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Supplementary Table S4. Enrichment analysis report: Top 200 GO processes for FLO-1LM vs. FLO1Par
Rank
Networks
FDR
In data
Total
Ratio
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
single-organism cellular process
response to organic substance
response to chemical
in utero embryonic development
multicellular organism development
regulation of cell migration
response to stress
regulation of cellular component movement
localization
regulation of locomotion
cell differentiation
immune system process
system development
regulation of cell motility
cellular developmental process
developmental process
embryo development
cellular response to chemical stimulus
regulation of localization
regulation of cellular component organization
anatomical structure development
single-organism developmental process
anatomical structure morphogenesis
chordate embryonic development
response to hyperoxia
response to increased oxygen levels
embryo development ending in birth or egg hatching
response to external stimulus
response to lipid
response to oxygen-containing compound
single-multicellular organism process
response to organic cyclic compound
response to estrogen
animal organ development
immune effector process
cell migration
response to inorganic substance
response to endogenous stimulus
cellular response to organic substance
negative regulation of biological process
respiratory electron transport chain
electron transport chain
cellular process
single-organism process
localization of cell
cell motility
cellular component organization
negative regulation of cellular process
endocytosis
cellular response to cytokine stimulus
response to stimulus
cellular component organization or biogenesis
defense response to virus
blood vessel morphogenesis
response to steroid hormone
response to acid chemical
locomotion
response to abiotic stimulus
regulation of biological quality
response to virus
7.82E-10
7.62E-09
1.93E-08
2.21E-08
2.88E-08
2.88E-08
3.57E-08
3.87E-08
3.87E-08
3.87E-08
3.87E-08
3.87E-08
3.87E-08
5.50E-08
6.93E-08
1.15E-07
1.24E-07
1.45E-07
1.90E-07
2.02E-07
2.02E-07
2.02E-07
2.10E-07
2.10E-07
2.40E-07
2.40E-07
2.40E-07
2.70E-07
3.06E-07
3.08E-07
3.09E-07
3.26E-07
4.58E-07
4.67E-07
4.70E-07
4.93E-07
5.38E-07
5.59E-07
6.45E-07
7.54E-07
1.11E-06
1.25E-06
1.31E-06
1.35E-06
1.59E-06
1.59E-06
1.94E-06
1.94E-06
2.34E-06
2.41E-06
2.41E-06
3.18E-06
4.12E-06
4.45E-06
5.04E-06
5.65E-06
6.42E-06
7.11E-06
7.90E-06
7.94E-06
192
85
107
28
110
34
91
36
104
36
88
67
100
34
90
117
42
74
67
64
112
115
66
32
10
10
32
66
43
57
116
44
21
78
27
33
30
57
64
100
13
13
206
194
34
34
105
93
26
31
144
106
14
22
29
25
43
43
80
17
15176
4290
6278
633
6641
951
5016
1082
6201
1095
4817
3154
5860
1006
5060
7560
1519
3823
3303
3088
7180
7467
3251
969
70
70
979
3284
1658
2625
7650
1732
453
4305
745
1078
913
2685
3226
6283
168
170
18572
16751
1203
1203
6873
5776
763
1048
10819
7037
227
581
968
748
1883
1891
4811
365
0.01
0.02
0.02
0.04
0.02
0.04
0.02
0.03
0.02
0.03
0.02
0.02
0.02
0.03
0.02
0.02
0.03
0.02
0.02
0.02
0.02
0.02
0.02
0.03
0.14
0.14
0.03
0.02
0.03
0.02
0.02
0.03
0.05
0.02
0.04
0.03
0.03
0.02
0.02
0.02
0.08
0.08
0.01
0.01
0.03
0.03
0.02
0.02
0.03
0.03
0.01
0.02
0.06
0.04
0.03
0.03
0.02
0.02
0.02
0.05
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
cellular localization
immune response
cellular component morphogenesis
negative regulation of viral genome replication
multi-organism process
muscle structure development
hematopoietic or lymphoid organ development
small molecule metabolic process
cell morphogenesis involved in differentiation
type I interferon signaling pathway
response to alcohol
cellular response to type I interferon
