leboulleux S, Daffara F, Berruti A, Chadarevian R, Schlumberger M, Allolio B, Haak HR, Baudin E 2011 Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study. J Clin Endocrinol Metab 96:1844-1851 55. Uhmann A, van den Brandt J, Dittmann K, Hess I, Dressel R, Binder C, Luhder F, Christiansen H, Fassnacht M, Bhandoola A, Wienands J, Reichardt HM, Hahn H 2011 T cell development critically depends on prethymic stromal patched expression. J Immunol 186:3383-3391 56. Arlt W, Biehl M, Taylor AE, Hahner S, Libe R, Hughes BA, Schneider P, Smith DJ, Stiekema H, Krone N, Porfiri E, Opocher G, Bertherat J, Mantero F, Allolio B, Terzolo M, Nightingale P, Shackleton CH, Bertagna X, Fassnacht M, Stewart PM 2011 Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. J Clin Endocrinol Metab 96:3775-3784 57. op den Winkel J, Pfannschmidt J, Muley T, Grunewald C, Dienemann H, Fassnacht M, Allolio B 2011 Metastatic adrenocortical carcinoma: results of 56 pulmonary metastasectomies in 24 patients. Ann Thorac Surg 92:1965-1970 58. Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Walitza S, Shoichet S, Dempfle A, Heine M, Boreatti-Hummer A, Romanos J, Gross-Lesch S, Zerlaut H, Wultsch T, Heinzel S, Fassnacht M, Fallgatter A, Allolio B, Schafer H, Warnke A, Reif A, Ropers HH, Ullmann R 2011 Genome-wide copy number variation analysis in attentiondeficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry 16:491-503 59. Kroiss M, Quinkler M, Lutz WK, Allolio B, Fassnacht M 2011 Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma. Clin Endocrinol (Oxf) 75:585-591 60. Hammer GD, Fassnacht M, Lalli E 2011 Adrenal cancer: clinical advances. Horm Cancer 2:323 61. Fassnacht M, Libe R, Kroiss M, Allolio B 2011 Adrenocortical carcinoma: a clinician's update. Nat Rev Endocrinol 7:323-335 62. Ronchi CL, Verrua E, Ferrante E, Bender G, Sala E, Lania AG, Fassnacht M, Beck-Peccoz P, Allolio B, Spada A, Arosio M 2011 Long-term effects of radiotherapy on cardiovascular risk factors in acromegaly. Eur J Endocrinol 164:675-684 63. Kroiss M, Reuss M, Kuhner D, Johanssen S, Beyer M, Zink M, Hartmann MF, Dhir V, Wudy SA, Arlt W, Sbiera S, Allolio B, Fassnacht M 2011 Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells. Front Endocrinol (Lausanne) 2:27 64. Zini L, Porpiglia F, Fassnacht M 2011 Contemporary management of adrenocortical carcinoma. Eur Urol 60:1055-1065 65. Fenske W, Quinkler M, Lorenz D, Zopf K, Haagen U, Papassotiriou J, Pfeiffer AF, Fassnacht M, Stork S, Allolio B 2011 Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests. J Clin Endocrinol Metab 96:1506-1515 66. Sbiera S, Dexneit T, Reichardt SD, Michel KD, van den Brandt J, Schmull S, Kraus L, Beyer M, Mlynski R, Wortmann S, Allolio B, Reichardt HM, Fassnacht M 2011 Influence of short-term glucocorticoid therapy on regulatory T cells in vivo. PLoS One 6:e24345 67. Frank-Raue K, Rybicki LA, Erlic Z, Schweizer H, Winter A, Milos I, Toledo SP, Toledo RA, Tavares MR, Alevizaki M, Mian C, Siggelkow H, Hufner M, Wohllk N, Opocher G, Dvorakova S, Bendlova B, Czetwertynska M, Skasko E, Barontini M, Sanso G, Vorlander C, Maia AL, Patocs A, Links TP, de Groot JW, Kerstens MN, Valk GD, Miehle K, Musholt TJ, Biarnes J, Damjanovic S, Muresan M, Wuster C, Fassnacht M, Peczkowska M, Fauth C, Golcher H, Walter MA, Pichl J, Raue F, Eng C, Neumann HP, International RETEC 2011 Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10. Hum Mutat 32:51-58 68. Gaujoux S, Grabar S, Fassnacht M, Ragazzon