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OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
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NAME: Qi Yang, MD., PhD
eRA COMMONS USER NAME (credential, e.g., agency login): Yangqi2
POSITION TITLE: Research Scientist, Biomedical Imaging Research Institute
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
Harbin Medical University, Harbin, China
DEGREE
(if
applicable)
B.S. MD
Completion
Date
MM/YYYY
06/2001
Harbin Medical University, Harbin, China
M.S.
06/2006
Capital Medical University, Beijing, China
PhD.
06/2009
INSTITUTION AND LOCATION
FIELD OF STUDY
Medicine
Medical Imaging and
Nuclear Medicine
Medical Imaging and
Nuclear Medicine
A. Personal Statement
I am currently a research scientist at the Department of Biomedical Sciences, Cedars-Sinai Medical Center. The
overall objective of my research is the development and clinical application of cardiovascular MR imaging
techniques. Throughout my >10 year career as an radiologist in China, I have made major contributions to
cardiovascular MR (CMR) imaging in China. Specific research interests include: to develop ultra-fast MRI
techniques to acquire high-resolution images of coronary arteries; to develop MR dark blood vessel wall imaging
including coronary, carotid, intracranial and peripheral arteries. I established and led CMR research programs at
Xuanwu hospital and have been awarded numerous NSFC grants throughout my career, each involving highly
collaborative and multi-disciplinary projects seeking to make a major clinical impact.
As a collaborating investigator in Dr. Li’s proposed project, I will provide clinical input on using MR to validate the
presence of vulnerable plaque features. I have been working on coronary MRA for nine years and accumulated
expertise and extensive hands-on experience in imaging protocol design, and image interpretation. I have full
access to software dedicated to image analysis of plaque morphology and composition. All above make me well
qualified for the role in this application. I look forward to fruitful collaboration with Dr. Li.
B. Positions and Honors
Positions and Employment
2001–2006
Resident of Radiology, 2nd Affiliated Hospital of Harbin Medical University , Harbin, China
2007–2008
Research Associate, Radiology, Northwestern University Medical School, Chicago, IL
2009–2012
Attending Physician of Radiology Department, Xuanwu Hospital, Beijing, China
2012–2014
Associate Chief Physician of Radiology Department, Xuanwu Hospital, Beijing, China
2013–2014
Associate Professor of Radiology Department, Capital Medical University, Beijing, China
2014-present Research Scientist, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los
Angeles
Honors
2007
Certificate of Merit, 93rd Scientific Assembly and Meeting, RSNA
2009
Regional Scholarship for Young Investigator, SCMR Scientific Sessions
2010
E. K. Zavoisky Stipend Award, 18th ISMRM Meeting
2010
James Potchen Award, 22nd International Conference on Magnetic Resonance Angiography
2011
Clinical Stipend Award, 19th ISMRM Meeting
2012
Best Doctoral Dissertation, Ministry of Education of the People's Republic of China
2012
Junior Fellow, 20th ISMRM Meeting
C. Contribution to Science
1. My early research focus was on developing coronary MR angiography (MRA) with slow infusion of
contrast agent. The current gold standard for the assessment of coronary artery disease (CAD) remains
invasive x-ray coronary angiography, which exposes patients to ionizing radiation and involves a risk of
complications. We proved in our research work that contrast-enhanced 3.0T whole-heart coronary MR
angiography has high accuracy in detecting coronary artery. This technique is the first MR approach to
provide isotropic high spatial resolution with a large spatial coverage in a feasible scan time. This
technique is now applied by many researchers and physicians in the world as an approach to
assessment of coronary artery stenosis.
a. Qi Yang, Kuncheng Li, et al., Debiao Li. Contrast-Enhanced Whole-Heart Coronary Magnetic
Resonance Angiography at 3.0-T: A Comparative Study with X-ray Coronary Angiography in a
Single Center. Journal of the American College of Cardiology 2009; 54:69-76
b. Qi Yang, Kuncheng Li, Debiao Li, et al. A preliminary study of the diagnostic performance of 3T contrast
enhanced whole-heart coronary MR angiography. Chinese Journal of Radiology 2009, 43:923-27
c. Qi Yang, Kuncheng Li, Debiao Li, et al. Preliminary study of 3.0 T contrast-enhanced whole heart coronary
MR angiography using 32-channel coils with high acceleration factor. Chinese Journal of Radiology 2010,
44:912-16
d. Himanshu Bhat*, Qi Yang*(co-first), et al., Debiao Li. Contrast-Enhanced Whole-Heart Coronary
Magnetic Resonance Angiography at 3.0-T Using Interleaved Echo Planar Imaging. Investigative
Radiology 2010; 45:458–464
e. Qi Yang, Kuncheng Li, Debiao Li. Coronary MRA: Technical Advances and Clinical Applications. Curr
Cardiovasc Imaging Rep 2011; 4:165–170
a. Qi Yang, Debiao Li. Contrast-Enhanced MR Angiography of the Coronary Arteries. Magnetic Resonance
Angiography: Principles and Application (Chapter 10). ISBN 978-1-4419-1685-3. Jan 2012
b. Yang Q, Li K, Liu X, Du X, Bi X, Huang F, Jerecic R, Liu Z, An J, Xu D, Zheng H, Fan Z, Li D. 3.0T
whole-heart coronary magnetic resonance angiography performed with 32-channel cardiac coils: a
single-center experience. Circulation: Cardiovascular Imaging 2012; 5:573-579.
