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CURRICULUM VITAE JASON M. FOSTER M.D. Business Address University of Nebraska Medical Center Department of Surgery Division of Surgical Oncology Associate Professor 984030 Nebraska Medical Center Work: (402)559-7272; Fax: (402) 559-7900 Email: [email protected] Education 1990-1994 Temple University School of Medicine – Philadelphia, PA 19140 Doctor of Medicine 1986-1990 Bucknell University – Lewisburg, PA 17837 BS, Chemistry Internship/Residency 2001-2002 Chief Resident: Case Western Reserve University/University Hospital of Cleveland, Cleveland, OH. 1994-2002 General Surgery: Case Western Reserve University/University Hospital of Cleveland, Cleveland, OH Fellowship 2004-2005 Gastrointestinal & Mixed Tumor Oncology: Roswell Park Cancer Institute, Buffalo, NY 2002-2004 Surgical Oncology: Roswell Park Cancer Institute, Buffalo, NY 1996-1999 Allen Scholar Basic Science Research Fellowship: Case Western Reserve University/University Hospital, Cleveland, OH 2 Academic Appointments 2010-present Associate Professor of Surgery: Department of Surgical Oncology, University of Nebraska Medical Center, Omaha, NE 2010-present Adjunct Associate Professor of Surgery: Department of Surgical Oncology, Creighton University, Omaha, NE 2006-2010 Assistant Professor of Surgery: Department of Surgical Oncology, Creighton University, Omaha, NE 2002-2006 Clinical Instructor: Department of Surgery, State University of New York at Buffalo, Buffalo, NY 2000-2002 Affiliate Clinical Instructor: Department of Surgery, Case Western Reserve University, Cleveland, OH 1996-2000 Adjunct Clinical Instructor: Department of Surgery, Case Western Reserve University, Cleveland OH Other Employment History 2002-present Fellow: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 1997-1999 Surgical Staff: Department of Surgery, SUMMA Health Systems, Akron, OH 1996-1999 Flight Surgeon: Department of Surgery, Metrohealth Medical Center/ Case Western Reserve University, Cleveland, OH 1994-2002 Resident: Department of General Surgery, Case Western Reserve University/ University Hospitals of Cleveland, Cleveland, OH 1987-1989 Summer Internship (Chemist): Mobay Chemical Corporation, Pittsburgh, PA Board Certification and State Licensures 2004-current 2/9/2024 1996-2005 2002-current 2005-current American Board of Surgery: 48798 Exp: Ohio: 35-07-1662-F New York: 225358-1 Exp: 5/31/2007 Nebraska: 23497 Exp: 10/1/2014 USMLE I,II,III 6/92,9/93,6/95 3 Special Training 2003 2002-2003 2002-2003 techniques 2010 2013 Sentinel Lymph Node Technique Interventional Endoscopy Radiofrequency Ablation Single Site Laparoscopic Surgery Robotic Surgery Training Awards and Honors 2008-2015 2008 1999 1998-1999 Grant 1996-1998 1996-1999 1997 1995 1990 Patient’s Choice Award Physicians CUMC Hospital Promising Young Physician Outstanding Young Americans NIH K-12 Translation Research Oncology Research NIH K-12 Research Oncology Training Grant Dudley P. Allen Scholar Fellow, CWRU Dept. of Surgery 2nd place Abstract/Presentation at 36th Annual Cleveland Surgical Society Invitation to AACR Molecular Biology Workshop Temple University Scholars Physiology Scientific and Medical Societies 2006 2005 2003 2002 2001 2000 1995 1990 2004 2010 2010 2012 North Central Cancer Treatment Group Creighton Medical Society American Society of Clinical Oncology Society of Surgical Oncology American College of Surgeons American Medical Association American Association for Cancer Research Student National Medical Association National Medical Association Southwestern Surgical Association for Academic Surgery Fellow of American College of Surgeons Committees and Organizations 2008-current 2008-2010 My Sister’s Keeper Breast Cancer Survivors Board of Directors Creighton University Colorectal Community Task Force for Screening and Prevention 2007-2010 Creighton University Medical School Education Environment Task Force Committee 2007-2010 Creighton Hospital Pharmacy & Therapeutics Anticoagulation Committee 2006-2008 Creighton University Committee on Cancer 1998-1999 Association of Residents and Fellows President 1998-1999 Graduate Medical Education Council Delegate 1998-2000 SNMA hospital delegate 1997-1999 Minority House Staff Organization Co-president 1997-1998 CWRU Advanced anatomy instructor for 4th year students 4 Clinical Interests Gastrointestinal malignancies – pancreas, biliary, gastric, metastatic liver, CRC Peritoneal metastasis Hyperthermic therapy – HIPEC and ILP/ILI Minimal Invasive GI surgery. Melanoma, Sarcoma & GIST tumor Current Research Interests Discovery of Prognostic Factors and Therapeutic Targets in Malignant Peritoneal Mesothelioma through the Identification of Gene Mutations and Molecular Pathway Perturbations Biological events and