B, Launay P, Libe R, Chokri I, Audebourg A, Royer B, Sbiera S, Vacher-Lavenu MC, Dousset B, Bertagna X, Allolio B, Bertherat J, Tissier F 2011 beta-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma. Clin Cancer Res 17:328336 69. Gruber M, Eisenhofer G, Fassnacht M, Bornstein SR 2011 [Recent advances in adrenal diseases]. Dtsch Med Wochenschr 136:1998-2001 70. Willhauck MJ, Schott M, Kreissl MC, Fassnacht M, Spitzweg C 2011 [New therapeutic options for advanced thyroid cancer]. Dtsch Med Wochenschr 136:1165-1168 71. Fassnacht M, Johanssen S, Fenske W, Weismann D, Agha A, Beuschlein F, Fuhrer D, Jurowich C, Quinkler M, Petersenn S, Spahn M, Hahner S, Allolio B, German ACCRG 2010 Improved survival in patients with stage II adrenocortical carcinoma followed up prospectively by specialized centers. J Clin Endocrinol Metab 95:4925-4932 72. Fassnacht M, Wittekind C, Allolio B 2010 [Current TNM classification systems for adrenocortical carcinoma]. Pathologe 31:374-378 73. Hahner S, Loeffler M, Bleicken B, Drechsler C, Milovanovic D, Fassnacht M, Ventz M, Quinkler M, Allolio B 2010 Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies. Eur J Endocrinol 162:597-602 74. Adam P, Hahner S, Hartmann M, Heinrich B, Quinkler M, Willenberg HS, Saeger W, Sbiera S, Schmull S, Voelker HU, Strobel P, Allolio B, Fassnacht M 2010 Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome. Mod Pathol 23:1596-1604 75. Johanssen S, Hahner S, Saeger W, Quinkler M, Beuschlein F, Dralle H, Haaf M, Kroiss M, Jurowich C, Langer P, Oelkers W, Spahn M, Willenberg HS, Mader U, Allolio B, Fassnacht M 2010 Deficits in the management of patients with adrenocortical carcinoma in Germany. Dtsch Arztebl Int 107:885-891 76. Quinkler M, Fassnacht M, Petersenn S, Reisch N, Willenberg HS, Diederich S 2010 [Pheochromocytoma: current diagnostics and treatment]. MMW Fortschr Med 152:36-38 77. Sbiera S, Schmull S, Assie G, Voelker HU, Kraus L, Beyer M, Ragazzon B, Beuschlein F, Willenberg HS, Hahner S, Saeger W, Bertherat J, Allolio B, Fassnacht M 2010 High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors. J Clin Endocrinol Metab 95:E161-171 78. Hahner S, Sturmer A, Fassnacht M, Hartmann RW, Schewe K, Cochran S, Zink M, Schirbel A, Allolio B 2010 Etomidate unmasks intraadrenal regulation of steroidogenesis and proliferation in adrenal cortical cell lines. Horm Metab Res 42:528-534 79. Alexandraki KI, Kaltsas GA, le Roux CW, Fassnacht M, Ajodha S, Christ-Crain M, Akker SA, Drake WM, Edwards R, Allolio B, Grossman AB 2010 Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study. Clin Endocrinol (Oxf) 72:305-311 80. Weismann D, Kleinbrahm K, Hu K, Fassnacht M, Frantz S, Ertl G, Allolio B, Maier SK 2010 Prevention of hypertensive crises in rats induced by acute and chronic norepinephrine excess. Horm Metab Res 42:803-808 81. Berruti A, Fassnacht M, Baudin E, Hammer G, Haak H, Leboulleux S, Skogseid B, Allolio B, Terzolo M 2010 Adjuvant therapy in patients with adrenocortical carcinoma: a position of an international panel. J Clin Oncol 28:e401-402; author reply e403 82. Brix D, Allolio B, Fenske W, Agha A, Dralle H, Jurowich C, Langer P, Mussack T, Nies C, Riedmiller H, Spahn M, Weismann D, Hahner S, Fassnacht M, German Adrenocortical Carcinoma Registry G 2010 Laparoscopic versus open adrenalectomy for adrenocortical carcinoma: surgical and oncologic outcome in 152 patients. Eur Urol 58:609-615 83. Fassnacht M, Allolio B 2010 What is the best approach