movement of cell or subcellular component
cell development
phagocytosis
organophosphate metabolic process
cytokine-mediated signaling pathway
nervous system development
blood vessel development
response to type I interferon
hemopoiesis
ATP metabolic process
cell morphogenesis
immune system development
regulation of cell adhesion
neurogenesis
cellular respiration
ribonucleoside monophosphate metabolic process
embryonic placenta development
response to other organism
vasculature development
response to cytokine
response to external biotic stimulus
nucleoside triphosphate metabolic process
regulation of anatomical structure size
regeneration
purine ribonucleoside triphosphate metabolic process
macrophage chemotaxis
response to estradiol
anatomical structure formation involved in morphogenesis
positive regulation of cellular component organization
cellular protein localization
regulation of actin cytoskeleton organization
nucleoside monophosphate metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
actin cytoskeleton organization
cellular macromolecule localization
organonitrogen compound metabolic process
single-organism cellular localization
response to biotic stimulus
negative regulation of protein complex assembly
cell death
regulation of protein targeting
innate immune response
establishment of localization
positive regulation of intracellular transport
establishment of T cell polarity
cell killing
regulation of cellular component size
leukocyte migration
negative regulation of viral life cycle
positive regulation of locomotion
negative regulation of fibroblast proliferation
9.77E-06
9.77E-06
9.77E-06
1.02E-05
1.02E-05
1.30E-05
1.38E-05
1.45E-05
1.52E-05
1.60E-05
1.63E-05
1.71E-05
1.93E-05
2.07E-05
2.07E-05
2.07E-05
2.13E-05
2.29E-05
2.29E-05
2.43E-05
2.79E-05
2.98E-05
3.02E-05
3.29E-05
3.51E-05
3.61E-05
4.49E-05
5.31E-05
5.31E-05
5.52E-05
5.60E-05
5.60E-05
5.60E-05
5.64E-05
5.86E-05
5.88E-05
6.58E-05
6.80E-05
6.80E-05
6.81E-05
7.00E-05
7.54E-05
7.54E-05
8.16E-05
8.19E-05
8.46E-05
8.60E-05
8.64E-05
9.84E-05
9.99E-05
1.03E-04
1.05E-04
1.05E-04
1.05E-04
1.05E-04
1.05E-04
1.05E-04
1.05E-04
1.20E-04
1.20E-04
1.27E-04
1.27E-04
1.28E-04
1.28E-04
53
45
39
8
64
24
28
58
31
9
25
9
44
50
15
30
23
61
23
9
26
13
36
28
27
49
13
14
10
34
23
31
34
14
22
15
13
5
14
33
36
35
16
14
13
13
19
35
47
30
34
10
35
16
33
79
18
4
8
17
15
9
20
6
2646
2059
1643
62
3512
733
965
3072
1154
91
801
92
2048
2496
308
1113
704
3366
708
97
889
236
1530
1019
962
2479
246
292
139
1439
752
1243
1442
295
699
341
257
21
301
1392
1599
1536
397
307
264
265
555
1549
2434
1223
1494
154
1567
411
1430
5105
513
11
92
467
370
124
631
43
0.02
0.02
0.02
0.13
0.02
0.03
0.03
0.02
0.03
0.10
0.03
0.10
0.02
0.02
0.05
0.03
0.03
0.02
0.03
0.09
0.03
0.06
0.02
0.03
0.03
0.02
0.05
0.05
0.07
0.02
0.03
0.02
0.02
0.05
0.03
0.04
0.05
0.24
0.05
0.02
0.02
0.02
0.04
0.05
0.05
0.05
0.03
0.02
0.02
0.02
0.02
0.06
0.02
0.04
0.02
0.02
0.04
0.36
0.09
0.04
0.04
0.07
0.03
0.14
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
purine ribonucleoside monophosphate metabolic process
regulation of protein processing in phagocytic vesicle
positive regulation of protein processing in phagocytic vesicle
purine nucleoside monophosphate metabolic process
actin filament-based process
negative regulation of cell proliferation
establishment of lymphocyte polarity
negative regulation of locomotion
response to metal ion
regulation of cytoskeleton organization
cellular protein complex assembly
cellular response to endogenous stimulus
generation of precursor metabolites and energy
regulation of viral genome replication
positive regulation of cell migration
negative regulation of viral process
positive regulation of cytoplasmic transport
nucleoside metabolic process