molecular signature of EGFR mutations in malignant mesothelioma cancer cells Efficacy of EGFR-TK inhibitors in mesothelioma tumors with and without EGFR mutations Investigation of the biological mechanism of tumor maintenance in colorectal tumors with overexpression of mucin glycoproteins (MUC-1, MUC-2) Role of hyperthermia in cancer therapy Current IRB Approved Investigations: 1. #298-12-EP: Monitoring of Cerebral Saturation During Cytoreductive Surgery (CS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) – Co-PI 2. #647-12-EP: Investigation of outcome of patient with peritoneal metastasis treated with CRS/HIPEC. Principal Investigator 3. #646-12-EP: Confirmation of the safety of epidural anesthesia and catheter use in patients receiving Dextran VTE prophylaxis. Principal Investigator 4. #709-13-EP: Identification of Genes, Pathways, and Mutations Active in Peritoneal Metastasis. Principal Investigator 5. #287-12-EP: Prospective neo-adjuvant REGISTRY trial linking MammaPrint, Subtyping and treatment response: Neoadjuvant Breast Registry - Symphony Trial (NBRST) (pronounced “in breast”). Participant 6. Submitted 2015: Clinical and genetic characterizations of hereditary cancer Principal Investigator Clinical Trials & Registry Trial Active: 2 1. #253-13-EP: Integrated Cancer Repository for Cancer Research (iCaRe ) GI & Abdominal Cancer Registry (GACC). Principal Investigator 2013 5 2. #253-13-EP: Integrated Cancer Repository for Cancer Researcyh (iCaRe2) Melanoma Cancer Registry (MeLCare). Co-Investigator 2016 Pending approval: 3. Peritoneal Metastasis & CRS/HIPEC tumor registry. Submitted February 2016 4. Phase II trial investigating HIPEC & peritoneal lavage in cytologically positive gastric cancer. In process Research Funding/Grants/Donations 2014-current $100,000 Mrs. Bobbye C. Hill Cancer Research Fund University of Nebraska Foundation 2012-current $42,000 Jonathan Platon Cancer Research Fund University of Nebraska Foundation 2006-2009 $225,000 Health Futures Foundations Grant Creighton University/State of Nebraska 2006-2010 $75,000 Center of Excellence Grant Creighton University 2007-2009 $200,000 LB595 Creighton University/State of Nebraska Research Project 1996-1999 Investigation of the autocrine and paracrine biological effects of growth factor TGFβ perturbations in colon cancer that facilitate and inhibit tumor progression Principal Investigator: J. K. V. Willson M.D. Ireland Cancer Center, Case Western Reserve University 1996-1999 Investigation of the autocrine and paracrine biological effects of TGFα up-regulation that facilitates colon cancer progression Principal Investigator: J. K. V. Willson M.D. Ireland Cancer Center, Case Western Reserve University 1991-1993 Role of free radicals in ischemic brain injury and the protective effects of antioxidants Preceptor: Ron Tuma PhD. Temple University School of Medicine 1990-1993 Role of neutrophils in the exacerbation of cerebral ischemia and the protective effects of neutropenia Preceptor: Ron Tuma PhD. Temple University School of Medicine 6 Publications: Peer Reviewed 1. Jaing, D, Yang H, Willson JKV, Liang J, Humphrey LE, Zborowska E, Wang D, Foster J, Fan R, Brattain MG. Autocrine Transforming Growth Factor α Provides a Growth Advantage to Malignant Cells by Facilitating Re-entry into the Cell Cycle from Suboptimal Growth States, 1998, J Biol Chem 273, 31471-9. 2. Ye SC, Foster JM*, Li WH, Liang JR, Zborowska E, Venkateswarlu S, Gong JG, Brattain MG, Willson JKV. Contextual Effects of TGFβ on the Tumorigenicity of Human Colon Carcinoma. 1999, Cancer Res 59, 4725-31. 3. Hurd TC, James T, Foster JM*. Factors Affecting Breast Cancer Treatment: Underserved and Minority Populations. 2005, Surg Oncol Clin North Am 14(1), 119-30. 4. Palesty JA, Foster JM*, Hurd TC, Watroba N, Rezaishiraz H, Edge SB. Axillary Recurrence in Women with a Negative Sentinel Lymph Node and No Axillary Dissection in Breast Cancer. 2006, J Surg Oncol 93, 129-32 5. Foster JM, Integan M, Litwin A, Kuvshinoff B, Gibbs JF. The utilization of laparoscopy to diagnose regenerative nodular hyperplasia, the “great masquerader” of liver tumors. 2006, J Gastrointest Surg 10(5), 727-33 6. Javle M, Yu J, Khoury T, Chadha K, Iyer RV, Kuvshinoff B, Gibbs JG, Geradts J, Foster JM, Black J, Brattain M. Akt expression may predict favorable prognosis in cholangiocarcinoma. 2006, J Gastroenterol Hepatol 21, 1744-51 7. J. Esquivel, R. Sticca, P. Sugarbaker, E. Levine, T.D. Yan and The Peritoneal Surface Malignancy Group: Foster J et al Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement. 2006, Ann Surg Onc 14(1), 128-33 8. Foster JM, Hoshi H, Chu Q, Smith JL, Driscoll D, Nava HR, Gibbs JF. Radical re-resection is indicated for all T2 and T3 gallbladder and results in the same survival as primarily resected gallbladder cancers. 