to an apparently nonmetastatic adrenocortical carcinoma? Clin Endocrinol (Oxf) 73:561-565 84. Fassnacht M, Beuschlein F, Quinkler M, Petersenn S 2010 [Arterial hypertension and subclinical Cushing's syndrome]. MMW Fortschr Med 152:39-41 85. Wortmann S, Quinkler M, Ritter C, Kroiss M, Johanssen S, Hahner S, Allolio B, Fassnacht M 2010 Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma. Eur J Endocrinol 162:349-356 86. Kopetschke R, Slisko M, Kilisli A, Tuschy U, Wallaschofski H, Fassnacht M, Ventz M, Beuschlein F, Reincke M, Reisch N, Quinkler M 2009 Frequent incidental discovery of phaeochromocytoma: data from a German cohort of 201 phaeochromocytoma. Eur J Endocrinol 161:355-361 87. Fassnacht M, Kreissl MC, Weismann D, Allolio B 2009 New targets and therapeutic approaches for endocrine malignancies. Pharmacol Ther 123:117-141 88. Fassnacht M, Johanssen S, Quinkler M, Bucsky P, Willenberg HS, Beuschlein F, Terzolo M, Mueller HH, Hahner S, Allolio B, German Adrenocortical Carcinoma Registry G, European Network for the Study of Adrenal T 2009 Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a Revised TNM Classification. Cancer 115:243-250 89. Castinetti F, Fassnacht M, Johanssen S, Terzolo M, Bouchard P, Chanson P, Do Cao C, Morange I, Pico A, Ouzounian S, Young J, Hahner S, Brue T, Allolio B, Conte-Devolx B 2009 Merits and pitfalls of mifepristone in Cushing's syndrome. Eur J Endocrinol 160:1003-1010 90. Weismann D, Briese J, Niemann J, Gruneberger M, Adam P, Hahner S, Johanssen S, Liu W, Ezzat S, Saeger W, Bamberger AM, Fassnacht M, Schulte HM, Asa SL, Allolio B, Bamberger CM 2009 Osteopontin stimulates invasion of NCI-h295 cells but is not associated with survival in adrenocortical carcinoma. J Pathol 218:232-240 91. Polat B, Fassnacht M, Pfreundner L, Guckenberger M, Bratengeier K, Johanssen S, Kenn W, Hahner S, Allolio B, Flentje M 2009 Radiotherapy in adrenocortical carcinoma. Cancer 115:2816-2823 92. Terzolo M, Fassnacht M, Ciccone G, Allolio B, Berruti A 2009 Adjuvant mitotane for adrenocortical cancer--working through uncertainty. J Clin Endocrinol Metab 94:1879-1880 93. Fassnacht M, Allolio B 2009 Clinical management of adrenocortical carcinoma. Best Pract Res Clin Endocrinol Metab 23:273-289 94. Erlic Z, Rybicki L, Peczkowska M, Golcher H, Kann PH, Brauckhoff M, Mussig K, Muresan M, Schaffler A, Reisch N, Schott M, Fassnacht M, Opocher G, Klose S, Fottner C, Forrer F, Plockinger U, Petersenn S, Zabolotny D, Kollukch O, Yaremchuk S, Januszewicz A, Walz MK, Eng C, Neumann HP, European-American Pheochromocytoma Study G 2009 Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients. Clin Cancer Res 15:6378-6385 95. Ronchi CL, Sbiera S, Kraus L, Wortmann S, Johanssen S, Adam P, Willenberg HS, Hahner S, Allolio B, Fassnacht M 2009 Expression of excision repair cross complementing group 1 and prognosis in adrenocortical carcinoma patients treated with platinum-based chemotherapy. Endocr Relat Cancer 16:907-918 96. Doyle P, Duren C, Nerlich K, Verburg FA, Grelle I, Jahn H, Fassnacht M, Mader U, Reiners C, Luster M 2009 Potency and tolerance of calcitonin stimulation with high-dose calcium versus pentagastrin in normal adults. J Clin Endocrinol Metab 94:2970-2974 97. Fenske W, Volker HU, Adam P, Hahner S, Johanssen S, Wortmann S, Schmidt M, Morcos M, Muller-Hermelink HK, Allolio B, Fassnacht M 2009 Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma. Endocr Relat Cancer 16:919-928 98. Sbiera S, Wortmann