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Supplementary Table S4. Enrichment analysis report: Top 200 GO processes for FLO-1LM vs. FLO1Par Rank Networks FDR In data Total Ratio 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 single-organism cellular process response to organic substance response to chemical in utero embryonic development multicellular organism development regulation of cell migration response to stress regulation of cellular component movement localization regulation of locomotion cell differentiation immune system process system development regulation of cell motility cellular developmental process developmental process embryo development cellular response to chemical stimulus regulation of localization regulation of cellular component organization anatomical structure development single-organism developmental process anatomical structure morphogenesis chordate embryonic development response to hyperoxia response to increased oxygen levels embryo development ending in birth or egg hatching response to external stimulus response to lipid response to oxygen-containing compound single-multicellular organism process response to organic cyclic compound response to estrogen animal organ development immune effector process cell migration response to inorganic substance response to endogenous stimulus cellular response to organic substance negative regulation of biological process respiratory electron transport chain electron transport chain cellular process single-organism process localization of cell cell motility cellular component organization negative regulation of cellular process endocytosis cellular response to cytokine stimulus response to stimulus cellular component organization or biogenesis defense response to virus blood vessel morphogenesis response to steroid hormone response to acid chemical locomotion response to abiotic stimulus regulation of biological quality response to virus 7.82E-10 7.62E-09 1.93E-08 2.21E-08 2.88E-08 2.88E-08 3.57E-08 3.87E-08 3.87E-08 3.87E-08 3.87E-08 3.87E-08 3.87E-08 5.50E-08 6.93E-08 1.15E-07 1.24E-07 1.45E-07 1.90E-07 2.02E-07 2.02E-07 2.02E-07 2.10E-07 2.10E-07 2.40E-07 2.40E-07 2.40E-07 2.70E-07 3.06E-07 3.08E-07 3.09E-07 3.26E-07 4.58E-07 4.67E-07 4.70E-07 4.93E-07 5.38E-07 5.59E-07 6.45E-07 7.54E-07 1.11E-06 1.25E-06 1.31E-06 1.35E-06 1.59E-06 1.59E-06 1.94E-06 1.94E-06 2.34E-06 2.41E-06 2.41E-06 3.18E-06 4.12E-06 4.45E-06 5.04E-06 5.65E-06 6.42E-06 7.11E-06 7.90E-06 7.94E-06 192 85 107 28 110 34 91 36 104 36 88 67 100 34 90 117 42 74 67 64 112 115 66 32 10 10 32 66 43 57 116 44 21 78 27 33 30 57 64 100 13 13 206 194 34 34 105 93 26 31 144 106 14 22 29 25 43 43 80 17 15176 4290 6278 633 6641 951 5016 1082 6201 1095 4817 3154 5860 1006 5060 7560 1519 3823 3303 3088 7180 7467 3251 969 70 70 979 3284 1658 2625 7650 1732 453 4305 745 1078 913 2685 3226 6283 168 170 18572 16751 1203 1203 6873 5776 763 1048 10819 7037 227 581 968 748 1883 1891 4811 365 0.01 0.02 0.02 0.04 0.02 0.04 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.02 0.03 0.14 0.14 0.03 0.02 0.03 0.02 0.02 0.03 0.05 0.02 0.04 0.03 0.03 0.02 0.02 0.02 0.08 0.08 0.01 0.01 0.03 0.03 0.02 0.02 0.03 0.03 0.01 0.02 0.06 0.04 0.03 0.03 0.02 0.02 0.02 0.05 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 cellular localization immune response cellular component morphogenesis negative regulation of viral genome replication multi-organism process muscle structure development hematopoietic or lymphoid organ development small molecule metabolic process cell morphogenesis involved in differentiation type I interferon signaling pathway response to alcohol cellular response to type I interferon movement of cell or subcellular