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Electrochemotherapy treatment of multiple
Basal Cell Carcinomas in a patient with
Gorlin syndrome
Dr Beth Emily Wright, ST4 Dermatology
on behalf of Dr Adam Bray
Mr Antonio Orlando & Dr Chris Herbert
Electrochemotherapy – how it works
Electrochemotherapy – the evidence
of
EvidenceNumber
patients
Author
treated
Intra
venous (IV)
OR Intra
tumour (IT)
Tumour
treated
Complete
response
rate
Follow up
period
Kis et al 2012
3 with Gorlin
(99 tumours)
IV bleomycin
BCC (all
subtypes)
87%
10-28 months
Glass et al
1997
20 (54
tumours)
IT bleomycin
Nodular BCC
94%
14 months
Heller et al
2001
34
IT bleomycin
SCC, Kaposi,
BCC and
Melanoma
Mets
80-95%
20 months
ESOPE study
2006
42 patients
IV / IT
bleomycin &
cisplatin
Any
cutaneous /
subcutaneous
malignancy
73-88%
2-12 months
(median 4)
Discussion - Electrochemotherapy
✗ Discontiguous areas of tumour,
possibly reduce effectiveness of Mohs
surgery
✗ Prolonged secondary intension
healing & post operative swelling
 Treat multiple areas
 Repeat treatments
 Reduce systemic effects of cytotoxic
agent if administered into tumour
directly
✗ Long term effects not known
 May reduce number & size of surgical
excisions
 Minimise facial disfigurement
Thank you for listening
We invite any questions or discussion of
similar experience
References

Kis, E., Baltás, E., Kinyó, Á., Varga, E., Nagy, N., Gyulai, R., Kemény, L. and Oláh, J., 2012. Successful treatment
of multiple basaliomas with bleomycin-based electrochemotherapy: a case series of three patients with GorlinGoltz syndrome. Acta dermato-venereologica, 92(6), pp.649-652.

Glass LF, Jaroszeski M, Gilbert R, Reintgen DS, Heller R. Intralesional bleomycin-mediated
electrochemotherapy in 20 patients with basal cell carcinoma. J Am Acad Dermatol 1997; 37: 596–599.

Heller R, Jaroszeski MJ, Reintgen DS, Puleo CA, DeConti RC, Gilbert RA, et al. Treatment of cutaneous and
subcuta- neous tumors with electrochemotherapy using intralesional bleomycin. Cancer 1998; 83: 148–157.
Rodriguez-Cuevas S, Barroso-Bravo S, Almanza-Estrada J, Cristobal-Martinez L, Gonzalez-Rodriguez E.
Electroche- motherapy in primary and metastatic skin tumors: phase II trial using intralesional bleomycin. Arch
Med Res 2001; 32: 273–276

Landströ m FJ, Nilsson CO, Crafoord S, Reizenstein JA, Adamsson GB, Lö fgren LA. Electroporation therapy of
skin cancer in the head and neck area. Dermatol Surg 2010; 36: 1245–1250

Mir, L.M., Gehl, J., Sersa, G., Collins, C.G., Garbay, J.R., Billard, V., Geertsen, P.F., Rudolf, Z., O’Sullivan, G.C.
and Marty, M., 2006. Standard operating procedures of the electrochemotherapy: instructions for the use of
bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the
Cliniporator TM by means of invasive or non-invasive electrodes. European Journal of Cancer Supplements,
4(11), pp.14-25.