S, Fassnacht M 2008 Dendritic cell based immunotherapy--a promising therapeutic approach for endocrine malignancies. Horm Metab Res 40:89-98 99. Lichtenauer UD, Shapiro I, Geiger K, Quinkler M, Fassnacht M, Nitschke R, Ruckauer KD, Beuschlein F 2008 Side population does not define stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R. Endocrinology 149:1314-1322 100. Lim HY, van den Brandt J, Fassnacht M, Allolio B, Herold MJ, Reichardt HM 2008 Silencing of the mineralocorticoid receptor by ribonucleic acid interference in transgenic rats disrupts endocrine homeostasis. Mol Endocrinol 22:1304-1311 101. Quinkler M, Hahner S, Wortmann S, Johanssen S, Adam P, Ritter C, Strasburger C, Allolio B, Fassnacht M 2008 Treatment of advanced adrenocortical carcinoma with erlotinib plus gemcitabine. J Clin Endocrinol Metab 93:2057-2062 102. Frantz S, Fassnacht M, Allolio B, Bauersachs J 2008 [Obesity and heart failure]. Internist (Berl) 49:389-390, 392-383 103. Johanssen S, Fassnacht M, Brix D, Koschker AC, Hahner S, Riedmiller H, Allolio B 2008 [Adrenocortical carcinoma. Diagnostic work-up and treatment]. Urologe A 47:172-181 104. Hahner S, Stuermer A, Kreissl M, Reiners C, Fassnacht M, Haenscheid H, Beuschlein F, Zink M, Lang K, Allolio B, Schirbel A 2008 [123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes. J Clin Endocrinol Metab 93:23582365 105. Nair S, Boczkowski D, Fassnacht M, Pisetsky D, Gilboa E 2007 Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity. Cancer Res 67:371380 106. Hahner S, Loeffler M, Fassnacht M, Weismann D, Koschker AC, Quinkler M, Decker O, Arlt W, Allolio B 2007 Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis. J Clin Endocrinol Metab 92:3912-3922 107. Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA, Rossetto R, Buci L, Sperone P, Grossrubatscher E, Reimondo G, Bollito E, Papotti M, Saeger W, Hahner S, Koschker AC, Arvat E, Ambrosi B, Loli P, Lombardi G, Mannelli M, Bruzzi P, Mantero F, Allolio B, Dogliotti L, Berruti A 2007 Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med 356:2372-2380 108. Coll AP, Fassnacht M, Klammer S, Hahner S, Schulte DM, Piper S, Tung YC, Challis BG, Weinstein Y, Allolio B, O'Rahilly S, Beuschlein F 2006 Peripheral administration of the Nterminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production. J Endocrinol 190:515-525 109. Koschker AC, Fassnacht M, Hahner S, Weismann D, Allolio B 2006 Adrenocortical carcinoma -- improving patient care by establishing new structures. Exp Clin Endocrinol Diabetes 114:45-51 110. Weismann D, Fassnacht M, Weinberger F, Hamelmann W, Diehl S, Lorenz K, Baerlehner E, Reincke M, Beuschlein F, Knoefel W, Nies C, Hahner S, Allolio B 2006 Intraoperative haemodynamic stability in patients with phaeochromocytoma--minimally invasive vs conventional open surgery. Clin Endocrinol (Oxf) 65:352-358 111. Fassnacht M, Hahner S, Polat B, Koschker AC, Kenn W, Flentje M, Allolio B 2006 Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma. J Clin Endocrinol Metab 91:4501-4504 112. Weismann D, Fassnacht M, Schubert B, Bonfig R, Tschammler A, Timm S, Hahner S, Wunder C, Allolio B 2006 A dangerous liaison--pheochromocytoma in patients with malignant disease. Ann Surg Oncol 13:1696-1701 113. Papewalis C, Fassnacht M, Willenberg HS, Domberg J, Fenk R, Rohr UP, Schinner S, Bornstein SR, Scherbaum WA, Schott M 2006 Dendritic cells as potential adjuvant for immunotherapy in adrenocortical carcinoma. Clin Endocrinol (Oxf) 