2006, Ann Surg Onc 14(2), 833-40 9. Rajput A, Koterba AP, Kreiserg JI, Foster JM, Willson JKV, Brattain M. A novel EGFR antagonism in vivo. 2007, Cancer Res. Jan 15;67(2):665-73 10. Foster J, Black J, LeVea C, Khoury T, Kuvshinoff B, Javle M, Gibbs JF. Cox-2 expression and EGFR expression with downstream pathway activation are prognostic predictors in hepatocellular carcinoma and are potential targets for biological therapies. 2007, Ann Surg Oncol. Feb;14(2):752-8. Epub 2006 Dec 5 11. Foster JM, Filacoma P, Brady, W, Nava H, Hicks W, Rigual N, Smith J, Loree T, Gibbs JF. The ‘Push’ technique is a safe method for placing percutaneous endoscopic gastrostomy tubes in head and neck cancer patients. 2007, Surg Endosc. Jun;21(6):897-901. Epub 2006 Dec 16 12. Gatalica Z, Foster JM, Loggie BW. HPV associated pseudomyxoma peritonei. Croat Med J. 2008 Oct;49(5):669-73. 13. Foster JM, Gatalica, Z, Lilleberg S, Haynatzki G, Loggie, BW. Novel and existing mutations in the EGF receptor tyrosine kinase domain are predictors of optimal resectability in malignant peritoneal mesothelioma. Ann Surg Oncol. 2009 Jan;16(1):152-8. Epub 2008 Nov 8 7 14. Lynch H, Steve Lanspa S, Sharma P. Gatalica Z, Foster JM. FAP, Gastric Cancer, and Genetic Counseling Featuring Children and Young Adults: A Family Study and Review. Fam Cancer 2010 Dec;9(4):581-8. 15. Foster JM, Uppala R, Carreau JH, Gatalica, Z, Lilleberg S, Loggie, BW. Novel and existing functional mutations in the EGF receptor tyrosine kinase domain are predictors of outcome in malignant peritoneal mesothelioma. World J Surg Oncol. 2010 Oct 13;8:88. 16. Gupta PK, Turaga KK, Gupta H, Miller WJ, Loggie BW, Foster JM. Determinants of Outcomes in Pancreatic Surgery and Related Use of Hospital Resources. J Surg Oncol 2011 Nov 1;104(6):634-40. 17. Gupta PK*, Carreau J*, Loggie, BW, Grotz TE, Gatalica, Z, Sharma P, Foster JM. Routine right hemicolectomy (RHC) may not be indicated in pseudomyxoma peritonei/mucinous appendiceal neoplasm (PMP/MAN). Am Surg 2012 Feb;78(2):171-72011. 18. Turaga K, Levine E, Barone R, Sticca R and The Peritoneal Surface Malignancy Group: Foster J et al Consensus guidelines from the ASPSM on the standardization of the delivery of HIPEC in colorectal cancer patients in the US, Ann Surg Onc 2014 May;21(5):1501-5. 19. Dhir M, Crocket D, Stevens TM, Silberstein P, Hunter W, Foster JM, Efficacy of Neoadjuvant Imatinib in the treatment of unresectable metastatic dermatofibrosarcoma protuberans. Clin Sarcoma Res J August 2014 4-8. 20. Foster JM , Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Patel A. The efficacy of Dextran-40 as a VTE prophylaxis option in CRS/HIPEC surgery. Submitted J Surg Oncol 2015 21. Foster JM, Sleightholm RL, Smith L, Ceelen W, Deraco M, Yildrim Y, Levine E, Munoz C, Ghehen O, Patel A, Esquivel J. The American Society of Peritoneal Surface Malignancies (ASPSM) Evaluation of Peritoneal Surface Disease Score (PSDS) in 1.051 Advanced Ovarian Cancer undergoing CRSHIPEC and evaluation of PSDSS. Re-Submitted February 2016 Ann Surg Oncol 2016 22. Foster JM, Grotz TE, Sleightholm RL, Gatalica, Z, Sharma P, Loggie BW. Analysis of immunohistochemical predictors of outcome in pseudomyxoma peritonei. Resubmitted J Surg Oncol 2016 23. Foster JM , Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Patel A. The efficacy of Dextran-40 as a VTE prophylaxis option in CRS/HIPEC surgery. Submitted Am Surg 2016 24. Foster JM, Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S. Early identification of DPAM in ‘at risk’ MAN patients a new approach to MAN surveillance. Submitted Am Surg 2016 25. El,-Abaseri T, Loggie BW, Foster JM. Novel illustration that MUC-2 over- expression promotes tumor growth by autocrine cellular events and signaling. Submitted J Surg Oncol 201 26. Wilcockson J, Sleightholm RL, Foster JM, Durden FL. Surgical management of metastatic basal cell carcinoma. Submitted J Plast Reconstr Surg 2015 27. Sleightholm RL, Hardie V, Nicholas T, Watley D, Broekhuis J, Wahlmeier S, Foster JM. Defining the safety of epidural pain control in CRS/HIPEC In conjunction with VTE prophylaxis. In preparation J Anesth 2016 28. Broekhuis J, Sleightholm RL, Watley D, Wahlmeier S, Foster JM. Safety and outcomes of cytoreductive surgery and HIPEC in elderly patients with high PCI large volume peritoneal metastasis. In preparation J Surg Oncol 2016 8 29. Watley D, Sleightholm RL, Broekhuis J, Foster JM. HIPEC outcomes in OEC at index surgery, salvage, and palliative CRS/HIPEC. In preparation World J Surg Oncol 30. Chadha KS, Thatikonda C, Schiff M, Miller A, Foster JM, Nava H, Sitrin MD. Outcomes of Percutaneous Endoscopic Gastrostomy Tube Placement using the Brown-Muller T-fastener technique in Head and Neck and Esophageal Cancer Patients. In preparation J Parent Ent Nut Publications: Book Chapters 1. Yi, B, Foster JM, Loggie BW. Hyperthermic Intraperitoneal Chemotherapy in Nongynecologic Cancer. Current Clinical Oncology: Intra-peritoneal Cancer Therapy. 