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ATP CO2+ H2O CA H+ + HCO3- ATP Cellular metabolism, protein synthesis CO2 CO2+ H2O CA H+ + HCO3- ATP CO2+ H2O Na+ Leak CA H+ + HCO3- ATP K+ VNa+ Cellular metabolism, protein synthesis VK+ AP VCa2+ CO2 CO2+ H2O CA H+ + HCO3- K+ ATP ATP CO2+ H2O Na+ Na+ Leak CA H+ + HCO3- ATP K+ CO2+ H2O CO2 Cellular metabolism, protein synthesis Ca2+ H+ PMCA ATP Ca2+ VNa+ VK+ AP CA VCa2+ H+ NHE Na+ Na+ NCX H+ + HCO3- K+ ATP ATP CO2+ H2O Na+ Na+ Leak CA H+ + HCO3- K+ CO2+ H2O CO2 ATP Cellular metabolism, protein synthesis Ca2+ H+ PMCA ATP Ca2+ VNa+ H+ VK+ AP CA ATP Na+ H+ glutamate VCa2+ H+ NHE Na+ NCX H+ + HCO3- Na-dependent & Na-independent Cl-/HCO3- cotransport Cl- GABA A Cl- HCO3- K+ HCO3- ATP ATP CO2+ H2O Na+ Na+ Leak CA H+ + HCO3CO2+ H2O CO2 ATP K+ Low pHo stimulates CA H+ + HCO3- Cellular metabolism, protein synthesis Ca2+ H+ PMCA ATP Ca2+ VNa+ H+ VK+ AP ATP HCO3- H+ Na+ glutamate VCa2+ H+ NHE Na+ Na+ NCX Na-HCO3 cotransport (NBCn) Na-dependent & Na-independent Cl-/HCO3- cotransport Cl- HCO3- K+ ATP CO2+ H2O Na+ Na+ CA H+ + HCO3CO2+ H2O CO2 ATP K+ Cl- HCO3- ATP Leak Low pHo stimulates GABA A CA H+ + HCO3- Cellular metabolism, protein synthesis Ca2+ H+ PMCA ATP Ca2+ VNa+ VK+ AP ATP VCa2+ H+ NHE Na+ H+ H+ HCO 3 + Na+ Na NCX glutamate ..... . glutamate EAAT Na-HCO3 cotransport (NBCn) 3 Na+ & 1 H+ inward 1 K+ outward
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