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Mean Percentage of cells staining posi3vely for immune cell markers 30 25 * * 20 Primary Tumor Tumor cell islets Primary Tumor Stroma 15 Metastases Tumor cell islets Metastases Stroma 10 * * 5 0 CD4+ cells CD8+ cells CD8/4 ra3o CD11c+ cells CD68+ cells CD8/68 ra3o CD163+ cells Supplementary Figure 1. Mean percentage of cells staining posi1vely for immune cell markers related to the total nucleated cell count in primary tumors (tumor cell islets and tumor stroma) and matched metastases (tumor cell islets and tumor stroma). Bars represen1ng standard error of the mean. Sta1s1cally significant differences are indicated by an asterisk. Supplementary Table 1. Clinicopathological Characteris1cs Characteris3cs Age mean (range) 62 (44-­‐72) Sex 21 (61.8%) 13 (38.2%) Male Female Ini1al stage I A/B II A/B IIIA IV 14 (41.2%) 11 (32.4%) 8 (23.5%) 1 (2.9%) Histology Adenocarcinoma Squamous cell carcinoma Large cell carcinoma Large cell neuroendocrine carcinoma 20 (58.8%) 11 (32.4%) 2 (5.9%) 1 (2.9%)