2007 2. Foster JM, Nava H, Hicks W, Gibbs J, Indications for pre- or peripercutaneous endoscopic gastrostomy tubes (PEG) and predictors of prolonged enteral feeding in head and neck cancer patients treated with surgical extirpiration. InTech: Gastrotomy. 2011 Publications in development Patel A; Batra S; Cushman-Volkoun A; Foster JM. Identifying glycoprotein signatures in peritoneal metastasis. Cushman-Volkoun A; Batra S; Foster JM. Identifying gene mutation and gene expression in peritoneal metastasis. Sleightholm RA; Patel A; Bodkin T; Burke A; Foster JM. Home Start Parental Nutrition Therapy is safe, cost effective strategy improving outcomes and reduces admissions/readmissions Burt JJ; Sleightholm RA; Patel A; Eastman S; Foster JM. The development of a RediVac (ambulatory wound vac therapy) improves outcomes and reduces cost and readmission. Published Abstracts and Presentations 1. Foster JM, Willis J, Brattain MG, Willson JKV. TGFα overexpression results in in vivo progression of colon cancer cells. 36th Annual Cleveland Surgical Society 1998 2. Foster JM, Willis J, Brattain MG, Willson JKV. TGFα overexpression results in in vivo progression of weakly tumorigenic human colon cancer cells. Digestive Disease Week (DDW) 1998 3. Foster JM, Willis J, Venkaeswarlu S, Lin Y, Ferguson K, Zboroskwa E, Brattain MG, Willson JKV. Ectopic TGFα expression in colon non-tumorigenic cancer cells results in in vivo progression by induction of angiogenesis, proliferation and the inhibition of apoptosis. 90th Annual AACR Meeting 1999 4. Hoshi H, Foster JM, Chu Q, Kuvshinoff B, Rajput A, Driscoll D, Nava HR, Gibbs JF. Radical re-resection is indicated for all T2 and T3 gallbladder and results in the same survival as primarily resected gallbladder cancers. SSO 2004 9 5. Foster JM, Hoshi H, Chu Q, Kuvshinoff B, Rajput A, Driscoll D, Nava HR, Gibbs JF. Radical re-resection is indicated for all T2 and T3 gallbladder and results in the same survival as primarily resected gallbladder cancers. Winter Gastrointestinal American of Clinical Oncology (ASCO-GI) 2005 6. Foster JM, Black J, LeVea C, Kuvshinoff B, Gibbs JF, Javle M. COX-2 and EGFR expression are common in hepatocellular carcinoma supporting biological targeted therapy directed at these pathways. Winter ASCO-GI 2005 7. Palesty JA, Foster JM, Kraybill WG, Banka T, Sheldon DG, Driscoll D, Kane JM. Melanoma patients and incidence of non-melanoma malignancies. SSO 2005 8. Rajput A, Wang J, Foster JM, Dawson D, Willis J, Brattain M, Wilson JKV. The role of autocrine transforming growth factor alpha in epidermal growth factor receptor mediated tumorigenicity. Society of University Surgeons 2006 9. Foster JM, Black J, LeVea C, Khoury T, Kuvshinoff B, Javle M, Gibbs JF. Cox-2 expression and EGFR expression with downstream pathway activation are prognostic predictors in hepatocellular carcinoma and are potential targets for biological therapies. Winter ASCO-GI 2006 10. Foster JM, Black J, LeVea C, Khoury T, Kuvshinoff B, Javle M, Gibbs JF. Cox-2 expression and EGFR expression with downstream pathway activation are prognostic predictors in hepatocellular carcinoma and are potential targets for biological therapies. Oral Plenary Session III SSO 2006 11. Foster JM, Filacoma P, Brady B, Nava H, Hill H, Hicks W, Rigual N, Loree T, Gibbs JF. Defining the indications for prophylactic percutaneous endoscopic gastrostomy tubes in head and neck cancer patients. SSO 2006 12. Foster JM, Gatalica, Z, Lilleberg S, Haynatzki G, Loggie, BW. Novel and existing mutations in the EGF receptor tyrosine kinase domain are predictors of optimal resectability (OR) in malignant peritoneal mesothelioma (MPM). Winter ASCO-GI 2007 13. Foster JM, Gatalica, Z, Lilleberg S, Haynatzki G, Loggie, BW. Novel and existing mutations in the EGF receptor tyrosine kinase domain are predictors of optimal resectability (OR) in malignant peritoneal mesothelioma (MPM). Oral Session Second International Symposium on Regional Cancer Therapies. 2007 14. Foster JM, Gatalica, Z, Lilleberg S, Haynatzki G, Loggie, BW. Novel and existing mutations in the EGF receptor tyrosine kinase domain are predictors of optimal resectability (OR) in malignant peritoneal mesothelioma (MPM). Oral Session SSO 2007 15. Foster JM, Gatalica, Z, Lilleberg S, Haynatzki G, Loggie, BW. Novel and existing mutations in the EGF receptor tyrosine kinase domain are predictors of optimal resectability (OR) in malignant peritoneal mesothelioma (MPM). Oral (Discussion) Session ASCO 2007 16. Foster JM, Grotz TE, Turaga KK, Gatalica, Z, Sharma P, Loggie, BW. Analysis of immunohistochemical predictors of outcome in pseudomyxoma peritonei. Winter ASCO-GI 2008 17. Foster JM, El,-Abaseri T, Loggie BW. Novel illustration that MUC-2 overexpression promotes tumor growth by autocrine cellular events and signaling. Winter ASCO-GI 2008 10 18. Foster JM, Grotz TE, Turaga KK, Gatalica, Z, Sharma P, Loggie, BW. Analysis of immunohistochemical predictors of outcome in pseudomyxoma peritonei. Oral Session Third International Symposium on Regional Cancer Therapies. 