component cell development phagocytosis organophosphate metabolic process cytokine-mediated signaling pathway nervous system development blood vessel development response to type I interferon hemopoiesis ATP metabolic process cell morphogenesis immune system development regulation of cell adhesion neurogenesis cellular respiration ribonucleoside monophosphate metabolic process embryonic placenta development response to other organism vasculature development response to cytokine response to external biotic stimulus nucleoside triphosphate metabolic process regulation of anatomical structure size regeneration purine ribonucleoside triphosphate metabolic process macrophage chemotaxis response to estradiol anatomical structure formation involved in morphogenesis positive regulation of cellular component organization cellular protein localization regulation of actin cytoskeleton organization nucleoside monophosphate metabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process actin cytoskeleton organization cellular macromolecule localization organonitrogen compound metabolic process single-organism cellular localization response to biotic stimulus negative regulation of protein complex assembly cell death regulation of protein targeting innate immune response establishment of localization positive regulation of intracellular transport establishment of T cell polarity cell killing regulation of cellular component size leukocyte migration negative regulation of viral life cycle positive regulation of locomotion negative regulation of fibroblast proliferation 9.77E-06 9.77E-06 9.77E-06 1.02E-05 1.02E-05 1.30E-05 1.38E-05 1.45E-05 1.52E-05 1.60E-05 1.63E-05 1.71E-05 1.93E-05 2.07E-05 2.07E-05 2.07E-05 2.13E-05 2.29E-05 2.29E-05 2.43E-05 2.79E-05 2.98E-05 3.02E-05 3.29E-05 3.51E-05 3.61E-05 4.49E-05 5.31E-05 5.31E-05 5.52E-05 5.60E-05 5.60E-05 5.60E-05 5.64E-05 5.86E-05 5.88E-05 6.58E-05 6.80E-05 6.80E-05 6.81E-05 7.00E-05 7.54E-05 7.54E-05 8.16E-05 8.19E-05 8.46E-05 8.60E-05 8.64E-05 9.84E-05 9.99E-05 1.03E-04 1.05E-04 1.05E-04 1.05E-04 1.05E-04 1.05E-04 1.05E-04 1.05E-04 1.20E-04 1.20E-04 1.27E-04 1.27E-04 1.28E-04 1.28E-04 53 45 39 8 64 24 28 58 31 9 25 9 44 50 15 30 23 61 23 9 26 13 36 28 27 49 13 14 10 34 23 31 34 14 22 15 13 5 14 33 36 35 16 14 13 13 19 35 47 30 34 10 35 16 33 79 18 4 8 17 15 9 20 6 2646 2059 1643 62 3512 733 965 3072 1154 91 801 92 2048 2496 308 1113 704 3366 708 97 889 236 1530 1019 962 2479 246 292 139 1439 752 1243 1442 295 699 341 257 21 301 1392 1599 1536 397 307 264 265 555 1549 2434 1223 1494 154 1567 411 1430 5105 513 11 92 467 370 124 631 43 0.02 0.02 0.02 0.13 0.02 0.03 0.03 0.02 0.03 0.10 0.03 0.10 0.02 0.02 0.05 0.03 0.03 0.02 0.03 0.09 0.03 0.06 0.02 0.03 0.03 0.02 0.05 0.05 0.07 0.02 0.03 0.02 0.02 0.05 0.03 0.04 0.05 0.24 0.05 0.02 0.02 0.02 0.04 0.05 0.05 0.05 0.03 0.02 0.02 0.02 0.02 0.06 0.02 0.04 0.02 0.02 0.04 0.36 0.09 0.04 0.04 0.07 0.03 0.14 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 purine ribonucleoside monophosphate metabolic process regulation of protein processing in phagocytic vesicle positive regulation of protein processing in phagocytic vesicle purine nucleoside monophosphate metabolic process actin filament-based process negative regulation of cell proliferation establishment of lymphocyte polarity negative regulation of locomotion response to metal ion regulation of cytoskeleton organization cellular protein complex assembly cellular response to endogenous stimulus generation of precursor metabolites and energy regulation of viral genome replication positive regulation of cell migration negative regulation of viral process positive regulation of cytoplasmic transport nucleoside metabolic