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V1.0 Data sheet for genetically modified lines (GM – strained or non-strained) or strained mutants Articles 23 and 28 Animal Experiments Ordinance (TVV) A. Decision of cantonal authority Decision of cantonal authority on constraint and further breeding of the line (Art. 127 Animal Welfare Ordinance TSchV) Line subject to clarification (no decision of cantonal authority) Non-strained line (no decision of cantonal authority) Strained line - decision of cantonal authority enclosed: Date: B. Number maximum degree of stress: Study director / owner of animal line Study director / owner of the line (of the local population) Surname, first name, institute, address, e-mail, phone C. Details of laboratory animal husbandry C1 Licence number of laboratory animal husbandry (if necessary, licence according to Art. 142 TSchV, Form-G: C2 Husbandry manager Surname, first name Address, e-mail, phone C3 Location of animal husbandry Address D. Basic scientific data D1 Animal species D2 Name of line (Nomenclature according to: http://www.informatics.jax.o rg/mgihome/nomen/ ) Mai 2011 (Art. 114 TSchV) (Annex 2 TVV) ) D3 Genetic modification Type of GM Database reference Literature details Purpose of line D4 Production Producer Method of production Year of production Number of generations Status of breeding (ongoing, stopped, cryo-preserved) D5 Genotype Genotype Genetic background Hygiene status E. Summary of monitoring of constraint (Annex 3 TVV) E1 Status of monitoring of constraint still subject to clarification still subject to clarification / stress provisionally reported completed, not strained completed / constraint definitively reported; decision of authority pending completed / strained line according to decision of authorities (cf. chapter A) E2 Record of constraint Scope of observations conducted Comparison of mortality and reproduction data with those of wild type E3 Phenotype Maximum effective degree of severity (retrospective): Description of the phenotype and the constraint Assessment of constraint Degree of severity and age of occurrence Expression of transgene (dominant/recessive, conditional, inducible) E4 Mitigation of constraint specific needs strain-reducing measures and their expected impact p. 2 / 3 E5 Criteria for withdrawal Euthanasia of strained individuals F. Remarks G. Date and author of revision of data sheet Date Author Contents / reason for revision p. 3 / 3