2008 19. Foster JM, El,-Abaseri T, Loggie BW. Novel illustration that MUC-2 overexpression promotes tumor growth by autocrine cellular events and signaling. Oral Session Third International Symposium on Regional Cancer Therapies. 2008 20. Foster JM, Grotz TE, Turaga KK, Gatalica, Z, Sharma P, Loggie, BW. Analysis of immunohistochemical predictors of outcome in pseudomyxoma peritonei. SSO 2008 21. El,-Abaseri T, Foster JM, Loggie BW. MUC-2 over-expression promotes tumor growth by autocrine cellular events and signaling. AACR 2008 22. Foster JM, Gupta P, Carreau J, Grotz TE, Gatalica, Z, Sharma P, Loggie, BW. Routine right hemicolectomy (RHC) may not be indicated in pseudomyxoma peritonei/mucinous appendiceal neoplasm (PMP/MAN). Winter ASCO-GI 2009 23. Foster JM, El-Abaseri T, Loggie BW. MUC-2 overexpression in colorectal cancer promotes tumor survival by regulation of Caspase-8 and Akt expression. Winter ASCO-GI 2009 24. Foster JM, Uppala P, Govindarajan V, Carreau J, Gatalica, Z, Lillleberg S, Nath S, Loggie BW. Novel and existing activating EGFR mutations are predictive of a ‘relative’ improved survival in malignant peritoneal mesothelioma (MPM) and responsive to EGFR-TK inhibitors (EGFR-TKI). Oral Session Fourth International Symposium on Regional Cancer Therapies. 2009 25. Foster JM, Gupta P, Carreau J, Grotz TE, Gatalica, Z, Sharma P, Loggie, BW. Routine right hemicolectomy (RHC) may not be indicated in pseudomyxoma peritonei/mucinous appendiceal neoplasm (PMP/MAN). Oral Session Fourth International Symposium on Regional Cancer Therapies. 2009 26. Foster JM, El-Abaseri T, Loggie BW. MUC-2 overexpression in colorectal cancer promotes tumor survival by regulation of Caspase-8 and Akt expression. SSO 2009 27. Lilleberg SL, Foster JM, Uppala R, Govindarajan V, Gatalica Z, Loggie BW. Malignant Peritoneal Mesotheliomas Harbor Somatic Mutations in EGFR, MET, and several Gate-Keeper Genes: Potential Predictive and Prognostic Markers for Focused Treatment Strategies. SSO 2009 28. Lilleberg SL, Foster JM, Uppala R, Govindarajan V, Gatalica Z, Loggie BW. Malignant Peritoneal Mesotheliomas Harbor Somatic Mutations in EGFR, MET, and several Gate-Keeper Genes: Potential Predictive and Prognostic Markers for Focused Treatment Strategies. AACR 2009 29. Lilleberg SL, Foster JM, Uppala R, Govindarajan V, Gatalica Z, Loggie BW. Analysis of Pseudomyxoma Peritonei and Appendiceal Adenocarcinomas reveal Somatic Mutations of Key Genes within the MAPK, AKT, and WNT Signaling Pathways: Potential Prognostic and Predictive Markers for Focused Treatment Strategies. AACR 2009 30. Foster JM, Uppala P, Govindarajan V, Carreau J, Gatalica, Z, Lillleberg S, Nath S, Loggie BW. Novel and existing activating EGFR mutations are predictive 11 of a ‘relative’ improved survival in malignant peritoneal mesothelioma (MPM) and responsive to EGFR-TK inhibitors (EGFR-TKI). Oral (Discussion) Session ASCO 2009 31. Foster JM, Gupta P, Blas JT, Carreau J, Grotz TE, Loggie, BW. Venous thromboembolism prophylaxis with Sequential compression devices, Early ambulation, and Dextran (SEED) is a safe, effective and easily reversible surgical prophylaxis intervention in peritoneal carcinomatosis management. Winter ASCO-GI 2010 32. Foster JM, Gupta P, Blas JT, Carreau J, Grotz TE, Loggie, BW. Venous thromboembolism prophylaxis with Sequential compression devices, Early ambulation, and Dextran (SEED) is a safe, effective and easily reversible surgical prophylaxis intervention in peritoneal carcinomatosis management. Oral Session 5th International Symposium on Regional Cancer Therapies. 2010 33. Foster JM, Carreau J, Loggie BW. The utility of laparoscopy in early Pseudomyxoma Pertonie (PMP). Oral Session 5th International Symposium on Regional Cancer Therapies. 2010 34. El-Abaseri T, Thomas P, Loggie BW, Foster JM. MUC-2 overexpression in colorectal cancer promotes tumor survival by regulation of Caspase-8 and akt expression. MUC2 Oral Session 5th International Symposium on Regional Cancer Therapies. 2010 35. Gupta P, Carreau J, Grotz TE, Gatalica, Z, Sharma P, Loggie, BW, Foster JM. Routine right hemicolectomy (RHC) may not be indicated in pseudomyxoma peritonei/mucinous appendiceal neoplasm (PMP/MAN). South Eastern Surgical Conference. 