neuron migration
positive regulation of endocytosis
vesicle-mediated transport
regulation of anatomical structure morphogenesis
response to hormone
positive regulation of intracellular protein transport
regulation of cellular component biogenesis
cytoskeleton organization
positive regulation of cellular process
angiogenesis
positive regulation of cell motility
regulation of actin filament depolymerization
placenta development
programmed cell death
membrane organization
cell surface receptor signaling pathway
regulation of actin filament-based process
actin filament capping
aging
actin cytoskeleton reorganization
regulation of immune complex clearance by monocytes and
macrophages
positive regulation of immune complex clearance by monocytes and
macrophages
response to ammonium ion
protein localization
response to oxygen levels
regulation of intracellular transport
regulation of cell morphogenesis
positive regulation of cellular component movement
phosphate-containing compound metabolic process
hepatocyte apoptotic process
glycosyl compound metabolic process
regulation of cellular localization
ribonucleoside metabolic process
defense response
generation of neurons
response to oxidative stress
macromolecule localization
apoptotic process
protein localization to membrane
negative regulation of multi-organism process
interspecies interaction between organisms
symbiosis, encompassing mutualism through parasitism
positive regulation of nitric oxide biosynthetic process
negative regulation of actin filament depolymerization
1.31E-04
1.31E-04
1.31E-04
1.34E-04
1.34E-04
1.39E-04
1.41E-04
1.41E-04
1.41E-04
1.42E-04
1.46E-04
1.50E-04
1.51E-04
1.53E-04
1.53E-04
1.73E-04
1.82E-04
1.86E-04
1.92E-04
1.92E-04
1.93E-04
1.93E-04
1.97E-04
2.06E-04
2.06E-04
2.06E-04
2.21E-04
2.21E-04
2.21E-04
2.21E-04
2.21E-04
2.21E-04
2.24E-04
2.37E-04
2.40E-04
2.45E-04
2.49E-04
2.50E-04
13
3
3
13
20
26
4
15
19
21
17
40
19
8
19
9
15
16
10
11
35
31
38
14
26
28
90
16
19
7
12
33
31
55
16
6
18
7
280
4
4
281
635
995
12
376
583
696
478
1964
587
97
588
131
386
437
169
208
1628
1350
1846
343
1025
1155
6241
446
608
74
255
1502
1365
3188
450
50
559
76
0.05
0.75
0.75
0.05
0.03
0.03
0.33
0.04
0.03
0.03
0.04
0.02
0.03
0.08
0.03
0.07
0.04
0.04
0.06
0.05
0.02
0.02
0.02
0.04
0.03
0.02
0.01
0.04
0.03
0.09
0.05
0.02
0.02
0.02
0.04
0.12
0.03
0.09
2.50E-04
3
5
0.60
2.50E-04
2.50E-04
2.52E-04
2.52E-04
2.70E-04
2.76E-04
2.77E-04
2.87E-04
2.90E-04
2.90E-04
3.02E-04
3.10E-04
3.25E-04
3.41E-04
3.44E-04
3.44E-04
3.46E-04
3.61E-04
3.61E-04
3.66E-04
3.66E-04
3.66E-04
3.70E-04
3
11
44
19
23
21
19
47
4
16
37
15
44
44
18
49
32
17
11
26
26
7
6
5
217
2327
617
858
738
622
2575
15
460
1821
411
2356
2361
577
2756
1475
524
228
1072
1072
82
55
0.60
0.05
0.02
0.03
0.03
0.03
0.03
0.02
0.27
0.03
0.02
0.04
0.02
0.02
0.03
0.02
0.02
0.03
0.05
0.02
0.02
0.09
0.11
187
188
189
190
191
192
193
194
195
196
197
198
199
200
positive regulation of nitric oxide metabolic process
response to fluid shear stress
striated muscle contraction
cellular component biogenesis
circulatory system process
receptor-mediated endocytosis
cellular macromolecular complex assembly
establishment of protein localization to organelle
cellular component assembly
cellular response to acid chemical
negative regulation of cellular component organization
negative regulation of cell death
nucleobase-containing small molecule metabolic process
regulation of developmental process
3.93E-04
4.05E-04
4.05E-04
4.05E-04
4.05E-04
4.34E-04
4.36E-04
4.37E-04
4.58E-04
4.58E-04
4.61E-04
4.61E-04
5.10E-04
5.10E-04
7
6
9
51
18
14
23
16
48
15
25
31
20
53
83
56
151
2940
587
375
892
480
2715
429
1025
1433
717
3134
0.08
0.11
0.06
0.02
0.03
0.04
0.03
0.03
0.02
0.03
0.02
0.02
0.03
0.02