65:215-222 114. Allolio B, Fassnacht M 2006 Clinical review: Adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab 91:2027-2037 115. Bausch B, Koschker AC, Fassnacht M, Stoevesandt J, Hoffmann MM, Eng C, Allolio B, Neumann HP 2006 Comprehensive mutation scanning of NF1 in apparently sporadic cases of pheochromocytoma. J Clin Endocrinol Metab 91:3478-3481 116. Saeger W, Fassnacht M 2006 [Effects of drugs on the adrenal cortex and its tumors]. Pathologe 27:61-64 117. Vallette-Kasic S, Brue T, Pulichino AM, Gueydan M, Barlier A, David M, Nicolino M, Malpuech G, Dechelotte P, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, de Zegher F, Beckers D, Kyllo J, Donohoue P, Fassnacht M, Hahner S, Allolio B, Noordam C, Dunkel L, Hero M, Pigeon B, Weill J, Yigit S, Brauner R, Heinrich JJ, Cummings E, Riddell C, Enjalbert A, Drouin J 2005 Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations. J Clin Endocrinol Metab 90:1323-1331 118. Hahner S, Fassnacht M, Hammer F, Schammann M, Weismann D, Hansen IA, Allolio B 2005 Evidence against a role of human airway trypsin-like protease--the human analogue of the growth-promoting rat adrenal secretory protease--in adrenal tumourigenesis. Eur J Endocrinol 152:143-153 119. Hahner S, Fassnacht M 2005 Mitotane for adrenocortical carcinoma treatment. Curr Opin Investig Drugs 6:386-394 120. Fassnacht M, Lee J, Milazzo C, Boczkowski D, Su Z, Nair S, Gilboa E 2005 Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. Clin Cancer Res 11:5566-5571 121. Fassnacht M, Weismann D, Ebert S, Adam P, Zink M, Beuschlein F, Hahner S, Allolio B 2005 AKT is highly phosphorylated in pheochromocytomas but not in benign adrenocortical tumors. J Clin Endocrinol Metab 90:4366-4370 122. Lee J, Fassnacht M, Nair S, Boczkowski D, Gilboa E 2005 Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. Cancer Res 65:11156-11163 123. Betz MJ, Shapiro I, Fassnacht M, Hahner S, Reincke M, Beuschlein F, German, Austrian Adrenal N 2005 Peroxisome proliferator-activated receptor-gamma agonists suppress adrenocortical tumor cell proliferation and induce differentiation. J Clin Endocrinol Metab 90:3886-3896 124. Allolio B, Hahner S, Weismann D, Fassnacht M 2004 Management of adrenocortical carcinoma. Clin Endocrinol (Oxf) 60:273-287 125. Vallette-Kasic S, Pulichino AM, Gueydan M, Barlier A, David M, Malpuech G, Deal C, Van Vliet G, de Vroede M, Riepe F, Partsch CJ, Sippell W, Berberoglu M, Atasay B, de Zegher F, Kyllo J, Donohoue P, Dechelotte P, Fassnacht M, Noordam K, Dunkel L, Pigeon B, Weill J, Yigit S, Brauner R, Leger J, Heinrich JJ, Enjalbert A, Brue T, Drouin J 2004 A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations. Endocr Res 30:943-944 126. Fassnacht M, Kenn W, Allolio B 2004 Adrenal tumors: how to establish malignancy ? J Endocrinol Invest 27:387-399 127. Hansen IA, Fassnacht M, Hahner S, Hammer F, Schammann M, Meyer SR, Bicknell AB, Allolio B 2004 The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease. Endocrinology 145:1898-1905 128. Hansen IA, To TT, Wortmann S, Burmester T, Winkler C, Meyer SR, Neuner C, Fassnacht M, Allolio B 2003 The pro-opiomelanocortin gene of the zebrafish (Danio rerio). Biochem Biophys Res Commun 303:1121-1128 129. Saeger W, Fassnacht M, Chita R, Prager G, Nies C, Lorenz K, Barlehner E, Simon D, Niederle B, Beuschlein F, Allolio B, Reincke M 2003 High diagnostic accuracy of adrenal core biopsy: results of the German and Austrian adrenal network multicenter trial in 