2010 36. Gupta P, Blas JT, Carreau J, Grotz TE, Loggie BW, Foster JM. Venous thromboembolism prophylaxis with Sequential compression devices, Early ambulation, and Dextran (SEED) is a safe, effective and easily reversible surgical prophylaxis intervention in peritoneal carcinomatosis management. South Eastern Surgical Conference. 2010 37. Gupta PK, Turaga KK, Gupta H, Miller WJ, Loggie BW, Foster JM. Determinants of Resource Utilization In Pancreatoduodenectomy: A Multicenter Analysis Of 1467 Patients. SSO 2010 38. Gupta PK, Gupta H, Turaga KK, Miller WJ, Loggie BW, Foster JM. Predictors of Pulmonary and Cardiac Complications Following Pancreatoduodenectomy for Cancer. SSO 2010 39. Foster JM, Uppala P, Govindarajan V, Carreau J, Gatalica, Z, Lillleberg S, Nath S, Loggie BW. Novel and existing activating EGFR mutations are predictive of a ‘relative’ improved survival in malignant peritoneal mesothelioma (MPM) and responsive to EGFR-TK inhibitors (EGFR-TKI). Oral. 10th Annual Mesothelioma Foundation meeting. 2010 40. Foster JM, Role of Neoadjuvant Chemotherapy in carcinomatosis arising from high grade appendix adenocarcinoma. Oral Session Sixth International Symposium on Regional Cancer Therapies. 2011 41. Bodkin T, Burke A, Skiedziel P, Tanner J, Foster JM. Collaboration between Referring Providers and Home Infusion Company Clinicians can Improve Outcomes and Avoid Hospital Admissions for Patients Requiring Home Parenteral Nutrition and May Represent a Safe, More Cost Effective Strategy. ASPEN Clinical Nutrition meeting 2012 12 42. El-Abaseri T, Brattain M, Howell G, Foster JM. Extracellular mucin MUC2 promotes colon cancer growth and transformation in non-mucinous and mucinous cancer cells. Regional Cancer Therapies 2013 43. Foster JM, Subbiah SP, Commers J, Fahed R. Is CRS & HIPEC a safe and effective palliative treatment strategy in patients with refractory symptomatic peritoneal metastasis? Regional Cancer Therapies. 2013 44. Foster JM, Subbiah SP, Commers J, Fahed R. Outcomes of untreated Stage IV Ovarian cancer patients treated with HIPEC and one case treated with synchronous HIPEC/HITHOC. Regional Cancer Therapies. 2013 45. Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Foster JM. Defining the safety of epidural pain control in CRS/HIPEC in conjunction with VTE prophylaxis. . The American Physician Scientists Association (APSA) (poster). 2014- 2015 46. Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Foster JM. Defining the safety of epidural pain control in CRS/HIPEC in conjunction with VTE prophylaxis. Regional Cancer Therapies (poster). 2014- 2015 47. Watley D, Sleightholm RL, Broekhuis J, Foster JM. HIPEC outcomes in OEC at index surgery, salvage, and palliative CRS/HIPEC. Regional Cancer Therapies. Regional Cancer Therapies (oral). 2014- 2015 48. Foster JM, Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S. Early identification of DPAM in ‘at risk’ MAN patients a new approach to MAN surveillance. Regional Cancer Therapies (poster). 2014- 2015 49. Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Foster JM. Safety and outcomes of cytoreductive surgery and HIPEC in elderly patients with high PCI large volume peritoneal metastasis. Regional Cancer Therapies. 2014- 2015 50. Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Foster JM. Defining the safety of epidural pain control in CRS/HIPEC in conjunction with VTE prophylaxis. 2014- 2015 51. Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Foster JM. Defining the safety of epidural pain control in CRS/HIPEC in conjunction with VTE prophylaxis. SWSC Quick Shot Oral Presentation. 2014- 2015 52. Watley D, Sleightholm RL, Broekhuis J, Foster JM. HIPEC outcomes in OEC at index surgery, salvage, and palliative SWSC Poster. CRS/HIPEC. 2014 53. Wahlmeier S, Sleightholm RL, Watley D, Broekhuis J, Foster JM. Early identification of DPAM in ‘at risk’ MAN patients a new approach to MAN surveillance. SWSC Poster. 2014- 2015 54. Broekhuis J, Sleightholm RL, Watley D, Wahlmeier S, Foster JM. Safety and outcomes of cytoreductive surgery and HIPEC in elderly patients with high PCI large volume peritoneal metastasis. SWSC Poster. 2014- 2015 55. Sleightholm RL, Watley D, Broekhuis J, Wahlmeier S, Foster JM. Defining the safety of epidural pain control in CRS/HIPEC in conjunction with VTE prophylaxis. Midwest Student Biomedical Research Forum. 2014- 2015 56. Watley D, Sleightholm RL, Broekhuis J, Foster JM. HIPEC outcomes in OEC at index surgery, salvage, and palliative CRS/HIPEC. Midwest Student Biomedical Research Forum. 2014- 2015 57. Wahlmeier S, Sleightholm RL, Watley D, Broekhuis J, Foster JM. Early identification of DPAM in ‘at risk’ MAN patients a new approach to MAN surveillance. Midwest Student Biomedical Research Forum. 