process neuron migration positive regulation of endocytosis vesicle-mediated transport regulation of anatomical structure morphogenesis response to hormone positive regulation of intracellular protein transport regulation of cellular component biogenesis cytoskeleton organization positive regulation of cellular process angiogenesis positive regulation of cell motility regulation of actin filament depolymerization placenta development programmed cell death membrane organization cell surface receptor signaling pathway regulation of actin filament-based process actin filament capping aging actin cytoskeleton reorganization regulation of immune complex clearance by monocytes and macrophages positive regulation of immune complex clearance by monocytes and macrophages response to ammonium ion protein localization response to oxygen levels regulation of intracellular transport regulation of cell morphogenesis positive regulation of cellular component movement phosphate-containing compound metabolic process hepatocyte apoptotic process glycosyl compound metabolic process regulation of cellular localization ribonucleoside metabolic process defense response generation of neurons response to oxidative stress macromolecule localization apoptotic process protein localization to membrane negative regulation of multi-organism process interspecies interaction between organisms symbiosis, encompassing mutualism through parasitism positive regulation of nitric oxide biosynthetic process negative regulation of actin filament depolymerization 1.31E-04 1.31E-04 1.31E-04 1.34E-04 1.34E-04 1.39E-04 1.41E-04 1.41E-04 1.41E-04 1.42E-04 1.46E-04 1.50E-04 1.51E-04 1.53E-04 1.53E-04 1.73E-04 1.82E-04 1.86E-04 1.92E-04 1.92E-04 1.93E-04 1.93E-04 1.97E-04 2.06E-04 2.06E-04 2.06E-04 2.21E-04 2.21E-04 2.21E-04 2.21E-04 2.21E-04 2.21E-04 2.24E-04 2.37E-04 2.40E-04 2.45E-04 2.49E-04 2.50E-04 13 3 3 13 20 26 4 15 19 21 17 40 19 8 19 9 15 16 10 11 35 31 38 14 26 28 90 16 19 7 12 33 31 55 16 6 18 7 280 4 4 281 635 995 12 376 583 696 478 1964 587 97 588 131 386 437 169 208 1628 1350 1846 343 1025 1155 6241 446 608 74 255 1502 1365 3188 450 50 559 76 0.05 0.75 0.75 0.05 0.03 0.03 0.33 0.04 0.03 0.03 0.04 0.02 0.03 0.08 0.03 0.07 0.04 0.04 0.06 0.05 0.02 0.02 0.02 0.04 0.03 0.02 0.01 0.04 0.03 0.09 0.05 0.02 0.02 0.02 0.04 0.12 0.03 0.09 2.50E-04 3 5 0.60 2.50E-04 2.50E-04 2.52E-04 2.52E-04 2.70E-04 2.76E-04 2.77E-04 2.87E-04 2.90E-04 2.90E-04 3.02E-04 3.10E-04 3.25E-04 3.41E-04 3.44E-04 3.44E-04 3.46E-04 3.61E-04 3.61E-04 3.66E-04 3.66E-04 3.66E-04 3.70E-04 3 11 44 19 23 21 19 47 4 16 37 15 44 44 18 49 32 17 11 26 26 7 6 5 217 2327 617 858 738 622 2575 15 460 1821 411 2356 2361 577 2756 1475 524 228 1072 1072 82 55 0.60 0.05 0.02 0.03 0.03 0.03 0.03 0.02 0.27 0.03 0.02 0.04 0.02 0.02 0.03 0.02 0.02 0.03 0.05 0.02 0.02 0.09 0.11 187 188 189 190 191 192 193 194 195 196 197 198 199 200 positive regulation of nitric oxide metabolic process response to fluid shear stress striated muscle contraction cellular component biogenesis circulatory system process receptor-mediated endocytosis cellular macromolecular complex assembly establishment of protein localization to organelle cellular component assembly cellular response to acid chemical negative regulation of cellular component organization negative regulation of cell death nucleobase-containing small molecule metabolic process regulation of developmental process 3.93E-04 4.05E-04 4.05E-04 4.05E-04 4.05E-04 4.34E-04 4.36E-04 4.37E-04 4.58E-04 4.58E-04 4.61E-04 4.61E-04 5.10E-04 5.10E-04 7 6 9 51 18 14 23 16 48 15 25 31 20 53 83 56 151 2940 587 375 892 480 2715 429 1025 1433 717 3134 0.08 0.11 0.06 0.02 0.03 0.04 0.03 0.03 0.02 0.03 0.02 0.02 0.03 0.02