220 consecutive patients. Hum Pathol 34:180-186 130. Fassnacht M, Hahner S, Hansen IA, Kreutzberger T, Zink M, Adermann K, Jakob F, Troppmair J, Allolio B 2003 N-terminal proopiomelanocortin acts as a mitogen in adrenocortical tumor cells and decreases adrenal steroidogenesis. J Clin Endocrinol Metab 88:2171-2179 131. Fassnacht M, Schlenz N, Schneider SB, Wudy SA, Allolio B, Arlt W 2003 Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88:2760-2766 132. Fassnacht M, Franke A, Dettling A, Hahner S, Zink M, Wudy S, Allolio B 2002 Clodronate inhibits adrenocortical cell proliferation and P450c21 activity. J Endocrinol 174:509-516 133. Saeger W, Fassnacht M, Reincke M, Allolio B 2002 Expression of HER-2/neu receptor protein in adrenal tumors. Pathol Res Pract 198:445-448 134. Allolio B, Fassnacht M, Arlt W 2002 [Malignant tumors of the adrenal cortex]. Internist (Berl) 43:186-195 135. Schubert B, Fassnacht M, Beuschlein F, Zenkert S, Allolio B, Reincke M 2001 Angiotensin II type 1 receptor and ACTH receptor expression in human adrenocortical neoplasms. Clin Endocrinol (Oxf) 54:627-632 136. Arlt W, Callies F, Koehler I, van Vlijmen JC, Fassnacht M, Strasburger CJ, Seibel MJ, Huebler D, Ernst M, Oettel M, Reincke M, Schulte HM, Allolio B 2001 Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion. J Clin Endocrinol Metab 86:4686-4692 137. Fassnacht M, Capeller B, Arlt W, Steck T, Allolio B 2001 Octreotide LAR treatment throughout pregnancy in an acromegalic woman. Clin Endocrinol (Oxf) 55:411-415 138. Wachenfeld C, Beuschlein F, Zwermann O, Mora P, Fassnacht M, Allolio B, Reincke M 2001 Discerning malignancy in adrenocortical tumors: are molecular markers useful? Eur J Endocrinol 145:335-341 139. Beuschlein F, Fassnacht M, Klink A, Allolio B, Reincke M 2001 ACTH-receptor expression, regulation and role in adrenocortial tumor formation. Eur J Endocrinol 144:199-206 140. Callies F, Fassnacht M, van Vlijmen JC, Koehler I, Huebler D, Seibel MJ, Arlt W, Allolio B 2001 Dehydroepiandrosterone replacement in women with adrenal insufficiency: effects on body composition, serum leptin, bone turnover, and exercise capacity. J Clin Endocrinol Metab 86:1968-1972 141. Blind E, Fassnacht M, Korber C, Korber-Hafner N, Reiners C, Allolio B 2001 [Severe Vitamin D(dihydrotachysterol)-intoxication with temporary anemia and hypercalcemia responsive to bisphosphonates]. Dtsch Med Wochenschr 126:T21-T24 142. Fassnacht M, Hahner S, Beuschlein F, Klink A, Reincke M, Allolio B 2000 New mechanisms of adrenostatic compounds in a human adrenocortical cancer cell line. Eur J Clin Invest 30 Suppl 3:76-82 143. Beuschlein F, Borgemeister M, Schirra J, Goke B, Fassnacht M, Arlt W, Allolio B, Reincke M 2000 Oral glucose tolerance testing but not intravenous glucose administration uncovers hyper-responsiveness of hypothalamo-pituitary-adrenal axis in patients with adrenal incidentalomas. Clin Endocrinol (Oxf) 52:617-623 144. Zenkert S, Schubert B, Fassnacht M, Beuschlein F, Allolio B, Reincke M 2000 Steroidogenic acute regulatory protein mRNA expression in adrenal tumours. Eur J Endocrinol 142:294299 145. Fassnacht M, Beuschlein F, Vay S, Mora P, Allolio B, Reincke M 1998 Aminoglutethimide suppresses adrenocorticotropin receptor expression in the NCI-h295 adrenocortical tumor cell line. J Endocrinol 159:35-42 146. Reincke M, Fassnacht M, Vath S, Mora P, Allolio B 1996 Adrenal incidentalomas: a manifestation of the metabolic syndrome? Endocr Res 22:757-761