2014- 2015 13 58. Broekhuis J, Sleightholm RL, Watley D, Wahlmeier S, Foster JM. Safety and outcomes of cytoreductive surgery and HIPEC in elderly patients with high PCI large volume peritoneal metastasis. Midwest Student Biomedical Research Forum. 2014- 2015 59. Patel A, Sukhwinder Kaur, Yuri Sheinin, Batra S, Foster JM. Evaluation of glycoprotein expression profiles in peritoneal metastases as a potential therapeutic target. 2015-16 60. Patel A, Cushman-Vokoun A, Sleightholm RL, Foster JM. Exploration of mutations in GI cancers with peritoneal metastasis. Regional Cancer Therapies Oral 2015-16 61. Sleightholm RL, Burt J, Watley D, Wahlmeier S, Foster JM. Reducing VTE event rates in complex abdominal cancer surgery: A retrospective, single institute comparison of dextran vs. heparin. ASCO 2015-16 Editorial Board 2010-current Journal of Surgical Oncology Invited 2015 Journal of Surgery and Operative Care Ad Hoc Journal Reviewer Cancer Annals of Surgical Oncology Journal of Surgical Oncology European Journal of Cancer European Journal of Surgical Oncology World Journal of Surgical Oncology Tumor Biology Asian-Pacific Journal of Hematology & Oncology Hernia Journal Invited Lectures 1. Contextual Effects of TGFβ on the tumorigenicity of Human Colon Carcinoma. Surgical Grand Rounds University Hospital of Cleveland, Case Western Reserve University 1997 2. The role of TGFα in colon cancer tumorigenesis and progression. Surgical Grand Rounds University Hospital of Cleveland, Case Western Reserve University 1998 3. Management of function and non-functional neuroendocrine tumors of the pancreas. Oncology Lecture Series MetroHealth Medical Center, Case Western Reserve University 1999 4. Current management of congenital tracheal-esophageal fistulas. Pediatric Grand Rounds Cleveland Clinic/MetroHealth Medical Center, Case Western Reserve University 2000 5. Total Mesorectal Excision in the management rectal cancer is superior to Conventional resection with radiation. Oncology Lecture series MetroHealth Medical Center, Case Western Reserve University 2001 14 6. Current Management of Gallbladder: What have the past 50 years taught us? Roswell Park Cancer Institute Surgical Grand Rounds 2003 7. The Role of Brachytherapy for sarcoma management. Roswell Park Cancer Institute Medical & Surgical Oncology joint lecture series 2004 8. Surgical management of hepatic neuroendocrine disease in the new millennium. Roswell Park Cancer Institute Surgical Grand Rounds 2004 9. Current Management of Gallbladder: What have the past 50 years taught us? State University of Buffalo Department of Surgery 2004 10. Advances in Breast cancer that have revolutionized the management of the disease. Fourth Annual Women Issues in the 21st Century sponsored by Creighton University October 7, 2005 11. Innovations in Surgical Oncology—Hyperthermic Therapy. Creighton University Department of Surgery Grand Rounds, June 12, 2006 12. Contemporary management of Melanoma & Sarcoma. Keynote Speaker at Metro Omaha Coder’s Association (MOCA) Creighton University November 10, 2006 13. The prevention and management of Skin and Colon Cancer. Senior Partner Seminar Creighton University January 27, 2007 14. Updates in Colorectal cancer detection and treatment. 2nd Annual: Surgical Techniques for Primary Care Physicians, Creighton University February 9, 2007 15. Diagnosis and management of Gastric and Pancreatic Cancer. Senior Partner Seminar Creighton University June 23rd, 2007 16. Diagnosis and management of melanoma and colorectal cancer. Offutt Air Force base Family Practice Grand Rounds February 6th 2008 17. Translational Research in Surgical Oncology. Creighton University Department of Surgery Grand Rounds, May 19th, 2008 18. The prevention and management of colorectal cancer. Creighton Community Health Center Health Fair June 13th, 2008 19. Common Cancer in women: prevention, screening, and management. Women’s Health Conference June 21, 2008 20. Contemporary screening strategies in oncology. Creighton Community Health Center Health Seminar July 11, 2008 21. Translational Research: MUC-2 in PMP & EGFR mutations in Mesothelioma. Creighton University Department of Surgery presentation to visiting professor—Timothy R. Billiar MD July 21st, 2008 22. My Sister’s Keeper Annual Breast Cancer Survivor Banquet: Chaired Round Table Discussion on Contemporary management of Breast Cancer October 2008 23. The current role of CRS/IPHC in the management of appendix and colorectal peritoneal surface disease. UNMC 4th Annual Thoracic and GI Conference September 30, 2009 24. Contemporary Management of Peritoneal Surface Malignancies- Part I (Appendix & Colorectal cancer). UNMC Grand Rounds December 16, 2009 25. Introduction to Peritoneal Surface Malignancies. UNMC OR Staff Education Conference March 17, 