2. Intracranial vessel wall MR imaging is an area I have contributed to. Technical development in black
blood vessel wall MR imaging which allows characterizing plaque components, and thus assessing
plaque vulnerability. In order to identify vulnerable plaque features indicative of plaque instability, I
developed a high resolution T1-weighted black-blood imaging sequence that offers whole-brain spatial
coverage. A large patient study is being conducted at Xuanwu hospital to validate its clinical value in
stroke etiology. I have also improved susceptibility weighted imaging for atherosclerosis studies. One of
the most important findings of this work is that the different components of plaque appear to have a
unique signature on SWI as do the arterial and venous vessel walls. This helps improving our
understanding of these components and structures, which leads to a much more accurate
determination of atherosclerosis in patients.
a. Fan Z*, Yang Q*(co-first), Deng Z, Shlee S, Bi X, Li D. Whole-brain intracranial vessel wall imaging at 3
Tesla using cerebrospinal fluid-attenuated T1-weighted 3D turbo spin-echo. Magn Reson Med. 2016
March online
b. Qi Yang, Kuncheng Li, E. Mark Haacke, et al. Imaging the Vessel Wall and Calcifications in Major
Peripheral Arteries using Susceptibility Weighted Imaging. Journal of Magnetic Resonance Imaging 2009;
30:357-365
c. Xie G, Bi X, Liu J, Yang Q, Natsuaki Y, Conte A.H., Liu X, Li K, Li D, Fan Z. 3D coronary dark-blood
interleaved with gray-blood (cDIG) magnetic resonance imaging at 3Tesla. Magnetic Resonance in
Medicine 2015 Apr 9.
d. Liu X, Zhang N, Fan Z, Feng F, Yang Q, Zheng H, Liu P, Li D. Detection of infragenual arterial disease
using non-contrast-enhanced MR angiography in patients with diabetes. J Magn Reson Imaging.
2014;40(6):1422-9.
e. Liu X, Fan Z, Zhang N, Yang Q, Feng F, Liu P, Zheng H, Li D. Unenhanced MR angiography of the foot:
initial experience of using flow-sensitive dephasing-prepared steady-state free precession in patients with
diabetes. Radiology. 2014;272(3):885-94.
f. Zou XD, Chung YC, Zhang L, Han Y, Yang Q, Jia J. Middle Cerebral Artery Atherosclerotic Plaques in
Recent Small Subcortical Infarction: A Three-Dimensional High-resolution MR Study. Biomed Res Int.
2015:540217. Epub 2015 Oct 11.
3. Technical development in black-blood Thrombus imaging(BTI). We proposed a black-blood thrombus
imaging methodology (BTI) based on DANTE-prepared 3D TSE. This approach is currently being applied to
cerebral venous thrombosis and deep vein thrombosis. Unlike conventional imaging techniques, BTI directly
targets the thrombus itself and depicts thrombus as hyperintense and other tissues as isointense based on
strong T1 contrast weighting. BTI allows selective visualization of thrombus with high accuracy and holds
promise to provide a valuable alternative to current techniques.
a. Yang Q, Duan J, Fan Z, Qu X, Nguyen C, Bi X, Xie Y, Du X, Li K, Ji X, Li D. Early detection of cerebral
venous and sinus thrombosis by black blood magnetic resonance direct thrombus imaging. Stroke
2016;47:404-9.
b. Xie Y, Yang Q, Xie G, Pang J, Fan Z, Li D. Improved black-blood imaging using DANTE-SPACE for
simultaneous carotid and intracranial vessel wall evaluation. Magn Reson Med. 2015 Jul 8. Epub ahead of
print
Complete List of Published Work in MyBibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/1dW_eGeU9YiAt/bibliography/48726163/public/?sort=date&direction
=ascending
D. Research Support
Youth Project from National Natural Science Foundation of China (NSFC)
2009-2012, total cost: 180,000 RMB
Role: Principal Investigator
Beijing New-star Plan of Science and Technology
2012-2014, total cost: 200,000 RMB
Role: Principal Investigator
Excellent Young Scientist Project from NSFC
2014-2016, total cost: 1000,000 RMB
Role: Principal Investigator
International Collaboration Project from NSFC
"Technical Developments for One-Stop Examination of Coronary Artery Disease Using MRI"
2012-2016, total cost: 2,000,000 RMB
Role: Co-Investigator