2010 26. Introduction to Peritoneal Surface Malignancies. UNMC ICU Staff Education Conference April 7 & 8, 2010 15 27. Contemporary Management of Peritoneal Surface Malignancies- Part (Appendix & Colorectal cancer). CUMC Grand Rounds April 17, 2010 28. Role of EGFR in Hepatocellular and Mesothelioma abdominal carcinomas. . Department of Surgery Weekly Research Forum May 26 2010 29. Introduction to Peritoneal Surface Malignancies. UNMC OR Peri-operative Staff Education Conference April 7 & 8, 2010 30. Introduction to Peritoneal Surface Malignancies. UNMC Oncology Nursing Staff Education Conference April 7 & 8, 2010 31. Management of patients with Peritoneal Surface Malignancies. AORN quarterly meeting Nebraska Chapter February 9, 2011 32. Management of patients with Peritoneal Surface Malignancies. Infuscience home health education conference February 15 2011 33. Contemporary Management of Peritoneal surface malignancies. Ob-Gyn Grand Rounds March 6, 2011 34. Innovations in management of peritoneal surface malignancies. Optum Conference July 26th, 2011. 35. Peritoneal Surface Malignancies Ripe for Research. UNMC Pathology Grand Rounds, March 3, 2012 36. Innovations in management of peritoneal surface malignancies. UNMC Oncology Nursing Fellowship Education, March 5, 2012 37. Innovations in management of peritoneal surface malignancies. UNMC Retired Physician Breakfast, April 11, 2012 38. Foraging the frontiers of peritoneal surface malignancies, Wisconsin Surgical Club, May 14, 2012 39. Peritoneal Surface Malignancies from a ‘Peritonealist’s’ Perspective: Optimization of management & opportunities for translational research. University of Maryland Oncology Grand Rounds, Visit Professor June 25, 2012 40. The role of home health care in improving patient outcomes. Annual Bioscrip National Meeting, Invited Speaker October 2, 2012 41. Homestart TPN -- Keeping patients out of the hospital with cost effective HHS. Annual Infuscience/UNMC Transplant & Oncology Meeting, May 9, 2013 42. Innovations in the Management of PSM – CRS & HIPEC. UNMC Patient Outreach & Development Lecture Series September 24, 2013 43. Regional Cancer Therapies in the Management of Metastasis—Another Example of Personalized Therapy. Marshall University Surgery Grand Rounds October 2, 2013. 44. Surgical Management of Appendiceal Tumors. 8th Annual UNMC Thoracic & GI Oncology Conference October 4th, 2013 45. Era of Personalized Oncology. UNMC Medical Student Surgical Society Interest group February 4, 2014 46. Regional Cancer Therapies in the Management of Metastasis—Another Example of Personalized Therapy. The Nebraska State Assembly of the Association of Surgical Technologist (NESA AST) Winter Assembly March 1, 2014. 47. Role of Adjuvant or Neoadjuvant Targeted Therapy in Peritoneal Mesothelioma: Is it time to study this? International Symposium on Malignant Mesothelioma March 7th 2014 (Invited) 16 48. Contemporary Management of Cutaneous Melanoma. UNMC Family Medicine Grand Rounds. March 23, 2014. 49. Personalized Therapy in Advanced Malignancies: Indications and Utility of Regional Surgical Therapies. UNMC 5-West Staff Education Conference July 11, 2014. 50. Contemporary Management of Cutaneous Melanoma. UNMC Surgery Grand Rounds. July 16, 2014. 51. Role of HIPEC in Peritoneal Mesothelioma Management. Panel Discussion Leader, International Symposium on Malignant Mesothelioma, March 7, 2015, Invited. 52. Personalized Surgical Therapy in Advanced and Metastatic Cancer. American Academy of Professional Coders—AAPC Quarterly Meeting, May 19, 2015. 53. Utilizing Cytoreductive Surgery in the Management of Colorectal Cancer. 10th Annual UNMC Thoracic & GI Oncology Conference, October 9, 2015. 54. Contemporary Management of Cutaneous Melanoma. UNMC Plastic Surgery Grand Rounds, February 10, 2016. 55. Skin Cancer Diagnosis, Management and Coding. American Academy of Professional Coders—AAPC Quarterly Meeting, March 15, 2016. 56. Personalized Surgical Therapy in Advanced and Metastatic Cancer. Nebraska Association of Nurse Anesthetists (NANA), April 9, 2016. 57. Contemporary Management of Cutaneous Melanoma, Advances in Primary, Nodal and Advance Disease, NANA, April 9, 2016. 58. Peritoneal Metastasis Management: A Field Rooted in Personalized Care & Robust with Research Opportunities. UNMC Pathology and Microbiology Grand Rounds, May 2016 59. ICU Management Considerations in Cytoreductive Surgery & HIPEC. UNMC ICU Staff Education Conference, May 2016. 60. Topic to be determined. Leader, International Symposium on Malignant Mesothelioma, May 20, 2016. Invited. 61. Peritoneal Metastasis Management: A Field Rooted in Personalized Care & Robust with Research Opportunities including Advance Reconstruction. UNMC, Plastic Surgery Grand Rounds, June 10, 2016.